Clinical Trials on Acute Respiratory Failure in South Africa

Total 4536 results

Medical University of South Carolina

Completed

LYmphangiogenesis FacTors in Heart Failure States (LYFT-HF)

Heart Failure | Heart Failure With Reduced Ejection Fraction | Heart Failure With Normal Ejection Fraction

United States
Henry M. Jackson Foundation for the Advancement...
RedHill Biopharma Limited; FHI Clinical, Inc.; Joint Program Executive Office...

Recruiting

PROTECT-APT 1: Early Treatment and Post-Exposure Prophylaxis of COVID-19 (PROTECT-APT 1)

SARS-CoV-2

United States, Côte D'Ivoire, South Africa, Thailand
Techfields Inc

Terminated

Evaluate the Efficacy and Safety of TF0023 in Treatments for COVID-19 in Hospitalized Adults

COVID-19 Pneumonia

United States, South Africa
Pfizer

Completed

Trial Of AG-013736, Cisplatin, And Gemcitabine For Patients With Squamous Non-Small Cell Lung Cancer

Carcinoma, Non-Small-Cell Lung (NSCLC)

Ukraine, Poland, Romania, South Africa
Evangelismos Hospital
National and Kapodistrian University of Athens; LONG COVID GREECE; 414 Military...

Recruiting

Post Covid-19 Dysautonomia Rehabilitation Randomized Controlled Trial (LoCoDiRe-Dys)

Dysautonomia | Post-Acute COVID-19 Syndrome

Greece
Alvea Holdings, LLC

Completed

Safety, Tolerability and Immunogenicity of Alveavax-v1.2, a BA.2/Omicron-optimized, DNA Vaccine for COVID-19 Prevention

Sars-CoV-2 Infection

South Africa
Medical University of South Carolina
Medtronic

Completed

Correlation of Intrathoracic Impedance Measures With Blood Plasma Volume in Congestive Heart Failure (Optivol)

Congestive Heart Failure

United States
Abbott Medical Devices

Completed

Spinal Cord Stimulation For Heart Failure (SCS HEART)

Systolic Heart Failure

Australia, Hong Kong, Japan
Medecins Sans Frontieres, Netherlands
London School of Hygiene and Tropical Medicine; University of Liverpool; Ministry... and other collaborators

Completed

Economic Evaluation of New MDR TB Regimens (PRACTECAL-EE)

Multi-drug Resistant Tuberculosis | Pulmonary Tuberculoses | Extensively Drug-Resistant Tuberculosis

Belarus, South Africa, Uzbekistan
Brian Houston
CVRx, Inc.

Recruiting

Baroreflex Activation Therapy in Left Ventricular Assist Device Patients Study (BAT-VAD)

Congestive Heart Failure

United States
Médecins Sans Frontières, France
Harvard Medical School (HMS and HSDM); Institute of Tropical Medicine, Belgium and other collaborators

Completed

Evaluating Newly Approved Drugs for Multidrug-resistant TB (endTB)

Tuberculosis, Multidrug-Resistant | Infection, Bacterial | Pulmonary Tuberculoses

Pakistan, Georgia, India, Kazakhstan, Lesotho, Peru, South Africa
Providence Therapeutics Holdings Inc.

Completed

PTX-COVID19-B, an mRNA Humoral Vaccine, Intended for Prevention of COVID-19 in a General Population. This Study is Designed to Demonstrate the Safety, Tolerability, and Immunogenicity of PTX-COVID19-B in Comparison to the Pfizer-BioNTech COVID-19 Vaccine.

Covid19 Vaccine

Canada, South Africa
Attikon Hospital

Completed

Correlation of the Hand Grip Force With Maximum Inspiratory and Maximum Expiratory Pressure, in Critical Ill Patients

Intensive Care Unit Syndrome

Greece
John Hunter Hospital
Newcastle University; Hunter Medical Research Institute

Completed

The Effect of Haemodialysis in Sleep Apnoea

Sleep | Renal Failure | Sleep Disturbance | End Stage Kidney Disease | Sleep Disorders | Sleep Apnoea

Australia
Texas Tech University Health Sciences Center

Terminated

Use of High Frequency Chest Compression in Pediatric Status Asthmaticus

Pediatric, Asthma, Acute Exacerbation, Pediatric ICU

United States
University of California, Los Angeles
Fenzian Ltd.

Completed

Fenzian Asthma Multicenter Outcomes Study (FAMOUS)

Asthma

United States, South Africa, United Kingdom
Tenax Therapeutics, Inc.

