Implementation of integrated stepped care for unhealthy alcohol use in HIV clinics

E Jennifer Edelman, Nathan B Hansen, Christopher J Cutter, Cheryl Danton, Lynn E Fiellin, Patrick G O'Connor, Emily C Williams, Stephen A Maisto, Kendall J Bryant, David A Fiellin, E Jennifer Edelman, Nathan B Hansen, Christopher J Cutter, Cheryl Danton, Lynn E Fiellin, Patrick G O'Connor, Emily C Williams, Stephen A Maisto, Kendall J Bryant, David A Fiellin

Abstract

Background: Effective counseling and pharmacotherapy for unhealthy alcohol use are rarely provided in HIV treatment settings to patients. Our goal was to describe factors influencing implementation of a stepped care model to address unhealthy alcohol use in HIV clinics from the perspectives of social workers, psychologists and addiction psychiatrists.

Methods: We conducted two focus groups with Social Workers (n = 4), Psychologists (n = 2), and Addiction Psychiatrists (n = 4) involved in an ongoing randomized controlled trial evaluating the effectiveness of integrated stepped care for unhealthy alcohol use in HIV-infected patients at five Veterans Health Administration (VA) HIV clinics. Data collection and analyses were guided by the Consolidated Framework for Implementation Research (CFIR) domains, with a focus on the three domains which we considered to be most relevant: intervention characteristics (i.e. motivational interviewing, pharmacotherapy), the inner setting (i.e. HIV clinics), and characteristics of individuals (i.e. the providers). A multidisciplinary team used directed content analysis to identify major themes.

Results: From the providers' perspective, the major implementation themes that emerged by CFIR domain included: (1) Intervention characteristics: providers valued tools and processes for facilitating patient motivation for treatment of unhealthy alcohol use given their perceived lack of motivation, but expressed a desire for greater flexibility; (2) Inner setting: treating unhealthy alcohol use in HIV clinics was perceived by providers to be consistent with VA priorities; and (3) Characteristics of individuals: there was high self-efficacy to conduct the intervention, an expressed need for more consistent utilization to maintain skills, and consideration of alternative models for delivering the components of the intervention.

Conclusions: Use of the CFIR framework reveals that implementation of integrated stepped care for unhealthy alcohol use in HIV clinics is facilitated by tools to help providers enhance patient motivation or address unhealthy alcohol use among patients perceived to be unmotivated. Implementation may be facilitated by its consistency with organizational values and existing models of care and attention to optimizing provider self-efficacy and roles (i.e. approaches to treatment integration).

Figures

Fig. 1
Fig. 1
Integrated stepped care for unhealthy alcohol use in HIV clinics: relevant CFIR domains and constructs*. *Adapted from Damschroder LJ, Aron DC, Keith RE, Kirsh SR, Alexander JA, Lowery JC. Fostering implementation of health services research findings into practice: A consolidated framework for advancing implementation science. CFIR Figure and Explanatory Text (http://www.implementationscience.com/content/supplementary/1748-5908-4-50-s1.pdf)

