Clinical Trials on Aplasia

Total 4828 results

Gruppo Italiano Malattie EMatologiche dell'Adulto

Completed

PENELOPE Observational Study: Prophylaxis and Treatment of Arterial and Venous Thromboembolism

Lymphoma | Multiple Myeloma | Acute Leukemia | Myelodysplastic Syndrome | Hematologic Neoplasm

Italy
Dicerna Pharmaceuticals, Inc.

Terminated

Phase I, Multicenter, Dose Escalation Study of DCR-MYC in Patients With Solid Tumors, Multiple Myeloma, or Lymphoma

Multiple Myeloma | PNET | Solid Tumors | Non-Hodgkins Lymphoma | NHL | Pancreatic Neuroendocrine Tumors

United States
Genzyme, a Sanofi Company

Completed

A Multi-centre, Open Label, Single-arm Study Intended to Further Investigate the Safety and Efficacy of Plerixafor as a Front-line Mobilisation Agent in Combination With G-CSF in Patients With Lymphoma or MM (Multiple Myeloma). (PREDICT)

Transplantation | Lymphoma (Non-Hodgkin's Lymphoma) | Hodgkin's Disease or Multiple Myeloma | Front Line Mobilization

Netherlands, France, Germany, Sweden, Spain, Italy, United Kingdom
Gilead Sciences

Terminated

A Trial of GS-9219 in Chronic Lymphocytic Leukemia (CLL), Non-Hodgkin's Lymphoma (NHL) or Multiple Myeloma (MM)

Multiple Myeloma | Non-Hodgkin's Lymphoma | Chronic Lymphocytic Leukemia

United States, Czech Republic, Russian Federation
Rocket Pharmaceuticals Inc.

Unknown

A Clinical Trial to Evaluate the Safety of RP-L102 in Pediatric Subjects With Fanconi Anemia Subtype A

Fanconi Anemia Complementation Group A

United States
Children's Hospital Medical Center, Cincinnati
Amgen

Completed

Pilot Study of Etanercept (Enbrel) in Children With Fanconi Anemia

Fanconi Anemia

United States
Rocket Pharmaceuticals Inc.

Enrolling by invitation

Long-Term Follow-up of Subjects With Fanconi Anaemia Subtype A Treated With ex Vivo Gene Therapy

Fanconi Anemia | Fanconi Anemia Complementation Group A

Spain
Tufts Medical Center
National Cancer Institute (NCI)

Not yet recruiting

Screening for AL Amyloidosis in Smoldering Multiple Myeloma

Smoldering Multiple Myeloma

United States
Dana-Farber Cancer Institute
National Cancer Institute (NCI)

Recruiting

PROFAST Intervention in Precursor Multiple Myeloma (PROFAST)

Multiple Myeloma | Weight Loss | Fasting | MGUS | Cancer Prevention | Smoldering Waldenstrom Macroglobulinemia(WM)

United States
Christoffer Johansen
Odense University Hospital; Zealand University Hospital; Aarhus University Hospital and other collaborators

Recruiting

Compassionate Communication and Advance Care Planning to Improve End of Life Care in Treatment of Hematological Disease (ACT) (ACT)

Lymphoma | Acute Myeloid Leukemia | Myelodysplastic Syndromes | Multiple Myeloma

Denmark
Peking Union Medical College Hospital
Bellco Hoxen Medical (Shanghai) Co., Ltd

Not yet recruiting

Effect of HFR-SUPRA in the Treatment of Multiple Myeloma-related Acute Kidney Injury

Multiple Myeloma | Acute Kidney Injury | Hemodiafiltration With Ultrafiltrate Regeneration (HFR)
Memorial Sloan Kettering Cancer Center
Pentixapharm AG

Recruiting

In-Human CXCR4 Imaging of Blood Cancers Using [68Ga]-Pentixafor-PET

Multiple Myeloma | Non-Hodgkin Lymphoma | Erdheim-Chester Disease | Rosai-Dorfman Disease | Histiocytic Neoplasms

United States
National Cancer Institute (NCI)

Active, not recruiting

Testing Sunitinib as Potentially Targeted Treatment in Cancers With cKIT Genetic Changes (MATCH - Subprotocol V)

