Clinical Trials on ARID1A Gene Mutation

Total 1881 results

ETH Zurich
Neural Control of Movement laboratory ETH Zurich

Recruiting

multiSENSory Stimulation to tArgeT Sensory Loss and chronIc Pain in neurOpathic patieNts (SENSATION)

Diabetic Neuropathies | Amputation | Neuropathy | Neuropathy, Painful | Sensory Neuropathy

Switzerland
Shirley Ryan AbilityLab

Active, not recruiting

Wearable Airbag Technology to Mitigate Falls in Individuals With High Fall Risk

Stroke | Parkinson Disease | Fall Injury | Fall Patients | Lower Limb Amputation Knee | Falling

United States
VA Office of Research and Development

Completed

Physical Activity Behavior Change for Older Adults After Dysvascular Amputation (PABC)

Diabetes Mellitus, Type 2 | Amputation | Peripheral Artery Disease

United States
Danish Pain Research Center
Aarhus University Hospital

Completed

Postamputation Pain: Peripheral Mechanisms

Neuropathic Pain | Amputation, Traumatic | Phantom Limb Pain | Nerve Block | Stump Pain

Denmark
Providence Health & Services

Recruiting

Encorafenib and Binimetinib With or Without Nivolumab in Treating Patients With Metastatic Radioiodine Refractory BRAF V600 Mutant Thyroid Cancer

BRAF V600E Mutation Present | Stage IV Differentiated Thyroid Gland Carcinoma AJCC v8 | Refractory Thyroid Gland Carcinoma | Metastatic Thyroid Gland Carcinoma | BRAF NP_004324.2:p.V600M | Stage IVA Differentiated Thyroid Gland Carcinoma AJCC v8 | Stage IVB Differentiated Thyroid Gland Carcinoma...

United States
Plexxikon

Terminated

Phase 1 Study of PLX7486 as Single Agent in Patients With Advanced Solid Tumors

Solid Tumor | Tenosynovial Giant Cell Tumor | Tumors of Any Histology With Activating Trk (NTRK) Point or NTRK Fusion Mutations

United States
Novartis Pharmaceuticals

Terminated

Safety and Efficacy of INC280 and Buparlisib (BKM120) in Patients With Recurrent Glioblastoma

c-MET Inhibitor; PI3K Inhibitor, PTEN Mutations, Homozygous Del. of PTEN or PTEN Neg. by IHC, c-Met Ampli. by FISH, INC280, BKM120, Buparlisib; Recurrent GBM

Spain, Switzerland, Germany, United States, Netherlands
Klus Pharma Inc.

Completed

Study of A166 in Patients With Relapsed/Refractory Cancers Expressing HER2 Antigen or Having Amplified HER2 Gene

Cervical Cancer | Head and Neck Cancer | Mucoepidermoid Carcinoma | Pancreatic Cancer | Recurrent Prostate Cancer | Lung Cancer | Rectal Cancer | Solid Tumor | Prostate Cancer | Cholangiocarcinoma | Bile Duct Cancer | Recurrent Ovarian Carcinoma | Bladder Cancer | Skin Cancer | HER2-positive Breast Cancer | Rare Diseases | Colo-rectal Cancer and other conditions

United States
University of Pennsylvania
Lions Club International Foundation; Berhan Public Health and Eye Care Consultancy... and other collaborators

Completed

Fluorometholone as Ancillary Therapy for TT Surgery

Trachoma | Trichiasis | Bilamellar Tarsal Rotation

Ethiopia
Samsung Medical Center

Unknown

The Intravitreal Autologous Platelet Concentrate Injection as an Adjunct of Vitrectomy for the Treatment of Refractory Macular Holes

Macular Hole With High Myopia (Spherical Equivalent ≤ -6.0 Diopters) or, | Large Size Macular Hole (Diameter > 600 Microns) or | Recurred or Failed Macular Hole From Previous Surgery | or Chronic Macular Hole (Symptom Duration > 6 Months)

