Pain management in laparoscopic donor nephrectomy: a review

U Mathuram Thiyagarajan, A Bagul, M L Nicholson, U Mathuram Thiyagarajan, A Bagul, M L Nicholson

Abstract

The management of postoperative pain is a key to patient early recovery, in particular, where the surgery was performed to benefit another human being. In recent years it has been recognized that multimodal analgesic methods are superior for postoperative pain relief. It is also imperative to remember that inadequately managed acute postoperative pain opens the doorway to possible suffering from chronic postoperative pain later. Although the laparoscopic donor nephrectomy has reduced the disincentives associated with open surgery, still significant percentage of donors suffers from postoperative pain. In the UK, patient-controlled analgesic system (PCAS) using morphine for postoperative pain relief is being used in majority of the transplant centres. Though opioids provide good analgesia, they are far from being an ideal analgesic due to their adverse effects. This paper pragmatically looks in depth on different modalities of pain management in patients undergoing laparoscopic live donor nephrectomy.

References

    1. Ratner LE, Ciseck LJ, Moore RG, Cigarroa FG, Kaufman HS, Kavoussi LR. Laparoscopic live donor nephrectomy. Transplantation. 1995;60(9):1047–1049.
    1. Nicholson ML, Kaushik M, Lewis GRR, et al. Randomized clinical trial of laparoscopic versus open donor nephrectomy. British Journal of Surgery. 2010;97(1):21–28.
    1. Greco F, Hoda MR, Alcaraz A, Bachmann A, Hakenberg OW, Fornara P. Laparoscopic living-donor nephrectomy: analysis of the existing literature. European Urology. 2010;58(4):498–509.
    1. Wilson CH, Sanni A, Rix DA, Soomro NA. Laparoscopic versus open nephrectomy for live kidney donors. Cochrane Database of Systematic Reviews. 2011;(11, article CD006124)
    1. Dillenburg W, Poulakis V, Skriapas K, et al. Retroperitoneoscopic versus open surgical radical nephrectomy for large renal cell carcinoma in clinical stage cT2 or cT3a: quality of life, pain and reconvalescence. European Urology. 2006;49(2):314–322.
    1. Bachmann A, Wolff T, Giannini O, et al. How painful is donor nephrectomy? Retrospective analysis of early pain and pain management in open versus laparoscopic versus retroperitoneoscopic nephrectomy. Transplantation. 2006;81(12):1735–1738.
    1. Perry KT, Freedland SJ, Hu JC, et al. Quality of life, pain and return to normal activities following laparoscopic donor nephrectomy versus open mini-incision donor nephrectomy. Journal of Urology. 2003;169(6):2018–2021.
    1. Andersen MH, Mathisen L, Øyen O, et al. Postoperative pain and convalescence in living kidney donors—laparoscopic versus open donor nephrectomy: a randomized study. American Journal of Transplantation. 2006;6(6):1438–1443.
    1. Jackobs S, Becker T, Lück R, et al. Quality of life following living donor nephrectomy comparing classical flank incision and anterior vertical mini-incision. World Journal of Urology. 2005;23(5):343–348.
    1. Williams M, Milner QJW. Postoperative analgesia following renal transplantation—current practice in the UK. Anaesthesia. 2003;58(7):712–713.
    1. Oefelein MG, Bayazit Y. Chronic pain syndrome after laparoscopic radical nephrectomy. Journal of Urology. 2003;170(5):1939–1940.
    1. Joshi GP. Multimodal analgesia techniques and postoperative rehabilitation. Anesthesiology Clinics of North America. 2005;23(1):185–202.
    1. Liu SS, Carpenter RL, Mackey DC, et al. Effects of perioperative analgesic technique on rate of recovery after colon surgery. Anesthesiology. 1995;83:757–765.
    1. Nikolajsen L, Sørensen HC, Jensen TS, Kehlet H. Chronic pain following Caesarean section. Acta Anaesthesiologica Scandinavica. 2004;48(1):111–116.
    1. Bay-Nielsen M, Perkins FM, Kehlet H. Pain and functional impairment 1 year after inguinal herniorrhaphy: a nationwide questionnaire study. Annals of Surgery. 2001;233(1):1–7.