References

    1. Saitz R. Clinical practice. Unhealthy alcohol use. N Engl J Med. 2005;352(6):596–607. doi: 10.1056/NEJMcp042262.
    1. Fabris P, Tositti G, Manfrin V, Giordani MT, Vaglia A, Cattelan AM, et al. Does alcohol intake affect highly active antiretroviral therapy (HAART) response in HIV-positive patients? J Acquir Immune Defic Syndr. 2000;25:92–93. doi: 10.1097/00126334-200009010-00013.
    1. Cook RL, Sereika SM, Hunt SC, Woodward WC, Erlen JA, Conigliaro J. Problem drinking and medication adherence among persons with HIV infection. J Gen Intern Med. 2001;16:83–88. doi: 10.1111/j.1525-1497.2001.00122.x.
    1. Galvan FH, Bing EG, Fleishman JA, London AS, Caetano R, Burnam MA, et al. The prevalence of alcohol consumption and heavy drinking among people with HIV in the United States: results from the HIV cost and services utilization study. J Stud Alcohol. 2002;63:179–186. doi: 10.15288/jsa.2002.63.179.
    1. Lucas GM, Gebo KA, Chaisson RE, Moore RD. Longitudinal assessment of the effects of drug and alcohol abuse on HIV-1 treatment outcomes in an urban clinic. Aids. 2002;16(5):767–774. doi: 10.1097/00002030-200203290-00012.
    1. Samet JH, Horton NJ, Traphagen ET, Lyon SM, Freedberg KA. Alcohol consumption and HIV disease progression: are they related? Alcohol Clin Exp Res. 2003;27(5):862–867. doi: 10.1097/01.ALC.0000065438.80967.56.
    1. Arnsten JH, Demas PA, Grant RW, Gourevitch MN, Farzadegan H, Howard AA, et al. Impact of active drug use on antiretroviral therapy adherence and viral suppression in HIV-infected drug users. J Gen Int Med. 2002;17:377–381. doi: 10.1007/s11606-002-0044-3.
    1. Williams EC, Bradley KA, Balderson BH, McClure JB, Grothaus L, McCoy K, et al. Alcohol and associated characteristics among older persons living with human immunodeficiency virus on antiretroviral therapy. Subst Abus. 2014;35(3):245–253. doi: 10.1080/08897077.2014.890997.
    1. Korthuis PT, Zephyrin LC, Fleishman JA, Saha S, Josephs JS, McGrath MM, et al. Health-related quality of life in HIV-infected patients: the role of substance use. AIDS Patient Care STDS. 2008;22(11):859–867. doi: 10.1089/apc.2008.0005.
    1. Korthuis PT, Fiellin DA, McGinnis KA, Skanderson M, Justice AC, Gordon AJ, et al. Unhealthy alcohol and illicit drug use are associated with decreased quality of HIV care. J Acquir Immune Defic Syndr. 2012;61(2):171–178. doi: 10.1097/QAI.0b013e31826741aa.
    1. Freiberg MS, McGinnis KA, Kraemer K, Samet JH, Conigliaro J, Curtis Ellison R, et al. The association between alcohol consumption and prevalent cardiovascular diseases among HIV-infected and HIV-uninfected men. J Acquir Immune Defic Syndr. 2010;53(2):247–253. doi: 10.1097/QAI.0b013e3181c6c4b7.
    1. Lim JK, Tate JP, Fultz SL, Goulet JL, Conigliaro J, Bryant KJ, et al. Relationship between alcohol use categories and noninvasive markers of advanced hepatic fibrosis in HIV-infected, chronic hepatitis C virus-infected, and uninfected patients. Clin Infect Dis. 2014
    1. McGinnis KA, Fultz SL, Skanderson M, Conigliaro J, Bryant K, Justice AC. Hepatocellular carcinoma and non-Hodgkin’s lymphoma: the roles of HIV, hepatitis C infection, and alcohol abuse. J Clin Oncol. 2006;24(31):5005–5009. doi: 10.1200/JCO.2006.05.7984.
    1. Mayer KH, Skeer MR, O’Cleirigh C, Goshe BM, Safren SA. Factors associated with amplified hiv transmission behavior among american men who have sex with men engaged in care: implications for clinical providers. Ann Behav Med. 2013
    1. Cook RL, McGinnis KA, Kraemer KL, Gordon AJ, Conigliaro J, Maisto SA, et al. Intoxication before intercourse and risky sexual behavior in male veterans with and without human immunodeficiency virus infection. Med Care. 2006;44(8 Suppl 2):S31–S36. doi: 10.1097/01.mlr.0000223710.35008.d9.
