Can We Prevent Depression in At-Risk Older Adults Using Self-Help? The UK SHARD Trial of Behavioral Activation
Simon Gilbody, Sally Brabyn, Alex Mitchell, David Ekers, Dean McMillan, Della Bailey, Deborah Hems, Carolyn A Chew Graham, Ada Keding, Kate Bosanquet, SHARD collaborative, Simon Gilbody, Sally Brabyn, Alex Mitchell, David Ekers, Dean McMillan, Della Bailey, Deborah Hems, Carolyn A Chew Graham, Ada Keding, Kate Bosanquet, SHARD collaborative
Abstract
Background: Treatment of established depression is the dominant approach to care of older adults, but prevention holds much promise. Self-help interventions are a feasible preventive approach, since they are scalable and low cost. There are few trials in this area. Behavioral Activation (BA) is a credible candidate psychological approach, which has been shown to work in therapist led care but not been trialled in a self-help form.
Aim: To test the effectiveness of an unguided self-help intervention based on BA for older adults.
Methods: We compared a self-help intervention based on BA for older people (n = 172) to usual care (n = 160) in a pragmatic randomized controlled trial. Outcomes were depression status and severity (PHQ9) and health related quality of life (SF12). The primary timepoint of the primary outcome was depression at 4 months, with longer term follow up at 12 months to test sustained impact of the primary outcome.
Results: At 4 months adjusted PHQ-9 scores for BA self-help were 0.79 lower (95% CI: -1.70 to 0.13; p = 0.09) and the proportion of participants with case-level depression was significantly reduced (BA 31/137 (22.6%) versus usual care 41/141 (29.1%); Odds Ratio 0.48; 95% CI: 0.26-0.92; p = 0.03). There was no PHQ-9 difference at 12 months or for health related quality of life at any point (4 or 12 months).
Discussion: Self-help using BA for older people at risk of depression is a feasible and scalable intervention with potential short-term benefits in preventing depression.
Keywords: Depression; RCT; behavioral activation; older adults; prevention.
Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.
Source: PubMed