Health-related quality of life in children with untreated intermittent exotropia and their parents
Jonathan M Holmes, Amra Hercinovic, B Michele Melia, David A Leske, Sarah R Hatt, Danielle L Chandler, Trevano W Dean, Raymond T Kraker, Laura B Enyedi, David K Wallace, Brian G Mohney, Susan A Cotter, Pediatric Eye Disease Investigator Group, Jonathan M Holmes, Amra Hercinovic, B Michele Melia, David A Leske, Sarah R Hatt, Danielle L Chandler, Trevano W Dean, Raymond T Kraker, Laura B Enyedi, David K Wallace, Brian G Mohney, Susan A Cotter, Pediatric Eye Disease Investigator Group
Abstract
Purpose: To determine whether health-related quality of life (HRQOL) scores improved or worsened over 3 years of observation in childhood intermittent exotropia without treatment.
Methods: A total of 111 children aged 3-11 years with intermittent exotropia were assigned to observation in a previously reported randomized trial comparing patching with observation. The intermittent exotropia questionnaire (IXTQ) was administered at baseline, 6 months, and 36 months. Rasch-calibrated IXTQ domain scores (Child, Proxy, Parent-psychosocial, Parent-function, and Parent-surgery) were compared between time points. The Child IXTQ was administered only to children ≥5 years of age (n = 78).
Results: Overall, Child IXTQ and Proxy IXTQ scores showed no significant change over 36 months (mean improvement from baseline to 36 months of 3.2 points [95% CI, -1.9 to 8.2] and -2.4 points [95% CI: -7.9 to 3.1], resp.). By contrast, Parent-psychosocial, Parent-function, and Parent-surgery domain scores all improved over 36 months (mean improvements of 12.8 points [95% CI, 5.9-19.6] and 14.2 points [95% CI, 8.0-20.3] and 18.5 points [95% CI, 9.7-27.3], resp.).
Conclusions: HRQOL of children with intermittent exotropia remains stable with observation over 3 years (by both child and proxy report), whereas parental HRQOL improves.
Trial registration: ClinicalTrials.gov NCT01032330.
Copyright © 2021 American Association for Pediatric Ophthalmology and Strabismus. Published by Elsevier Inc. All rights reserved.
Figures
![FIG 1.](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/8628477/bin/nihms-1700686-f0001.jpg)
Source: PubMed