Technology-based cognitive training and rehabilitation interventions for individuals with mild cognitive impairment: a systematic review

Shaoqing Ge, Zheng Zhu, Bei Wu, Eleanor S McConnell, Shaoqing Ge, Zheng Zhu, Bei Wu, Eleanor S McConnell

Abstract

Background: Individuals with mild cognitive impairment (MCI) are at heightened risk of developing dementia. Rapid advances in computing technology have enabled researchers to conduct cognitive training and rehabilitation interventions with the assistance of technology. This systematic review aims to evaluate the effects of technology-based cognitive training or rehabilitation interventions to improve cognitive function among individuals with MCI.

Methods: We conducted a systematic review using the following criteria: individuals with MCI, empirical studies, and evaluated a technology-based cognitive training or rehabilitation intervention. Twenty-six articles met the criteria.

Results: Studies were characterized by considerable variation in study design, intervention content, and technologies applied. The major types of technologies applied included computerized software, tablets, gaming consoles, and virtual reality. Use of technology to adjust the difficulties of tasks based on participants' performance was an important feature. Technology-based cognitive training and rehabilitation interventions had significant effect on global cognitive function in 8 out of 22 studies; 8 out of 18 studies found positive effects on attention, 9 out of 16 studies on executive function, and 16 out of 19 studies on memory. Some cognitive interventions improved non-cognitive symptoms such as anxiety, depression, and ADLs.

Conclusion: Technology-based cognitive training and rehabilitation interventions show promise, but the findings were inconsistent due to the variations in study design. Future studies should consider using more consistent methodologies. Appropriate control groups should be designed to understand the additional benefits of cognitive training and rehabilitation delivered with the assistance of technology.

Keywords: Cognition; Cognitive rehabilitation; Cognitive training; Systematic review; Technology.

Conflict of interest statement

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Competing interests

The authors declare that they have no competing interests.

