Clinical Trials on Anal Cancer in United Kingdom

Total 23841 results

ECOG-ACRIN Cancer Research Group
National Cancer Institute (NCI)

Active, not recruiting

Cisplatin and Fluorouracil Compared With Carboplatin and Paclitaxel in Treating Patients With Inoperable Locally Recurrent or Metastatic Anal Cancer (InterAACT)

Anal Squamous Cell Carcinoma | Anal Basaloid Carcinoma | Anal Canal Cloacogenic Carcinoma | Metastatic Anal Canal Carcinoma | Recurrent Anal Canal Carcinoma | Stage IIIB Anal Canal Cancer | Stage IV Anal Canal Cancer

United States
National Cancer Institute (NCI)

Active, not recruiting

Nivolumab With or Without Ipilimumab in Treating Patients With Refractory Metastatic Anal Canal Cancer

Anal Canal Squamous Cell Carcinoma | Metastatic Anal Canal Carcinoma | Stage IV Anal Canal Cancer AJCC v6 and v7

United States, Canada
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

Linear Energy Transfer (LET)-Optimized Intensity Modulated Proton Therapy (IMPT) as a Component of Definitive Chemoradiation for Newly Diagnosed Squamous Cell Carcinoma of the Anal Canal: a Feasibility Trial

Stage III Anal Cancer AJCC v8 | Anal Canal Squamous Cell Carcinoma | Stage IIB Anal Cancer AJCC v8 | Stage IIIA Anal Cancer AJCC v8 | Stage IIIB Anal Cancer AJCC v8 | Stage IIIC Anal Cancer AJCC v8 | Stage I Anal Cancer AJCC v8 | Stage II Anal Cancer AJCC v8 | Stage IIA Anal Cancer AJCC v8

United States
ECOG-ACRIN Cancer Research Group
National Cancer Institute (NCI)

Recruiting

Lower-Dose Chemoradiation in Treating Patients With Early-Stage Anal Cancer, the DECREASE Study

Anal Basaloid Carcinoma | Anal Canal Cloacogenic Carcinoma | Anal Canal Squamous Cell Carcinoma | Anal Margin Squamous Cell Carcinoma | Stage I Anal Cancer AJCC v8 | Stage IIA Anal Cancer AJCC v8

United States
Cardiff University

Recruiting

Phase 1b/II Trial of Pembrolizumab Plus IMRT in Stage III/IV Carcinoma of Anus (CORINTH)

Anal Cancer Stage III A | Anal Cancer Stage III B

United Kingdom, Norway
National Cancer Institute (NCI)

Recruiting

Therapy Adapted for High Risk and Low Risk HIV-Associated Anal Cancer

HIV Infection | Anal Squamous Cell Carcinoma | Anal Canal Cloacogenic Carcinoma | Stage III Anal Cancer AJCC v8 | Stage III Rectal Cancer AJCC v8 | Stage II Rectal Cancer AJCC v8 | Anal Margin Squamous Cell Carcinoma | AIDS-Related Anal Carcinoma | Rectal Squamous Cell Carcinoma | Stage I Anal Cancer AJCC... and other conditions

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

4-Point Therapy Response Score With PET/CT for Anal Squamous Cell Cancer

Anal Squamous Cell Carcinoma | Stage III Anal Cancer AJCC v8 | Stage IIB Anal Cancer AJCC v8 | Stage IIIA Anal Cancer AJCC v8 | Stage IIIB Anal Cancer AJCC v8 | Stage IIIC Anal Cancer AJCC v8 | Stage I Anal Cancer AJCC v8 | Stage II Anal Cancer AJCC v8 | Stage IIA Anal Cancer AJCC v8 | Stage 0 Anal Cancer...

United States
National Cancer Institute (NCI)

Recruiting

EA2176: Phase 3 Clinical Trial of Carboplatin and Paclitaxel +/- Nivolumab in Metastatic Anal Cancer Patients

Anal Canal Cloacogenic Carcinoma | Metastatic Anal Squamous Cell Carcinoma | Recurrent Anal Squamous Cell Carcinoma | Stage III Anal Cancer AJCC v8 | Stage IV Anal Cancer AJCC v8 | Unresectable Anal Squamous Cell Carcinoma | Anal Basaloid Squamous Cell Carcinoma

United States
National Cancer Institute (NCI)
Canadian Cancer Trials Group

Active, not recruiting

Nivolumab After Combined Modality Therapy in Treating Patients With High Risk Stage II-IIIB Anal Cancer

