Qualitative and Quantitative Assessment of Remineralizing Effect of Prophylactic Toothpaste Promoting Brushite Formation: A Randomized Clinical Trial

Maria A Polyakova, Marianna G Arakelyan, Ksenia S Babina, Edita G Margaryan, Inna A Sokhova, Vladlena Yu Doroshina, Nina E Novozhilova, Maria A Polyakova, Marianna G Arakelyan, Ksenia S Babina, Edita G Margaryan, Inna A Sokhova, Vladlena Yu Doroshina, Nina E Novozhilova

Abstract

Background: Currently various studies are conducted to improve the effect of existing and developing new remineralizing agents. One of the trends in remineralizing therapy is the development of toothpaste allowing brushite crystals formation in the demineralized lesions of hard tooth tissues.

Aim: The aim of this study was to assess the effect of toothpaste, forming a brushite, on the functional acid resistance of enamel and the speed of its remineralization.

Materials and methods: This was a randomized controlled double-blind clinical study. Sixty consent patients aged 20-25 years were enrolled in the three groups: test group (n = 20), positive control group (n = 20), and negative control group (n = 20), which used brushite-forming toothpaste, toothpaste with hydroxyapatite (HAP), and toothpaste without remineralizing agents, respectively. The hygiene indices, the rate of enamel remineralization, the dynamics of acid resistance of enamel, and the level of enamel sensitivity were determined at baseline, after 2 and 4 weeks to assess the effectiveness of toothpastes. Friedman rank sum test (for related variables) and the Kruskal-Wallis rank sum test (for independent variables) with Nemenyi post hoc test were used for statistical comparisons.

Results: The study test and positive control groups showed significantly greater acid resistance of enamel (P > 0.05) and rate of its remineralization at the study endpoints as compared with negative control group.In the test and positive control groups, Schiff index values significantly decreased after 4 weeks, whereas in the negative control group no significant differences were observed at the study time points. The oral hygiene level improved significantly after 2 and 4 weeks in all groups.

Conclusion: The 30-day use of paste that promotes brushite formation and paste with hydroxyapatite resulted in faster enamel remineralization and higher enamel resistance. Brushite-containing toothpaste may be used as an alternative to HAP containing for remineralizing and desensitizing treatment.

Keywords: Brushite; enamel acid resistance; hypersensitivity; remineralization; toothpastes.

Conflict of interest statement

Nil.

Copyright: © 2020 Journal of International Society of Preventive and Community Dentistry.

Figures

Figure 1
Figure 1
Participant flow diagram
Figure 2
Figure 2
Dynamics of Shiff test
Figure 3
Figure 3
Enamel acidic resistance

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