Task shifting for point of care ultrasound in primary healthcare in low- and middle-income countries-a systematic review

Seth Kofi Abrokwa, Lisa C Ruby, Charlotte C Heuvelings, Sabine Bélard, Seth Kofi Abrokwa, Lisa C Ruby, Charlotte C Heuvelings, Sabine Bélard

Abstract

Low-and middle-income countries (LMIC) are faced with healthcare challenges including lack of specialized healthcare workforce and limited diagnostic infrastructure. Task shifting for point-of-care ultrasound (POCUS) can overcome both shortcomings. This review aimed at identifying benefits and challenges of task shifting for POCUS in primary healthcare settings in LMIC. Medline and Embase were searched up to November 22nd, 2021. Publications reporting original data on POCUS performed by local ultrasound naïve healthcare providers in any medical field at primary healthcare were included. Data were analyzed descriptively. PROSPERO registration number CRD42021223302. Overall, 36 publications were included, most (n = 35) were prospective observational studies. Medical fields of POCUS application included obstetrics, gynecology, emergency medicine, infectious diseases, and cardiac, abdominal, and pulmonary conditions. POCUS was performed by midwives, nurses, clinical officers, physicians, technicians, and community health workers following varying periods of short-term training and using different ultrasound devices. Benefits of POCUS were yields of diagnostic images with adequate interpretation impacting patient management and outcome. High cost of face-to-face training, poor internet connectivity hindering telemedicine components, and unstable electrici'ty were among reported drawbacks for successful implementation of task shifting POCUS. At the primary care level in resource-limited settings task shifting for POCUS has the potential to expand diagnostic imaging capacity and impact patient management leading to meaningful health outcomes.

Keywords: Low- and middle-income country; Point of care; Task shifting; Ultrasound.

Conflict of interest statement

Sabine Bélard is a board member (unpaid) for the Deutsche Gesellschaft für Tropenmedizin, Reisemedizin und Globale Gesundheit e.V. Lisa C. Ruby report a Medizinernachwuchs.de travel grant and a Charité SEED grant for travel support for a research project in India. The other authors have nothing to declare.

© 2022 Published by Elsevier Ltd.

Figures

Figure 1
Figure 1
PRISMA Flow diagram of study selection.
Figure 2
Figure 2
Medical fields and conditions of task shifting for POCUS studies identified by this review across continents. The outer circle displays POCUS applications, the inner circle continents where POCUS applications were applied. The relative sizes of cells indicate the frequency of studies evaluating respective POCUS applications and the continent origin, respectively. (POCUS: point-of-care ultrasound, FAST: focused assessment with sonography for trauma, FASH: focused assessment with sonography for HIV-associated tuberculosis, FASE: focused assessment with sonography for echinococcosis).