Anal Canal Cloacogenic Carcinoma | Stage III Anal Cancer AJCC v8 | Anal Margin Squamous Cell Carcinoma | Stage IIB Anal Cancer AJCC v8 | Anal Basaloid Squamous Cell Carcinoma

United States, Canada
AIDS Malignancy Consortium
National Cancer Institute (NCI); University of Arkansas; The Emmes Company, LLC; AIDS and Cancer Specimen Resource

Active, not recruiting

Surgery in Treating Patients With Early Stage Anal Canal or Perianal Cancer and HIV Infection

HIV Infection | Anal Squamous Cell Carcinoma | Stage 0 Anal Canal Cancer | Stage I Anal Canal Cancer

United States
Fred Hutchinson Cancer Center
National Cancer Institute (NCI)

Terminated

HPV Vaccine Therapy in Interrupting Progression in Patients With High-Grade Vulvar or Anal Lesions

High Grade Anal Canal Intraepithelial Neoplasia | High Grade Vulvar Squamous Intraepithelial Lesion

United States
Imperial College London

Recruiting

Anal Cancer Risk In Women

Anal Cancer | Human Papilloma Virus | Anal Intraepithelial Neoplasia | Genital Neoplasm | Genital Cancer

United Kingdom
Laser Surgery Care
QIAGEN Gaithersburg, Inc

Completed

Hybrid Capture 2 Human Papiloma Virus (HPV) High-Risk Anal DNA Test

Anal Cancer | Anal Canal HPV Infection Diagnosis | Anal Dysplasia Diagnosis

United States
London North West Healthcare NHS Trust

Recruiting

CArE for OAsI Study: Care Pathways and Anorectal Evaluation for OASI Associated Incontinence (CArE for OAsI)

Anal Incontinence | Faecal Incontinence | Follow-up | Biofeedback | Obstetric Anal Sphincter Injury | Urogynaecology | Urgency | Severe Perineal Trauma | Grade 3 Perineal Tear | Grade 4 Perineal Tear | Deferral Time | Pathways | Review | Endo-anal Ultrasound

United Kingdom
Lewisham and Greenwich NHS Trust

Completed

Diagnosis of Obstetric Anal Sphincter Injuries (OASIs) Using Transperineal Ultrasound Scan (TPUS)

Obstetric Anal Sphincter Injury

United Kingdom
Imperial College London

Recruiting

Anal Intraepithelial Neoplasia and Anal Squamous Cell Carcinoma

Anal Cancer | Anal Squamous Intraepithelial Neoplasia

United Kingdom
Massachusetts General Hospital
National Cancer Institute (NCI)

Unknown

Concurrent Chemoradiation + 5-FU + Mitomycin-C in Anal Carcinoma

Carcinoma of the Anal Canal

United States
London North West Healthcare NHS Trust

Completed

Primary Repair of Obstetric Anal Sphincter Injuries (OASIS) by Surgeons (PROS Study) (PROS)

Obstetric Anal Sphincter Injury

United Kingdom
Incyte Corporation

Completed

A Study of INCMGA00012 in Squamous Carcinoma of the Anal Canal Following Platinum-Based Chemotherapy (POD1UM-202)

Squamous Cell Carcinoma of Anal Canal

Spain, United Kingdom, United States, Germany, Belgium, France, Denmark, Italy, Norway
Cambridge University Hospitals NHS Foundation Trust
The Christie NHS Foundation Trust; Bowel Disease Research Foundation

Unknown

Functional Outcomes Following Anal Cancer Treatment (FOFACT)

Anal Cancer

United Kingdom
Ascopharm Groupe Novasco

Completed

Open, Multicentric Trial Evaluating the Efficacy and the Clinical Tolerance of PA0903 as Root Canal Sealer (PA0903)

Root Canal Obturation

France, United Kingdom
Stanford University
Caring for Carcinoid Foundation; GI Cancer Research Gift Fund

Withdrawn

Collection of Biospecimen & Clinical Information in Patients w/ Gastrointestinal Cancers

Gastrointestinal Neoplasms | Pancreatic Cancer | Anal Cancer | Colon/Rectal Cancer | Hepatobiliary Cancers | Gastric (Stomach) Cancer | Gynecologic Cancers | Gastro-Esophageal(GE) Junction Cancer | Gynecologic Cancers Cervical Cancer | Gastrointenstinal Stromal Tumor (GIST) | Colon/Rectal Cancer Colon Cancer and other conditions

