Increased Incidence of Barotrauma in Patients with COVID-19 on Invasive Mechanical Ventilation
Georgeann McGuinness, Chenyang Zhan, Noah Rosenberg, Lea Azour, Maj Wickstrom, Derek M Mason, Kristen M Thomas, William H Moore, Georgeann McGuinness, Chenyang Zhan, Noah Rosenberg, Lea Azour, Maj Wickstrom, Derek M Mason, Kristen M Thomas, William H Moore
Abstract
Background A high number of patients with coronavirus disease 2019 (COVID-19) pneumonia who had barotrauma related to invasive mechanical ventilation at the authors' institution were observed. Purpose To determine if the rate of barotrauma in patients with COVID-19 infection was greater than in other patients requiring invasive mechanical ventilation at the authors' institution. Materials and Methods In this retrospective study, clinical and imaging data of patients seen between March 1, 2020, and April 6, 2020, who tested positive for COVID-19 and experienced barotrauma associated with invasive mechanical ventilation, were compared with patients without COVID-19 infection during the same period. Historical comparison was made to barotrauma rates of patients with acute respiratory distress syndrome from February 1, 2016, to February 1, 2020, at the authors' institution. Comparison of patient groups was performed using categoric or continuous statistical testing as appropriate, with multivariable regression analysis. Patient survival was assessed using Kaplan-Meier curves analysis. Results A total of 601 patients with COVID-19 infection underwent invasive mechanical ventilation (mean age, 63 years ± 15 [standard deviation]; 71% men). Of the total, there were 89 (15%) patients with one or more barotrauma events for a total of 145 barotrauma events (24% overall events) (95% confidence interval [CI]: 21%, 28%). During the same period, 196 patients without COVID-19 infection (mean age, 64 years ± 19; 52% men) with invasive mechanical ventilation had one barotrauma event (0.5%; 95% CI: 0%, 3%; P < .001 vs the group with COVID-19 infection). Of 285 patients with acute respiratory distress syndrome on invasive mechanical ventilation during the previous 4 years (mean age, 68 years ± 17; 60% men), 28 patients (10%) had 31 barotrauma events, with an overall barotrauma rate of 11% (95% CI: 8%, 15%; P < .001 vs the group with COVID-19 infection). Barotrauma is an independent risk factor for death in COVID-19 (odds ratio = 2.2; P = .03) and is associated with a longer hospital stay (odds ratio = 0.92; P < .001). Conclusion Patients with coronavirus disease 2019 (COVID-19) infection and invasive mechanical ventilation had a higher rate of barotrauma than patients with acute respiratory distress syndrome and patients without COVID-19 infection. © RSNA, 2020 Online supplemental material is available for this article.
Figures
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![Figure 5a:](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/7336751/bin/radiol.2020202352.fig5a.jpg)
Figure 5b:
Kaplan-Meier survival curves. (A) Overall…
Figure 5b:
Kaplan-Meier survival curves. (A) Overall survival of patients with COVID-19 infection on invasive…
Figure 5c:
Kaplan-Meier survival curves. (A) Overall…
Figure 5c:
Kaplan-Meier survival curves. (A) Overall survival of patients with COVID-19 infection on invasive…
Figure 5d:
Kaplan-Meier survival curves. (A) Overall…
Figure 5d:
Kaplan-Meier survival curves. (A) Overall survival of patients with COVID-19 infection on invasive…
- Cohort of Four Thousand Four Hundred Four Persons Under Investigation for COVID-19 in a New York Hospital and Predictors of ICU Care and Ventilation.Singer AJ, Morley EJ, Meyers K, Fernandes R, Rowe AL, Viccellio P, Thode HC, Bracey A, Henry MC. Singer AJ, et al. Ann Emerg Med. 2020 Oct;76(4):394-404. doi: 10.1016/j.annemergmed.2020.05.011. Epub 2020 May 11. Ann Emerg Med. 2020. PMID: 32563601 Free PMC article.