References

    1. Okyere E., Mwanri L., Ward P. Is task-shifting a solution to the health workers’ shortage in Northern Ghana? PLoS One. 2017;12(3)
    1. Scheffler R., Bruckner T., Spetz J. The labour market for human resources for health in low-and middle-income countries. Hum Resour Health Obs. 2012;11
    1. World Health Organization . World Health Organization; 2016. Global Strategy on Human Resources for Health: Workforce 2030.
    1. Frija G., Blažić I., Frush D.P., et al. How to improve access to medical imaging in low- and middle-income countries ? eClinicalMedicine. 2021;38
    1. Hricak H., Abdel-Wahab M., Atun R., et al. Medical imaging and nuclear medicine: a lancet oncology commission. Lancet Oncol. 2021;22(4):e136–172.
    1. Darzi A., Evans T. The global shortage of health workers-an opportunity to transform care. Lancet. 2016;388(10060):2576–2577.
    1. World Health Organization . World Health Organization; Geneva: 2008. Task shifting: Global Recommendations and Guidelines.
    1. World Health Organization . World Health Organization; 2007. Task Shifting: Rational Redistribution of Tasks Among Health Workforce Teams: Global Recommendations and Guidelines.
    1. World Health Organization . OECD Publishing; 2018. Delivering Quality Health Services: A Global Imperative.
    1. Stolz L.A., Muruganandan K.M., Bisanzo M.C., et al. Point-of-care ultrasound education for non-physician clinicians in a resource-limited emergency department. Trop Med Int Health. 2015;20(8):1067–1072.
    1. Fleming K.A., Horton S., Wilson M.L., et al. 10315th. Vol. 398. Lancet; 2021 Nov 27. The lancet Commission on diagnostics: transforming access to diagnostics; pp. 1997–2050.
    1. Moore C.L., Copel J.A. Point-of-care ultrasonography. N Engl J Med. 2011;364(8):749–757.
    1. Reynolds T.A., Amato S., Kulola I., Chen C.J., Mfinanga J., Sawe H.R. Impact of point-of-care ultrasound on clinical decision-making at an urban emergency department in Tanzania. PLoS One. 2018;13(4)
    1. Jones T., Leng P. Clinical impact of point of care ultrasound (POCUS) consult service in a teaching hospital: effect on diagnoses and cost savings. Chest. 2016;149(4):170–179.
    1. Page M.J., McKenzie J.E., Bossuyt P.M., et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:n71.
    1. World Bank Country and Lending Groups. Country Classification. June 2020. Accessed 10 May 2021.
    1. World Health Organization . World Health Organization; 1998. Training in Diagnostic Ultrasound: Essentials, Principles and Standards: Report of a WHO Study Group.
    1. The EndNote Team . EndNote X9 ed. Clarivate; Philadelphia, PA: 2013. Endnote.
    1. Ouzzani M., Hammady H., Fedorowicz Z., Elmagarmid A. Rayyan-a web and mobile app for systematic reviews. Syst Rev. 2016;5(1):210.
    1. National Heart Lung and Blood Institue . National Heart Lung and Blood Institue; 2021. Study Quality Assessment Tools. Accessed 20 May.
    1. Adler D., Mgalula K., Price D., Taylor O. Introduction of a portable ultrasound unit into the health services of the Lugufu refugee camp, Kigoma District, Tanzania. Int J Emerg Med. 2008;1(4):261–266.
    1. Chebli H., Laamrani El Idrissi A., Benazzouz M., et al. Human cystic echinococcosis in Morocco: ultrasound screening in the Mid Atlas through an Italian-Moroccan partnership. PLoS Negl Trop Dis. 2017;11(3):e0005384.
    1. Colquhoun S.M., Carapetis J.R., Kado J.H., et al. Pilot study of nurse-led rheumatic heart disease echocardiography screening in Fiji-a novel approach in a resource-poor setting. Cardiol Young. 2013;23(4):546–552.