Advanced Lymphoma | Advanced Malignant Solid Neoplasm | Refractory Lymphoma | Refractory Malignant Solid Neoplasm | Refractory Multiple Myeloma

United States
National Cancer Institute (NCI)

Active, not recruiting

Testing Binimetinib as a Potential Targeted Treatment in Cancers With NRAS Genetic Changes (MATCH-Subprotocol Z1A)

Hematopoietic and Lymphoid Cell Neoplasm | Advanced Lymphoma | Advanced Malignant Solid Neoplasm | Refractory Lymphoma | Refractory Malignant Solid Neoplasm | Refractory Multiple Myeloma

United States
Lawson Health Research Institute
The Ottawa Hospital; Hamilton Health Sciences Corporation; Dalhousie University; Niagara Health System

Active, not recruiting

Rivaroxaban or Aspirin As Thromboprophylaxis in Multiple Myeloma (RithMM)

Multiple Myeloma in Relapse | Multiple Myeloma With Failed Remission | Multiple Myeloma Stage I | Multiple Myeloma Progression | Multiple Myeloma Stage II | Multiple Myeloma Stage III

Canada
Dana-Farber Cancer Institute

Active, not recruiting

Questionnaire and Tissue Banking For Multiple Myeloma, Waldenstrom Macroglobulinemia and Related Disorders

Multiple Myeloma | Lymphoblastic Lymphoma | Waldenstrom's Macroglobulinemia | Smoldering Multiple Myeloma

United States
Weill Medical College of Cornell University
Mayo Clinic; Janssen Scientific Affairs, LLC

Terminated

Daratumumab Plus Ibrutinib in Patients With Waldenstrӧm's Macroglobulinemia

Waldenstrom Macroglobulinemia | Waldenstrom's Macroglobulinemia Recurrent | Waldenstrom's Macroglobulinemia Refractory | Waldenstrom's Disease | Waldenström; Hypergammaglobulinemia | Waldenstrom's Macroglobulinemia of Lymph Nodes | Waldenstrom's Macroglobulinaemia, Without Mention of Remission

United States
Barbara Ann Karmanos Cancer Institute
National Cancer Institute (NCI)

Terminated

First-line Pomalidomide, Bortezomib, and Dexamethasone For AL Amyloidosis or LCDD

Primary Systemic Amyloidosis | Light Chain Deposition Disease

United States, Canada
Centre Hospitalier Intercommunal Creteil
ANSES

Completed

Identification of Occupational Exposures in Acute Hematologic Malignancy (RHELYPRO)

Multiple Myeloma | Chronic Lymphocytic Leukemia | Non Hodgkin Lymphoma

France
Sherif S. Farag

Withdrawn

Analysis of Oral Mucositis in Patient's Undergoing Melphalan Conditioning and Autologous Stem Cell Transplant

Multiple Myeloma | Amyloidosis | Mucositis | Oral Mucositis

United States
Oxford University Hospitals NHS Trust
Amgen

Completed

The Development and Pilot Testing of a New MR Imaging Protocol to Quantify Myeloma Disease Burden and Bone Loss (LOOMIS)

Myeloma | Smouldering Myeloma | Monoclonal Gammopathy of Undetermined Significance (MGUS)

United Kingdom
Radboud University Medical Center

Completed

Anakinra: Safety and Efficacy in the Management of Fever During Neutropenia and Mucositis in ASCT (AFFECT-1)

Multiple Myeloma

Netherlands
Massachusetts General Hospital

Completed

Combined Bone Marrow Transplantation (BMT) and Renal Transplant for Multiple Myeloma (MM) With End Stage Renal Disease (ESRD)

Multiple Myeloma | End Stage Renal Disease

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Bone Marrow Transplant Studies for Safe and Effective Treatment of Leukemia

Leukemia | Multiple Myeloma | Myelodysplastic Syndrome | Graft vs Host Disease | Hematologic Neoplasm

United States
Virginia Commonwealth University
Novartis Pharmaceuticals

Completed

Interleukin-1 Blockade With Canakinumab to Improve Exercise Capacity in Patients With Chronic Systolic Heart Failure and Elevated High Sensitivity C-reactive Protein (Hs-CRP)