- Incidence of Barotrauma in Patients With COVID-19 Pneumonia During Prolonged Invasive Mechanical Ventilation - A Case-Control Study.Udi J, Lang CN, Zotzmann V, Krueger K, Fluegler A, Bamberg F, Bode C, Duerschmied D, Wengenmayer T, Staudacher DL. Udi J, et al. J Intensive Care Med. 2021 Apr;36(4):477-483. doi: 10.1177/0885066620954364. Epub 2020 Sep 22. J Intensive Care Med. 2021. PMID: 32959730
- New York Inner City Hospital COVID-19 Experience and Current Data: Retrospective Analysis at the Epicenter of the American Coronavirus Outbreak.Mani VR, Kalabin A, Valdivieso SC, Murray-Ramcharan M, Donaldson B. Mani VR, et al. J Med Internet Res. 2020 Sep 18;22(9):e20548. doi: 10.2196/20548. J Med Internet Res. 2020. PMID: 32540837 Free PMC article.
- Pulmonary Barotrauma in COVID-19 Patients With ARDS on Invasive and Non-Invasive Positive Pressure Ventilation.Rajdev K, Spanel AJ, McMillan S, Lahan S, Boer B, Birge J, Thi M. Rajdev K, et al. J Intensive Care Med. 2021 Sep;36(9):1013-1017. doi: 10.1177/08850666211019719. Epub 2021 May 20. J Intensive Care Med. 2021. PMID: 34013825
- Clinical Characteristics and Morbidity Associated With Coronavirus Disease 2019 in a Series of Patients in Metropolitan Detroit.Suleyman G, Fadel RA, Malette KM, Hammond C, Abdulla H, Entz A, Demertzis Z, Hanna Z, Failla A, Dagher C, Chaudhry Z, Vahia A, Abreu Lanfranco O, Ramesh M, Zervos MJ, Alangaden G, Miller J, Brar I. Suleyman G, et al. JAMA Netw Open. 2020 Jun 1;3(6):e2012270. doi: 10.1001/jamanetworkopen.2020.12270. JAMA Netw Open. 2020. PMID: 32543702 Free PMC article. Review.
- Incidence of Air Leaks in Critically Ill Patients with Acute Hypoxemic Respiratory Failure Due to COVID-19.Goossen RL, Verboom M, Blacha M, Smesseim I, Beenen LFM, Meenen DMPV, Paulus F, Schultz MJ, On Behalf Of The PRoVENT-Covid And PRoAcT-Covid Investigators. Goossen RL, et al. Diagnostics (Basel). 2023 Mar 17;13(6):1156. doi: 10.3390/diagnostics13061156. Diagnostics (Basel). 2023. PMID: 36980464 Free PMC article.
- COVID-19-associated pulmonary aspergillosis (CAPA) might be associated with increased risk for pneumopleural fistula.Naendrup JH, Steinke J, Grans-Siebel J, Koehler P, Böll B. Naendrup JH, et al. Intensive Care Med. 2023 Mar 28:1-3. doi: 10.1007/s00134-023-07040-9. Online ahead of print. Intensive Care Med. 2023. PMID: 36976304 Free PMC article. No abstract available.
- COVID-19 and pneumothorax, pneumomediastinum, subcutaneous emphysema: Analysis of risk factors.Büyükkarabacak Y, Pirzirenli MG, Gurz S, Abacı H, Taslak Şengül A, Çelik B, Basoğlu A. Büyükkarabacak Y, et al. Turk Gogus Kalp Damar Cerrahisi Derg. 2023 Jan 30;31(1):69-77. doi: 10.5606/tgkdc.dergisi.2023.23081. eCollection 2023 Jan. Turk Gogus Kalp Damar Cerrahisi Derg. 2023. PMID: 36926149 Free PMC article.
