Motivational Enhancement System for Adherence (MESA): pilot randomized trial of a brief computer-delivered prevention intervention for youth initiating antiretroviral treatment
Sylvie Naar-King, Angulique Y Outlaw, Moussa Sarr, Jeffrey T Parsons, Marvin Belzer, Karen Macdonell, Mary Tanney, Steven J Ondersma, Adolescent Medicine Network for HIV/AIDS Interventions, Belzer, Tucker, Salata, Douglas, Rudy, Tanney, DiBenedetto, Aagenes, Seth, D'Angelo, Trexler, Hagler, Klamberg, Martinez, Henry-Reid, Bojan, Jackson, Futterman, Enriquez-Bruce, Campos, Flynn, Stender, Dillard, McKinley, Abdalian, Baker, Kozina, Friedman, Maturo, Major-Wilson, Emmanuel, Lujan-Zilbermann, Straub, Callejas, Sylvie Naar-King, Angulique Y Outlaw, Moussa Sarr, Jeffrey T Parsons, Marvin Belzer, Karen Macdonell, Mary Tanney, Steven J Ondersma, Adolescent Medicine Network for HIV/AIDS Interventions, Belzer, Tucker, Salata, Douglas, Rudy, Tanney, DiBenedetto, Aagenes, Seth, D'Angelo, Trexler, Hagler, Klamberg, Martinez, Henry-Reid, Bojan, Jackson, Futterman, Enriquez-Bruce, Campos, Flynn, Stender, Dillard, McKinley, Abdalian, Baker, Kozina, Friedman, Maturo, Major-Wilson, Emmanuel, Lujan-Zilbermann, Straub, Callejas
Abstract
Objective: To pilot test a two-session computer-delivered motivational intervention to facilitate adherence among youth with HIV newly prescribed antiretroviral treatment (ART).
Methods: Youth (N = 76) newly prescribed ART were recruited from 8 sites, and were randomized to the intervention or an active nutrition and physical activity control. Primary outcomes were HIV-1 viral load at baseline, 3 months, and 6 months, and self-reported adherence at 3 and 6 months.
Results: Satisfaction ratings were high. Effect sizes suggested that the intervention group showed a greater drop than controls in viral load from baseline to 6 months (Cohen's d = 0.39 at 3 months; d = 0.19 at 6 months), and had greater percent undetectable by 6 months (d = 0.28). Effects sizes were medium to large for 7-day and weekend adherence.
Conclusions: A brief computer-delivered motivational intervention showed promise for youth starting ART and is ready to be tested in a full-scale clinical trial.
Keywords: HIV; adherence; adolescent; eHealth.
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Source: PubMed