Completed

Hemodynamic Evaluation of Levosimendan in Patients With PH-HFpEF (HELP)

Heart Failure With Normal Ejection Fraction | Heart Failure, Right Sided | Hypertension Pulmonary Secondary

United States
Argon Medical Devices
NAMSA

Not yet recruiting

CLEANer Aspiration for Pulmonary Embolism (CLEAN-PE)

Cardiovascular Diseases | Venous Thromboembolism | Pulmonary Embolism | Acute Pulmonary Embolism

United States
NeuroRx, Inc.

Recruiting

Inhaled ZYESAMI™ (Aviptadil Acetate) for the Treatment of Severe COVID-19 (AVICOVID-2)

SARS-CoV 2 | COVID | ARDS | Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS) | Dyspnea | ALI

United States
University of Glasgow

Terminated

Evaluation of the Normal Range of Urinary Sodium Levels in Healthy Newborn Babies (USALTI)

Growth Failure | Stoma Ileostomy | Stoma Colostomy | Electrolyte Depletion

United Kingdom
Naval Health Research Center
U.S. Army Medical Research and Development Command

Completed

Effectiveness of the Pneumococcal Polysaccharide Vaccine in Military Recruits

Pneumonia | Acute Respiratory Disease

United States
GlaxoSmithKline

Completed

A Study on the Immune Response and Safety Elicited by a Vaccine Against Respiratory Syncytial Virus (RSV) When Given Alone and Together With a Vaccine Against Influenza in Adults Aged 60 Years and Above

Respiratory Syncytial Virus Infections

Panama, New Zealand, South Africa
CSL Limited

Completed

Safety, Tolerability and Pharmacokinetics of CSL360 in the Treatment of Acute Myeloid Leukemia

Acute Myeloid Leukemia (AML)

Australia
Prof Gerhard Walzl
London School of Hygiene and Tropical Medicine; Makerere University; Leiden University... and other collaborators

Completed

Evaluation of Host Biomarker-based Point-of-care Tests for Targeted Screening for Active TB (ScreenTB)

Pulmonary Tuberculosis

United Kingdom, Uganda, Ethiopia, Gambia, Germany, Namibia, Netherlands, South Africa
The George Institute
Victor Chang Cardiac Research Institute; St Vincent's Centre for Applied Medical...

Recruiting

Polydiuretic Therapy for HFpEF, a Randomised Controlled Trial

Heart Failure With Preserved Ejection Fraction

Australia
Tenax Therapeutics, Inc.

Active, not recruiting

Open-Label Rollover Study of Levosimendan in PH-HFpEF Patients

Heart Failure With Normal Ejection Fraction | Hypertension Pulmonary Secondary Heart Failure | Right Sided Heart Failure With Normal Ejection Fraction

United States
Australian and New Zealand Intensive Care Research...

Terminated

A Multi-centre Trial of an Open Lung Strategy Including Permissive Hypercapnia, Alveolar Recruitment and Low Airway Pressure in Patients With Acute Respiratory Distress Syndrome (PHARLAP)

Acute Respiratory Distress Syndrome

Australia, Ireland, United Kingdom, New Zealand, Saudi Arabia
PENTA Foundation
King's College Hospital NHS Trust; Karolinska Institutet; Hospital General Universitario... and other collaborators

Recruiting

European Pregnancy and Paediatric Infections Cohort Collaboration (EPPICC) SARS-CoV-2 Antibody Study Protocol. Covid-19 (SARS-Cov2)

Sars-Cov2 Antibodies in Children and Adolescents Living With HIV

Spain, United Kingdom, South Africa, Belgium, Greece, Ukraine
TaiGen Biotechnology Co., Ltd.
Quintiles, Inc.

Completed

Safety and Efficacy Comparison of TG-873870(Nemonoxacin) to Levofloxacin in Community-Acquired Pneumonia

Community-Acquired Pneumonia

Taiwan, South Africa
Dey

Completed

Pilot Study to Determine Efficacy of Cyclamen Europaeum Extract Nasal Spray in Patients With Acute Sinusitis

ACUTE SINUSITIS

United States
University of Sydney
Melbourne Health; Royal Brisbane and Women's Hospital

Unknown

Chemotherapy Followed by Infusion of Partially HLA Matched Unrelated Donor Cells for Patients With AML Who Are Ineligible for Stem Cell Transplantation (SCRAMBLE)

Acute Myeloid Leukaemia

Australia
Pharmaxis

Completed

Inspiratory Flow and Volumes in Bronchiectatics

Bronchiectasis

Australia
BioNTech SE

Completed

Safety and Immunogenicity of RNA-based Vaccines Against SARS-CoV-2 Variants in Healthy Participants

