Clinical Trials: SEARCH[Study] TILT[Study:StudyFirstPostDate] AREA[BasicSearch] Intensified insulin treatment
#
NCTID/Status
Study
Last Changed
1
NCT01957930
Completed
Completed
Intensive Insulin Treatment and Ischemic Foot Ulcer
Conditions: Ischemic Foot Ulcer
Intervention: Intensified Conventional Insulin Treatment, Standard Treatment
Conditions: Ischemic Foot Ulcer
Intervention: Intensified Conventional Insulin Treatment, Standard Treatment
November 16, 2015
2
NCT01220557
Completed
Completed
Evaluation of a Treatment and Education Programme for Type 1 Diabetic Patients (PRIMAS)
Conditions: Type 1 Diabetes
Intervention: PRIMAS, DTTP
Conditions: Type 1 Diabetes
Intervention: PRIMAS, DTTP
August 8, 2014
3
NCT03469492
Recruiting
Recruiting
Investigating the Role of the Polyol Pathway in the Central Nervous System Production of Fructose
Conditions: Hyperglycaemia (Diabetic)
Intervention: Insulin, Exercise, Dietary Counseling
Conditions: Hyperglycaemia (Diabetic)
Intervention: Insulin, Exercise, Dietary Counseling
May 22, 2019
4
NCT00365170
Completed
Completed
Efficacy and Safety of Insulin Aspart vs. Human Insulin During Pregnancy by Women With Type 1 Diabetes
Conditions: Diabetes; Diabetes Mellitus, Type 1
Intervention: Human Insulin, Insulin Aspart
Conditions: Diabetes; Diabetes Mellitus, Type 1
Intervention: Human Insulin, Insulin Aspart
December 20, 2016
5
NCT03682640
Recruiting
Recruiting
Azithromycin Insulin Diet Intervention Trial in Type 1 Diabetes
Conditions: Diabetes Mellitus, Type 1; Diabetes Mellitus; Metabolic Disease; Glucose Metabolism Disorders; Endocrine System Diseases; Juvenile Diabetes; Insulin Dependent Diabetes; Type 1 Diabetes Mellitus; Inflammation; Diet Modification
Intervention: Azithromycin Monohydrate, Insulin Lispro, Dietician Support
Conditions: Diabetes Mellitus, Type 1; Diabetes Mellitus; Metabolic Disease; Glucose Metabolism Disorders; Endocrine System Diseases; Juvenile Diabetes; Insulin Dependent Diabetes; Type 1 Diabetes Mellitus; Inflammation; Diet Modification
Intervention: Azithromycin Monohydrate, Insulin Lispro, Dietician Support
September 21, 2018
6
NCT00535483
Completed
Completed
Closed Loop Insulin Therapy in Type 1 Diabetics Based on Blood Microdialysis, Online Sensors and an eMPC Algorithm
Conditions: Type 1 Diabetes
Conditions: Type 1 Diabetes
April 3, 2014
7
NCT00733148
Completed
Completed
Correlation Between the Interstitial and Arterial Glucose in Post Surgery Patients
Conditions: Intensive Care
Intervention: Dosing Of Insulin
Conditions: Intensive Care
Intervention: Dosing Of Insulin
August 7, 2008
8
NCT00481598
Completed
Completed
Non Invasive Assessment of Liver Glycogen Kinetics and ATP Synthesis in Type1 Diabetics
Conditions: Type 1 Diabetes Mellitus
Intervention: Magnet Resonance Spectroscopy
Conditions: Type 1 Diabetes Mellitus
Intervention: Magnet Resonance Spectroscopy
September 11, 2008
9
NCT00901992
Completed
Completed
Evaluation of a Self-management Oriented Diabetes Education Program for Intensified Insulin Therapy in Type 2 Diabetes
Conditions: Type 2 Diabetes
Intervention: MEDIAS 2 ICT, Current ICT Program (ACC-ICT)
Conditions: Type 2 Diabetes
Intervention: MEDIAS 2 ICT, Current ICT Program (ACC-ICT)
August 8, 2014
10
NCT01150617
Terminated
Terminated
Normalization of Fasting Glucose and the Incidence of Restenosis After Peripheral Angioplasty
Conditions: Type 2 Diabetes Mellitus; Peripheral Vascular Disease
Intervention: Insulin Glargine Plus Insulin Analogues
Conditions: Type 2 Diabetes Mellitus; Peripheral Vascular Disease
Intervention: Insulin Glargine Plus Insulin Analogues
September 12, 2012
11
NCT03437551
Completed
Completed
Prevalence of DRP and DME Among Type 1 Diabetics Treated With Long-term Intensified Insulin Therapy
Conditions: Insulin-Dependent Diabetes Mellitus 1
Intervention: Cross-sectional Observation
Conditions: Insulin-Dependent Diabetes Mellitus 1
Intervention: Cross-sectional Observation
February 26, 2018
12
NCT02307110
Completed
Completed