    1. Crispín Milart P.H., Diaz Molina C.A., Prieto-Egido I., Martínez-Fernández A. Use of a portable system with ultrasound and blood tests to improve prenatal controls in rural Guatemala. Reprod Health. 2016;13(1):110.
    1. Crispín Milart P.H., Prieto-Egido I., Díaz Molina C.A., Martínez-Fernández A. Detection of high-risk pregnancies in low-resource settings: a case study in Guatemala. Reprod Health. 2019;16(1):80.
    1. Dalmacion G.V., Reyles R.T., Habana A.E., et al. Handheld ultrasound to avert maternal and neonatal deaths in 2 regions of the Philippines: an iBuntis® intervention study. BMC Pregnancy Childbirth. 2018;18(1):32.
    1. Del Carpio M., Hugo Mercapide C., Salvitti J.C., et al. Early diagnosis, treatment and follow-up of cystic echinococcosis in remote rural areas in Patagonia: impact of ultrasound training of non-specialists. PLoS Negl Trop Dis. 2012;6(1):e1444.
    1. Engelman D., Kado J.H., Reményi B., et al. Screening for rheumatic heart disease: quality and agreement of focused cardiac ultrasound by briefly trained health workers. BMC Cardiovasc Disord. 2016;16:30.
    1. Fentress M., Ugarte-Gil C., Cervantes M., et al. Lung ultrasound findings compared with chest X-ray findings in known pulmonary tuberculosis patients: a cross-sectional study in Lima, Peru. Am J Trop Med Hyg. 2020;103(5):1827–1833.
    1. Goldenberg R.L., Nathan R.O., Swanson D., et al. Routine antenatal ultrasound in low- and middle-income countries: first look - a cluster randomised trial. BJOG. 2018;125(12):1591–1599.
    1. Greenwold N., Wallace S., Prost A., Jauniaux E. Implementing an obstetric ultrasound training program in rural Africa. Int J Gynaecol Obstet. 2014;124(3):274–277.
    1. Henwood P.C., Mackenzie D.C., Liteplo A.S., et al. Point-of-care ultrasound use, accuracy, and impact on clinical decision making in Rwanda hospitals. J Ultrasound Med. 2017;36(6):1189–1194.
    1. Kahn D., Pool K.L., Phiri L., et al. Diagnostic utility and impact on clinical decision making of focused assessment with sonography for HIV-associated tuberculosis in malawi: a prospective cohort study. Glob Health Sci Pract. 2020;8(1):28–37.
    1. Kawooya M.G., Nathan R.O., Swanson J., et al. Impact of introducing routine antenatal ultrasound services on reproductive health indicators in Mpigi District, Central Uganda. Ultrasound Q. 2015;31(4):285–289.
    1. Kimberly H.H., Murray A., Mennicke M., et al. Focused maternal ultrasound by midwives in rural Zambia. Ultrasound Med Biol. 2010;36(8):1267–1272.
    1. Kirkpatrick J.N., Nguyen H.T.T., Doan L.D., et al. Focused cardiac ultrasound by nurses in rural Vietnam. J Am Soc Echocardiogr. 2018;31(10):1109–1115.
    1. Levine A.C., Shah S., Noble V.E., Epino H. Ultrasound assessment of dehydration in children with gastroenteritis. Ann Emerg Med. 2009;54(3):S91.
    1. Nascimento BR, Beaton AZ, Nunes MC, et al. PROVAR (Programa de RastreamentO da VAlvopatia Reumática) investigators. Echocardiographic prevalence of rheumatic heart disease in Brazilian schoolchildren: Data from the PROVAR study. Int J Cardiol. 2016 Sep 15;219:439-45.
    1. Ploutz M., Lu J.C., Scheel J., et al. Handheld echocardiographic screening for rheumatic heart disease by non-experts. Heart. 2016;102(1):35–39.
    1. Raza S., Frost E., Kwait D., et al. Training nonradiologist clinicians in diagnostic breast ultrasound in rural Rwanda: impact on knowledge and skills. J Am Coll Radiol. 2021;18(1):121–127.
    1. Rominger A.H., Gomez G.A.A., Elliott P. The implementation of a longitudinal POCUS curriculum for physicians working at rural outpatient clinics in Chiapas, Mexico. Crit Ultrasound J. 2018;10(1):19.