- Time dependency and unique etiology of barotrauma in COVID-19: A retrospective cohort study with landmark analysis and pathological approach.Kabuto T, Seo R, Miyakoshi C, Shimizu Y, Shima Y, Yamashita D, Hara S, Hirabayashi R, Tomii K, Takayama M, Tetsumoto K, Saito M, Hamakawa H, Suki B, Takahashi Y. Kabuto T, et al. PLoS One. 2023 Mar 15;18(3):e0282868. doi: 10.1371/journal.pone.0282868. eCollection 2023. PLoS One. 2023. PMID: 36921007 Free PMC article.
- High incidence of barotrauma in patients admitted with COVID-19 to ICU and associated mortality in rural Appalachia: An observational study.Sharma S, Badami V, Rojas E, Sangani R, Chapman K, Avalon C, King A, Wen S. Sharma S, et al. PLoS One. 2023 Mar 9;18(3):e0282735. doi: 10.1371/journal.pone.0282735. eCollection 2023. PLoS One. 2023. PMID: 36893088 Free PMC article.
-
- Petrilli CM, Jones SA, Yang J, et al. . Factors associated with hospitalization and critical illness among 4,103 patients with COVID-19 disease in New York City. medRxiv. 2020:2020.2004.2008.20057794. Accepted for publication, British Journal of Medicine 2020
-
- Anzueto A, Frutos–Vivar F, Esteban A, et al. . Incidence, risk factors and outcome of barotrauma in mechanically ventilated patients. Intensive care medicine. 2004;30(4):612-619. - PubMed
-
- Boussarsar M, Thierry G, Jaber S, Roudot-Thoraval F, Lemaire F, Brochard L. Relationship between ventilatory settings and barotrauma in the acute respiratory distress syndrome. Intensive care medicine. 2002;28(4):406-413. - PubMed
-
- Briel M, Meade M, Mercat A, et al. . Higher vs lower positive end-expiratory pressure in patients with acute lung injury and acute respiratory distress syndrome: systematic review and meta-analysis. Jama. 2010;303(9):865-873. - PubMed
-
- Grasso S, Stripoli T, De Michele M, et al. . ARDSnet ventilatory protocol and alveolar hyperinflation: role of positive end-expiratory pressure. American journal of respiratory and critical care medicine. 2007;176(8):761-767. - PubMed
- Aged
- Barotrauma / epidemiology*
- Betacoronavirus*
- COVID-19
- Causality
- Comorbidity
- Coronavirus Infections / epidemiology*
- Coronavirus Infections / therapy*
- Female
- Humans
- Incidence
- Male
- Middle Aged
- New York / epidemiology
- Pandemics
- Pneumonia, Viral / epidemiology*
- Pneumonia, Viral / therapy*
- Respiration, Artificial / adverse effects
- Respiration, Artificial / methods*
- Respiration, Artificial / statistics & numerical data*
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![Figure 5b:](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/7336751/bin/radiol.2020202352.fig5b.jpg)
Figure 5c:
Kaplan-Meier survival curves. (A) Overall…
Figure 5c:
Kaplan-Meier survival curves. (A) Overall survival of patients with COVID-19 infection on invasive…
Figure 5d:
Kaplan-Meier survival curves. (A) Overall…
Figure 5d:
Kaplan-Meier survival curves. (A) Overall survival of patients with COVID-19 infection on invasive…
- Cohort of Four Thousand Four Hundred Four Persons Under Investigation for COVID-19 in a New York Hospital and Predictors of ICU Care and Ventilation.Singer AJ, Morley EJ, Meyers K, Fernandes R, Rowe AL, Viccellio P, Thode HC, Bracey A, Henry MC. Singer AJ, et al. Ann Emerg Med. 2020 Oct;76(4):394-404. doi: 10.1016/j.annemergmed.2020.05.011. Epub 2020 May 11. Ann Emerg Med. 2020. PMID: 32563601 Free PMC article.
