Defective CD8 T cell memory following acute infection without CD4 T cell help
Joseph C Sun, Michael J Bevan, Joseph C Sun, Michael J Bevan
Abstract
The CD8+ cytotoxic T cell response to pathogens is thought to be CD4+ helper T cell independent because infectious agents provide their own inflammatory signals. Mice that lack CD4+ T cells mount a primary CD8 response to Listeria monocytogenes equal to that of wild-type mice and rapidly clear the infection. However, protective memory to a challenge is gradually lost in the former animals. Memory CD8+ T cells from normal mice can respond rapidly, but memory CD8+ T cells that are generated without CD4 help are defective in their ability to respond to secondary encounters with antigen. The results highlight a previously undescribed role for CD4 help in promoting protective CD8 memory development.
Figures
![Fig. 1](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2778341/bin/nihms155804f1.jpg)
![Fig. 2](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2778341/bin/nihms155804f2.jpg)
![Fig. 3](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2778341/bin/nihms155804f3.jpg)
Source: PubMed