COVID-19 | SARS-CoV2 Infection | SARS-CoV-2 Acute Respiratory Disease | SARS (Disease)

United States, Germany, Turkey, South Africa
The University of Queensland

Recruiting

The TELO-SCOPE Study: Attenuating Telomere Attrition With Danazol. Is There Scope to Dramatically Improve Health Outcomes for Adults and Children With Pulmonary Fibrosis

Pulmonary Fibrosis | Dyskeratosis Congenita | Telomere Shortening | Telomere Disease

Australia
Sheffield Teaching Hospitals NHS Foundation Trust
University of Sheffield

Recruiting

MUlti-nuclear MR Imaging Investigation of Respiratory Disease-associated CHanges in Lung Physiology (MURDOCH)

Covid19 | Asthma | COPD | Long COVID

United Kingdom
McGill University Health Centre/Research Institute...
King's College London; University of Wisconsin, Madison; University Hospital... and other collaborators

Completed

Breathing-Induced Myocardial Oxygenation Reserve (B-MORE-Pilot)

Coronary Artery Disease

United States, Germany, United Kingdom, Canada, South Africa
American Health Research
Vitaccess Ltd

Recruiting

A Study to Explore if Long-term Use of Mucinex Can Help With Symptoms in Patients With Stable Chronic Bronchitis. (AHR CB)

Chronic Bronchitis

United States
GlaxoSmithKline

Completed

A Study in Asthmatics to Determine the Efficacy and Dose Response of Repeat Doses of GW870086X on Forced Expiratory Volume in 1 Second (FEV1)

Asthma

Germany, South Africa, Bulgaria
National and Kapodistrian University of Athens

Completed

Endometrial Injury and IVF Outcome Parameters in Patients With Failed IVF Cycles

Repeated Implantation Failures

Greece
Fresenius Kabi
B. Braun Melsungen AG; European Society of Anaesthesiology and Intensive Care

Completed

Safety and Efficacy of a 6% Hydroxyethyl Starch (HES) Solution Versus an Electrolyte Solution in Trauma Patients (TETHYS)

Hypovolemia Due to Acute Blood Loss

Germany, Spain, France, Czechia, South Africa, Belgium, Netherlands
Brno University Hospital
Masaryk University

Recruiting

Negative Pressure Ventilation in Paediatric Patients During Weaning (NEGWEAN)

Weaning Failure

Czechia
Restem, LLC.

Completed

Umbilical Cord Lining Stem Cells (ULSC) in Patients With COVID-19 ARDS (ULSC)

Covid19 | Corona Virus Infection | ARDS | SARS-CoV Infection | Coronavirus

United States
Medical University of South Carolina

Completed

Weight Loss as Therapy for Heart Failure With Preserved Ejection Fraction (WTLSSCHF)

Weight Loss | Heart Failure, Diastolic

United States
Mitchell Horwitz, MD
Genzyme, a Sanofi Company

Completed

Donor Enhancement With Plerixafor Post Myeloablative Allogeneic Transplant

Failure of Bone Marrow Graft

United States
Varian, a Siemens Healthineers Company

Completed

Evaluating an Anchored Transponder in Lung Cancer Patients Receiving Radiation Therapy

Lung Cancer

United States, Switzerland, Germany, South Africa
Samsung Medical Center

Unknown

Genetic Predictive Model Based on Single Nucleotide Polymorphisms in the DNA Repair Pathway and Drug Metabolis/Transport Pharmacogenetics in the Prediction of Response and Treatment Outcomes in Acute Myeloid Leukemia

Patients With Acute Myeloid Leukemia | Patients Receiving Induction/Consolidation Chemotherapy

Korea, Republic of
Alexandra Papadopoulou
BioGaia AB

Completed

Efficacy of an Oral Rehydration Solution Containing the Probiotic Lactobacillus Reuteri Protectis and Zinc in Infants With Acute Gastroenteritis

Acute Gastroenteritis

Greece
Boston Scientific Corporation

Completed

Bronchial Thermoplasty Global Registry (BTGR)

Asthma

Spain, Italy, Germany, Netherlands, Australia, Czechia, South Africa, United Kingdom
Attikon Hospital

Completed

Nurse-led Educational Intervention on Heart Failure Patients

Heart Failure

Greece
Medtronic Cardiac Rhythm and Heart Failure

Completed

Determining the Feasibility of Spinal Cord Neuromodulation for the Treatment of Chronic Heart Failure (DEFEAT-HF)

Heart Failure

United States, Germany, South Africa, Canada, Czech Republic, Netherlands, Italy, Sweden

Clinical Trials on Acute Respiratory Failure in South Africa

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