Prior Acute Myocardial Infarction | Evidence of Systemic Inflammation (C Reactive Protein Plasma >2 mg/l) | Reduced Left Ventricle Ejection Fraction (<50%) | Symptoms of Heart Failure (NYHA Class II-III)

United States
Medtronic Spine LLC

Completed

FREE Study - Fracture Reduction Evaluation

Multiple Myeloma | Bone Neoplasms | Osteoporosis | Osteopenia

United States
National Heart, Lung, and Blood Institute (NHLBI)
Blood and Marrow Transplant Clinical Trials Network

Completed

Blood and Marrow Transplant Clinical Research Network

Myelodysplastic Syndromes | Leukemia | Multiple Myeloma | Blood Disease | Bone Marrow Transplantation | Hematopoietic Stem Cell Transplantation | Graft vs Host Disease

United States
French Study Group on Chronic Lymphoid Leukemia
French Innovative Leukemia Organisation; Lymphoma Study Association; Département...

Completed

Trial Comparing Chlorambucil to Fludarabine in Patients With Advanced Waldenström Macroglobulinemia

Splenic Marginal Zone Lymphoma | Waldenström Macroglobulinemia | Lymphoplasmacytic Lymphoma

France
Washington University School of Medicine

Completed

Infusion of Genetically Modified T Cell for Post Transplant Patients With Relapsed Disease

Lymphoma, Non-Hodgkin | Myelodysplastic Syndromes | Leukemia | Multiple Myeloma | Hodgkin Disease

United States
Vertex Pharmaceuticals Incorporated

Completed

Trial of AVN-944 in Patients With Advanced Hematologic Malignancies

Multiple Myeloma | Hodgkin's Lymphoma | Non-Hodgkin's Lymphoma | Waldenstrom's Macroglobulinemia | Acute Leukemia | Chronic Leukemia

United States
Chroma Therapeutics

Completed

Safety and Anti-Disease Activity of CHR-2797 (Tosedostat) in Elderly and/or Treatment Refractory Patients With Acute Myeloid Leukemia (AML) and Multiple Myeloma (MM)

Acute Myeloid Leukemia | Multiple Myeloma | Myelodysplastic Syndrome

United Kingdom
University of Pisa

Unknown

Study on the Incidence of Febrile Episodes During Stem Cells Collection After Chemotherapy in Patients With Multiple Myeloma

G-CSF, Multiple Myeloma, Febrile Episode, Filgrastim, Leograstim
Brenda Cooper, MD

Completed

Phase I Trial of Universal Donor NK Cell Therapy in Combination With ALT803

Soft Tissue Sarcoma | Acute Myeloid Leukemia | Hodgkin Lymphoma | Acute Lymphoblastic Leukemia | Chronic Lymphocytic Leukemia | Non Hodgkin Lymphoma | Chronic Myeloid Leukemia | Myelodysplastic Syndrome | Plasma Cell Myeloma | Rhabdomyosarcoma | Colon Carcinoma | Adenocarcinoma of Rectum | Myeloproliferative Syndromes and other conditions

United States
Regeneron Pharmaceuticals

Not yet recruiting

A Proof-of-Concept Study to Learn Whether Linvoseltamab Can Eliminate Abnormal Plasma Cells That May Lead to Multiple Myeloma in Adult Patients With High-Risk Monoclonal Gammopathy of Undetermined Significance or Non-High-Risk Smoldering Multiple Myeloma (LINKER-MGUS1)

Monoclonal Gammopathy of Undetermined Significance (MGUS) | Smoldering Multiple Myeloma (SMM)
Hebei Senlang Biotechnology Inc., Ltd.
Cangzhou People's Hospital

Recruiting

CAR-T Cells in the Treatment of Malignant Hematological Tumors

Lymphoma, B-Cell | Multiple Myeloma | Leukemia, T-Cell | Leukemia, B-cell

China
University Hospital, Montpellier

Recruiting

Impact of a Sensory Rehabilitation Program on Olfactory-gustatory Alterations in Patients Treated With Chemotherapy for Haematological Cancer (RE-NEZ-SENS)

Lymphoma | Multiple Myeloma | Olfactivo-gustatory Disorder | Haematological Cancer

France
National Cancer Institute (NCI)