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Figures

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PRISMA Flow Chart

References

    1. Alzheimer's Disease International: World Alzheimer Report 2016. In.; 2016.
    1. Prince M, Guerchet M, Prina M. The epidemiology and impact of dementia: current state and future trends. Geneva: World Health Organization; 2015.
    1. Gates NJ, Sachdev PS, Singh MAF, Valenzuela M. Cognitive and memory training in adults at risk of dementia: a systematic review. BMC Geriatr. 2011;11(1):55. doi: 10.1186/1471-2318-11-55.
    1. The White House Office of the Press Secretary: FACT SHEET: the white house conference on Aging 2015. In.; 2015.
    1. Petersen RC. Mild cognitive impairment as a diagnostic entity. J Intern Med. 2004;256(3):183–194. doi: 10.1111/j.1365-2796.2004.01388.x.
    1. Feldman HH, Jacova C. Mild cognitive impairment. Am J Geriatr Psychiatry. 2005;13(8):645–655. doi: 10.1097/00019442-200508000-00003.
    1. Jean L, Bergeron M-È, Thivierge S, Simard M. Cognitive intervention programs for individuals with mild cognitive impairment: systematic review of the literature. Am J Geriatr Psychiatry. 2010;18(4):281–296. doi: 10.1097/JGP.0b013e3181c37ce9.
    1. Zheng G, Xia R, Zhou W, Tao J, Chen L. Aerobic exercise ameliorates cognitive function in older adults with mild cognitive impairment: a systematic review and meta-analysis of randomised controlled trials. Br J Sports Med. 2016;50(23):1443. doi: 10.1136/bjsports-2015-095699.
    1. Belleville S. Cognitive training for persons with mild cognitive impairment. Int Psychogeriatr. 2008;20(1):57–66. doi: 10.1017/S104161020700631X.
    1. Reijnders J, van Heugten C, van Boxtel M. Cognitive interventions in healthy older adults and people with mild cognitive impairment: a systematic review. Ageing Res Rev. 2013;12(1):263–275. doi: 10.1016/j.arr.2012.07.003.
    1. Faucounau V, Wu Y-H, Boulay M, De Rotrou J, Rigaud A-S. Cognitive intervention programmes on patients affected by mild cognitive impairment: a promising intervention tool for MCI? J Nutr Health Aging. 2010;14(1):31–35. doi: 10.1007/s12603-010-0006-0.
    1. Hagovská M, Dzvoník O, Olekszyová Z. Comparison of two cognitive training programs with effects on functional activities and quality of life. Res Gerontol Nurs. 2017;10:172–180. doi: 10.3928/19404921-20170524-01.
    1. Man D, Chung J, Lee G: Evaluation of a virtual reality-based memory training programme for Hong Kong Chinese older adults with questionable dementia: a pilot study. 2012.
    1. Chandler MJ, Parks AC, Marsiske M, Rotblatt LJ, Smith GE. Everyday impact of cognitive interventions in mild cognitive impairment: a systematic review and meta-analysis. Neuropsychol Rev. 2016;26(3):225–251. doi: 10.1007/s11065-016-9330-4.
    1. Coyle H, Traynor V, Solowij N. Computerized and virtual reality cognitive training for individuals at high risk of cognitive decline: systematic review of the literature. Am J Geriatr Psychiatr. 2015;23(4):335–359. doi: 10.1016/j.jagp.2014.04.009.
    1. Hill NT, Mowszowski L, Naismith SL, Chadwick VL, Valenzuela M, Lampit A. Computerized cognitive training in older adults with mild cognitive impairment or dementia: a systematic review and meta-analysis. Am J Psychiatr. 2017;174(4):329–340. doi: 10.1176/appi.ajp.2016.16030360.
    1. Visser PJ, Kester A, Jolles J, Verhey F. Ten-year risk of dementia in subjects with mild cognitive impairment. Neurology. 2006;67(7):1201–1207. doi: 10.1212/01.wnl.0000238517.59286.c5.
    1. Moher D, Liberati A, Tetzlaff J, Altman DG, Group P Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009;6(7):e1000097. doi: 10.1371/journal.pmed.1000097.
    1. Tufanaru C, Munn Z, Aromataris E, Campbell J, Hopp L: Chapter 3: Systematic reviews of effectiveness. In: Joanna Briggs Institute Reviewer's Manual The Joanna Briggs Institute, 2017. Edited by Aromataris E, Munn Z; 2017.
    1. Nordmann AJ, Kasenda B, Briel M. Meta-analyses: what they can and cannot do. Swiss Med Wkly. 2012;142:w13518.
    1. Greco T, Zangrillo A, Biondi-Zoccai G, Landoni G. Meta-analysis: pitfalls and hints. Heart, lung and vessels. 2013;5(4):219.
    1. Barnes DE, Yaffe K, Belfor N, Jagust WJ, DeCarli C, Reed BR, et al. Computer-based cognitive training for mild cognitive impairment: results from a pilot randomized, controlled trial. Alzheimer Dis Assoc Disord. 2009;23:205–210. doi: 10.1097/WAD.0b013e31819c6137.
    1. Rosen AC, Sugiura L, Kramer JH, Whitfield-Gabrieli S, Gabrieli JD. Cognitive training changes hippocampal function in mild cognitive impairment: a pilot study. 2011. pp. 617–625.
    1. RevMan . Copenhagen: the Nordic Cochrane Centre, the Cochrane collaboration. 5.3 2014.
    1. Finn M, McDonald S. Computerised cognitive training for older persons with mild cognitive impairment: a pilot study using a randomised controlled trial design. Brain Impairment. 2011;12(3):187–199. doi: 10.1375/brim.12.3.187.
    1. Fiatarone Singh MA, Gates N, Saigal N, Wilson GC, Meiklejohn J, Brodaty H, et al. The study of mental and resistance training (SMART) study—resistance training and/or cognitive training in mild cognitive impairment: a randomized, double-blind, double-sham controlled trial. J Am Med Dir Assoc. 2014;15(12):873–880. doi: 10.1016/j.jamda.2014.09.010.
    1. Bahar-Fuchs A, Webb S, Bartsch L, Clare L, Rebok G, Cherbuin N, et al. Tailored and adaptive computerized cognitive training in older adults at risk for dementia: a randomized controlled trial. J Alzheimers Dis. 2017;60(3):889–911. doi: 10.3233/JAD-170404.