    1. Merskey H, Bogduk N. Description of Chronic Pain Syndromes and Definitions of Pain Terms. Seattle, Wash, USA: IASP Press; 1994.
    1. Owen M, Lorgelly P, Serpell M. Chronic pain following donor nephrectomy—a study of the incidence, nature and impact of chronic post-nephrectomy pain. European Journal of Pain. 2010;14(7):732–734.
    1. Chatterjee S, Nam R, Fleshner N, Klotz L. Permanent flank bulge is a consequence of flank incision for radical nephrectomy in one half of patients. Urologic Oncology. 2004;22(1):36–39.
    1. Waller JR, Hiley AL, Mullin EJ, Veitch PS, Nicholson ML. Living kidney donation: a comparison of laparoscopic and conventional open operations. Postgraduate Medical Journal. 2002;78(917):153–157.
    1. Katz J, Jackson M, Kavanagh BP, Sandler AN. Acute pain after thoracic surgery predicts long-term post-thoracotomy pain. Clinical Journal of Pain. 1996;12(1):50–55.
    1. Tasmuth T, Kataja M, Blomqvist C, Von Smitten K, Kalso E. Treatment-related factors predisposing to chronic pain in patients with breast cancer: a multivariate approach. Acta Oncologica. 1997;36(6):625–630.
    1. Callesen T, Bech K, Kehlet H. Prospective study of chronic pain after groin hernia repair. British Journal of Surgery. 1999;86(12):1528–1531.
    1. Aasvang E, Kehlet H. Chronic postoperative pain: the case of inguinal herniorrhaphy. British Journal of Anaesthesia. 2005;95(1):69–76.
    1. Bisgaard T, Klarskov B, Rosenberg J, Kehlet H. Characteristics and prediction of early pain after laparoscopic cholecystectomy. Pain. 2001;90(3):261–269.
    1. Poleshuck EL, Katz J, Andrus CH, et al. Risk factors for chronic pain following breast cancer surgery: a prospective study. Journal of Pain. 2006;7(9):626–634.
    1. Gerbershagen HJ, Dagtekin O, Rothe T, et al. Risk factors for acute and chronic postoperative pain in patients with benign and malignant renal disease after nephrectomy. European Journal of Pain. 2009;13(8):853–860.
    1. Kehlet H. Postoperative pain relief—what is the issue? British Journal of Anaesthesia. 1994;72(4):375–378.
    1. Tverskoy M, Oren M, Dashkovsky I, Kissin I. Alfentanil dose-response relationships for relief of postoperative pain. Anesthesia and Analgesia. 1996;83(2):387–393.
    1. Wilder-Smith CH, Hill L, Wilkins J, Denny L. Effects of morphine and tramadol on somatic and visceral sensory function and gastrointestinal motility after abdominal surgery. Anesthesiology. 1999;91(3):639–647.
    1. Kehlet H. Multimodal approach to control postoperative pathophysiology and rehabilitation. British Journal of Anaesthesia. 1997;78(5):606–617.
    1. Kehlet H. Modification of responses to surgery by neural blockade: clinical implications. In: Cousins MJ, Bridenbaugh, editors. Neural Blockade in Clinical Aneathesia and Management of Pain. 3rd edition. Philadelphia, Pa, USA: Lippincott-Raven; 1998. pp. 129–171.
    1. Freedland SJ, Blanco-Yarosh M, Sun JC, et al. Ketorolac-based analgesia improves outcomes for living kidney donors. Transplantation. 2002;73(5):741–745.
    1. Gillis JC, Brogden RN. Ketorolac: a reappraial of its pharmacodynamic and pharmacokinetic properties and therapeutic use in pain management. Drugs. 1997;53(1):139–188.
    1. Feldman HI, Kinman JL, Berlin JA, et al. Parenteral ketorolac: the risk for acute renal failure. Annals of Internal Medicine. 1997;126(3):193–199.
    1. Strom BL, Berlin JA, Kinman JL, et al. Parenteral ketorolac and risk of gastrointestinal and operative site bleeding: a postmarketing surveillance study. Journal of the American Medical Association. 1996;275(5):376–382.
    1. Chang AM, Ip WY, Cheung TH. Patient-controlled analgesia versus conventional intramuscular injection: a cost effectiveness analysis. Journal of Advanced Nursing. 2004;46(5):531–541.