    1. Sabatino V., Caramia M.R., Curatola A., et al. Point-of-care ultrasound (POCUS) in a remote area of Sierra Leone: impact on patient management and training program for community health officers. J Ultrasound. 2020;23(4):521–527.
    1. Shah S., Santos N., Kisa R., et al. Efficacy of an ultrasound training program for nurse midwives to assess high-risk conditions at labor triage in rural Uganda. PLoS One. 2020;15(6):e0235269.
    1. Shah S.P., Epino H., Bukhman G., et al. Impact of the introduction of ultrasound services in a limited resource setting: rural Rwanda 2008. BMC Int Health Hum Rights. 2008;9:4.
    1. Shah S.P., Shah S.P., Fils-Aime R., et al. Focused cardiopulmonary ultrasound for assessment of dyspnea in a resource-limited setting. Crit Ultrasound J. 2016;8(1):7.
    1. Swanson J.O., Kawooya M.G., Swanson D.L., Hippe D.S., Dungu-Matovu P., Nathan R. The diagnostic impact of limited, screening obstetric ultrasound when performed by midwives in rural Uganda. J Perinatol. 2014;34(7):508–512.
    1. Vinayak S. Training midwives to perform basic obstetric pocus in rural areas using a tablet platform and mobile phone transmission technology. Ultrasound Med Biol. 2017;43:S84.
    1. Terry B., Polan D.L., Nambaziira R., Mugisha J., Bisanzo M., Gaspari R. Rapid, remote education for point-of-care ultrasound among non-physician emergency care providers in a resource limited setting. Afr J Emerg Med. 2019 Sep;9(3):140–144.
    1. Remppis J., Verheyden A., Bustinduy A.L., et al. Focused assessment with sonography for urinary schistosomiasis (FASUS)-pilot evaluation of a simple point-of-care ultrasound protocol and short training program for detecting urinary tract morbidity in highly endemic settings. Trans R Soc Trop Med Hyg. 2020;114(1):38–48.
    1. Terry B., Polan D., Islam R., Mugisha J., Gaspari R., Bisanzo M. Rapid Internet-based review of point-of-care ultrasound studies at a remote hospital in Uganda. Ann Glob Health. 2014;80(3):222–223.
    1. Bonnard P., Boutouaba S., Diakhate I., Seck M., Dompnier J.P., Riveau G. Learning curve of vesico-urinary ultrasonography in Schistosoma haematobium infection with WHO practical guide: a "simple to learn" examination. Am J Trop Med Hyg. 2011;85(6):1071–1074.
    1. Salisbury T., Redfern A., Fletcher E.K., et al. Correct diagnosis of childhood pneumonia in public facilities in Tanzania: a randomised comparison of diagnostic methods. BMJ Open. 2021;11(5)
    1. Nadimpalli A, Tsung JW, Sanchez R, et al. Feasibility of Training Clinical Officers in Point-of-Care Ultrasound for Pediatric Respiratory Diseases in Aweil, South Sudan. Am J Trop Med Hyg. 2019;101(3):689–695. doi: 10.4269/ajtmh.18-0745.
    1. Kolbe N., Killu K., Coba V., et al. Point of care ultrasound (POCUS) telemedicine project in rural Nicaragua and its impact on patient management. J Ultrasound. 2015;18(2):179–185.
    1. Nascimento B.R., Sable C., Nunes M.C.P., et al. Echocardiographic screening of pregnant women by non-physicians with remote interpretation in primary care. Fam Pract. 2021;38(3):225–230.
    1. Aklilu S., Bain C., Bansil P., et al. Evaluation of diagnostic ultrasound use in a breast cancer detection strategy in Northern Peru. PLoS One. 2021;16(6)
    1. Voleti S., Adelbai M., Hovis I., et al. Novel handheld ultrasound technology to enhance non-expert screening for rheumatic heart disease in the Republic of Palau: a descriptive study. J Paediatr Child Health. 2021;57(7):1089–1095.
    1. Muhame R.M., Dragulescu A., Nadimpalli A., et al. Cardiac point of care ultrasound in resource limited settings to manage children with congenital and acquired heart disease. Cardiol Young. 2021;31(10):1–7.
