Clinical Trials on Anal Sphincter Injury

Total 10392 results

Poitiers University Hospital

Recruiting

Reproducibility of External Anal Sphincter Elastic Properties Assessment Using Elastography During Pregnancy (SEA ELASTO 1)

Obstetric Anal Sphincter Injury

France
Croydon University Hospital

Completed

Use of 3D Ultrasound to Predict Anal Sphincter Defects

Obstetric Anal Sphincter Injury
Chinese University of Hong Kong

Recruiting

Prevalence of Obstetric Anal Sphincter Injury With a Reducing Episiotomy Rate

Anal Sphincter Injury

Hong Kong
Lena Sagi-Dain
Rambam Health Care Campus; Hillel Yaffe Medical Center; Bnai Zion Medical Center and other collaborators

Terminated

The Effect of Episiotomy on Maternal and Fetal Outcomes (EPITRIAL)

Anal Sphincter Injury

Israel
Northwestern University
Evergreen Invitational

Completed

Vaginal Electrical Stimulation for Postpartum Neuromuscular Recovery (VESPR)

Obstetric Anal Sphincter Injury | Vaginal Electrical Stimulation

United States
Lewisham and Greenwich NHS Trust

Completed

Diagnosis of Obstetric Anal Sphincter Injuries (OASIs) Using Transperineal Ultrasound Scan (TPUS)

Obstetric Anal Sphincter Injury

United Kingdom
University of California, Irvine

Completed

3-D Endoanal Ultrasound: Normative Anatomy of the Anal Sphincter in Nulliparous Females

Normal (no Known Injury) Anal Sphincter Female Anatomy

United States
OASIS Diagnostics S.A.

Completed

Impedance Spectroscopy in Detection of Obstetric Anal Sphincter Injuries

Delivery, Obstetric | Obstetric Anal Sphincter Injury

Poland
OASIS Diagnostics S.A.

Completed

Impedance Spectroscopy for Obstetric Anal Sphincter Injuries Detection

Obstetric Complication | Delivery Complication | Obstetric Anal Sphincter Injury

Poland
University of Turku
Medtronic

Completed

External Phase MRI in Diagnosis of OASI

Anal Sphincter Injury | Obstetrics Trauma
London North West Healthcare NHS Trust

Completed

Primary Repair of Obstetric Anal Sphincter Injuries (OASIS) by Surgeons (PROS Study) (PROS)

Obstetric Anal Sphincter Injury

United Kingdom
OASIS Diagnostics S.A.
National Center for Research and Development, Poland

Completed

Detection of Obstetric Anal Sphincter Injuries With ONIRY Device

Obstetric Complication | Delivery Complication | Obstetric Anal Sphincter Injury

Spain, Czechia, Poland, Slovakia
University Hospital, Angers

Not yet recruiting

Anal Incontinence After Obstetrical Anal Sphincter Injury (INCONT-LOSA)

Anal Sphincter Injury | Anal Incontinence | Obstetric Trauma
Hadassah Medical Organization

Completed

Risk Factors for Anal Sphincter Damage During Vaginal Delivery (AnaSphRF)

Anal Sphincter Injury | Fecal Incontinence

Israel
University Hospital, Strasbourg, France

Not yet recruiting

Retrospective Study on Sexual Health in the Aftermath of an Obstetric Lesion of the Anal Sphincter (LOSA)

Lesions of the Anal Sphincter

France
Assiut University

Recruiting

Traumatic Anal Sphincteric Injury Immediate vs Delayed Repair

Traumatic Anal Sphincteric Injury,Immediate vs Delayed Repair

Egypt
Croydon Health Services NHS Trust

Completed

The Effect of Perineal Wound Infection on the Anal Sphincter

Anal Sphincter Injury | Obstetric Trauma | Perineal Infection | Perineum; Injury

United Kingdom
Kasr El Aini Hospital

Completed

Efficacy of Caudal Block on Intra-operative Anal Sphincter Muscle Tone and Post-operative Analgesia During Anal Sphincter Sparing Procedures Under General Anaesthesia

Efficacy of Caudal Block on Intra-operative Anal Sphincter Muscle Tone

Egypt
Cairo University

Completed

Peripartum Ultrasound in the Prediction and Diagnosis of OASIs

Anal Sphincter Tear Complicating Delivery

Egypt
Gérard Amarenco

Completed

External Anal Sphincter Fatigability (EASF)

External Anal Sphincter Fatigability

France
Maria Gyhagen

Completed

Development and Validation of a Logistic Regression Algorithm to Predict the Risk of Obstetric Anal Sphincter Injury.