United States
Stanford University

Terminated

Clinical and Pathologic Studies of Patients Undergoing Treatment With EGFR Inhibitors

Head and Neck Cancer | Colorectal Neoplasms | Lung Cancer | Colon Cancer | Colonic Neoplasms | Head and Neck Cancers | Anal, Colon, and Rectal Cancers | Colon/Rectal Cancer | Colon/Rectal Cancer Colon Cancer | Colon/Rectal Cancer Rectal Cancer | Colon/Rectal Cancer Anal Cancer | Head and Neck Cancers Lip | Head... and other conditions

United States
The Cleveland Clinic
Bard Ltd

Completed

Comparative Study Between Two Fecal Management Systems

Anal Erosion

United States
King's College London
Guy's and St Thomas' NHS Foundation Trust

Unknown

Prevalence of Bacteria Following Endodontic Treatment

Root Canal Infection

United Kingdom
University of Oxford
Oxford University Hospitals NHS Trust

Completed

ART: Anal Squamous Cell Carcinoma: Investigation of Functional Imaging During chemoRadioTherapy (ART)

Anal Cancer

United Kingdom
Castle Biosciences Incorporated

Terminated

Prospective Validation Study for the Proprietary Rectal and Anal Cancer Protein Expression Assays

Anal Squamous Cell Carcinoma | Rectal Adenocarcinoma | Anal Adenocarcinoma

United States
Croydon Health Services NHS Trust

Completed

The Effect of Perineal Wound Infection on the Anal Sphincter

Anal Sphincter Injury | Obstetric Trauma | Perineal Infection | Perineum; Injury

United Kingdom
King's College London
National Health Service, United Kingdom

Enrolling by invitation

Impact of an Enhanced Sterile Protocol on Root Canal Treatment Outcome

Endodontic Disease | Root Canal Infection | Root Canal Treatment

United Kingdom
S.L.A. Pharma AG

Completed

Diltiazem Hydrochloride Cream for Anal Fissure

Chronic Anal Fissure

United Kingdom, Spain, Bulgaria, Germany, Lithuania, Romania
University of Nebraska
BioMimetix JV, LLC

Recruiting

Safety Study of BMX-001 (Radio-protector) in Patients With Newly Diagnosed Anal Cancer

Radiation Exposure | Anal Cancer, Squamous Cell Carcinoma

United States
Duke University

Recruiting

Intratreatment FDG-PET During Radiation Therapy for Gynecologic and Gastrointestinal Cancers

Esophageal Cancer | Vulvar Cancer | Anal Canal Cancer | Cancer of the Cervix

United States
Branimir Sikic
AstraZeneca

Completed

Phase I Vandetanib Plus Capecitabine, Oxaliplatin and Bevacizumab for Metastatic Colorectal Cancer

Colorectal Neoplasms | Anal, Colon, and Rectal Cancers | Colon/Rectal Cancer

United States
Cedars-Sinai Medical Center
National Cancer Institute (NCI)

Recruiting

Virtual Reality for GI Cancer Pain to Improve Patient Reported Outcomes

Gastrointestinal Neoplasms | Stomach Cancer | Small Intestine Cancer | Rectal Cancer | Neuroendocrine Tumor | Bile Duct Cancer | Colon Cancer | Pancreas Cancer | Anal Cancer | Liver Cancer | Biliary Tract Cancer | Peritoneal Cancer | Carcinoid Tumor | Gallbladder Cancer | Cancer Pain | Carcinoid Tumor of the Small Bowel | Visceral... and other conditions

United States
Memorial Sloan Kettering Cancer Center

Active, not recruiting

Dose Escalation Trial of Endoluminal High-Dose-Rate Brachytherapy With Concurrent Chemotherapy for Rectal or Anal Cancer in Patients With Recurrent Disease or Undergoing Non-Operative Management

Rectal or Anal Cancer

United States
Incyte Corporation

Active, not recruiting

Carboplatin-paclitaxel With Retifanlimab or Placebo in Participants With Locally Advanced or Metastatic Squamous Cell Anal Carcinoma (POD1UM-303/InterAACT 2).