    1. Chavez M.A., Naithani N., Gilman R.H., et al. Agreement between the world health organization algorithm and lung consolidation identified using point-of-care ultrasound for the diagnosis of childhood pneumonia by general practitioners. Lung. 2015;193(4):531–538.
    1. Goldenberg R.L., McClure E.M. Maternal mortality. Am J Obstet Gynecol. 2011;205(4):293–295.
    1. Jehan I., Harris H., Salat S., et al. Neonatal mortality, risk factors and causes: a prospective population-based cohort study in urban Pakistan. Bull World Health Organ. 2009;87(2):130–138.
    1. Whitworth M., Bricker L., Mullan C. Ultrasound for fetal assessment in early pregnancy. Cochrane Database Syst Rev. 2015;2015(7)
    1. Gaziano T.A. Reducing the growing burden of cardiovascular disease in the developing world. Health Aff (Millwood) 2007;26(1):13–24.
    1. World Health Organization . World Health Organization; 2021. Cardiovascular Diseases (CVDs) Accessed 4 August 2021.
    1. Huson M.A.M., Kaminstein D., Kahn D., et al. Cardiac ultrasound in resource-limited settings (CURLS): towards a wider use of basic echo applications in Africa. Ultrasound J. 2019;11(1):34.
    1. Nelson B.P., Sanghvi A. Point-of-care cardiac ultrasound: feasibility of performance by noncardiologists. Glob Heart. 2013;8(4):293–297.
    1. World Health Organization . World Health Organization; 2021. Road Traffic Injuries. Accessed 1 September 2021.
    1. Gaarder C., Kroepelien C.F., Loekke R., Hestnes M., Dormage J.B., Naess P.A. Ultrasound performed by radiologists-confirming the truth about FAST in trauma. J Trauma Acute Care Surg. 2009;67(2):323–329.
    1. Boulanger B.R., McLellan B.A., Brenneman F.D., Ochoa J., Kirkpatrick A.W. Prospective evidence of the superiority of a sonography-based algorithm in the assessment of blunt abdominal injury. J Trauma Acute Care Surg. 1999;47(4):632.
    1. Savatmongkorngul S., Wongwaisayawan S., Kaewlai R. Focused assessment with sonography for trauma: current perspectives. Open Access Emerg Med. 2017;9:57–62.
    1. Nandipati K.C., Allamaneni S., Kakarla R., et al. Extended focused assessment with sonography for trauma (EFAST) in the diagnosis of pneumothorax: experience at a community based level I trauma center. Injury. 2011;42(5):511–514.
    1. Ianniello S., Di Giacomo V., Sessa B., Miele V. First-line sonographic diagnosis of pneumothorax in major trauma: accuracy of e-FAST and comparison with multidetector computed tomography. Radiol Med. 2014;119(9):674–680.
    1. Troeger C., Forouzanfar M., Rao P.C., et al. Estimates of the global, regional, and national morbidity, mortality, and aetiologies of lower respiratory tract infections in 195 countries: a systematic analysis for the global burden of disease study 2015. Lancet Infect Dis. 2017;17(11):1133–1161.
    1. Heuvelings C.C., Bélard S., Familusi M.A., Spijker R., Grobusch M.P., Zar H.J. Chest ultrasound for the diagnosis of paediatric pulmonary diseases: a systematic review and meta-analysis of diagnostic test accuracy. Br Med Bull. 2019;129(1):35–51.
    1. Heuvelings C.C., Bélard S., Andronikou S., Jamieson-Luff N., Grobusch M.P., Zar H.J. Chest ultrasound findings in children with suspected pulmonary tuberculosis. Pediatr Pulmonol. 2019;54(4):463–470.
    1. Agostinis P., Copetti R., Lapini L., Badona Monteiro G., N'Deque A., Baritussio A. Chest ultrasound findings in pulmonary tuberculosis. Trop Dr. 2017;47(4):320–328.
    1. Heller T., Wallrauch C., Goblirsch S., Brunetti E. Focused assessment with sonography for HIV-associated tuberculosis (FASH): a short protocol and a pictorial review. Crit Ultrasound J. 2012;4(1):21.