Withdrawn

Testing Nivolumab and BMS-986016 (Relatlimab) as Potentially Targeting Treatment in Cancers That Are LAG-3+ and Have Mismatch Repair Deficiency (MATCH - Subprotocol Z1M)

Advanced Lymphoma | Advanced Malignant Solid Neoplasm | Refractory Lymphoma | Refractory Malignant Solid Neoplasm | Refractory Multiple Myeloma
Duke University

Completed

Multiple Myeloma/Chronic Lymphocytic Leukemia Coach RCT

Multiple Myeloma | Chronic Lymphocytic Leukemia

United States
ASH Research Collaborative

Enrolling by invitation

ASH Research Collaborative Data Hub

Multiple Myeloma | Sickle Cell Disease

United States
Autolus Limited

Enrolling by invitation

Long-term Follow-up of Patients Treated With Autologous T Cells Genetically Modified

Multiple Myeloma | DLBCL | T Cell Lymphoma | Patients Followed for up to 15 Years Following Their First Dose of AUTO CAR T Cell Therapy | ALL, Adult and Pediatric

United Kingdom
Prelude Therapeutics

Completed

A Study of PRT1419 in Patients With Relapsed/Refractory Hematologic Malignancies

Acute Myeloid Leukemia | Myelodysplastic Syndromes | Multiple Myeloma | Non Hodgkin Lymphoma

United States
German Cancer Research Center
Heidelberg University

Active, not recruiting

Investigation of Bone Defects and Microcirculation With Computed Tomography and Magnetic Resonance Imaging

Multiple Myeloma | Osteoporosis | Vertebral Fracture

Germany
Azienda Ospedaliera Universitaria Mater Domini,...
Associazione Italiana per la Ricerca sul Cancro

Completed

A Dose Escalation Study of LNA-i-Mir-221 for Cancer Treatment (LNA-i-miR221)

Advanced Solid Tumor | Hepatocarcinoma | Multiple Myeloma, Refractory

Italy
City of Hope Medical Center

Completed

Melphalan and Radiation Therapy Followed By Lenalidomide in Treating Patients Who Are Undergoing Autologous Stem Cell Transplant for Stage I, Stage II, or Stage III Multiple Myeloma

Stage I Multiple Myeloma | Stage II Multiple Myeloma | Stage III Multiple Myeloma | Smoldering Multiple Myeloma | Refractory Multiple Myeloma

United States
Yale University
Peter MacCallum Cancer Centre, Australia

Terminated

An Open Label, International, Multi-centre, Phase I/IIa Study of Lenalidomide (Revlimid) and Romidepsin (Istodax) for Relapsed /Refractory Hodgkin Lymphoma, Mature T-cell Lymphoma and Multiple Myeloma. (RId Study) (RID)

Multiple Myeloma | Hodgkin's Lymphoma | Mature T-cell Lymphoma

United States
Alexion Pharmaceuticals

Terminated

Safety and Dose Ranging Study of Samalizumab to Treat Relapsing or Refractory CLL or MM

Multiple Myeloma | B-cell Chronic Lymphocytic Leukemia

United States
Calithera Biosciences, Inc

Completed

Study of the Glutaminase Inhibitor CB-839 in Hematological Tumors

Multiple Myeloma | Non-Hodgkin's Lymphoma (NHL) | Waldenstrom's Macroglobulinemia (WM) | Other B-cell NHL Subtypes, Including WM | T-cell NHL

United States
Celyad Oncology SA
National Heart, Lung, and Blood Institute (NHLBI); Dana-Farber Cancer Institute

Completed

Safety Study of Chimeric Antigen Receptor Modified T-cells Targeting NKG2D-Ligands

Acute Myeloid Leukemia | Multiple Myeloma | Myelodysplastic Syndrome

United States
IRCCS Policlinico S. Matteo

Withdrawn

High Cut-off Hemodialysis in Patients With Advanced Cardiac AL Amyloidosis and End Stage Renal Disease (DIACAL)

Primary Amyloidosis of Light Chain Type

Italy
Assistance Publique - Hôpitaux de Paris

Terminated

Treatment of Malignant Vertebral Fractures With Percutaneous Balloon Kyphoplasty. (KYPHOK)

Multiple Myeloma | Vertebral Fracture | Osteolytic Metastases

France

Clinical Trials on Aplasia

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