Squamous Cell Carcinoma of the Anal Canal

United States, Italy, Spain, United Kingdom, Australia, France, Germany, Sweden, Japan, Norway, Belgium, Denmark, Puerto Rico
London North West Healthcare NHS Trust

Completed

The Impact of 3D Anal Fistula Models on Patient Understanding and Decision Making (3DAF)

Fistula in Ano | Ano Fistula

United Kingdom
Royal Marsden NHS Foundation Trust

Completed

Low-Fiber Diet or High-Fiber Diet in Preventing Bowel Side Effects in Patients Undergoing Radiation Therapy for Gynecological Cancer, Bladder Cancer, Colorectal Cancer, or Anal Cancer

Sarcoma | Cervical Cancer | Colorectal Cancer | Ovarian Cancer | Fallopian Tube Cancer | Bladder Cancer | Anal Cancer | Radiation Toxicity | Gastrointestinal Complications

United Kingdom
University College London (UCL) Cancer Institute

Completed

Radiation Therapy Plus Fluorouracil With or Without Additional Chemotherapy in Treating Patients With Primary Anal Cancer

Anal Cancer

United Kingdom
National Cancer Institute (NCI)

Withdrawn

Administration of Autologous T-Cells Genetically Engineered to Express T-Cell Receptors Reactive Against Mutated or Viral Neoantigens in a Patient With Metastatic Cancer Plus the Administration of Pembrolizumab

Metastatic HPV-16 Positive Squamous Cell Anal Cancer

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

DNA Plasmid-encoding Interleukin-12/HPV DNA Plasmids Therapeutic Vaccine INO-3112 and Durvalumab in Treating Patients With Recurrent or Metastatic Human Papillomavirus Associated Cancers

Stage IV Anal Cancer AJCC v8 | Recurrent Cervical Carcinoma | Metastatic Malignant Neoplasm | Stage IV Penile Cancer AJCC v8 | Recurrent Malignant Neoplasm | Refractory Malignant Neoplasm | Stage IV Cervical Cancer AJCC v8 | Stage IVA Cervical Cancer AJCC v8 | Stage IVB Cervical Cancer AJCC v8 | Stage... and other conditions

United States
Ventrus Biosciences, Inc

Unknown

An Open-Label, Single- and Multi-Dose Pharmacokinetic (PK) Study of Oral Diltiazem and Topical Diltiazem Hydrochloride

Adult Subjects With Anal Fissures.

United States
Incyte Corporation

Completed

INCB106385 Alone or in Combination With Immunotherapy in Advanced Solid Tumors

Hepatocellular Carcinoma | Colorectal Cancer | Ovarian Cancer | Non Small Cell Lung Cancer | Squamous Cell Carcinoma of Head and Neck | Bladder Cancer | Triple Negative Breast Cancer | Pancreatic Ductal Adenocarcinoma | Castration Resistant Prostate Cancer | Gastric/ Gastroesophageal Junction | Squamous Carcinoma...

United States, Spain, France, United Kingdom, Italy, Belgium
Homerton University Hospital NHS Foundation Trust
Barts & The London NHS Trust

Recruiting

Function Following Laser for Anal Intraepithelial Neoplasia (FLAN) (FLAN)

Post Operative Pain | Fecal Incontinence | Anal Intraepithelial Neoplasia | Anus Cancer

United Kingdom
Northwestern University
Evergreen Invitational

Completed

Vaginal Electrical Stimulation for Postpartum Neuromuscular Recovery (VESPR)

Obstetric Anal Sphincter Injury | Vaginal Electrical Stimulation

United States
Duke University

Completed

Adaptive Pet Study

Head and Neck Cancers | Lung and Esophagus Cancers | Anal, Cervix, Vulvar, Vaginal, and Endometrium Cancers

United States
University of California, Irvine

Completed

3-D Endoanal Ultrasound: Normative Anatomy of the Anal Sphincter in Nulliparous Females

Normal (no Known Injury) Anal Sphincter Female Anatomy

United States
Emory University

Completed

Reducing Perinatal Anal Incontinence Through Early Pelvic Floor Muscle Training: a Prospective Pilot Study

Perinatal and Postpartum Anal Incontinence

United States
Stanford University
Genentech, Inc.

Completed

Avastin/[18-F]-5-fluorouracil PET/CT Imaging Feasibility Project

Colorectal Neoplasms | Rectal Cancer | Colon Cancer | Anal Cancer

United States
Royal Marsden NHS Foundation Trust
Cancer Research UK; European Organisation for Research and Treatment of Cancer... and other collaborators

Unknown

International Multicentre Study in Advanced Anal Cancer Comparing Cisplatin Plus 5 FU vs Carboplatin Plus Weekly Paclitaxel (InterAACT)

Squamous Cell Carcinoma of the Anus

United States, Australia, United Kingdom

Clinical Trials on Anal Cancer in United Kingdom

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