Clinical Trials on BRCA 1/2 in New Zealand

Total 2008 results

Abramson Cancer Center of the University of Pennsylvania

Completed

A Study of the Communication of Genetic Test Results By Telephone: A Multi-Center Study

Candidates for BRCA 1/2 Genetic Testing

United States
Weill Medical College of Cornell University
Basser Research Center for BRCA

Recruiting

FaCT Trial (Facilitated Cascade Testing Trial)

BRCA1 Mutation | BRCA2 Mutation

United States
Pfizer
Medivation, Inc.; Myriad Genetic Laboratories, Inc.

Terminated

A Phase 2, 2-Stage, 2-Cohort Study of Talazoparib (BMN 673), in Locally Advanced and/or Metastatic Breast Cancer Patients With BRCA Mutation (ABRAZO Study) (ABRAZO)

Breast Neoplasms | BRCA 1 Gene Mutation | BRCA 2 Gene Mutation

United States, Spain, United Kingdom, Germany, France
Memorial Sloan Kettering Cancer Center
University of Pennsylvania; University of California, Los Angeles; Dana-Farber... and other collaborators

Active, not recruiting

BRCA Founder OutReach (BFOR) Study (BFOR)

BRCA1 Mutation | BRCA2 Mutation

United States
Pfizer
Medivation, Inc.

Completed

A Study Evaluating Talazoparib (BMN 673), a PARP Inhibitor, in Advanced and/or Metastatic Breast Cancer Patients With BRCA Mutation (EMBRACA Study) (EMBRACA)

Breast Neoplasms | BRCA 1 Gene Mutation | BRCA 2 Gene Mutation

Korea, Republic of, United States, Australia, Spain, Belgium, France, Ireland, Taiwan, Poland, Germany, Israel, Brazil, United Kingdom, Italy, Russian Federation, Ukraine
AstraZeneca
Merck Sharp & Dohme LLC; Myriad Genetic Laboratories, Inc.

Active, not recruiting

Assessment of the Efficacy and Safety of Olaparib Monotherapy Versus Physicians Choice Chemotherapy in the Treatment of Metastatic Breast Cancer Patients With Germline BRCA1/2 Mutations. (OlympiAD)

Breast Cancer Metastatic | BRCA 1 Gene Mutation | BRCA 2 Gene Mutation

Italy, Spain, United States, Czechia, Romania, France, Korea, Republic of, United Kingdom, Hungary, Japan, Peru, Poland, Russian Federation, Turkey, China, Taiwan, Bulgaria, Switzerland, Mexico
Pfizer

Terminated

Javelin BRCA/ATM: Avelumab Plus Talazoparib in Patients With BRCA or ATM Mutant Solid Tumors

Locally Advanced or Metastatic Solid Tumors | Genes, BRCA 1

United States, Belgium, Spain, Denmark, Japan, France, Italy, Netherlands, United Kingdom
Memorial Sloan Kettering Cancer Center
Phenogen Sciences

Recruiting

Responses to Genetic Risk Modifier Testing Among Women With BRCA1/2 Mutations

Genetic Testing | BRCA1/2

United States
Weill Medical College of Cornell University

Completed

Web-based Family History Tool (Progeny)

Breast Cancer | Gynecologic Cancer | BRCA1 Mutation | BRCA2 Mutation

United States
Alvotech Swiss AG

Completed

PK, Safety and Tolerability Study of AVT02 (Adalimumab) Pre-filled Syringe (PFS) vs, AVT02 Autoinjector (AI)

Phase 1

New Zealand
NYU Langone Health

Withdrawn

3.0 Tesla Magnetic Resonance Imaging for Breast Cancer Detection in High Risk Women

Breast Cancer | BRCA1 Mutation | BRCA2 Mutation

United States
Diatranz Otsuka Limited

Completed

Open-label Investigation of the Safety and Effectiveness of DIABECELL(R) in Patients With Type I Diabetes Mellitus

Type 1 Diabetes

New Zealand
Edgar National Centre for Diabetes Research
University of Otago

Unknown

LOADD (Lifestyle Over and Above Drugs in Diabetes) Study

Type 2 Diabetes Mellitus

New Zealand
Christchurch Clinical Studies Trust Ltd
Medtronic

Unknown

Assessment of Two Insulin Pump Insulin Delivery Systems in Type 1 Diabetes.