Korea, Republic of
Lynkcell Europe

Available

An Expanded Access Program to Axitinib is Available for Patients With Advanced Forms of Kidney Cancer (Ductal; Papillary; Chromophobic; Oncocytic) With Mutations in VHL, PBRM1 / BAP1, SETD2, VEGF)

Kidney Cancer | Clear Cell Kidney Cancer | Kidney Cancer With PBRM1/BAP1/VHL/SETD2 Mutations
Cothera Bioscience, Inc

Recruiting

Sepantronium Bromide for the Treatment of High-grade B-cell Lymphoma

Lymphoma, B-Cell | Lymphoma, Large B-Cell, Diffuse | Lymphatic Diseases | Burkitt Lymphoma | High-grade B-cell Lymphoma | C-MYC/BCL6 Double-Hit High-Grade B-Cell Lymphoma | C-MYC/BCL2 Double-Hit High-Grade B-Cell Lymphoma | Lymphoma, High-Grade | C-Myc Gene Rearrangement

Korea, Republic of, China
University of California, San Francisco

Terminated

Capmatinib, Ceritinib, Regorafenib, or Entrectinib in Treating Patients With BRAF/NRAS Wild-Type Stage III-IV Melanoma

ALK Fusion Protein Expression | Stage III Cutaneous Melanoma | Stage IIIA Cutaneous Melanoma | Stage IIIB Cutaneous Melanoma | Stage IIIC Cutaneous Melanoma | Stage IV Cutaneous Melanoma | ROS1 Fusion Positive | BRAF wt Allele | Invasive Skin Melanoma | MET Fusion Gene Positive | NRAS wt Allele | NTRK1 Fusion... and other conditions

United States
University of Alberta
Social Sciences and Humanities Research Council of Canada

Recruiting

LIVInG With chrONic Cancer TrEatments (LONGEVITI) Study (LONGEVITI)

Melanoma | Cancer | Breast Cancer | Multiple Myeloma | Colorectal Cancer | Ovarian Cancer | Lung Cancer | Prostate Cancer | Chronic Leukemia | Tyrosine Kinase Mutation

Canada
Covenant Health
Alberta Innovates Health Solutions

Unknown

Comparison Between Postoperative Tubular Dressing and a Vacuum Removable Rigid Dressing After Transtibial Amputation (EMPAR)

Amputation Stump | Edema Leg | Wound Healing Delayed | Peripheral Vascular Disease With Complications
King Abdulaziz University

Completed

Pattern and Type of Amputation and Mortality Rate Associated With Diabetic Foot in Jeddah, Saudi Arabia: A Retrospective Cohort Study

Diabetic Foot | Amputation

Saudi Arabia
National Human Genome Research Institute (NHGRI)
National Center for Advancing Translational Sciences (NCATS); Therapeutics...

Completed

Phase I Clinical Trial of ManNAc in Patients With GNE Myopathy or Hereditary Inclusion Body Myopathy (HIBM)

GNE Myopathy | Hereditary Inclusion Body Myopathy (HIBM)

United States
Icahn School of Medicine at Mount Sinai

Recruiting

Pancreas Registry and High Risk Registry

Pancreatitis | Chronic Pancreatitis | Pancreas Cancer | Pancreatic Cyst | Genetic Mutations | Family History of Pancreas Cancer

United States
Lei Li

Unknown

A Genomic Analysis of Evolution of Epithelia Ovarian Tumors

Epithelial Ovarian Cancer | Progression-free Survival | Epithelial Ovarian Tumor of Borderline Malignancy | Driving Mutations

China
Lei Li

Recruiting

Genetic Mutation in Epithelial Ovarian Cancer

Epithelial Ovarian Cancer | Microsatellite Instability | PD-L1 | Nucleotide Variant | Copy Number Variation | Insertion-deletion Variation | Genomic Structural Variation | Total Mutation Burden | PD-1

China
National Cancer Institute (NCI)