- Incidence of Barotrauma in Patients With COVID-19 Pneumonia During Prolonged Invasive Mechanical Ventilation - A Case-Control Study.Udi J, Lang CN, Zotzmann V, Krueger K, Fluegler A, Bamberg F, Bode C, Duerschmied D, Wengenmayer T, Staudacher DL. Udi J, et al. J Intensive Care Med. 2021 Apr;36(4):477-483. doi: 10.1177/0885066620954364. Epub 2020 Sep 22. J Intensive Care Med. 2021. PMID: 32959730
- New York Inner City Hospital COVID-19 Experience and Current Data: Retrospective Analysis at the Epicenter of the American Coronavirus Outbreak.Mani VR, Kalabin A, Valdivieso SC, Murray-Ramcharan M, Donaldson B. Mani VR, et al. J Med Internet Res. 2020 Sep 18;22(9):e20548. doi: 10.2196/20548. J Med Internet Res. 2020. PMID: 32540837 Free PMC article.
- Pulmonary Barotrauma in COVID-19 Patients With ARDS on Invasive and Non-Invasive Positive Pressure Ventilation.Rajdev K, Spanel AJ, McMillan S, Lahan S, Boer B, Birge J, Thi M. Rajdev K, et al. J Intensive Care Med. 2021 Sep;36(9):1013-1017. doi: 10.1177/08850666211019719. Epub 2021 May 20. J Intensive Care Med. 2021. PMID: 34013825
- Clinical Characteristics and Morbidity Associated With Coronavirus Disease 2019 in a Series of Patients in Metropolitan Detroit.Suleyman G, Fadel RA, Malette KM, Hammond C, Abdulla H, Entz A, Demertzis Z, Hanna Z, Failla A, Dagher C, Chaudhry Z, Vahia A, Abreu Lanfranco O, Ramesh M, Zervos MJ, Alangaden G, Miller J, Brar I. Suleyman G, et al. JAMA Netw Open. 2020 Jun 1;3(6):e2012270. doi: 10.1001/jamanetworkopen.2020.12270. JAMA Netw Open. 2020. PMID: 32543702 Free PMC article. Review.
- Incidence of Air Leaks in Critically Ill Patients with Acute Hypoxemic Respiratory Failure Due to COVID-19.Goossen RL, Verboom M, Blacha M, Smesseim I, Beenen LFM, Meenen DMPV, Paulus F, Schultz MJ, On Behalf Of The PRoVENT-Covid And PRoAcT-Covid Investigators. Goossen RL, et al. Diagnostics (Basel). 2023 Mar 17;13(6):1156. doi: 10.3390/diagnostics13061156. Diagnostics (Basel). 2023. PMID: 36980464 Free PMC article.
- COVID-19-associated pulmonary aspergillosis (CAPA) might be associated with increased risk for pneumopleural fistula.Naendrup JH, Steinke J, Grans-Siebel J, Koehler P, Böll B. Naendrup JH, et al. Intensive Care Med. 2023 Mar 28:1-3. doi: 10.1007/s00134-023-07040-9. Online ahead of print. Intensive Care Med. 2023. PMID: 36976304 Free PMC article. No abstract available.
- COVID-19 and pneumothorax, pneumomediastinum, subcutaneous emphysema: Analysis of risk factors.Büyükkarabacak Y, Pirzirenli MG, Gurz S, Abacı H, Taslak Şengül A, Çelik B, Basoğlu A. Büyükkarabacak Y, et al. Turk Gogus Kalp Damar Cerrahisi Derg. 2023 Jan 30;31(1):69-77. doi: 10.5606/tgkdc.dergisi.2023.23081. eCollection 2023 Jan. Turk Gogus Kalp Damar Cerrahisi Derg. 2023. PMID: 36926149 Free PMC article.