Prevalence of DRP and DME Among Type 1 Diabetics Treated With Long-term Intensified Insulin Therapy
Conditions: Insulin-Dependent Diabetes Mellitus 1
Intervention: Cross-sectional Observation
Conditions: Insulin-Dependent Diabetes Mellitus 1
Intervention: Cross-sectional Observation
January 2, 2018
13
NCT03175315
Completed
Completed
Evaluation of a Treatment and Education Program for Diabetic Patients Who Use Flash Glucose Monitoring
Conditions: Diabetes Mellitus
Intervention: Treatment And Education Program For Patients With Diabetes Who Use Flash Glucose Monitoring (FLASH)
Conditions: Diabetes Mellitus
Intervention: Treatment And Education Program For Patients With Diabetes Who Use Flash Glucose Monitoring (FLASH)
August 2, 2018
14
NCT01517490
Unknown status
Unknown status
Retinal Adaptation to Intensified Insulin Therapy and Bariatric Surgery in Patients With Diabetes
Conditions: Diabetes Mellitus; Diabetic Retinopathy
Intervention: Insulin Pump, Multiple Daily Insulin Injections, Bariatric Surgery, Medical Therapy For Type 2 Diabetes
Conditions: Diabetes Mellitus; Diabetic Retinopathy
Intervention: Insulin Pump, Multiple Daily Insulin Injections, Bariatric Surgery, Medical Therapy For Type 2 Diabetes
March 10, 2015
15
NCT01006889
Completed
Completed
Adding Exenatide to Insulin Therapy for Patients With Type 2 Diabetes and Non-Alcoholic Fatty Liver Disease
Conditions: Nonalcoholic Fatty Liver Disease; Type 2 Diabetes Mellitus
Intervention: Exenatide
Conditions: Nonalcoholic Fatty Liver Disease; Type 2 Diabetes Mellitus
Intervention: Exenatide
August 22, 2016
16
NCT02863276
Completed
Completed
Modulating the Stress Response in Diabetes Mellitus Type 2 Patients Undergoing Colon Surgery
Conditions: Diabetes Mellitus Type 2; Insulin Resistance
Intervention: Intensified Insulin Therapy
Conditions: Diabetes Mellitus Type 2; Insulin Resistance
Intervention: Intensified Insulin Therapy
August 8, 2016
17
NCT00174668
Completed
Completed
Insulin Glulisine in Diabetes Mellitus, Type 2
Conditions: Diabetes Mellitus, Type 2
Intervention: Insulin Glulisine, Insulin Therapy, Insulin Glargine
Conditions: Diabetes Mellitus, Type 2
Intervention: Insulin Glulisine, Insulin Therapy, Insulin Glargine
September 14, 2009
18
NCT01068652
Completed
Completed
Effect of Different Insulin Administrations, All in Combination With Metformin, on Glycaemic Control in Subjects With Type 2 Diabetes Inadequately Controlled by Oral Anti-diabetic Drugs
Conditions: Diabetes; Diabetes Mellitus, Type 2
Intervention: Insulin Detemir, Insulin Aspart, Biphasic Insulin Aspart 30, Metformin
Conditions: Diabetes; Diabetes Mellitus, Type 2
Intervention: Insulin Detemir, Insulin Aspart, Biphasic Insulin Aspart 30, Metformin
November 23, 2016
19
NCT03570138
Recruiting
Recruiting
Efficacy of Flash Glucose-Sensing Technology on the Occurrence of Cardiac Arrhythmias Associated With Hypoglycemia
Conditions: Insulin Treated Type 2 Diabetes With High Risk of Hypoglycemia
Intervention: FREESTYLE LIBRE Device, A Flash Continuous Glucose Monitoring System, Usual Self Monitoring Blood Glucose Device
Conditions: Insulin Treated Type 2 Diabetes With High Risk of Hypoglycemia
Intervention: FREESTYLE LIBRE Device, A Flash Continuous Glucose Monitoring System, Usual Self Monitoring Blood Glucose Device
March 13, 2019
20
NCT03815487
Enrolling by invitation
Enrolling by invitation
Comparison of Two Management Systems in Patients With Type 1 Diabetes (Pediatric SmartHome)
Conditions: Patient Care; Drug Therapy
Intervention: Medtronic MiniMed 670G Insulin Pump In Auto Mode, Medtronic MiniMed 670G Insulin Pump Without Auto Mode
Conditions: Patient Care; Drug Therapy
Intervention: Medtronic MiniMed 670G Insulin Pump In Auto Mode, Medtronic MiniMed 670G Insulin Pump Without Auto Mode
July 8, 2019
21
NCT02084498
Completed
Completed
Advanced Carbohydrate Counting and Automated Bolus Calculation
Conditions: Type 1 Diabetes
Intervention: Automated Bolus Calculator, Advanced Carbohydrate Counting