Active, not recruiting

Testing Whether Cancers With Specific Mutations Respond Better to Glutaminase Inhibitor, Telaglenastat Hydrochloride, Anti-Cancer Treatment, BeGIN Study

Advanced Malignant Solid Neoplasm | Unresectable Malignant Solid Neoplasm | Metastatic Malignant Solid Neoplasm | NF1 Mutation Positive Malignant Peripheral Nerve Sheath Tumor

United States
M.D. Anderson Cancer Center

Active, not recruiting

Overall and Disease Specific Survival in Patients With Confirmed MEN1 With or Without PNET (Pancreatic Neuroendocrine Tumors)

Genetic Mutation | MEN1

United States
Ultragenyx Pharmaceutical Inc

Completed

An Open Label Phase 2 Extension Study of Higher Dose Sialic Acid-Extended Release (SA-ER) Tablets and Sialic Acid-Immediate Release (SA-IR) Capsules in Patients With Glucosamine (UDP-N-acetyl)-2-Epimerase (GNE) Myopathy

GNE Myopathy | Hereditary Inclusion Body Myopathy (HIBM)

United States, Israel
National University of Singapore

Completed

Tele-Rehabilitation Pilot Evaluation Study

Stroke | Pneumonia | Fractures, Bone | Fall | Lower Limb Amputation | Deconditioning | Lower Limb Joint Replacement (Hip or Knee) | Musculoskeletal Conditions (e.g., Tendinitis, Capsulitis)

Singapore
Washington University School of Medicine

Suspended

N-Acetyl-Cysteine (NAC) for Healing of Amputation Stumps in the Setting of Diabetes

Diabetes Mellitus | Peripheral Arterial Disease | Critical Limb Ischemia | Lower Limb Amputation Knee

United States
Johns Hopkins University
The Plastic Surgery Foundation

Enrolling by invitation

Surgical Treatments for Neuroma Pain in Amputees (STOCAP)

Phantom Limb Pain | Pain, Neuropathic | Amputation Neuroma

United States
University of Washington
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Completed

Telephone Intervention for Pain Study (TIPS) (TIPS)

Multiple Sclerosis | Chronic Pain | Amputation | Spinal Cord Injury

United States
National Cancer Institute (NCI)

Recruiting

Prospective Evaluation of High Resolution Dual Energy Computed Tomographic Imaging, Noninvasive (Liquid) Biopsies, and Minimally Invasive Surgical Surveillance for Early Detection of Mesotheliomas in Patients With BAP1 Tumor Predisposition Syndrome

Mesothelioma | Familial Cancer | BRCA1-Associated Protein-1 (BAP1) Mutations | Tumor Predisposition Syndrome (TPDS)

United States
Samsung Medical Center

Active, not recruiting

Study of AZD9291 in NSCLC Patients Harboring T790M Mutation Who Failed EGFR TKI and With Brain and/or LMS

Non-Small Cell Lung Cancer With EGFR T790M Mutation | With Brain and/or Leptomeningeal Metastasis | Failed Tyrosine Kinase Inhibitors

Korea, Republic of
Chinese PLA General Hospital

Unknown

A Chinese Randomized Crossover Study of Erlotinib Versus Docetaxel/Cisplatin in Previously Untreated Stage IIIB/IV Lung Adenocarcinoma With EGFR Mutations

Neoplasms, Lung | Carcinoma, Non-Small Cell Lung | Drug Therapy | Genes, EGFR

China
Mayo Clinic
Astellas Pharma Inc; Casimir, LLC

Recruiting

Genomic Profiling of Mitochondrial Disease - Imaging Analysis for Precise Mitochondrial Medicine

Mitochondrial Diseases | Mitochondrial Myopathies | Kearns-Sayre Syndrome | Mitochondrial DNA Mutation | Chronic Progressive External Ophthalmoplegia With Myopathy

United States
University of Pennsylvania
Memorial Sloan Kettering Cancer Center; Susan G. Komen Breast Cancer Foundation

Enrolling by invitation

Polygenic Risk Scores and Multi-cancer Early Detection for Ovarian Cancer (PROMISE)

