Inadequate gastric preparation and its associated factors for magnetically controlled capsule endoscopy

Qing-Zhou Kong, Cheng Peng, Zhen Li, Bao-Ling Tian, Yue-Yue Li, Fei-Xue Chen, Xiu-Li Zuo, Yan-Qing Li, Qing-Zhou Kong, Cheng Peng, Zhen Li, Bao-Ling Tian, Yue-Yue Li, Fei-Xue Chen, Xiu-Li Zuo, Yan-Qing Li

Abstract

Goals: To explore factors associated with inadequate gastric preparation for MCE. Background: Factors associated with inadequate gastric preparation for magnetically controlled capsule endoscopy (MCE) remains unclear. Study: Data of patients who underwent MCE from June 2021 to July 2022 were prospectively collected. The gastric cleanliness score (GCS) of the six stomach regions (gastric cardia, fundus, body, angulus, antrum, and pylorus) was recorded. Patients with GCS score ≥18 were defined as the adequate preparation. Factors related to inadequate gastric preparation were analyzed using a logistic regression model with estimated odds ratios (OR). Results: The mean GCS score of 211 patients was 17.01 ± 2.82. In the multivariable analysis, proton pump inhibitor (PPI) use (OR 3.57; 95% CI 1.69-7.95; p < 0.01) and premedication time after administering simethicone <30 min (OR 2.86; 95% CI 1.10-7.39; p = 0.03) were independent risk factors for inadequate gastric preparation. Comparing the gastric cleanliness of different locations, the median GCS of the lower stomach [10.00, IQR (9.50, 11.00)] was significantly higher than that of the upper stomach [7.00, IQR (6.00, 8.00)] (p <0.001). Conclusion: PPI use and inadequate premedication time (<30 min) may reduce the quality of gastric preparation for MCE. The type, dose, duration of medication, and discontinuation time of PPIs was well worth further exploration. Appropriate control of the type and time of premedication may be the key to improving overall gastric cleanliness.

Keywords: gastric disease; magnetically controlled capsule endoscopy; preparation; proton pump inhibitor; simethicone.

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Copyright © 2023 Kong, Peng, Li, Tian, Li, Chen, Zuo and Li.

Figures

FIGURE 1
FIGURE 1
The 4-point grading scales for the gastric cleanliness of six gastric landmarks in MCE.
FIGURE 2
FIGURE 2
Comparison of upper and lower gastric cleanliness score. The median GCS of lower stomach was significantly higher than that of upper stomach (*** represents p <0.001).

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