Conditions: Type 1 Diabetes
Intervention: Automated Bolus Calculator, Advanced Carbohydrate Counting
November 20, 2014
22
NCT02379299
Withdrawn
Withdrawn
DiaCon Dual-Hormone Closed-Loop Glucose Control
Conditions: Type 1 Diabetes
Intervention: DiaCon Dual-hormone Closed-loop Glucose Control Algorithm, DiaCon Single-hormone Closed-loop Glucose Control Algorithm
Conditions: Type 1 Diabetes
Intervention: DiaCon Dual-hormone Closed-loop Glucose Control Algorithm, DiaCon Single-hormone Closed-loop Glucose Control Algorithm
August 8, 2017
23
NCT00537251
Completed
Completed
32 Week, Open, Randomized, 2 Way Cross Over Multicentre Trial to Compare Safety & Efficacy of Combination of HOE901 Insulin Analogue Once Daily at Bedtime + Lispro Insulin Before Meals vs NPH Insulin (Twice a Day) + Regular in Type 1 Diabetes Mellitus
Conditions: Diabetes Mellitus, Type 1
Intervention: Insulin Glargine
Conditions: Diabetes Mellitus, Type 1
Intervention: Insulin Glargine
September 28, 2007
24
NCT02229240
Withdrawn
Withdrawn
Albiglutide Versus Placebo Added-on to Basal-Bolus Insulin Therapy in Subjects With Type 2 Diabetes Mellitus
Conditions: Diabetes Mellitus, Type 2
Intervention: Albiglutide, Matching Albiglutide Placebo
Conditions: Diabetes Mellitus, Type 2
Intervention: Albiglutide, Matching Albiglutide Placebo
January 7, 2016
25
NCT00575172
Completed
Completed
Nippon Ultra-Rapid Insulin and Diabetic Complication Evaluation-Study (NICE-Study)
Conditions: Diabetes Mellitus
Conditions: Diabetes Mellitus
January 7, 2008
26
NCT03436212
Recruiting
Recruiting
Real-Life Home Glucose Monitoring Over 14 Days in T2D Patients With Intensified Therapy Using Insulin Pump.
Conditions: Type 2 Diabetes Mellitus
Intervention: Continuous Glucose Monitoring (CGM)
Conditions: Type 2 Diabetes Mellitus
Intervention: Continuous Glucose Monitoring (CGM)
February 12, 2018
27
NCT01215435
Completed
Completed
Comparison of Two Biphasic Insulin Aspart 30 Treatment Regimens in Subjects With Type 2 Diabetes Not Achieving HbA1c Treatment Targets on OADs Alone
Conditions: Diabetes; Diabetes Mellitus, Type 2
Intervention: Biphasic Insulin Aspart 30, Biphasic Insulin Aspart 30
Conditions: Diabetes; Diabetes Mellitus, Type 2
Intervention: Biphasic Insulin Aspart 30, Biphasic Insulin Aspart 30
October 22, 2014
28
NCT00982644
Completed
Completed
Comparison of NN1250 Versus Insulin Glargine in Subjects With Type 2 Diabetes
Conditions: Diabetes; Diabetes Mellitus, Type 2
Intervention: Insulin Degludec, Insulin Glargine
Conditions: Diabetes; Diabetes Mellitus, Type 2
Intervention: Insulin Degludec, Insulin Glargine
December 16, 2016
29
NCT01486966
Terminated
Terminated
Comparing Efficacy and Safety of Insulin Detemir Plus Insulin Aspart and NPH Insulin Plus Human Soluble Insulin With or Without Metformin in Chinese Patients With Type 2 Diabetes
Conditions: Diabetes; Diabetes Mellitus, Type 2
Intervention: Insulin Detemir, Insulin Aspart, Insulin NPH, Human Soluble Insulin, Metformin
Conditions: Diabetes; Diabetes Mellitus, Type 2
Intervention: Insulin Detemir, Insulin Aspart, Insulin NPH, Human Soluble Insulin, Metformin
February 9, 2017
30
NCT01076647
Completed
Completed
Comparison of NN1250 With Insulin Glargine in Subjects With Type 2 Diabetes
Conditions: Diabetes; Diabetes Mellitus, Type 2
Intervention: Insulin Degludec, Insulin Glargine
Conditions: Diabetes; Diabetes Mellitus, Type 2
Intervention: Insulin Degludec, Insulin Glargine
January 20, 2017
31
NCT02048189
Unknown status
Unknown status
Treatment With Continuous Sub-cutaneous Insulin Infusion Via a Portable Pump Versus Discontinuous Insulin Infusion Via Multiple-injections in Type 2 Diabetes
Conditions: Patient With Type 2 Diabetes Treated With Insulin Using a Baseline/Bolus Strategy
Intervention: LEVEMIR, APIDRA
Conditions: Patient With Type 2 Diabetes Treated With Insulin Using a Baseline/Bolus Strategy
Intervention: LEVEMIR, APIDRA
September 9, 2015
32
NCT00972283
Completed
Completed