Sphincter (Anal); Perineal Rupture, Obstetric

Sweden
Poitiers University Hospital

Recruiting

Mediolateral Episiotomy and Obstetric Anal Sphincter Injuries in Instrumental Delivery (INSTRUMODA)

Depression | Pelvic Floor Disorders | Anal Incontinence | Episiotomy Wound | Obstetric Anal Sphincter Injury

France
London North West Healthcare NHS Trust

Recruiting

CArE for OAsI Study: Care Pathways and Anorectal Evaluation for OASI Associated Incontinence (CArE for OAsI)

Anal Incontinence | Faecal Incontinence | Follow-up | Biofeedback | Obstetric Anal Sphincter Injury | Urogynaecology | Urgency | Severe Perineal Trauma | Grade 3 Perineal Tear | Grade 4 Perineal Tear | Deferral Time | Pathways | Review | Endo-anal Ultrasound

United Kingdom
ECOG-ACRIN Cancer Research Group
National Cancer Institute (NCI)

Active, not recruiting

Cisplatin and Fluorouracil Compared With Carboplatin and Paclitaxel in Treating Patients With Inoperable Locally Recurrent or Metastatic Anal Cancer (InterAACT)

Anal Squamous Cell Carcinoma | Anal Basaloid Carcinoma | Anal Canal Cloacogenic Carcinoma | Metastatic Anal Canal Carcinoma | Recurrent Anal Canal Carcinoma | Stage IIIB Anal Canal Cancer | Stage IV Anal Canal Cancer

United States
Sun Yat-sen University

Enrolling by invitation

PD-1 Blockade Combined With Chemotherapy Followed by Concurrent Immunoradiotherapy for Locally Advanced SCCA Patients

Anal Canal Cancer | Anal Squamous Cell Carcinoma | Anal Cancer | Anal Canal Cancer Stage I | Anal Canal Cancer Stage II | Anal Canal Cancer Stage III

China
National Cancer Institute (NCI)

Active, not recruiting

Nivolumab With or Without Ipilimumab in Treating Patients With Refractory Metastatic Anal Canal Cancer

Anal Canal Squamous Cell Carcinoma | Metastatic Anal Canal Carcinoma | Stage IV Anal Canal Cancer AJCC v6 and v7

United States, Canada
Oslo University Hospital

Enrolling by invitation

Pelvic Floor Function After Obstetric Injury to the Anal Sphincter (PFF)

Urinary Incontinence | Sexual Dysfunction | Anal Incontinence | Obstetric Anal Sphincter Injury

Norway
ECOG-ACRIN Cancer Research Group
National Cancer Institute (NCI)

Recruiting

Lower-Dose Chemoradiation in Treating Patients With Early-Stage Anal Cancer, the DECREASE Study

Anal Basaloid Carcinoma | Anal Canal Cloacogenic Carcinoma | Anal Canal Squamous Cell Carcinoma | Anal Margin Squamous Cell Carcinoma | Stage I Anal Cancer AJCC v8 | Stage IIA Anal Cancer AJCC v8

United States
Region Skane
Karolinska University Hospital

Completed

One Plus One Equals Two, Will That do? (Oneplus)

Pelvic Floor Disorders | Perineal Tear | Second Stage of Labor | Experience, Life | Sphincter (Anal); Perineal Rupture, Obstetric

Sweden
Sixth Affiliated Hospital, Sun Yat-sen University

Recruiting

Chemoradiotherapy Combined With or Without PD-1 Blockade in Anal Canal Squamous Carcinoma Patients

Anal Canal Cancer | Anal Squamous Cell Carcinoma | Anal Cancer | Anal Canal Cancer Stage III

China
Mansoura University

Completed

Idiopathic Hypertensive Anal Canal: a Place of Internal Sphincterotomy

Hypertensive Anal Canal

Egypt
AHS Cancer Control Alberta

Unknown

A Phase II Study to Assess Acute Toxicity and Quality of Life of Patients With Carcinoma of the Anal Canal Receiving Chemotherapy and Radiation Using Helical Tomotherapy

Anal Canal Cancer

Canada
Surp Pırgiç Armenian Hospital

Unknown

Laser Closure of Anal Fistula (FiLaC)

Anal Fistula | Fistula in Ano | Sphincter Ani Incontinence

Turkey
Fred Hutchinson Cancer Center
National Cancer Institute (NCI)

Terminated

HPV Vaccine Therapy in Interrupting Progression in Patients With High-Grade Vulvar or Anal Lesions