- Time dependency and unique etiology of barotrauma in COVID-19: A retrospective cohort study with landmark analysis and pathological approach.Kabuto T, Seo R, Miyakoshi C, Shimizu Y, Shima Y, Yamashita D, Hara S, Hirabayashi R, Tomii K, Takayama M, Tetsumoto K, Saito M, Hamakawa H, Suki B, Takahashi Y. Kabuto T, et al. PLoS One. 2023 Mar 15;18(3):e0282868. doi: 10.1371/journal.pone.0282868. eCollection 2023. PLoS One. 2023. PMID: 36921007 Free PMC article.
- High incidence of barotrauma in patients admitted with COVID-19 to ICU and associated mortality in rural Appalachia: An observational study.Sharma S, Badami V, Rojas E, Sangani R, Chapman K, Avalon C, King A, Wen S. Sharma S, et al. PLoS One. 2023 Mar 9;18(3):e0282735. doi: 10.1371/journal.pone.0282735. eCollection 2023. PLoS One. 2023. PMID: 36893088 Free PMC article.
-
- Petrilli CM, Jones SA, Yang J, et al. . Factors associated with hospitalization and critical illness among 4,103 patients with COVID-19 disease in New York City. medRxiv. 2020:2020.2004.2008.20057794. Accepted for publication, British Journal of Medicine 2020
-
- Anzueto A, Frutos–Vivar F, Esteban A, et al. . Incidence, risk factors and outcome of barotrauma in mechanically ventilated patients. Intensive care medicine. 2004;30(4):612-619. - PubMed
-
- Boussarsar M, Thierry G, Jaber S, Roudot-Thoraval F, Lemaire F, Brochard L. Relationship between ventilatory settings and barotrauma in the acute respiratory distress syndrome. Intensive care medicine. 2002;28(4):406-413. - PubMed
-
- Briel M, Meade M, Mercat A, et al. . Higher vs lower positive end-expiratory pressure in patients with acute lung injury and acute respiratory distress syndrome: systematic review and meta-analysis. Jama. 2010;303(9):865-873. - PubMed
-
- Grasso S, Stripoli T, De Michele M, et al. . ARDSnet ventilatory protocol and alveolar hyperinflation: role of positive end-expiratory pressure. American journal of respiratory and critical care medicine. 2007;176(8):761-767. - PubMed
- Aged
- Barotrauma / epidemiology*
- Betacoronavirus*
- COVID-19
- Causality
- Comorbidity
- Coronavirus Infections / epidemiology*
- Coronavirus Infections / therapy*
- Female
- Humans
- Incidence
- Male
- Middle Aged
- New York / epidemiology
- Pandemics
- Pneumonia, Viral / epidemiology*
- Pneumonia, Viral / therapy*
- Respiration, Artificial / adverse effects
- Respiration, Artificial / methods*
- Respiration, Artificial / statistics & numerical data*
- Retrospective Studies
- SARS-CoV-2
- Full Text Sources
- Medical
- Miscellaneous
NCBI Literature Resources
The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited.
National Library of Medicine
8600 Rockville Pike
Bethesda, MD 20894
![Figure 5c:](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/7336751/bin/radiol.2020202352.fig5c.jpg)
Figure 5d:
Kaplan-Meier survival curves. (A) Overall…
Figure 5d:
Kaplan-Meier survival curves. (A) Overall survival of patients with COVID-19 infection on invasive…
- Cohort of Four Thousand Four Hundred Four Persons Under Investigation for COVID-19 in a New York Hospital and Predictors of ICU Care and Ventilation.Singer AJ, Morley EJ, Meyers K, Fernandes R, Rowe AL, Viccellio P, Thode HC, Bracey A, Henry MC. Singer AJ, et al. Ann Emerg Med. 2020 Oct;76(4):394-404. doi: 10.1016/j.annemergmed.2020.05.011. Epub 2020 May 11. Ann Emerg Med. 2020. PMID: 32563601 Free PMC article.
