The value of glioma extent of resection in the modern neurosurgical era

Douglas A Hardesty, Nader Sanai, Douglas A Hardesty, Nader Sanai

Abstract

Objective: There remains no general consensus in the neurosurgical oncology literature regarding the role of extent of glioma resection in improving patient outcome. Although the value of resection in establishing a diagnosis and alleviating mass effect is clear, there is less certainty in ascertaining the influence of extent of resection (EOR). Here, we review the recent literature to synthesize a comprehensive review of the value of extent of resection for gliomas in the modern neurosurgical era.

Methods: We reviewed every major peer-reviewed clinical publication since 1990 on the role of EOR in glioma outcome.

Results: Thirty-two high-grade glioma articles and 11 low-grade glioma articles were examined in terms of quality of evidence, expected EOR, and survival benefit.

Conclusion: Despite limitations in the quality of data, mounting evidence suggests that more extensive surgical resection is associated with longer life expectancy for both low- and high-grade newly diagnosed gliomas.

Keywords: extent of resection; glioma; high-grade glioma; low-grade glioma; malignant transformation.

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