    1. Hyer L, Scott C, Atkinson MM, Mullen CM, Lee A, Johnson A, et al. Cognitive training program to improve working memory in older adults with MCI. Clinical Gerontologist: The Journal of Aging and Mental Health. 2016;39(5):410–427. doi: 10.1080/07317115.2015.1120257.
    1. Cipriani G, Bianchetti A, Trabucchi M. Outcomes of a computer-based cognitive rehabilitation program on Alzheimer's disease patients compared with those on patients affected by mild cognitive impairment. Archives of Gerontology & Geriatrics. 2006;43(3):327–335. doi: 10.1016/j.archger.2005.12.003.
    1. Han JW, Oh K, Yoo S, Kim E, Ahn KH, Son YJ, et al. Development of the ubiquitous spaced retrieval-based memory advancement and rehabilitation training program. Psychiatry investigation. 2014;11(1):52–58. doi: 10.4306/pi.2014.11.1.52.
    1. Vermeij A, Claassen JA, Dautzenberg PL, Kessels RP. Transfer and maintenance effects of online working-memory training in normal ageing and mild cognitive impairment. Neuropsychol Rehabil. 2016;26(5–6):783–809. doi: 10.1080/09602011.2015.1048694.
    1. Manera V, Petit PD, Derreumaux A, Orvieto I, Romagnoli M, Lyttle G, et al. ‘Kitchen and cooking,’ a serious game for mild cognitive impairment and Alzheimer’s disease: a pilot study. Front Aging Neurosci. 2015;7:24. doi: 10.3389/fnagi.2015.00024.
    1. Gonzalez-Palau F, Franco M, Bamidis P, Losada R, Parra E, Papageorgiou SG, et al. The effects of a computer-based cognitive and physical training program in a healthy and mildly cognitive impaired aging sample. Aging Ment Health. 2014;18(7):838–846. doi: 10.1080/13607863.2014.899972.
    1. Styliadis C, Kartsidis P, Paraskevopoulos E, Ioannides AA, Bamidis PD. Neuroplastic effects of combined computerized physical and cognitive training in elderly individuals at risk for dementia: an eLORETA controlled study on resting states. Neural plasticity. 2015;2015:172192. doi: 10.1155/2015/172192.
    1. Gooding AL, Choi J, Fiszdon JM, Wilkins K, Kirwin PD, van Dyck CH, et al. Comparing three methods of computerised cognitive training for older adults with subclinical cognitive decline. Neuropsychol Rehabil. 2016;26(5/6):810–821. doi: 10.1080/09602011.2015.1118389.
    1. Talassi E., Guerreschi M., Feriani M., Fedi V., Bianchetti A., Trabucchi M. Effectiveness of a cognitive rehabilitation program in mild dementia (MD) and mild cognitive impairment (MCI): A case control study. Archives of Gerontology and Geriatrics. 2007;44:391–399. doi: 10.1016/j.archger.2007.01.055.
    1. Klados MA, Styliadis C, Frantzidis CA, Paraskevopoulos E, Bamidis PD. Beta-band functional connectivity is reorganized in mild cognitive impairment after combined computerized physical and cognitive training. Front Neurosci. 2016;10:55.
    1. Mansbach WE, Mace RA, Clark KM. The efficacy of a computer-assisted cognitive rehabilitation program for patients with mild cognitive deficits: a pilot study. Exp Aging Res. 2017;43:94–104. doi: 10.1080/0361073X.2017.1258256.
    1. Barban F, Annicchiarico R, Pantelopoulos S, Federici A, Perri R, Fadda L, et al. Protecting cognition from aging and Alzheimer's disease: a computerized cognitive training combined with reminiscence therapy. Int J Geriatr Psychiatry. 2016;31(4):340–348. doi: 10.1002/gps.4328.
    1. Rozzini Luca, Costardi Daniela, Chilovi Barbara Vicini, Franzoni Simone, Trabucchi Marco, Padovani Alessandro. Efficacy of cognitive rehabilitation in patients with mild cognitive impairment treated with cholinesterase inhibitors. International Journal of Geriatric Psychiatry. 2007;22(4):356–360. doi: 10.1002/gps.1681.
    1. Savulich G, Piercy T, Fox C, Suckling J, Rowe JB, O'Brien JT, et al. Cognitive training using a novel memory game on an iPad in patients with amnestic mild cognitive impairment (aMCI) Int J Neuropsychopharmacol. 2017;20:624–633. doi: 10.1093/ijnp/pyx040.
    1. Herrera C, Chambon C, Michel BF, Paban V, Alescio-Lautier B. Positive effects of computer-based cognitive training in adults with mild cognitive impairment. Neuropsychologia. 2012;50(8):1871–1881. doi: 10.1016/j.neuropsychologia.2012.04.012.
    1. Gagnon Lyssa G., Belleville Sylvie. Training of attentional control in mild cognitive impairment with executive deficits: Results from a double-blind randomised controlled study. Neuropsychological Rehabilitation. 2012;22(6):809–835. doi: 10.1080/09602011.2012.691044.
    1. Lin F, Heffner KL, Ren P, Tivarus ME, Brasch J, Chen DG, et al. Cognitive and neural effects of vision-based speed-of-processing training in older adults with amnestic mild cognitive impairment: a pilot study. J Am Geriatr Soc. 2016;64:1293–1298. doi: 10.1111/jgs.14132.
    1. Hughes TF, Flatt JD, Fu B, Butters MA, Chang CCH, Ganguli M. Interactive video gaming compared with health education in older adults with mild cognitive impairment: a feasibility study. Int J Geriatr Psychiatry. 2014;29(9):890–898. doi: 10.1002/gps.4075.
    1. Law LL, Barnett F, Yau MK, Gray MA. Effects of combined cognitive and exercise interventions on cognition in older adults with and without cognitive impairment: a systematic review. Ageing Res Rev. 2014;15:61–75. doi: 10.1016/j.arr.2014.02.008.
    1. Delbroek Tom, Vermeylen Wietse, Spildooren Joke. The effect of cognitive-motor dual task training with the biorescue force platform on cognition, balance and dual task performance in institutionalized older adults: a randomized controlled trial. Journal of Physical Therapy Science. 2017;29(7):1137–1143. doi: 10.1589/jpts.29.1137.

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