- Incidence of Barotrauma in Patients With COVID-19 Pneumonia During Prolonged Invasive Mechanical Ventilation - A Case-Control Study.Udi J, Lang CN, Zotzmann V, Krueger K, Fluegler A, Bamberg F, Bode C, Duerschmied D, Wengenmayer T, Staudacher DL. Udi J, et al. J Intensive Care Med. 2021 Apr;36(4):477-483. doi: 10.1177/0885066620954364. Epub 2020 Sep 22. J Intensive Care Med. 2021. PMID: 32959730
- New York Inner City Hospital COVID-19 Experience and Current Data: Retrospective Analysis at the Epicenter of the American Coronavirus Outbreak.Mani VR, Kalabin A, Valdivieso SC, Murray-Ramcharan M, Donaldson B. Mani VR, et al. J Med Internet Res. 2020 Sep 18;22(9):e20548. doi: 10.2196/20548. J Med Internet Res. 2020. PMID: 32540837 Free PMC article.
- Pulmonary Barotrauma in COVID-19 Patients With ARDS on Invasive and Non-Invasive Positive Pressure Ventilation.Rajdev K, Spanel AJ, McMillan S, Lahan S, Boer B, Birge J, Thi M. Rajdev K, et al. J Intensive Care Med. 2021 Sep;36(9):1013-1017. doi: 10.1177/08850666211019719. Epub 2021 May 20. J Intensive Care Med. 2021. PMID: 34013825
- Clinical Characteristics and Morbidity Associated With Coronavirus Disease 2019 in a Series of Patients in Metropolitan Detroit.Suleyman G, Fadel RA, Malette KM, Hammond C, Abdulla H, Entz A, Demertzis Z, Hanna Z, Failla A, Dagher C, Chaudhry Z, Vahia A, Abreu Lanfranco O, Ramesh M, Zervos MJ, Alangaden G, Miller J, Brar I. Suleyman G, et al. JAMA Netw Open. 2020 Jun 1;3(6):e2012270. doi: 10.1001/jamanetworkopen.2020.12270. JAMA Netw Open. 2020. PMID: 32543702 Free PMC article. Review.
- Incidence of Air Leaks in Critically Ill Patients with Acute Hypoxemic Respiratory Failure Due to COVID-19.Goossen RL, Verboom M, Blacha M, Smesseim I, Beenen LFM, Meenen DMPV, Paulus F, Schultz MJ, On Behalf Of The PRoVENT-Covid And PRoAcT-Covid Investigators. Goossen RL, et al. Diagnostics (Basel). 2023 Mar 17;13(6):1156. doi: 10.3390/diagnostics13061156. Diagnostics (Basel). 2023. PMID: 36980464 Free PMC article.
- COVID-19-associated pulmonary aspergillosis (CAPA) might be associated with increased risk for pneumopleural fistula.Naendrup JH, Steinke J, Grans-Siebel J, Koehler P, Böll B. Naendrup JH, et al. Intensive Care Med. 2023 Mar 28:1-3. doi: 10.1007/s00134-023-07040-9. Online ahead of print. Intensive Care Med. 2023. PMID: 36976304 Free PMC article. No abstract available.
- COVID-19 and pneumothorax, pneumomediastinum, subcutaneous emphysema: Analysis of risk factors.Büyükkarabacak Y, Pirzirenli MG, Gurz S, Abacı H, Taslak Şengül A, Çelik B, Basoğlu A. Büyükkarabacak Y, et al. Turk Gogus Kalp Damar Cerrahisi Derg. 2023 Jan 30;31(1):69-77. doi: 10.5606/tgkdc.dergisi.2023.23081. eCollection 2023 Jan. Turk Gogus Kalp Damar Cerrahisi Derg. 2023. PMID: 36926149 Free PMC article.
- Time dependency and unique etiology of barotrauma in COVID-19: A retrospective cohort study with landmark analysis and pathological approach.Kabuto T, Seo R, Miyakoshi C, Shimizu Y, Shima Y, Yamashita D, Hara S, Hirabayashi R, Tomii K, Takayama M, Tetsumoto K, Saito M, Hamakawa H, Suki B, Takahashi Y. Kabuto T, et al. PLoS One. 2023 Mar 15;18(3):e0282868. doi: 10.1371/journal.pone.0282868. eCollection 2023. PLoS One. 2023. PMID: 36921007 Free PMC article.