Comparison of NN1250 With Insulin Glargine Plus Insulin Aspart With/Without Metformin and With/Without Pioglitazone in Type 2 Diabetes
Conditions: Diabetes; Diabetes Mellitus, Type 2
Intervention: Insulin Degludec, Insulin Glargine, Insulin Aspart
Conditions: Diabetes; Diabetes Mellitus, Type 2
Intervention: Insulin Degludec, Insulin Glargine, Insulin Aspart
March 8, 2017
33
NCT02423993
Completed
Completed
Education Effectiveness for Type 1 Diabetes Mellitus on Insulin Pump Therapy
Conditions: Diabetes Mellitus, Type 1
Intervention: Education By Structured Programme, CSII, CGM-RT, Screening For Complications, Glycaemic Control Assessment, QoL Assessment, Knowledge Assessment
Conditions: Diabetes Mellitus, Type 1
Intervention: Education By Structured Programme, CSII, CGM-RT, Screening For Complications, Glycaemic Control Assessment, QoL Assessment, Knowledge Assessment
December 7, 2015
34
NCT03047486
Completed
Completed
Smartguard Use in Real Life : a Longitudinal Study in Patients With Type 1 Diabetes
Conditions: Type 1 Diabetes Mellitus Maturity Onset
Conditions: Type 1 Diabetes Mellitus Maturity Onset
January 24, 2018
Last Updated
The last updated date is the most recent date when changes to a clinical trial were
submitted to ClinicalTrials.gov. There is often a delay of a few days before the
updated trial is available on the clinical trials website.
Specify a From date to find the most recently changed trials. Specify both From and To dates to find trials changed during a certain period. If no dates are given, all trials will be included.
Dates should be given in a MM/DD/YYYY format, as in 1/1/2006 or 8/17/2004.
Specify a From date to find the most recently changed trials. Specify both From and To dates to find trials changed during a certain period. If no dates are given, all trials will be included.
Dates should be given in a MM/DD/YYYY format, as in 1/1/2006 or 8/17/2004.
First Received
The first received date is the date when the clinical trial was first submitted
to ClinicalTrials.gov. There is often a delay of a few days before the
trial is available on the clinical trials website.
Clinical trial records are often updated after they have been published. The first received, last updated, start, and end dates are all displayed in the full text view of the clinical trial.
Specify a From date to find the most recent trials. Specify both From and To dates to find trials submitted during a certain period. If no dates are given, all trials will be included.
Dates should be given in a MM/DD/YYYY format, as in 1/1/2006 or 8/17/2004.
Clinical trial records are often updated after they have been published. The first received, last updated, start, and end dates are all displayed in the full text view of the clinical trial.
Specify a From date to find the most recent trials. Specify both From and To dates to find trials submitted during a certain period. If no dates are given, all trials will be included.
Dates should be given in a MM/DD/YYYY format, as in 1/1/2006 or 8/17/2004.
Safety Issue
If selected, restricts search results to those studies which have
an outcome measure designated as a safety issue. Note that this is a
poor estimate of the safety of a treatment or intervention, but it is
all we have now.
Funded By
Studies are supported by one or more organizations called sponsors.
Support includes contributions of facilities, expertise, and/or financial resources.
All sponsors in the database have been assigned one of the following organization types:
National Institutes of Health (NIH)
Other U.S. Federal Agency - Food and Drug Administration (FDA), Centers for Disease Control and Prevention (CDC), Department of Veterans Affairs (VA), etc.
Industry - the pharmaceutical companies
University/Organization - all others, including community-based organizations
Click the check box to the left of each organization type that you wish to include in your search. You can select more than one organization type. If you do not select any type, all types will be included.