Ovarian Cancer | BRCA Mutation

United States
Tempest Therapeutics

Active, not recruiting

Phase 1a/1b Study of TPST-1495 as a Single Agent and in Combination With Pembrolizumab in Subjects With Solid Tumors

Colorectal Cancer | Solid Tumor | Gastric Adenocarcinoma | Non Small Cell Lung Cancer | Squamous Cell Carcinoma of Head and Neck | Endometrial Cancer | Urothelial Carcinoma | Gastroesophageal Junction Adenocarcinoma | Solid Tumors With PIK3Ca Mutation

United States
Memorial Sloan Kettering Cancer Center

Active, not recruiting

Randomized Study of Stereotactic Body Radiation Therapy (SBRT) in Patients With Oligoprogressive Metastatic Cancers of the Breast and Lung

NSCLC | Non Small Cell Lung Cancer | Triple Negative Breast Cancer | Non Small Cell Lung Cancer Metastatic | NSCLC Stage IV | TNBC - Triple-Negative Breast Cancer | NSCLC Stage IV Without EGFR/ALK Mutation

United States, Canada
Lynkcell Europe

Enrolling by invitation

Phase I Clinical Trials Investigating the Potential Efficacy of Axitinib in Patients With a BRCA 1/2 Mutations

Breast Cancer | Breast Neoplasms | Ovarian Neoplasms | Ovarian Cancer | HER2-positive Breast Cancer | HER2-negative Breast Cancer | HER-2 Protein Overexpression | BRCA Mutation

Ukraine
National Cancer Institute (NCI)

Recruiting

Decitabine/Cedazuridine (INQOVI), an Oral DNA Demethylating Agent, in Subjects With BAP1 Cancer Predisposition Syndrome and Subclinical, Early-Stage Mesothelioma

Mesothelioma | BRCA1-Associated Protein-1 (BAP1) Mutations | Malignant Mesothelioma (MM) | Early-stage Mesothelioma | Subclinical Mesothelioma | Early-stage BAP1-associated Malignancies

United States
Assistance Publique - Hôpitaux de Paris

Recruiting

Impact of COVID-19 SARS-CoV-2 Variability in ICU Hospitalized Patients With Severe Disease (SEVARVIR)

SARS-CoV2 Infection | Mutation | COVID-19 Acute Respiratory Distress Syndrome

France
UNICANCER
Bristol-Myers Squibb; National Cancer Institute, France; Ligue contre le cancer...

Completed

Secured Access to Nivolumab for Adult Patients With Selected Rare Cancer Types (AcSé)

Carcinoma, Renal Cell | Skin Neoplasms | Microsatellite Instability | Penile Neoplasms | Head and Neck Neoplasm | Cancer With POLE Exonucleasic Domain Mutation

France
Hong Yang
LanZhou University; Qilu Hospital of Shandong University; Xuanwu Hospital, Beijing and other collaborators

Completed

Analgesia-first Minimal Sedation for Spontaneous Intracerebral Hemorrhage Early Antihypertensive Treatment (ASSICHH)

Blood Pressure Variability | Early Systolic Blood Pressure Control Rate | Hematoma Growth | Healthcare Worker Satisfaction | Duration of ICU Treatment and Mechanical Ventilation

China
Rambam Health Care Campus

Unknown

Focused Ultrasound Treatment of Stump Neuromas for the Relief of Chronic Post-Amputation Neuropathic Pain

Amputation | Phantom Limb Pain | Residual Limbs

Israel
Orthocare Innovations, LLC
National Institute on Disability, Independent Living, and Rehabilitation...

