Clinical Trials on Advanced Malignancies in Netherlands

Total 253 results

Novartis Pharmaceuticals

Completed

Study to Evaluate Panobinostat (DACi) Pharmacokinetics and Safety in Solid Tumors and Varying Renal Function

Advanced Solid Tumors

Switzerland, Netherlands, United States, United Kingdom
Merck Sharp & Dohme LLC

Recruiting

Study of MK-4464 as Monotherapy and in Combination With Pembrolizumab in Participants With Advanced/Metastatic Solid Tumors (MK-4464-001)

Neoplasms | Advanced/Metastatic Solid Tumors

Canada, Israel, United States, Netherlands
University Medical Center Groningen

Completed

89Zr-AMG211 PET Imaging Study

Advanced Gastrointestinal Cancer

Netherlands
Vall d'Hebron Institute of Oncology
Taisho Pharmaceutical Co., Ltd.; Roche Pharma AG; Iqvia Pty Ltd; Janssen, LP

Recruiting

A Modular Multi-Basket Trial to Improve Personalized Medicine in Cancer Patients (Basket of Baskets) (BoB)

Advanced Solid Tumor

Spain, France, Germany, Netherlands, Sweden, United Kingdom, Italy
Kite, A Gilead Company

Enrolling by invitation

Long-term Follow-up Study for Participants of Kite-Sponsored Interventional Studies Treated With Gene-Modified Cells

Solid and Hematological Malignancies

United States, Netherlands, Japan, Australia, France, Israel, Germany, Canada, United Kingdom
Novartis Pharmaceuticals

Completed

Pharmacokinetics and Safety of Panobinostat in Patients With Advanced Solid Tumors and Various Degrees of Hepatic Function

Advanced Solid Tumors

Switzerland, Sweden, Netherlands, United States, United Kingdom
Eisai Inc.

Completed

A Study to Determine the Metabolism and Elimination of 14C-E7080 in Patients With Advanced Solid Tumors or Lymphomas, Who Are Unsuitable For, or Have Failed, Existing Therapies.

Advanced Solid Tumors | Lymphomas

Netherlands
Academisch Ziekenhuis Maastricht
Eli Lilly and Company; Novartis; Pfizer; Gilead Sciences; Roche Pharma AG; AstraZeneca and other collaborators

Recruiting

Southeast Netherlands Advanced Metastatic Breast Cancer Registry (SONABRE)

Advanced Breast Cancer | Metastatic Breast Cancer

Netherlands
Amsterdam UMC, location VUmc
ZonMw: The Netherlands Organisation for Health Research and Development

Completed

Early Recognition and Optimal Treatment of Delirium in Patients With Advanced Cancer

Delirium | Advanced Cancer

Netherlands
Maastricht University Medical Center
Dirinco B.V.

Terminated

Concentrated Citrate Locking to Reduce the Incidence of CVC-related Complications in Hematological Patients

Thrombosis | Bacteremia | Hematological Malignancies

Netherlands
Amsterdam UMC, location VUmc
ZonMw: The Netherlands Organisation for Health Research and Development; Fo...

Completed

Short Versus Extended Antibiotic Treatment With a Carbapenem for High-risk Febrile Neutropenia in Hematology Patients With FUO (SHORT)

Febrile Neutropenia | Hematological Malignancy

Netherlands
BeiGene

Recruiting

Long-term Extension Study of Zanubrutinib (BGB-3111) Regimens in Participants With B-cell Malignancies

B-cell Malignancies

China, Italy, United States, Spain, United Kingdom, Poland, Czechia, Netherlands, Greece, France, Sweden, Korea, Republic of, Turkey
T-knife GmbH

Terminated

A Phase 1/ 2, First-in-Human, Open-Label, Accelerated-Titration, Two-Part Clinical Trial of TK-8001 in Patients With HLA-A*02:01 Genotype and Advanced-Stage/ Metastatic MAGE-A1+ Solid Tumors (IMAG1NE)

Advanced Solid Tumors

Germany, Belgium, Spain, Netherlands, United Kingdom
University Medical Center Groningen

Not yet recruiting

Evaluating PD-1/PD-L1 in Locally Advanced Rectal Cancer by Quantitative Fluorescence Molecular Endoscopy (PREDICT)

Locally Advanced Rectal Carcinoma

Netherlands
UMC Utrecht

Completed

Safety Study of Radiofrequency Ablation of Locally Advanced Pancreatic Cancer (RFA of LAPC)

Locally Advanced Pancreatic Cancer

Netherlands
Ferring Pharmaceuticals

Completed

Real-life Data of Cardiovascular Events Occuring During Degarelix Therapy for Prostate Cancer

Advanced Hormone Sensitive Prostate Cancer

Netherlands
Academisch Medisch Centrum - Universiteit van Amsterdam...