    1. Lefevre F, O’Leary B, Moran M, Mossar M, Yarnold PR, Martin GJ, et al. Alcohol consumption among HIV-infected patients. J Gen Intern Med. 1995;10(8):458–460. doi: 10.1007/BF02599920.
    1. Petry NM. Alcohol use in HIV patients: what we don’t know may hurt us. Int J STD AIDS. 1999;10(9):561–570. doi: 10.1258/0956462991914654.
    1. Cook RL, Sereika SM, Hunt SC, Woodward WC, Erlen JA, Conigliaro J. Problem drinking and medication adherence among persons with HIV infection. J Gen Intern Med. 2001;16(2):83–88. doi: 10.1111/j.1525-1497.2001.00122.x.
    1. Samet JH, Cheng DM, Libman H, Nunes DP, Alperen JK, Saitz R. Alcohol consumption and HIV disease progression. J Acquir Immune Defic Syndr. 2007;46(2):194–199. doi: 10.1097/QAI.0b013e318142aabb.
    1. Samet JH, Horton NJ, Traphagen ET, Lyon SM, Freedberg KA. Alcohol consumption and HIV disease progression: are they related? Alcohol Clin Exp Res. 2003;27(5):862–867. doi: 10.1097/01.ALC.0000065438.80967.56.
    1. Samet JH, Phillips SJ, Horton NJ, Traphagen ET, Freedberg KA. Detecting alcohol problems in HIV-infected patients: use of the CAGE questionnaire. AIDS Res Hum Retroviruses. 2004;20(2):151–155. doi: 10.1089/088922204773004860.
    1. Jonas DE, Garbutt JC, Amick HR, Brown JM, Brownley KA, Council CL, et al. Behavioral counseling after screening for alcohol misuse in primary care: a systematic review and meta-analysis for the US preventive services task force. Ann Intern Med. 2012
    1. Anton RF, O’Malley SS, Ciraulo DA, Cisler RA, Couper D, Donovan DM, et al. Combined pharmacotherapies and behavioral interventions for alcohol dependence: the COMBINE study: a randomized controlled trial. JAMA. 2006;295(17):2003–2017. doi: 10.1001/jama.295.17.2003.
    1. Jonas DE, Amick HR, Feltner C, Bobashev G, Thomas K, Wines R, et al. Pharmacotherapy for adults with alcohol use disorders in outpatient settings: a systematic review and meta-analysis. JAMA. 2014;311(18):1889–1900. doi: 10.1001/jama.2014.3628.
    1. Brown JL, DeMartini KS, Sales JM, Swartzendruber AL, DiClemente RJ. Interventions to reduce alcohol use among HIV-infected individuals: a review and critique of the literature. Curr HIV/AIDS Rep. 2013;10(4):356–370. doi: 10.1007/s11904-013-0174-8.
    1. Hasin DS, Aharonovich E, O’Leary A, Greenstein E, Pavlicova M, Arunajadai S, et al. Reducing heavy drinking in HIV primary care: a randomized trial of brief intervention, with and without technological enhancement. Addiction. 2013;108(7):1230–1240. doi: 10.1111/add.12127.
    1. Elliott JC, Aharonovich E, O’Leary A, Wainberg M, Hasin DS. Drinking motives as prospective predictors of outcome in an intervention trial with heavily drinking HIV patients. Drug Alcohol Depend. 2014;134:290–295. doi: 10.1016/j.drugalcdep.2013.10.026.
    1. Elliott JC, Aharonovich E, O’Leary A, Wainberg M, Hasin DS. Drinking motives among HIV primary care patients. AIDS Behav. 2014;18(7):1315–1323. doi: 10.1007/s10461-013-0644-4.
    1. Metsch LR, Pereyra M, Colfax G, Dawson-Rose C, Cardenas G, McKirnan D, et al. HIV-positive patients’ discussion of alcohol use with their HIV primary care providers. Drug Alcohol Depend. 2008;95(1–2):37–44. doi: 10.1016/j.drugalcdep.2007.12.006.
    1. Conigliaro J, Gordon AJ, McGinnis KA, Rabeneck L, Justice AC. How harmful is hazardous alcohol use and abuse in HIV infection: do health care providers know who is at risk? J Acquir Immune Defic Syndr. 2003;33(4):521–525. doi: 10.1097/00126334-200308010-00014.
    1. Conigliaro J, Justice AC, Gordon AJ, Bryant K. Role of alcohol in determining human immunodeficiency virus (HIV)-relevant outcomes: a conceptual model to guide the implementation of evidence-based interventions into practice. Med Care. 2006;44(8 Suppl 2):S1–S6. doi: 10.1097/.