National Institutes of Health (NIH)
Other U.S. Federal Agency - Food and Drug Administration (FDA), Centers for Disease Control and Prevention (CDC), Department of Veterans Affairs (VA), etc.
Industry - the pharmaceutical companies
University/Organization - all others, including community-based organizations
Click the check box to the left of each organization type that you wish to include in your search. You can select more than one organization type. If you do not select any type, all types will be included.
Study Phase
Click the check box to the left of each study phase that you wish to include in your search. You can select more than one study phase. If you do not select a any phase, all phases will be included.
Most clinical trials are designated as phase 1, 2, 3, or 4, based on the type of questions
that study is seeking to answer:
In Phase 1 (Phase I) clinical trials, researchers test a new drug or treatment in a small group of people (20-80) for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
In Phase 2 (Phase II) clinical trials, the study drug or treatment is given to a larger group of people (100-300) to see if it is effective and to further evaluate its safety.
In Phase 3 (Phase III) clinical trials, the study drug or treatment is given to large groups of people (1,000-3,000) to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
In Phase 4 (Phase IV) clinical trials, post marketing studies delineate additional information including the drug's risks, benefits, and optimal use.
These phases are defined by the Food and Drug Administration in the Code of Federal Regulations.
In Phase 1 (Phase I) clinical trials, researchers test a new drug or treatment in a small group of people (20-80) for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
In Phase 2 (Phase II) clinical trials, the study drug or treatment is given to a larger group of people (100-300) to see if it is effective and to further evaluate its safety.
In Phase 3 (Phase III) clinical trials, the study drug or treatment is given to large groups of people (1,000-3,000) to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
In Phase 4 (Phase IV) clinical trials, post marketing studies delineate additional information including the drug's risks, benefits, and optimal use.
These phases are defined by the Food and Drug Administration in the Code of Federal Regulations.
Click the check box to the left of each study phase that you wish to include in your search. You can select more than one study phase. If you do not select a any phase, all phases will be included.
Age Group
Studies may be designed for participants of particular ages:
Children (birth-17 yrs old)
Adults (18-65 yrs old)
Senior (66+ yrs old)
Click the check box to the left of each age group that you wish to include in your search. You can select more than one age group. If you do not select a any group, all groups will be included.
Children (birth-17 yrs old)
Adults (18-65 yrs old)
Senior (66+ yrs old)
Click the check box to the left of each age group that you wish to include in your search. You can select more than one age group. If you do not select a any group, all groups will be included.
Gender
Searches can be restricted to studies which accept female or male participants.
Location Terms
If you are interested in a specific city (such as Los Angeles) or facility
name (such as the Mayo Clinic), enter it as a location term. Not all studies
include this level of detail, but if they do, this will find them.
Countries and States
Trials are often conducted at many locations around the world.
Select up to three locations to find trials conducted in
specific countries. Some countries (currently limited to the
United States, Canada, and Australia), locations can be narrowed
further by selecting a state.
Study IDs
Each trial is assigned one or more identification numbers by the institute, agency,
or organization sponsoring the trial. In addition, clinical trials assigns a
unique NCT identifier of the form NCTxxxxxxxx where each x is a numeric digit.
Use this box to search for a trial by NCT identifier or any other study
identification numbers.
Examples:
Examples:
NCT00001789
97-h-0197
ia0006
actg 076
97-h-0197
ia0006
actg 076
Sponsor (Lead)
Use this box to specify the name of an institute, organization, or company that is
conducting a trial.
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the sponsor is decided by the data provider.
A search in this area will check only the sponsor field. To also look for collaborators, use the Sponsor/Collaborators search box.
When the Exact Match checkbox is checked, the sponsor name in the study must exactly match the sponsor name in the search. For example, if unchecked, a search for Merck in the lead sponsor field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Examples:
National Cancer Institute
Mayo Clinic
Bristol-Myers Squibb
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the sponsor is decided by the data provider.
A search in this area will check only the sponsor field. To also look for collaborators, use the Sponsor/Collaborators search box.
When the Exact Match checkbox is checked, the sponsor name in the study must exactly match the sponsor name in the search. For example, if unchecked, a search for Merck in the lead sponsor field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Examples:
National Cancer Institute
Mayo Clinic
Bristol-Myers Squibb
Sponsor/Collaborators
Use this box to specify institutes, organizations, or companies that are
conducting or otherwise supporting a trial.
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the sponsor is decided by the data provider.
Searching this area will look in both the sponsor field and in the collaborators field. To only look in the sponsor field, use the Sponsor (Lead) search box.
When the Exact Match checkbox is checked, the name in the study must exactly match the name in the search. For example, if unchecked, a search for Merck will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Examples:
National Cancer Institute
Mayo Clinic
Bristol-Myers Squibb
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the sponsor is decided by the data provider.
