Gastric cancer originating from bone marrow-derived cells
Jeanmarie Houghton, Calin Stoicov, Sachiyo Nomura, Arlin B Rogers, Jane Carlson, Hanchen Li, Xun Cai, James G Fox, James R Goldenring, Timothy C Wang, Jeanmarie Houghton, Calin Stoicov, Sachiyo Nomura, Arlin B Rogers, Jane Carlson, Hanchen Li, Xun Cai, James G Fox, James R Goldenring, Timothy C Wang
Abstract
Epithelial cancers are believed to originate from transformation of tissue stem cells. However, bone marrow-derived cells (BMDCs), which are frequently recruited to sites of tissue injury and inflammation, might also represent a potential source of malignancy. We show that although acute injury, acute inflammation, or transient parietal cell loss within the stomach do not lead to BMDC recruitment, chronic infection of C57BL/6 mice with Helicobacter, a known carcinogen, induces repopulation of the stomach with BMDCs. Subsequently, these cells progress through metaplasia and dysplasia to intraepithelial cancer. These findings suggest that epithelial cancers can originate from marrow-derived sources and thus have broad implications for the multistep model of cancer progression.
Source: PubMed