Intraocular lens dislocation in pseudoexfoliation: a systematic review and meta-analysis
Pedro Vazquez-Ferreiro, Francisco J Carrera-Hueso, Narjis Fikri-Benbrahim, Lidia Barreiro-Rodriguez, Marta Diaz-Rey, María Auxiliadora Ramón Barrios, Pedro Vazquez-Ferreiro, Francisco J Carrera-Hueso, Narjis Fikri-Benbrahim, Lidia Barreiro-Rodriguez, Marta Diaz-Rey, María Auxiliadora Ramón Barrios
Abstract
Purpose: To evaluate the impact of pseudoexfoliation syndrome on intraocular lens (IOL) dislocation after phacoemulsification cataract surgery and explore possible associations related to surgical technique.
Methods: We systematically searched the MEDLINE, Embase, Web of Science, Cochrane, and Lilacs databases and grey literature sources and identified (on March 1, 2016) 14 cohort and case-control studies comparing IOL dislocation in patients with and without pseudoexfoliation syndrome who had undergone phacoemulsification. Study quality was assessed using the STROBE scale. An inverse-variance fixed-effects model was used to calculate weighted odds ratios (ORs) and 95% confidence intervals (CI).
Results: The pooled analysis yielded an OR of 6.02 (95% CI: 3.7, 9.79) for IOL dislocation in patients with pseudoexfoliation, and similarly, high ORs were detected for both early and late (3 months after surgery) dislocation (OR 5.26; 95% CI: 1.05; 26.32 versus OR 6.02; 95% CI: 3.67; 10.17). No significant associations were detected when the results were stratified by year, incision size or use of hooks or retractors.
Conclusions: Patients with pseudoexfoliation syndrome have a high risk of late IOL dislocation after phacoemulsification cataract surgery, and this risk may be related to the use of large incisions and hooks or retractors.
Keywords: exfoliation syndrome; intraoperative complications; lens subluxation; meta-analysis; phacoemulsification.
© 2016 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.
Source: PubMed