Searching this area will look in both the sponsor field and in the collaborators field. To only look in the sponsor field, use the Sponsor (Lead) search box.
When the Exact Match checkbox is checked, the name in the study must exactly match the name in the search. For example, if unchecked, a search for Merck will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Examples:
National Cancer Institute
Mayo Clinic
Bristol-Myers Squibb
Outcome Measures
Use this box to specify an outcome measure used to evaluate trial results.
Examples:
weight loss
heart failure
suicide
Outcome measures are used to evaluate trial results. For example, an obesity treatment
might be evaluated by a measure of weight loss after 6 months. Measures can also be used
to quantify side effects, such as number of myocardial infarctions,
number of patients with heart arrhythmia, number of suicides, etc.
Use this box to specify an outcome measure used to evaluate trial results.
Examples:
weight loss
heart failure
suicide
Interventions
Use this box to specify drugs, devices, procedures, or vaccines used in a trial.
Examples:
clofibrate
cyclosporine
vitamin e
Interventions refer to the drug, vaccine, procedure, device, or other potential treatment being studied.
Interventions can also include less intrusive possibilities such as surveys, education, and interviews.
Use this box to specify drugs, devices, procedures, or vaccines used in a trial.
Examples:
clofibrate
cyclosporine
vitamin e
Conditions
Use this box to specify the conditions being studied.
Examples:
lupus
heart attack
leukemia
risk factors for breast cancer
Conditions usually refer to a disease, disorder, syndrome, illness, or injury. In ClinicalTrials.gov,
conditions include any health issue worth studying, such as lifespan, quality of life, health risks, etc.
Use this box to specify the conditions being studied.
Examples:
lupus
heart attack
leukemia
risk factors for breast cancer
Study Type
There are three types of studies available in ClinicalTrials.gov:
There are three types of studies available in ClinicalTrials.gov:
Interventional:
Observational:
Expanded Access:
Studies where individuals are assigned to receive specific interventions.
Participants may receive diagnostic, therapeutic or other types of interventions.
Assignment of the intervention may or may not be random.
Individuals are tracked and biomedical and/or health outcomes are assessed.
Observational:
Studies without an intervention.
Studies where biomedical and/or health outcomes are assessed in a pre-defined group of individuals.
Participants may receive diagnostic, therapeutic, or other interventions, but the investigator
does not assign specific interventions to the participants of the study.
Expanded Access:
Records describing the procedure for obtaining an experimental drug or device for patients who
are failing on currently available treatments for their condition and also are unable to
participate in ongoing clinical trials. Expanded Access records are used to register all
types of non-protocol access to experimental treatments, including protocol exception,
single-patient IND, treatment IND, compassionate use, emergency use, continued access and parallel track.
Study Results
Searches can be restricted to studies with or without results.
The inclusion of study results is a relatively new feature of ClinicalTrials.gov. Collection of results began in September of 2008. Almost all older studies and some newer studies do not include results. As time goes on, there will be more results available.
The inclusion of study results is a relatively new feature of ClinicalTrials.gov. Collection of results began in September of 2008. Almost all older studies and some newer studies do not include results. As time goes on, there will be more results available.
Recruitment Status
Also known as Enrollment Status.
Not all clinical trials in this database are accepting new participants. If you are looking for studies that are currently recruiting participants, will be recruiting in the future, or are about drugs that are available for expanded access, select Open Studies in the recruitment menu.
If you are interested in all trials, whether they are recruiting new participants or not, leave the menu with All Studies selected.
Trials may not be recruiting because they are full, completed, or halted for various reasons. In addition, some trials have very restrictive eligibility requirements and must seek participants by invitation only. To see these studies, Select Closed Studies in the recruitment menu.
Full list of all possible recruitment status values:
Open recruitment status values:
Closed recruitment status values:
Values are color coded (as shown) in the search results.
Not all clinical trials in this database are accepting new participants. If you are looking for studies that are currently recruiting participants, will be recruiting in the future, or are about drugs that are available for expanded access, select Open Studies in the recruitment menu.
If you are interested in all trials, whether they are recruiting new participants or not, leave the menu with All Studies selected.
Trials may not be recruiting because they are full, completed, or halted for various reasons. In addition, some trials have very restrictive eligibility requirements and must seek participants by invitation only. To see these studies, Select Closed Studies in the recruitment menu.
Full list of all possible recruitment status values:
Open recruitment status values:
Recruiting,
Not yet recruiting, or
Available for expanded access.
Not yet recruiting, or
Available for expanded access.