    1. Korthuis PT, Saha S, Chander G, McCarty D, Moore RD, Cohn JA, et al. Substance use and the quality of patient-provider communication in HIV clinics. AIDS Behav. 2011;15(4):832–841. doi: 10.1007/s10461-010-9779-8.
    1. Montague BT, Kahler CW, Colby SM, McHugh RK, Squires D, Fitzgerald B, et al. Attitudes and training needs of new england hiv care and addiction treatment providers: opportunities for better integration of hiv and alcohol treatment services. Addict Disord Their Treat. 2015;14(1):16–28. doi: 10.1097/ADT.0000000000000040.
    1. van Straten A, Hill J, Richards DA, Cuijpers P. Stepped care treatment delivery for depression: a systematic review and meta-analysis. Psychol Med. 2014;45:1–16.
    1. James PA, Oparil S, Carter BL, Cushman WC, Dennison-Himmelfarb C, Handler J, et al. 2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8) JAMA. 2014;311(5):507–520. doi: 10.1001/jama.2013.284427.
    1. National Institute on Alcohol Abuse and Alcoholism. What’s “at-risk” or “heavy” drinking? . Accessed 18 July 2011.
    1. Sterling RK, Lissen E, Clumeck N, Sola R, Correa MC, Montaner J, et al. Development of a simple noninvasive index to predict significant fibrosis in patients with HIV/HCV coinfection. Hepatology. 2006;43(6):1317–1325. doi: 10.1002/hep.21178.
    1. Mendeni M, Foca E, Gotti D, Ladisa N, Angarano G, Albini L, et al. Evaluation of liver fibrosis: concordance analysis between noninvasive scores (APRI and FIB-4) evolution and predictors in a cohort of HIV-infected patients without hepatitis C and B infection. Clin Infect Dis. 2011;52(9):1164–1173. doi: 10.1093/cid/cir071.
    1. American Psychiatric Association . Diagnostic and Statistical Manual of Mental Disorders (DSM-IV), fourth edition Washington. Washington: American Psychiatric Press; 1994.
    1. D’Onofrio G, Pantalon MV, Degutis LC, Fiellin DA, O’Connor PG. Development and implementation of an emergency practitioner-performed brief intervention for hazardous and harmful drinkers in the emergency department. Acad Emerg Med. 2005;12(3):249–256.
    1. Pantalon MV, Martino S, Dziura J, Li FY, Owens PH, Fiellin DA, et al. Development of a scale to measure practitioner adherence to a brief intervention in the emergency department. J Subst Abuse Treat. 2012;43(4):382–388. doi: 10.1016/j.jsat.2012.08.011.
    1. D’Onofrio G, Fiellin DA, Pantalon MV, Chawarski MC, Owens PH, Degutis LC, et al. A brief intervention reduces hazardous and harmful drinking in emergency department patients. Ann Emerg Med. 2012
    1. Miller WR, Zweben A, DiClememte CC, Rycharik RG. Motivational enhancement therapy manual: a clinical research guide for therapists treating individuals with alcohol abuse and dependence, NIAAA Project MATCH Monograph. 1992. . Accessed 1 Jan 2015
    1. Justice AC, McGinnis KA, Skanderson M, Chang CC, Gibert CL, Goetz MB, et al. Towards a combined prognostic index for survival in HIV infection: the role of ‘non-HIV’ biomarkers. HIV Med. 2010;11(2):143–151. doi: 10.1111/j.1468-1293.2009.00757.x.
    1. Justice AC, Modur SP, Tate JP, Althoff KN, Jacobson LP, Gebo KA, et al. Predictive accuracy of the veterans aging cohort study index for mortality with HIV infection: a North American cross cohort analysis. J Acquir Immune Defic Syndr. 2013;62(2):149–163. doi: 10.1097/QAI.0b013e31827df36c.
    1. Tate JP, Justice AC, Hughes MD, Bonnet F, Reiss P, Mocroft A, et al. An internationally generalizable risk index for mortality after 1 year of antiretroviral therapy. AIDS. 2013;27(4):563–572. doi: 10.1097/QAD.0b013e32835b8c7f.
    1. Rosland AM, Nelson K, Sun H, Dolan ED, Maynard C, Bryson C, et al. The patient-centered medical home in the Veterans Health Administration. Am J Manag Care. 2013;19(7):e263–e272.