    1. Lange MP, Dahn MS, Jacobs LA. Patient-controlled analgesia versus intermittent analgesia dosing. Heart and Lung. 1988;17(5):495–498.
    1. Rosen DM, Lam AM, Carlton MA, Cario GM, McBride L. Analgesia following major gynecological laparoscopic surgery–PCA versus intermittent intramuscular injection. Journal of the Society of Laparoendoscopic Surgeons. 1998;2(1):25–29.
    1. Gorevski E, Wead S, Tevar A, Succop P, Volek P, Martin-Boone J. Retrospective evaluation of donor pain and pain management after laprascopic nephrectomy. Transplantation Proceedings. 2011;43(7):2487–2491.
    1. Ballantyne JC, Carr DB, Chalmers TC, Dear KBG, Angelillo IF, Mosteller F. Postoperative patient-controlled analgesia: meta-analyses of initial randomized control trials. Journal of Clinical Anesthesia. 1993;5(3):182–193.
    1. Boulanger A, Choiniere M, Roy D, et al. Comparison between patient-controlled analgesia and intramuscular meperidine after thoracotomy. Canadian Journal of Anaesthesia. 1993;40(5 I):409–415.
    1. Dolin SJ, Cashman JN, Bland JM. Effectiveness of acute postoperative pain management: I. Evidence from published data. British Journal of Anaesthesia. 2002;89(3):409–423.
    1. Chan VWS, Chung F, McQuestion M, Gomez M. Impact of patient-controlled analgesia on required nursing time and duration of postoperative recovery. Regional Anesthesia. 1995;20(6):506–514.
    1. Colwell CW, Jr., Morris BA. Patient-controlled analgesia compared with intramuscular injection of analgesics for the management of pain after an orthopaedic procedure. Journal of Bone and Joint Surgery A. 1995;77(5):726–733.
    1. Egbert AM, Parks LH, Short LM, Burnett ML. Randomized trial of postoperative patient-controlled analgesia vs intramuscular narcotics in frail elderly men. Archives of Internal Medicine. 1990;150(9):1897–1903.
    1. Gust R, Pecher S, Gust A, Hoffmann V, Böhrer H, Martin E. Effect of patient-controlled analgesia on pulmonary complications after coronary artery bypass grafting. Critical Care Medicine. 1999;27(10):2218–2223.
    1. Kehlet H, Holte K. Effect of postoperative analgesia on surgical outcome. British Journal of Anaesthesia. 2001;87(1):62–72.
    1. Addison NV, Brear FA, Budd K, Whittaker M. Epidural analgesia following cholecystectomy. British Journal of Surgery. 1974;61(10):850–852.
    1. Suarez-Sanchez L, Perales-Caldera E, Pelaez-Luna MC, Bernal-Flores R. Postoperative outcome of open donor nephrectomy under epidural analgesia: a descriptive analysis. Transplantation Proceedings. 2006;38(3):877–881.
    1. Ashcraft EE, Baillie GM, Shafizadeh SF, et al. Further improvements in laparoscopic donor nephrectomy: decreased pain and accelerated recovery. Clinical Transplantation. 2001;15(6):59–61.
    1. Kehlet H. General versus regional anaesthesia. In: Rogers M, Tinker J, Covino B, Longnecker DE, editors. Principles and Practice of Anesthesiology. St. Louis, Mo, USA: Mosby; 1993. pp. 1218–1234.
    1. Yndgaard S, Holst P, Bjerre-Jepsen K, Thomsen CB, Struckmann J, Mogensen T. Subcutaneously versus subfascially administered lidocaine in pain treatment after inguinal herniotomy. Anesthesia and Analgesia. 1994;79(2):324–327.
    1. Rafi AN. Abdominal field block: a new approach via the lumbar triangle. Anaesthesia. 2001;56(10):1024–1026.
    1. McDonnell JG, O’Donnell B, Curley G, Heffernan A, Power C, Laffey JG. The analgesic efficacy of transversus abdominis plane block after abdominal surgery: a prospective randomized controlled trial. Anesthesia and Analgesia. 2007;104(1):193–197.
    1. McDonnell JG, Curley G, Carney J, et al. The analgesic efficacy of transversus abdominis plane block after cesarean delivery: a randomized controlled trial. Anesthesia and Analgesia. 2008;106(1):186–191.
    1. Biglarnia AR, Tufveson G, Lorant T, Lennmyr F, Wadström J. Efficacy and safety of continuous local infusion of ropivacaine after retroperitoneoscopic live donor nephrectomy. American Journal of Transplantation. 2011;11(1):93–100.