Recruiting

mGain - sEMG-based Gamified Therapy for Improved Upper Limb Rehabilitation

Stroke | Upper Limb Amputation | Upper Limb Weakness Due to Central Neurologic Injury | Upper Limb Weakness Due to Peripheral Neurologic Injury | Upper Limb Weakness Due to Nerve Reconstruction | Upper Limb Weakness Due to Tendon Transfer Surgery

United States
Hunter Holmes Mcguire Veteran Affairs Medical Center

Completed

Postoperative Peripheral Nerve Stimulation for Management of Post-amputation Pain

Chronic Pain | Postoperative Pain | Amputation | Acute Pain | Phantom Limb Pain | Neuroma | Residual Limbs

United States
University of British Columbia
Vancouver Coastal Health Research Institute; Genome British Columbia

Recruiting

Advancing Cardiac Care Unit-based Rapid Assessment and Treatment of hypErcholesterolemia (ACCURATE)

Acute Coronary Syndrome | Familial Hypercholesterolemia | STEMI | NSTEMI - Non-ST Segment Elevation MI | Familial Hypercholesterolemia - Heterozygous | Familial Hypercholesterolemia Due to Genetic Defect of Apolipoprotein B | Familial Hypercholesterolemia Due to Heterozygous LDL Receptor Mutation and other conditions

Canada
AstraZeneca
Merck Sharp & Dohme LLC; GOG Foundation; Myriad Genetic Laboratories, Inc.

Active, not recruiting

Olaparib Maintenance Monotherapy in Patients With BRCA Mutated Ovarian Cancer Following First Line Platinum Based Chemotherapy. (SOLO-1)

Advanced Ovarian Cancer | Newly Diagnosed | FIGO Stage III-IV | Partial Response | Complete Response | BRCA Mutation | First Line Platinum Chemotherapy

Korea, Republic of, France, Italy, United States, Israel, Canada, China, Brazil, United Kingdom, Poland, Australia, Japan, Netherlands, Russian Federation, Spain
Intergroupe Francophone de Cancerologie Thoracique

Active, not recruiting

Study of Osimertinib in Patients With a Lung Cancer With Brain or Leptomeningeal Metastases With EGFR Mutation (ORBITAL)

Non Small Cell Lung Cancer Metastatic | Brain Metastases | EGFR Activating Mutation | Leptomeningeal Metastasis

France
Enzyvant Therapeutics GmBH

Completed

Farber Disease Natural History Study

Farber Disease | Farber's Disease | Farber Lipogranulomatosis | Acid Ceramidase Deficiency | Ceramidase Deficiency | N-Laurylsphingosine Deacylase Deficiency | ASAH1 Mutation

United States, Egypt, Canada, Italy, Turkey, Argentina, Germany, India, Sweden
M.D. Anderson Cancer Center
National Cancer Institute (NCI); Exelixis

Active, not recruiting

Cabozantinib or Sunitinib Malate in Treating Participants With Metastatic Variant Histology Renal Cell Carcinoma

Renal Cell Carcinoma | Metastatic Renal Cell Carcinoma | Stage IV Renal Cell Cancer AJCC v8 | Sarcomatoid Renal Cell Carcinoma | Chromophobe Renal Cell Carcinoma | Papillary Renal Cell Carcinoma | Malignant Neoplasms of Urinary Tract | Renal Cell Carcinoma Associated With Xp11.2 Translocations/TFE3... and other conditions

United States
Tampere University Hospital

Recruiting

Toe Amputations in Patients With Diabetes (PANDORAT)

Infections | Diabetic Foot | Amputation

Finland
Center for Bionics and Pain Research
Massachusetts General Hospital; Göteborg University; University of Michigan; University... and other collaborators

Recruiting

Surgical Treatments for Postamputation Pain

Phantom Limb Pain | Pain, Neuropathic | Amputation Neuroma | Residual Limb Pain | Pain, Nerve

United States, Canada, Australia, Chile, Italy, Sweden, United Kingdom
University of Nove de Julho
Daniela de Fátima Teixeira da Silva; Monica Ribeiro Ventura

Withdrawn

Phototherapy in DM Amputation Ulcers.

Diabetes Mellitus | Diabetic Foot | Amputation Stumps

Brazil

Clinical Trials on ARID1A Gene Mutation

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Turkmenistan

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations