Clinical Trials on APOL1-mediated Kidney Disease

Total 11859 results

Vertex Pharmaceuticals Incorporated

Completed

A Phase 1 Dose Escalation Study to Evaluate Safety and Pharmacokinetics (PK) of VX-840 in Healthy Participants

APOL1-mediated Kidney Disease

United States
First Affiliated Hospital of Zhejiang University

Recruiting

The Safety and Efficacy of CD38 Monoclonal Antibody Monotherapy for CaAMR in Renal Transplantation

Antibody-mediated Rejection | Kidney Tranplant

China
Charite University, Berlin, Germany

Active, not recruiting

Donor-derived Cell-free DNA for Early Diagnosis of Antibody-mediated Rejection (cfDNA-DSA)

Kidney Transplant Rejection | Antibody-mediated Rejection | Kidney Transplant Failure

Germany
University Medical Center Groningen
Radboud University Medical Center; Maastricht University Medical Center; UMC... and other collaborators

Recruiting

Incidence, Course and Outcome of ABMR in Kidney Transplantation (PROCARE2)

Kidney Transplantation | Immunosuppression | Antibody-mediated Rejection

Netherlands
Assistance Publique - Hôpitaux de Paris
Janssen, LP

Completed

Desensitization in Kidney Allograft Using Daratumumab (DARDAR)

Kidney Transplant Rejection | Antibody-mediated Rejection | Allosensitization

France
University Hospital, Grenoble

Unknown

Treatment of Chronic Active Antibody Mediated Rejection After Kidney Transplantation by Double-Filtration PlasmaPheresis or Plasma Exchange (DFPP)

Kidney Transplantation | Antibody Mediated Rejection

France
CSL Behring
UBC Late Stage (UK) Ltd.

Completed

Assess Burden of Disease Among Kidney Transplant Recipients With Chronic Active Antibody Mediated Rejection

Antibody-mediated Rejection in Kidney Transplant

United States
Imperial College London
Cambridge University Hospitals NHS Foundation Trust; National Institute for... and other collaborators

Active, not recruiting

Transplant Antibody-Mediated Rejection: Guiding Effective Treatments (TAR:GET-1)

Kidney Transplant Rejection | Antibody-mediated Rejection

United Kingdom
Seoul National University Hospital

Active, not recruiting

Diagnostic Efficacy of Molecular Diagnostic Method for AMR in ABOiKT

Antibody-mediated Rejection | ABO Blood Type Incompatible Kidney Transplantation

Korea, Republic of
Rigshospitalet, Denmark
Department of Cardiovascular and Renal Research, University of Southern Denmark

Completed

Acute Effects of GLP-1 on Renal Hemodynamics (GLP1RRBF)

The GLP-1-mediated Gut-kidney Axis

Denmark
Assistance Publique - Hôpitaux de Paris
Institut National de la Santé Et de la Recherche Médicale, France; Alexion...

Withdrawn

Eculizumab Therapy for Subclinical Antibody-mediated Rejection in Kidney Transplantation (TAMARCIN)

Subclinical Acute Antibody-mediated Rejection in Kidney Transplantation
Istanbul University

Completed

Effects of A Standardized Treatment Approach on Kidney Transplant Recipients With Antibody-Mediated Rejection

Kidney Transplant Rejection | Antibody-mediated Rejection | Graft Loss

Turkey
Stanley Jordan, MD

Completed

Clazakizumab for Chronic and Active Antibody Mediated Rejection Post-Kidney Transplant

Kidney Transplant Rejection | Kidney Transplant; Complications | Antibody-mediated Rejection | Transplant Glomerulopathy | Transplant Glomerulopathy - Late Form | Transplant Glomerulopathy - Early Form

United States
Istituto Ortopedico Galeazzi

Not yet recruiting

Registry and Monitoring of ImmuNe-mediated Inflammatory Diseases

ImmuNe-Mediated Inflammatory Diseases

Italy
Sidekick Health

Recruiting

Digital Health Program With Participants Using an Autoinjector

Immune-Mediated Inflammatory Disease

Iceland
NYU Langone Health
CSL Behring

Completed

C1-Inhibitor (INH) for Refractory Antibody Mediated Renal Allograft Rejection

Antibody Mediated Rejection of Kidney Transplant

United States
University of Wisconsin, Madison
Bristol-Myers Squibb

Withdrawn

Belatacept in Kidney Transplantation of Moderately Sensitized Patients (BelatPilot)

End Stage Renal Disease | Antibody Mediated Rejection

United States
Ra Pharmaceuticals

Terminated

Safety and Efficacy Study of Zilucoplan in Subjects With Immune-Mediated Necrotizing Myopathy

Immune Mediated Necrotizing Myopathy

United States, Netherlands, France, United Kingdom
Siolta Therapeutics, Inc.
Integrium

Unknown

A Phase 1b Study of STMC-103H in Multi-Sensitized Allergic Subjects Who Are Otherwise Healthy

Atopic Immunoglobulin E-Mediated Allergic Disorder

United States
Vastra Gotaland Region
Karolinska University Hospital; The Swedish Research Council; Uppsala University...

Recruiting

TocIlizumab in Chronic Antibody-mediated Rejection in Kidney Transplant Recipients (INTERCEPT)

Antibody-mediated Rejection

Sweden
Alexion Pharmaceuticals

Terminated

Safety & Efficacy of Eculizumab to Prevent AMR in Living Donor Kidney Transplant Recipients Requiring Desensitization

Antibody Mediated Rejection

United States, Germany, Italy, France, United Kingdom, Spain, Sweden, Australia, Netherlands, Norway
CSL Behring
ICON Clinical Research

Terminated

Clazakizumab for the Treatment of Chronic Active Antibody Mediated Rejection in Kidney Transplant Recipients (IMAGINE)

Antibody-mediated Rejection

Korea, Republic of, United States, New Zealand, Spain, Taiwan, Netherlands, Australia, France, Canada, Belgium, Czechia, Hungary, Sweden, Austria, Germany
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Using Fostamatinib to Treat Post-Hematopoietic Stem Cell Transplant Immune-mediated Cytopenias

Immune Mediated Anemia | Immune Mediated Thrombocytopenia | Chronic GVHD

United States
Stanley Jordan, MD

Active, not recruiting

Clazakizumab in Highly-HLA Sensitized Patients Awaiting Renal Transplant

Kidney Failure, Chronic | End-Stage Renal Disease | Kidney Transplant; Complications | Antibody-mediated Rejection | Kidney Transplant Failure and Rejection | Transplant;Failure,Kidney | Transplant Glomerulopathy

United States
Clinical Hospital Center Rijeka

Completed

Cellular Immunity and Renal Cell Cancer

Kidney Cancer | NK Cell Mediated Immunity | NK Cell Cytokine Production

Croatia
National Heart, Lung, and Blood Institute (NHLBI)

Enrolling by invitation

Extension Study (Extended Access) of Syk-inhibition Using Fostamatinib to Treat Posttransplant Immune-mediated Cytopenias

Immune Mediated Anemia | Immune Mediated Thrombocytopenia | Chronic GVHD

United States
Assistance Publique - Hôpitaux de Paris
Fondation Centaure

Completed

Bortezomib in Rejection of Kidney Transplants (TRIBUTE)

Chronic Antibody-mediated Transplant Rejection

France
Shire

Terminated

A Multicenter Study to Evaluate the Efficacy and Safety of Cinryze® for the Treatment of Acute Antibody-mediated Rejection in Participants With Kidney Transplant

Acute Antibody-Mediated Rejection (AMR)

United States, Spain, France, Netherlands, Germany, Canada
Bayer

Completed

A Trial to Learn How BAY1834845 and BAY1830839 Affect Inflammation When Taken by Mouth Twice a Day for 7 Days in a Row in Healthy Male Participants

Immune Mediated Inflammatory Diseases

Netherlands
University Hospital, Montpellier
Hycor Biomedical

Terminated

Validation Study of NOVEOS® System (HYCOR) (HYCOR)

Allergen-mediated IgE Allergy

France
Jonathan Schoenfeld, MD, MPH
Naveris

Recruiting

Risk-adapted Therapy in HPV+ Oropharyngeal Cancer Using Circulating Tumor (ct)HPV DNA Profile - The ReACT Study

HPV Positive Oropharyngeal Squamous Cell Carcinoma | Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC... and other conditions

United States
University of Nottingham
Pfizer

Recruiting

Checkpoint Inhibitor-induced Liver Injury (ChILI)

Immune-Mediated Hepatitis

United Kingdom
CSL Behring

Terminated

Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Subcutaneous CSL730 in Healthy Adult Subjects

Immune Complex-mediated Autoimmune Diseases

United Kingdom
Omeros Corporation

Recruiting

Safety and Efficacy Study of OMS906 in Patients With C3G and ICGN

C3 Glomerulopathy | Idiopathic Immune Complex-Mediated Glomerulonephritis

Lithuania, New Zealand, Poland, Tunisia, Turkey, United Kingdom
Children's Hospital of Philadelphia
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Active, not recruiting