    1. Panaro F, Gheza F, Piardi T, et al. Continuous infusion of local anesthesia after living donor nephrectomy: a comparative analysis. Transplantation Proceedings. 2011;43(4):985–987.
    1. Vloka JD, Hadžić A, Mulcare R, Lesser JB, Kitain E, Thys DM. Femoral and genitofemoral nerve blocks versus spinal anesthesia for outpatients undergoing long saphenous vein stripping surgery. Anesthesia and Analgesia. 1997;84(4):749–752.
    1. Li S, Coloma M, White PF, et al. Comparison of the costs and recovery profiles of three anesthetic techniques for ambulatory anorectal surgery. Anesthesiology. 2000;93(5):1225–1230.
    1. Song D, Greilich NB, White PF, Watcha MF, Tongier WK. Recovery profiles and costs of anesthesia for outpatient unilateral inguinal herniorrhaphy. Anesthesia and Analgesia. 2000;91(4):876–881.
    1. Michaloliakou C, Chung F, Sharma S. Preoperative multimodal analgesia facilitates recovery after ambulatory laparoscopic cholecystectomy. Anesthesia and Analgesia. 1996;82(1):44–51.
    1. Gharaibeh KIA, Al-Jaberi TM. Bupivacaine instillation into gallbladder bed after laparoscopic cholecystectomy: does it decrease shoulder pain? Journal of Laparoendoscopic and Advanced Surgical Techniques A. 2000;10(3):137–141.
    1. Bisgaard T, Klarskov B, Kristiansen VB, et al. Multi-regional local anesthetic infiltration during laparoscopic cholecystectomy in patients receiving prophylactic multi-modal analgesia: a randomized, double-blinded, placebo-controlled study. Anesthesia and Analgesia. 1999;89(4):1017–1024.
    1. Fong SY, Pavy TJ, Yeo ST, Paech MJ, Gurrin LC. Assessment of wound infiltration with bupivacaine in women undergoing day-case gynecological laparoscopy. Regional Anesthesia and Pain Medicine. 2001;26(2):131–136.
    1. Hasaniya NW, Zayed FF, Faiz H, Severino R. Preinsertion local anesthesia at the trocar site improves perioperative pain and decreases costs of laparoscopic cholecystectomy. Surgical Endoscopy. 2001;15(9):962–964.
    1. Sarac AM, Aktan AO, Baykan N, Yegen C, Yalin R. The effect and timing of local anesthesia in laparoscopic cholecystectomy. Surgical Laparoscopy, Endoscopy and Percutaneous Techniques. 1996;6(5):362–366.
    1. Møiniche S, Jørgensen H, Wetterslev J, Dahl JB. Local anesthetic infiltration for postoperative pain relief after laparoscopy: a qualitative and quantitative systematic review of intraperitoneal, port-site infiltration and mesosalpinx block. Anesthesia and Analgesia. 2000;90(4):899–912.
    1. Hariharan S, Moseley H, Kumar A, Raju S. The effect of preemptive analgesia in postoperative pain relief—a prospective double-blind randomized study. Pain Medicine. 2009;10(1):49–53.
    1. Klein JR, Heaton JP, Thompson JP, Cotton BR, Davidson AC, Smith G. Infiltration of the abdominal wall with local anaesthetic after total abdominal hysterectomy has no opioid-sparing effect. British Journal of Anaesthesia. 2000;84(2):248–249.
    1. Lowenstein L, Zimmer EZ, Deutsch M, Paz Y, Yaniv D, Jakobi P. Preoperative analgesia with local lidocaine infiltration for abdominal hysterectomy pain management. European Journal of Obstetrics Gynecology and Reproductive Biology. 2008;136(2):239–242.
    1. Ives HIE. Diuretic Agents. In: Katzung BG, editor. Basic and Clinical Pharmacology. 9th edition. New York, NY, USA: Lange; 2004. pp. 241–258.
    1. Harvey JW, Otterson M, Yun H, Connolly LA, Eastwood D, Colpaert K. Acetazolamide reduces referred postoperative pain after laparoscopic surgery with carbon dioxide insufflation. Anesthesiology. 2003;99(4):924–928.
    1. Singh R, Sen I, Wig J, Minz M, Sharma A, Bala I. An acetazolamide based multimodal analgesic approach versus conventional pain management in patients undergoing laparoscopic living donor nephrectomy. Indian Journal of Anaesthesia. 2009;53(4):434–441.

Source: PubMed

3
Subscribe