High Grade Anal Canal Intraepithelial Neoplasia | High Grade Vulvar Squamous Intraepithelial Lesion

United States
Dr. Te Vuong
YM BioSciences

Terminated

Nimotuzumab With Radiotherapy in the Treatment of Anal Canal Cancers

Squamous Cell Carcinoma of Anal Canal

Canada
Institut Cancerologie de l'Ouest

Completed

Medico-economic Evaluation Comparing Intensity-Modulated Radiation Therapy (IMRT) Performed by Helical Tomotherapy and Dynamic Arc Therapy in Prostate, Cervical and Anal Canal Cancers (RCMI PELVIS)

Cervical Cancer | Prostate Cancer | Anal Canal Cancers

France
Centre Francois Baclesse
Accuray Incorporated

Active, not recruiting

Study of SIB-IMRT in Combination With 5-FU and Mitomycin-C Among Patients With Locally Advanced Anal Canal Cancer: Efficacy, Safety and Quality of Life (CANAL-IMRT-01)

Locally Advanced Anal Canal Cancer

France
Peking University Third Hospital

Unknown

Endoclip Papillaplasty Restores Sphincter of Oddi Function

Sphincter of Oddi Function

China
Region Örebro County

Completed

The Effect of an Opioid on the Lower Esophageal Sphincter During Anesthesia Induction

Lower Esophageal Sphincter

Sweden
University of Alabama at Birmingham
Astellas Pharma Inc

Completed

Medication Effects on Periurethral Sensation,Urethral Sphincter Activity and Pressure Flow Parameters

Urethral Sphincter Activity

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

Linear Energy Transfer (LET)-Optimized Intensity Modulated Proton Therapy (IMPT) as a Component of Definitive Chemoradiation for Newly Diagnosed Squamous Cell Carcinoma of the Anal Canal: a Feasibility Trial

Stage III Anal Cancer AJCC v8 | Anal Canal Squamous Cell Carcinoma | Stage IIB Anal Cancer AJCC v8 | Stage IIIA Anal Cancer AJCC v8 | Stage IIIB Anal Cancer AJCC v8 | Stage IIIC Anal Cancer AJCC v8 | Stage I Anal Cancer AJCC v8 | Stage II Anal Cancer AJCC v8 | Stage IIA Anal Cancer AJCC v8

United States
University Hospital, Strasbourg, France

Unknown

Cricopharyngeal Dysfunction in Adults

Upper Esophageal Sphincter

France
Groupe Hospitalier Paris Saint Joseph

Completed

Pelvic-perineal Disorders in Women With Sphincter Tears (PAPOASI)

Obstetrical Perineal Injury and Anal Incontinence

France
Hanna Jangö

Completed

Translation and Validation of the ICIQ-B in Danish

Quality of Life | Pelvic Floor Disorders | Anal Incontinence | Anal Sphincter Tear

Denmark
Centre Hospitalier Universitaire de Besancon

Completed

Evaluation of Immune Response Against Human Papillomavirus (HPV)in Patients With Metastatic Cancer of the Anal Canal (Epitopes-HPV01)

Metastatic Anal Canal Cancer | Human Papillomavirus

France
xpgeng

Not yet recruiting

The Approach of Biliary Drainage in Hepatolithiasis Patients With Sphincter of Oddi Laxity (BD)

Sphincter of Oddi Laxity
Centre Hospitalier Universitaire de Besancon

Withdrawn

Immunomonitoring and Biomarker Research in Patients With Squamous Cell Anal Carcinoma (LAND)

Anal Canal Cancer

France
Asian Institute of Gastroenterology, India

Completed

Assessment of Pyloric Sphincter Physiology

Physiology of Pyloric Sphincter

India
National Cancer Institute (NCI)

Recruiting

EA2176: Phase 3 Clinical Trial of Carboplatin and Paclitaxel +/- Nivolumab in Metastatic Anal Cancer Patients

Anal Canal Cloacogenic Carcinoma | Metastatic Anal Squamous Cell Carcinoma | Recurrent Anal Squamous Cell Carcinoma | Stage III Anal Cancer AJCC v8 | Stage IV Anal Cancer AJCC v8 | Unresectable Anal Squamous Cell Carcinoma | Anal Basaloid Squamous Cell Carcinoma

United States
AHS Cancer Control Alberta

Recruiting

Inguinal Node Sparing Radiotherapy For Patients With Early Stage Anal Cancer (INSPIRE)

Anal Canal Cancer

Canada

Clinical Trials on Anal Sphincter Injury

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