    1. van Hoving D.J., Lamprecht H.H., Stander M., et al. Adequacy of the emergency point-of-care ultrasound core curriculum for the local burden of disease in South Africa. Emerg Med J. 2013;30(4):312–315.
    1. Heller T., Mtemang'ombe E.A., Huson M.A., et al. Ultrasound for patients in a high HIV/tuberculosis prevalence setting: a needs assessment and review of focused applications for Sub-Saharan Africa. Int J Infect Dis. 2017;56:229–236.
    1. Heller T., Wallrauch C., Lessells R.J., Goblirsch S., Brunetti E. Short course for focused assessment with sonography for human immunodeficiency virus/tuberculosis: preliminary results in a rural setting in South Africa with high prevalence of human immunodeficiency virus and tuberculosis. Am J Trop Med Hyg. 2010;82(3):512–515.
    1. Heller T., Goblirsch S., Wallrauch C., Lessells R., Brunetti E. Abdominal tuberculosis: sonographic diagnosis and treatment response in HIV-positive adults in rural South Africa. Int J Infect Dis. 2010;14(6):e108–e112. Suppl 3.
    1. Heller T., Goblirsch S., Bahlas S., et al. Diagnostic value of FASH ultrasound and chest X-ray in HIV-co-infected patients with abdominal tuberculosis. Int J Tuberc Lung Dis. 2013;17(3):342–344.
    1. Bélard S., Heuvelings C.C., Banderker E., et al. Utility of point-of-care ultrasound in children with pulmonary tuberculosis. Pediatr Infect Dis J. 2018;37(7):637–642.
    1. Bobbio F., Di Gennaro F., Marotta C., et al. Focused ultrasound to diagnose HIV-associated tuberculosis (FASH) in the extremely resource-limited setting of South Sudan: a cross-sectional study. BMJ Open. 2019;9(4)
    1. Weber S.F., Saravu K., Heller T., et al. Point-of-care ultrasound for extrapulmonary tuberculosis in india: a prospective cohort study in HIV-Positive and HIV-negative presumptive tuberculosis patients. Am J Trop Med Hyg. 2018;98(1):266–273.
    1. Group W.I.W. International classification of ultrasound images in cystic echinococcosis for application in clinical and field epidemiological settings. Acta Trop. 2003;85(2):253–261.
    1. Pugliese C.M., Adegbite B.R., Edoa J.R., et al. Point-of-care ultrasound to assess volume status and pulmonary oedema in malaria patients. Infection. 2022;50(1):65–82.
    1. Dewan N., Zuluaga D., Osorio L., Krienke M.E., Bakker C., Kirsch J. Ultrasound in dengue: a scoping review. Am J Trop Med Hyg. 2021;104(3):826–835.
    1. Mohammed R., Gebrewold Y., Schuster A., et al. Abdominal ultrasound in the diagnostic work-up of visceral leishmaniasis and for detection of complications of spleen aspiration. PLoS Negl Trop Dis. 2021;15(2)
    1. Bélard S., Stratta E., Zhao A., et al. Sonographic findings in visceral leishmaniasis-a narrative review. Travel Med Infect Dis. 2021;39
    1. Heller T., Wallrauch C., Brunetti E., Giordani M.T. Changes of FASH ultrasound findings in TB-HIV patients during anti-tuberculosis treatment. Int J Tuberc Lung Dis. 2014;18(7):837–839.
    1. Weber S.F., Weber M., Tenbrock K., Bélard S. Call for ultrasound in paediatric tuberculosis work-up: a case report from Germany. J Paediatr Child Health. 2020;56(6):964–966.
    1. Nguyen Q., Nguyen P.T., Huynh V.D.B., Nguyen L.T. Application Chang's extent analysis method for ranking barriers in the e-learning model based on multi-stakeholder decision making. Univers J Educ Res. 2020;8(5):1759–1766.
    1. Zalat M.M., Hamed M.S., Bolbol S.A. The experiences, challenges, and acceptance of e-learning as a tool for teaching during the COVID-19 pandemic among university medical staff. PLoS One. 2021;16(3)
    1. Naresh B., Reddy B.S. Challenges and opportunity of E-learning in developed and developing countries-a review. Int J Emerg Res Manag Technol. 2015;4(6):259–262.

Source: PubMed

3
Subscribe