Closed recruitment status values:
Active, not recruiting,
Completed,
Terminated,
Suspended,
Withdrawn,
Enrolling by invitation,
Temporarily not available for expanded access,
No longer available for expanded access,
Approved for marketing, or
Unknown.
Completed,
Terminated,
Suspended,
Withdrawn,
Enrolling by invitation,
Temporarily not available for expanded access,
No longer available for expanded access,
Approved for marketing, or
Unknown.
Search Terms
Use this box to specify general search terms found anywhere in the trial record.
Multiple terms can be separated by an AND (all uppercase).
Examples:
type ii diabetes
veterans affairs medical center
heart attacks in older adults
nhlbi AND heart disease
Cisplatin AND safety study
Multiple terms can be separated by an AND (all uppercase).
Examples:
type ii diabetes
veterans affairs medical center
heart attacks in older adults
nhlbi AND heart disease
Cisplatin AND safety study
Help for Searching clinical trials
Help Topics:
Basic Search:
On the Basic Search page, enter a word or word(s) that you want to use to find studies.
These may include diseases, interventions, and/or locations.
Medical terms are often several words long, such as Percutaneous Coronary Intervention. To only find studies where the words are together as a phrase, put the term in quotes (e.g., "Percutaneous Coronary Intervention"). If you search for a multi-word term without quotes, studies with all words together as a phrase will appear higher in the results list than studies where the words are separated and spread throughout the document. For example, a search for Heart Attack will list a study about,
A search for "Heart Attack" would not find the second study. Synonyms are known for some terms and are used where possible. For example, a search for Heart Attack will also find occurrences of Myocardial Infarction.
Medical terms are often several words long, such as Percutaneous Coronary Intervention. To only find studies where the words are together as a phrase, put the term in quotes (e.g., "Percutaneous Coronary Intervention"). If you search for a multi-word term without quotes, studies with all words together as a phrase will appear higher in the results list than studies where the words are separated and spread throughout the document. For example, a search for Heart Attack will list a study about,
Use of a Pacemaker Following a Heart Attack.
higher than the study,
Heart Defects and Transient Ischemic Attacks
A search for "Heart Attack" would not find the second study. Synonyms are known for some terms and are used where possible. For example, a search for Heart Attack will also find occurrences of Myocardial Infarction.
Advanced Search:
Many searches are a single term and can be performed with a few words in the
search box. But, sometimes you need more control. Click on the Advanced Search tab
(if starting a new search) or Refine Search tab (if modifying an existing search)
to show additional search fields.
The additional search fields can be used to limit your search results. Note that it is not necessary to fill in all the fields, only those that are needed for your search. If you are finding too few studies, consider clearing a field and searching again.
Search Terms:
Recruitment:
Interventions:
Outcomes Measures:
Sponsor/Collaborators:
Sponsor (Lead):
Study IDs:
Country/State:
Location Terms:
Gender:
Age Group:
Phase:
Funded By:
Safety Issue:
First Received:
Last Updated:
The additional search fields can be used to limit your search results. Note that it is not necessary to fill in all the fields, only those that are needed for your search. If you are finding too few studies, consider clearing a field and searching again.
Search Terms:
Performs a general search in all sections of the study record, including title,
description, conditions, interventions, locations, etc. Terms in this field are
searched the same as Basic Search.
Recruitment:
Limits search results to studies that are open or closed. New volunteers may be
able to participate in open studies, but not closed studies.
Open recruitment status values:
Closed recruitment status values:
Values are color coded (as shown) in the search results.
Study Results:Open recruitment status values:
Recruiting,
Not yet recruiting, or
Available for expanded access.
Not yet recruiting, or
Available for expanded access.
Closed recruitment status values:
Active, not recruiting,
Completed,
Terminated,
Suspended,
Withdrawn,
Enrolling by invitation,
Temporarily not available for expanded access,
No longer available for expanded access,
Approved for marketing, or
Unknown.
Completed,
Terminated,
Suspended,
Withdrawn,
Enrolling by invitation,
Temporarily not available for expanded access,
No longer available for expanded access,
Approved for marketing, or
Unknown.
Values are color coded (as shown) in the search results.
Limits search results based on whether the study has results or not:
Study Type:
All Studies,
Studies With Results, or
Studies Without Results
The inclusion of Study Results is a new feature of ClinicalTrials.gov.
Only a few studies have results available.Studies With Results, or
Studies Without Results
Limits search results to any of the following study types:
Conditions:
Interventional,
Observational, or
Expanded Access
Observational, or
Expanded Access
Performs a search on fields describing the diseases or conditions being studied.
Interventions:
Performs a search on fields listing the drugs or interventions being studied.