Completed

Lymphatic Mapping for Image Guided Radiotherapy in Patients With LACC - a Feasibility Study (LaMA)

Locally Advanced Cervical Cancer

Netherlands
Maastricht University Medical Center

Completed

Local Pilocarpine for Relieving Dry Mouth

Patients of Advanced Age (≥ 70 Years) With a Clinical Diagnosis of Chronic Dry Mouth

Netherlands
MedImmune LLC

Completed

A Phase 1/2, Open-label Study to Evaluate the Safety and Antitumor Activity of MEDI0680 (AMP-514) in Combination With Durvalumab Versus Nivolumab Monotherapy in Participants With Select Advanced Malignancies

Kidney Cancer | Clear Cell Renal Cell Carcinoma | Select Advanced Malignancies

United States, France, Canada, United Kingdom, Netherlands, Australia
Erasmus Medical Center
University Medical Center Groningen; Leiden University Medical Center

Recruiting

FUnctional Selection of Advanced Breast Cancer Patients for Talazoparib Treatment Using the REpair Capacity (RECAP) Test (FUTURE)

Advanced Breast Cancer

Netherlands
Maastricht University Medical Center

Completed

Minimal Invasive Strategies for Good and Complete Response to Chemoradiation in Rectal Cancer

Locally Advanced Rectal Cancer

Netherlands
ExCellThera inc.
Fred Hutchinson Cancer Center

Active, not recruiting

US Study of UM171-Expanded CB in Patients With High Risk Leukemia/Myelodysplasia

High Risk Hematological Malignancy | Cord Blood Transplant

United States, Netherlands
Academisch Medisch Centrum - Universiteit van Amsterdam...

Completed

Metformin Combined With Chemotherapy for Pancreatic Cancer (GEM)

Metastatic Pancreatic Cancer | Locally Advanced Pancreatic Cancer

Netherlands
Vrije Universiteit Brussel
King's College London; University of Copenhagen; Erasmus Medical Center; University... and other collaborators

Active, not recruiting

International Study to Evaluate Two Programs of Support for Patients With Advanced Cancer and Their Families (DIAdIC)

Advanced Cancer

Belgium, Netherlands, Denmark, Ireland, United Kingdom, Italy
Radboud University Medical Center
Genzyme Europe B.V.

Recruiting

Cemiplimab for Secondary Angiosarcomas

Metastasis | Locally Advanced Sarcoma | Secondary Angiosarcoma

Netherlands
The Netherlands Cancer Institute

Completed

Phase I of Carboplatin-Olaparib Followed by Olaparib Monotherapy in Advanced Cancer (REVIVAL)

Breast Cancer | Ovarian Cancer | Advanced Cancer

Netherlands
UMC Utrecht
Radboud University Medical Center; Catharina Ziekenhuis Eindhoven; Amsterdam... and other collaborators

Not yet recruiting

Locally Advanced Pancreatic Cancer After Systemic Therapy: Ablative MR-guided Radiotherapy (LAPSTAR)

Locally Advanced Pancreatic Adenocarcinoma

Netherlands
MedImmune LLC

Completed

A Study to Evaluate MEDI0562 in Combination With Immune Therapeutic Agents in Adult Subjects With Advanced Solid Tumors

Select Advanced Solid Tumors

United States, France, Netherlands
Bristol-Myers Squibb

Completed

An Investigational Immuno-Therapy Study of Experimental Medication BMS-986178 by Itself or in Combination With Nivolumab and/or Ipilimumab in Participants With Solid Cancers That Are Advanced or Have Spread

Advanced Cancer

United States, Canada, Italy, Netherlands, Spain, Israel
The Netherlands Cancer Institute

Completed

Olaparib and Radiotherapy in Inoperable Breast Cancer

Locally Advanced Malignant Neoplasm | Triple-Negative Invasive Breast Carcinoma | Inflammatory Breast Carcinoma

Netherlands
Novartis Pharmaceuticals

Completed

Pharmacokinetic Drug-drug Interaction Study of Dovitinib (TKI258) in Patients With Advanced Solid Tumors. (CTKI258A2120)

Advanced Solid Tumors, Excluding Breast Cancer

Netherlands, Switzerland, Denmark, United States
Incyte Corporation

Active, not recruiting

A Study Exploring the Safety and Tolerability of INCB081776 in Participants With Advanced Malignancies

Advanced Solid Tumors

United States, Sweden, Netherlands, Norway, Denmark
The Netherlands Cancer Institute

Completed

Combined CFRT and SABR in Stage II and III NSCLC With Peripheral Tumors Smaller Than 5 cm. (N12HYB)

Inoperable Locally Advanced Non Small Cell Lung Cancer

Netherlands
Bristol-Myers Squibb

Terminated

A Study of BMS-986148 in Patients With Select Advanced Solid Tumors

Advanced Cancer

United States, Netherlands, Australia, Belgium, Canada, Italy, United Kingdom
The Netherlands Cancer Institute

Recruiting

Treatment of Locally Advanced VULvar CArcinoma in a Neoadjuvant Setting With Carboplatin and Paclitaxel Chemotherapy (VULCANize) (VULCANize)

Locally Advanced, Squamous Cell Carcinoma of the Vulva

Netherlands
Amsterdam UMC, location VUmc
Boehringer Ingelheim

Recruiting

A Clinical Imaging Study of the Changes in [18F]F-AraG Uptake Following Anti-PD-1 Therapy in Non-small Cell Lung Cancer (SHARP)

Advanced Stage Non-small Cell Lung Cancer

Netherlands
Takeda

Completed

A Phase 1 Drug-Drug Interaction Study Between Brigatinib and the CYP3A Substrate, Midazolam, in Participants With ALK-Positive or ROS1-Positive Solid Tumors

Carcinoma, Advanced ALK+ or ROS1+Non-Small-Cell Lung, Neoplasm, Advanced ALK+ or ROS1+Solid Tumors

Spain, Italy, Netherlands, France
Amsterdam UMC, location VUmc
University Hospital, Essen; Institut Curie; Ligue contre le cancer, France

Completed

New Strategies to Detect Cancers in Carriers of Mutations in RB1 (NIRBTEST)

Retinoblastoma | Secondary Primary Malignancies After Retinoblastoma

Netherlands, France, Germany
EMD Serono Research & Development Institute, Inc.
Merck KGaA, Darmstadt, Germany

Completed

Phase 1 Trial of MSC2490484A, an Inhibitor of a DNA-dependent Protein Kinase, in Combination With Radiotherapy

Advanced Solid Tumors

United States, Germany, Norway, Netherlands, Belgium, Denmark, Sweden, Switzerland
Incyte Corporation

Active, not recruiting

Study of INCA 0186 in Subjects With Advanced Solid Tumors

Advanced Solid Tumors | Squamous Cell Carcinoma of the Head and Neck (SCCHN) | Gastrointestinal (GI) Malignancies

United States, Netherlands, Spain, United Kingdom, Belgium, Austria
Academisch Medisch Centrum - Universiteit van Amsterdam...
Comprehensive Cancer Centre The Netherlands; Olympus; Dutch Cancer Society

Unknown

Pancreatic Locally Advanced Irresectable Cancer Ablation (PELICAN)

Locally Advanced Pancreatic Cancer

Netherlands
University Medical Center Groningen
Human Genome Sciences Inc.

Completed

Mapatumumab, Cisplatin and Radiotherapy for Advanced Cervical Cancer

Advanced Cervical Cancer

Netherlands
Novartis Pharmaceuticals

Completed

A Trial of Oral BEZ235 and BKM120 in Combination With Paclitaxel With or Without Trastuzumab

Metastatic or Locally Advanced Solid Tumors

Netherlands, Spain, Germany, Switzerland, Belgium
Maastricht University Medical Center

Completed

Restriction of Dietary AGEs to Prevent Diabetes in Overweight Individuals

Diet | Vascular Function | Insulin Sensitivity/Resistance | Beta-cell Function | Advanced Glycation Endproducts | AGEs

Netherlands
Novartis Pharmaceuticals

Completed

A Dose Escalation Study to Assess PK, Safety and Tolerability of INC280 When Taken With Food in cMET Dysregulated Advanced Solid Tumors.

cMET Dysegulation Advanced Solid Tumors

Austria, Denmark, Sweden, United Kingdom, Spain, Germany, Netherlands, United States
Bayer

Completed

A Study to Learn How BAY2927088 is Taken up and Handled by the Body in Healthy Male Participants

Healthy Volunteers | Advanced Non-small Cell Lung Cancer | EGFR Mutation | HER2 Mutation

Netherlands
EMD Serono Research & Development Institute, Inc.
Merck KGaA, Darmstadt, Germany

Completed

First in Human Study of M4344 in Participants With Advanced Solid Tumors

Solid Tumor | Advanced Solid Tumor

Spain, United States, Netherlands, United Kingdom
Bayer

Completed

First-in-human Study of BAY2287411 Injection, a Thorium-227 Labeled Antibody-chelator Conjugate, in Patients With Tumors Known to Express Mesothelin

Advanced Recurrent Malignant Pleural Epithelioid Mesothelioma | Advanced Recurrent Malignant Peritoneal Epithelioid Mesothelioma | Advanced Recurrent Serous Ovarian Cancer | Advanced Pancreatic Ductal Adenocarcinoma (Optional, Dose Expansion, Not Initiated)

United States, Sweden, Netherlands, United Kingdom, Finland
Amgen

Completed

Study of the Pharmacokinetics and Safety of Carfilzomib in Patients With Advanced Malignancies and Hepatic Impairment

Hepatic Impairment | Solid Tumors | Hematologic Malignancies

United Kingdom, Netherlands, United States, France
Hoffmann-La Roche

Completed

Study Evaluating the Safety, Pharmacokinetics (PK), Pharmacodynamics (PD), and Therapeutic Activity of Selicrelumab (RO7009789) With Vanucizumab or Bevacizumab in Participants With Metastatic Solid Tumors

Advanced/Metastatic Solid Tumors

United States, Belgium, Denmark, Spain, Netherlands, Canada, Italy

Clinical Trials on Advanced Malignancies in Netherlands

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