    1. Kearney LK, Post EP, Zeiss A, Goldstein MG, Dundon M. The role of mental and behavioral health in the application of the patient-centered medical home in the department of veterans affairs. Transl Behav Med. 2011;1(4):624–628. doi: 10.1007/s13142-011-0093-4.
    1. Curran GM, Bauer M, Mittman B, Pyne JM, Stetler C. Effectiveness-implementation hybrid designs: combining elements of clinical effectiveness and implementation research to enhance public health impact. Med Care. 2012;50(3):217–226. doi: 10.1097/MLR.0b013e3182408812.
    1. McGovern MP, Saunders EC, Kim E. Substance abuse treatment implementation research. J Subst Abuse Treat. 2013;44(1):1–3. doi: 10.1016/j.jsat.2012.09.006.
    1. Green CA, McCarty D, Mertens J, Lynch FL, Hilde A, Firemark A, et al. A qualitative study of the adoption of buprenorphine for opioid addiction treatment. J Subst Abuse Treat. 2014;46(3):390–401. doi: 10.1016/j.jsat.2013.09.002.
    1. Hartzler B, Lash SJ, Roll JM. Contingency management in substance abuse treatment: a structured review of the evidence for its transportability. Drug Alcohol Depend. 2012;122(1–2):1–10. doi: 10.1016/j.drugalcdep.2011.11.011.
    1. Damschroder LJ, Hagedorn HJ. A guiding framework and approach for implementation research in substance use disorders treatment. Psychol Addict Behav. 2011;25(2):194–205. doi: 10.1037/a0022284.
    1. Damschroder LJ, Aron DC, Keith RE, Kirsh SR, Alexander JA, Lowery JC. Fostering implementation of health services research findings into practice: a consolidated framework for advancing implementation science. Implement Sci. 2009;4:50. doi: 10.1186/1748-5908-4-50.
    1. Curry LA, Nembhard IM, Bradley EH. Qualitative and mixed methods provide unique contributions to outcomes research. Circulation. 2009;119(10):1442–1452. doi: 10.1161/CIRCULATIONAHA.107.742775.
    1. Hsieh HF, Shannon SE. Three approaches to qualitative content analysis. Qual Health Res. 2005;15(9):1277–1288. doi: 10.1177/1049732305276687.
    1. Elo S, Kyngas H. The qualitative content analysis process. J Adv Nurs. 2008;62(1):107–115. doi: 10.1111/j.1365-2648.2007.04569.x.
    1. Fredriksson M, Eldh A, Vengberg S, Dahlstrom T, Halford C, Wallin L, et al. Local politico-administrative perspectives on quality improvement based on national registry data in Sweden: a qualitative study using the consolidated framework for implementation research. Implement Sci. 2014;9(1):777. doi: 10.1186/s13012-014-0189-6.
    1. Damschroder LJ, Lowery JC. Evaluation of a large-scale weight management program using the consolidated framework for implementation research (CFIR) Implement Sci. 2013;8:51. doi: 10.1186/1748-5908-8-51.
    1. Murphy K, O’Connor DA, Browning CJ, French SD, Michie S, Francis JJ, et al. Understanding diagnosis and management of dementia and guideline implementation in general practice: a qualitative study using the theoretical domains framework. Implement Sci. 2014;9:31. doi: 10.1186/1748-5908-9-31.
    1. Bergstrom A, Peterson S, Namusoko S, Waiswa P, Wallin L. Knowledge translation in Uganda: a qualitative study of Ugandan midwives’ and managers’ perceived relevance of the sub-elements of the context cornerstone in the PARIHS framework. Implement Sci. 2012;7:117. doi: 10.1186/1748-5908-7-117.
    1. Barry DT, Irwin KS, Jones ES, Becker WC, Tetrault JM, Sullivan LE, et al. Opioids, chronic pain, and addiction in primary care. J Pain. 2010;11(12):1442–1450. doi: 10.1016/j.jpain.2010.04.002.
    1. Barry DT, Irwin KS, Jones ES, Becker WC, Tetrault JM, Sullivan LE, et al. Integrating buprenorphine treatment into office-based practice: a qualitative study. J Gen Intern Med. 2009;24(2):218–225. doi: 10.1007/s11606-008-0881-9.
    1. Hieftje K, Rosenthal MS, Camenga DR, Edelman EJ, Fiellin LE. A qualitative study to inform the development of a video game for adolescent HIV prevention. Games Health J. 2012;1(4):294–298. doi: 10.1089/g4h.2012.0025.
