Irreversible electroporation of lung neoplasm: a case series
Mumal Usman, William Moore, Ronak Talati, Kevin Watkins, Thomas V Bilfinger, Mumal Usman, William Moore, Ronak Talati, Kevin Watkins, Thomas V Bilfinger
Abstract
Background: Percutaneous irreversible electroporation (IRE) of lung tumors is a new minimally invasive technique which has recently been used in the treatment of soft tissue tumors.
Case reports: The case histories are presented of two patients with unresectable malignancies in the lung, who underwent irreversible electroporation as a treatment attempt. The procedure was performed under CT guidance and was uneventful.
Conclusions: At follow up 6 months later, the tumors both appeared to have recurred. To our knowledge, no similar cases have previously been reported in the literature.
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References
- Miyamoto T, Baba M, Sugane T, et al. Carbon ion radiotherapy for stage 1 non-small cell lung cancer using a regimen of four fractions during 1 week. J Thorac Oncol. 2007;2:916–26.
- Ghosh S, Sujendran V, Alexiou C, et al. Long term results of surgery versus continuous hyperfractionated accelerated radiotherapy(CHART) in patients aged 70 years with stage 1 non small cell lung cancer. Eur J Cardiothorac Surg. 2003;24:1002–7.
- Dupuy DE, Mayo-Smith WW, Abbott GF, et al. Clinical application of radiofrequency tumour ablation in thorax. Radiographics. 2002;22(Special Issue):S259–69.
- Steinke K, King J, Glenn D, et al. Radiologic appearance and complications of percutaneous computed tomography – guided radiofrequency – ablated pulmonary metastases from colorectal carcinoma. J Comput Assist Tomogr. 2003;27(5):750–57.
- Herrera LJ, Fernando HC, Perry Y, et al. Radiofrequency ablation of pulmonary malignant tumors in non surgical candidates. J ThoracCardiovasc Surg. 2003;12:5929–37.
- Mussi A, Ambrogi MC. Percutaneous thermal ablation of lung tumours (editorial) Ann Osp San Camillo Forlanini. 2003:5225–27.
- Ambrogi MC, Fontanini G, Lencioni R, et al. A preliminary study on thermal ablation of lung tumour. Contemporary Oncol. 2004:8373–79.
- Thomson KR, Cheung W, Ellis SJ, et al. Investigation of the safety of irreversible electroporation in humans. J Vasc Interv Radiol. 2011;22(5):611–21.
- Lee EW, Chen C, Prieto VE, et al. Advanced Hepatic Ablation Technique for Creating Complete Cell Death: Irreversible Electroporation. Radiology. 2010;255:426–33.
- Zemlyak A, Moore W, Bilfinger T. Comparison of Survival after Sub-lobar Resections and Ablative Therapies for Stage I Non-small Cell Lung Cancer (NSCLC) J Am Coll Surg. 2010;211(1):68–72.
- Al-Sakere B, Andre F, Bernat C, et al. Tumor Ablation with Irreversible Electroporation. PLoS ONE. 2007;2(11):e1135.
Source: PubMed