- High incidence of barotrauma in patients admitted with COVID-19 to ICU and associated mortality in rural Appalachia: An observational study.Sharma S, Badami V, Rojas E, Sangani R, Chapman K, Avalon C, King A, Wen S. Sharma S, et al. PLoS One. 2023 Mar 9;18(3):e0282735. doi: 10.1371/journal.pone.0282735. eCollection 2023. PLoS One. 2023. PMID: 36893088 Free PMC article.
-
- Petrilli CM, Jones SA, Yang J, et al. . Factors associated with hospitalization and critical illness among 4,103 patients with COVID-19 disease in New York City. medRxiv. 2020:2020.2004.2008.20057794. Accepted for publication, British Journal of Medicine 2020
-
- Anzueto A, Frutos–Vivar F, Esteban A, et al. . Incidence, risk factors and outcome of barotrauma in mechanically ventilated patients. Intensive care medicine. 2004;30(4):612-619. - PubMed
-
- Boussarsar M, Thierry G, Jaber S, Roudot-Thoraval F, Lemaire F, Brochard L. Relationship between ventilatory settings and barotrauma in the acute respiratory distress syndrome. Intensive care medicine. 2002;28(4):406-413. - PubMed
-
- Briel M, Meade M, Mercat A, et al. . Higher vs lower positive end-expiratory pressure in patients with acute lung injury and acute respiratory distress syndrome: systematic review and meta-analysis. Jama. 2010;303(9):865-873. - PubMed
-
- Grasso S, Stripoli T, De Michele M, et al. . ARDSnet ventilatory protocol and alveolar hyperinflation: role of positive end-expiratory pressure. American journal of respiratory and critical care medicine. 2007;176(8):761-767. - PubMed
- Aged
- Barotrauma / epidemiology*
- Betacoronavirus*
- COVID-19
- Causality
- Comorbidity
- Coronavirus Infections / epidemiology*
- Coronavirus Infections / therapy*
- Female
- Humans
- Incidence
- Male
- Middle Aged
- New York / epidemiology
- Pandemics
- Pneumonia, Viral / epidemiology*
- Pneumonia, Viral / therapy*
- Respiration, Artificial / adverse effects
- Respiration, Artificial / methods*
- Respiration, Artificial / statistics & numerical data*
- Retrospective Studies
- SARS-CoV-2
- Full Text Sources
- Medical
- Miscellaneous
![Figure 5d:](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/7336751/bin/radiol.2020202352.fig5d.jpg)
References
- Petrilli CM, Jones SA, Yang J, et al. . Factors associated with hospitalization and critical illness among 4,103 patients with COVID-19 disease in New York City. medRxiv. 2020:2020.2004.2008.20057794. Accepted for publication, British Journal of Medicine 2020
- Anzueto A, Frutos–Vivar F, Esteban A, et al. . Incidence, risk factors and outcome of barotrauma in mechanically ventilated patients. Intensive care medicine. 2004;30(4):612-619.
- Boussarsar M, Thierry G, Jaber S, Roudot-Thoraval F, Lemaire F, Brochard L. Relationship between ventilatory settings and barotrauma in the acute respiratory distress syndrome. Intensive care medicine. 2002;28(4):406-413.
- Briel M, Meade M, Mercat A, et al. . Higher vs lower positive end-expiratory pressure in patients with acute lung injury and acute respiratory distress syndrome: systematic review and meta-analysis. Jama. 2010;303(9):865-873.
- Grasso S, Stripoli T, De Michele M, et al. . ARDSnet ventilatory protocol and alveolar hyperinflation: role of positive end-expiratory pressure. American journal of respiratory and critical care medicine. 2007;176(8):761-767.
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Source: PubMed