    1. Edelman EJ, Cole CA, Richardson W, Boshnack N, Jenkins H, Rosenthal MS. Opportunities for improving partner notification for HIV: results from a community-based participatory research study. AIDS Behav. 2014
    1. Maisto SA, Carey KB, Carey MP, Purnine DM, Barnes KL. Methods of changing patterns of substance use among individuals with co-occurring schizophrenia and substance use disorder. J Subst Abuse Treat. 1999;17(3):221–227. doi: 10.1016/S0740-5472(99)00005-7.
    1. Noel NE, Ogle RL, Maisto SA, Jackson LA., Jr What Do Women Want? A qualitative study of dating. Violence Against Women. 2014
    1. Fox AM, Jackson SS, Hansen NB, Gasa N, Crewe M, Sikkema KJ. In their own voices: a qualitative study of women’s risk for intimate partner violence and HIV in South Africa. Violence Against Women. 2007;13(6):583–602. doi: 10.1177/1077801207299209.
    1. Crabtree BF, Miller WL. Doing Qualitative Research. 2. Thousand Oaks: Sage Publications; 1999.
    1. Elliott JC, Aharonovich E, Hasin DS. Reasons for limiting drinking in an HIV primary care sample. Alcohol Clin Exp Res. 2014;38(6):1720–1727. doi: 10.1111/acer.12401.
    1. Bradley KA, Williams EC, Achtmeyer CE, Volpp B, Collins BJ, Kivlahan DR. Implementation of evidence-based alcohol screening in the Veterans Health Administration. Am J Manag Care. 2006;12(10):597–606.
    1. Williams EC, Rubinsky AD, Chavez LJ, Lapham GT, Rittmueller SE, Achtmeyer CE, et al. An early evaluation of implementation of brief intervention for unhealthy alcohol use in the US veterans health administration. Addiction. 2014;109(9):1472–1481. doi: 10.1111/add.12600.
    1. Iheanacho T, Issa M, Marienfeld C, Rosenheck R. Use of naltrexone for alcohol use disorders in the Veterans’ Health Administration: a national study. Drug Alcohol Depend. 2013;132(1–2):122–126. doi: 10.1016/j.drugalcdep.2013.01.016.
    1. Marienfeld C, Iheanacho T, Issa M, Rosenheck RA. Long-acting injectable depot naltrexone use in the Veterans’ Health Administration: a national study. Addict Behav. 2014;39(2):434–438. doi: 10.1016/j.addbeh.2013.05.006.
    1. Del Re AC, Gordon AJ, Lembke A, Harris AH. Prescription of topiramate to treat alcohol use disorders in the veterans health administration. Addict Sci Clin Pract. 2013;8:12. doi: 10.1186/1940-0640-8-12.
    1. Group; TMoSUDW. VA/DoD Clinical practice guideline for management of Substance Use Disorders (SUD). In: Department of veterans affairs DoD. 2009.
    1. Bradley KA, Kivlahan DR. Bringing patient-centered care to patients with alcohol use disorders. JAMA. 2014;311(18):1861–1862. doi: 10.1001/jama.2014.3629.
    1. Korthuis PT, Josephs JS, Fleishman JA, Hellinger J, Himelhoch S, Chander G, et al. Substance abuse treatment in human immunodeficiency virus: the role of patient-provider discussions. J Subst Abuse Treat. 2008;35(3):294–303. doi: 10.1016/j.jsat.2007.11.005.
    1. Fiellin DA, Weiss L, Botsko M, Egan JE, Altice FL, Bazerman LB, et al. Drug treatment outcomes among HIV-infected opioid-dependent patients receiving buprenorphine/naloxone. J Acquir Immune Defic Syndr. 2011;56(Suppl 1):S33–S38. doi: 10.1097/QAI.0b013e3182097537.
    1. Korthuis PT, Fiellin DA, Fu R, Lum PJ, Altice FL, Sohler N, et al. Improving adherence to HIV quality of care indicators in persons with opioid dependence: the role of buprenorphine. J Acquir Immune Defic Syndr. 2011;56(Suppl 1):S83–S90. doi: 10.1097/QAI.0b013e31820bc9a5.
    1. Drainoni ML, Farrell C, Sorensen-Alawad A, Palmisano JN, Chaisson C, Walley AY. Patient perspectives of an integrated program of medical care and substance use treatment. AIDS Patient Care STDS. 2014;28(2):71–81. doi: 10.1089/apc.2013.0179.

Source: PubMed

3
Subscribe