Outcomes Measures:
Performs a search on fields listing the outcome measures used to quantify study results.
Sponsor/Collaborators:
Performs a search on fields listing the sponsor and collaborators of a study.
When the Exact Match checkbox is checked, the sponsor/collaborator name in the study must exactly match the name in the search. For example, if unchecked, a search for Merck in the sponsor/collaborator field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
When the Exact Match checkbox is checked, the sponsor/collaborator name in the study must exactly match the name in the search. For example, if unchecked, a search for Merck in the sponsor/collaborator field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Sponsor (Lead):
Performs a search on the sponsor field of a study.
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the "sponsor" is decided by the data provider.
When the Exact Match checkbox is checked, the lead sponsor name in the study must exactly match the lead sponsor name in the search. For example, if unchecked, a search for Merck in the lead sponsor field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the "sponsor" is decided by the data provider.
When the Exact Match checkbox is checked, the lead sponsor name in the study must exactly match the lead sponsor name in the search. For example, if unchecked, a search for Merck in the lead sponsor field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Study IDs:
Performs a search on fields listing ID numbers.
Country/State:
Trials are often conducted at many locations around the world.
Select up to three locations to find trials conducted in
specific countries. Some countries (currently limited to the
United States, Canada, and Australia), locations can be narrowed
further by selecting a state (e.g., United States, Alabama).
Location Terms:
Finds studies in specific locations such as a city (Los Angeles) or facility (Mayo Clinic).
Not all studies include this level of detail, but if they do, this will find them.
Gender:
Limits search results to those studies that accept female or male participants.
Age Group:
Limits search results to those studies that include at least one of the specified age
ranges. More than one age group can be selected.
Phase:
Limits search results to studies that are labeled with at least one of the specified
phases. More than one Phase can be selected.
Funded By:
Limits search results to studies that have at least one sponsor of the specified types.
More than one sponsor type can be selected.
Safety Issue:
Limits search results to studies that have at least one outcome measure designated as a safety issue.
First Received:
Limits search results to studies that were received by clinical trials within a
specified date range. The "From" or "To" field can be left blank.
Last Updated:
Limits search results to studies that were modified within a
specified date range. The "From" or "To" field can be left blank.
Refine Search:
Searches display a list of studies found (List Results tab). If you are not content with
the search results, click on the Refine Search tab at the top of the list to modify your
search.
Add terms to empty fields to search within your current result. You can also add terms to fields that contain terms. For best results, use an AND (all upper case) as a separator between terms in the same field.
For example:
When you are done making changes, click Search to display the new results.
Add terms to empty fields to search within your current result. You can also add terms to fields that contain terms. For best results, use an AND (all upper case) as a separator between terms in the same field.
For example:
heart attack
heart attack AND aspirin
heart attack AND aspirin AND older adults
heart attack AND aspirin AND older adults AND California
heart attack AND aspirin
heart attack AND aspirin AND older adults
heart attack AND aspirin AND older adults AND California
When you are done making changes, click Search to display the new results.
Search Expressions:
Use AND (all upper case) to find study records that contain all terms connected by AND.
For example:
Use OR (all upper case) to find study records that contain either term connected by OR.
For example:
Use NOT (all upper case) to find study records that do not contain the term following NOT.
For example:
Likewise, AND, OR, NOT, and parentheses can be used to create more complicated search expressions.
For example:
Note that the use of AND and OR as logical operators can be confusing.
An appropriate search for a list such as,
To search for AND as a word, instead of using it as an operator, put it in quotes.
Likewise, you can quote OR, NOT, and parentheses.
For example:
prostate cancer AND radiation
heart disease AND stroke AND California
heart disease AND stroke AND California
Use OR (all upper case) to find study records that contain either term connected by OR.
For example:
Aspirin OR ibuprofen
heart disease OR heart attack
heart disease OR heart attack
Use NOT (all upper case) to find study records that do not contain the term following NOT.
For example:
Immunodeficiency NOT AIDS
Likewise, AND, OR, NOT, and parentheses can be used to create more complicated search expressions.
For example:
prostate cancer AND NOT ( radiation OR homeopathic remedies )
( heart disease OR heart attack ) AND ( stroke OR clot )
( heart disease OR heart attack ) AND ( stroke OR clot )
Note that the use of AND and OR as logical operators can be confusing.
An appropriate search for a list such as,
Ear, Nose, and Throat Conditions
is the expression
( Ear OR Nose OR Throat ) AND Conditions
Fortunately, search will do a pretty good job of finding the right studies either way.To search for AND as a word, instead of using it as an operator, put it in quotes.
Likewise, you can quote OR, NOT, and parentheses.