CD4+ cytolytic T cell clone confers protection against murine malaria

M Tsuji, P Romero, R S Nussenzweig, F Zavala, M Tsuji, P Romero, R S Nussenzweig, F Zavala

Abstract

A CD4+ T cell clone (A1.6) was derived from spleen cells of mice immunized with irradiated sporozoites. This T cell clone recognizes an antigen that is shared by sporozoites and blood forms of Plasmodium berghei and differs from the circumsporozoite protein. Clone A1.6 displays cytotoxic activity, produces IFN-gamma and IL-2 in vitro, and recognizes the plasmodial antigen in the context of the class II I-Ed molecule. Passive transfer of this CD4+ clone into naive mice resulted in a high degree of protection against sporozoite challenge.

References

    1. Eur J Immunol. 1988 Sep;18(9):1385-9
    1. Adv Immunol. 1989;45:283-334
    1. J Immunol. 1989 Sep 15;143(6):2038-44
    1. J Parasitol. 1968 Dec;54(6):1175-80
    1. Hepatology. 1988 May-Jun;8(3):449-54
    1. Eur J Immunol. 1987 May;17(5):675-81
    1. J Immunol. 1987 Nov 15;139(10):3493-6
    1. Nature. 1987 Dec 17-23;330(6149):664-6
    1. Proc Natl Acad Sci U S A. 1988 Jan;85(2):573-6
    1. Science. 1986 May 16;232(4752):881-4

Source: PubMed

Sponsors and Collaborators

Medical Conditions

Drug Interventions

3
Subscribe