VIRTUUS Children's Study (VIRTUUS)

End Stage Renal Disease | Nephropathy | Renal Transplant Rejection | Pediatric Kidney Disease | BK Virus (Nephropathy) | Antibody-mediated Rejection | Acute Cellular Graft Rejection

United States, Canada
University Hospital, Bordeaux

Recruiting

Quantitative Parameters of HLA-DQ Antibodies in Lung Transplantation (AFFIHLA-P)

Lung Transplantation | Antibody Mediated Rejection | Chronic Lung Allograft Dysfunction

France
Alnylam Pharmaceuticals

Completed

Phase 2 Study to Evaluate ALN-TTRSC (Revusiran) in Patients With Transthyretin (TTR) Cardiac Amyloidosis

TTR-mediated Amyloidosis

United States, United Kingdom
Guangzhou First People's Hospital
LanZhou University; Sun Yat-sen University; The Third Affiliated Hospital of... and other collaborators

Completed

HPA Antibodies and the Distribution of Antigen and Antibodies

Blood Disease | Antibody-mediated Rejection | Platelet Refractoriness

China
Alexion Pharmaceuticals
Achillion, a wholly owned subsidiary of Alexion

Completed

A Proof-of-Mechanism Study to Determine the Effect of Danicopan on C3 Levels in Participants With C3G or IC-MPGN

C3 Glomerulopathy | C3 Glomerulonephritis | Dense Deposit Disease | Immune Complex Mediated Membranoproliferative Glomerulonephritis | Membranoproliferative Glomerulonephritis Types I, II, and III

Netherlands, Australia, Belgium
Mayo Clinic
National Cancer Institute (NCI)

Completed

Study of Mucosal Sparing Adjuvant Radiotherapy After Surgical Exploration in HPV+ Head and Neck Cancer of Unknown Primaries

Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Pathologic Stage I HPV-Mediated (p16-Positive)... and other conditions

United States
Alnylam Pharmaceuticals

Recruiting

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ALN-TTRSC04 in Healthy Subjects

Transthyretin-Mediated Amyloidosis

United Kingdom
Alnylam Pharmaceuticals

Completed

Safety and Tolerability of Patisiran (ALN-TTR02) in Transthyretin (TTR) Amyloidosis

TTR-mediated Amyloidosis

Portugal, Spain, Sweden, Brazil, United States, France, Germany
Alnylam Pharmaceuticals

Completed

A Phase 1, Single- and Multi-Dose, Dose Escalation Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Subcutaneously Administered ALN-TTRSC (Revusiran) in Healthy Volunteers

TTR-mediated Amyloidosis

United Kingdom
Alnylam Pharmaceuticals

Completed

Trial to Evaluate Safety, Tolerability, and Parmacokinetics of ALN-TTR02 in Healthy Volunteer Subjects

TTR-mediated Amyloidosis

United Kingdom
Catholic University of the Sacred Heart
Merck Sharp & Dohme LLC

Unknown

Safety of Ertapenem in Beta-lactam Allergic Patients.

Allergy | IgE-Mediated Hypersensitivity

Italy
National Cancer Institute (NCI)

Recruiting

Testing Immunotherapy Versus Observation in Patients With HPV Throat Cancer

Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Pathologic Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Pathologic Stage III HPV-Mediated (p16-Positive)...

United States
Bayer

Completed

A Cross-sectional, Observational Multicenter Study to Assess the Reasons for Choosing the 3-year Hormonal IUD and Level of IUDs Knowledge Among Women Aged 18 to 29 Years (ANALIA)

Intrauterine Devices, Medicated

Spain
Assistance Publique - Hôpitaux de Paris
Bristol-Myers Squibb

Completed

Belatacept (Nulojix) in Renal Transplant Recipient With Mild Immunologic Risk Factor: a Pilot Prospective Study. (BELACOR)

Renal Transplant | Acute Antibody Mediated Rejection | Mild Immunologic Risk Factor

France
Jonsson Comprehensive Cancer Center
AstraZeneca

Terminated

Stereotactic Body Radiation Therapy and Durvalumab With or Without Tremelimumab Before Surgery in Treating Participants With Human Papillomavirus Positive Oropharyngeal Squamous Cell Caner

Oropharyngeal Squamous Cell Carcinoma | Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Pathologic Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Pathologic... and other conditions

United States
Alnylam Pharmaceuticals

Completed

A Study of the Safety, Tolerability and Pharmacokinetics of ALN-TTR02 in Japanese Healthy Volunteers

Transthyretin (TTR)-Mediated Amyloidosis

United Kingdom

Clinical Trials on APOL1-mediated Kidney Disease

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