Type1diabetes

New Zealand
Insulet Corporation

Completed

Evaluating Glucose Control Using a Next Generation Automated Insulin Delivery Algorithm in Patients With Type 1 and Type 2 Diabetes (Evolution)

Diabetes Mellitus

New Zealand
North Shore Hospital, New Zealand

Completed

Silastic Ring Gastric Bypass Versus Sleeve Gastrectomy for Type 2 Diabetes Mellitus in Obese Patients

Obesity | Type 2 Diabetes Mellitus

New Zealand
University of Otago
Edgar National Centre for Diabetes Research

Completed

The Heat Study: 2 Year Lifestyle Intervention in Overweight Women to Encourage Weight Management

Obesity | Type 2 Diabetes Mellitus

New Zealand
Suzhou Alphamab Co., Ltd.
Novotech (Australia) Pty Limited

Recruiting

A Study to Evaluate Effects of KN056 in Healthy Participants

Type 2 Diabetes

New Zealand
Dicerna Pharmaceuticals, Inc.

Withdrawn

An Extension Study of Belcesiran in Patients With Alpha-1 Antitrypsin Deficiency Associated Liver Disease (AATLD)

Alpha 1-Antitrypsin Deficiency

New Zealand
Arrowhead Pharmaceuticals

Completed

Study of ARO-AAT in Normal Adult Volunteers

Alpha 1-Antitrypsin Deficiency

New Zealand
Columbia University
American Cancer Society, Inc.

Completed

Decision Support for BRCA Testing in Ethnically Diverse Women

Breast Cancer | Ovarian Cancer | BRCA1 Mutation | BRCA2 Mutation

United States
Syneos Health
US Specialty Formulations, LLC

Completed

First-In-Human Study Of Orally Administered CoV2-OGEN1 In Healthy Subjects

SARS-CoV-2 (COVID-19)

New Zealand
Dicerna Pharmaceuticals, Inc., a Novo Nordisk company

Completed

Study of DCR-A1AT in Healthy Adult Volunteers

Alpha 1-Antitrypsin Deficiency

New Zealand, Sweden
Southwest Oncology Group
National Cancer Institute (NCI)

Completed

S0812 High Dose Cholecalciferol in Premenopausal Women at High-Risk for Breast Cancer

Breast Cancer | brca1 Mutation Carrier | brca2 Mutation Carrier

United States
Zhejiang Doer Biologics Co., Ltd.

Recruiting

A First in Human (FIH) Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of DR10624

Healthy, Obesity, Metabolically

New Zealand
Christchurch Hospital

Unknown

How Does the Diabetes Drug, Pioglitazone, Reduce Protein Loss in the Urine?

Diabetes Mellitus, Type 2

New Zealand
Rutgers, The State University of New Jersey

Recruiting

Internet Assisted Career-Oriented Soft-skills Training for Transition Age Youth With Mental Health Conditions (iCareer)

Mental Health Wellness 1 | Occupational Problems | Mental Health Wellness 2

United States
Arrowhead Pharmaceuticals

Recruiting

Study of ARO-DM1 in Subjects With Type 1 Myotonic Dystrophy

Myotonic Dystrophy 1

New Zealand, Australia
Melbourne Health

Completed

Trial of Intranasal Insulin in Children and Young Adults at Risk of Type 1 Diabetes (INITII)

Type 1 Diabetes

Australia, New Zealand
Dicerna Pharmaceuticals, Inc.

Completed

A Study to Evaluate DCR-PHXC in Children and Adults With Primary Hyperoxaluria Type 1 and Primary Hyperoxaluria Type 2 (PHYOX2)

Kidney Diseases | Urologic Diseases | Genetic Disease | Primary Hyperoxaluria Type 1 (PH1) | Primary Hyperoxaluria Type 2 (PH2)

Poland, United Kingdom, New Zealand, United States, Australia, Canada, France, Germany, Israel, Italy, Japan, Lebanon, Netherlands, Romania, Spain
Boston Scientific Corporation

Completed

Subcutaneous Implantable Defibrillator (S-ICD) System - CE Clinical Investigation

ACC/AHA/NASPE Class 1, IIa or IIb Indications

Netherlands, Italy, United Kingdom, New Zealand
Mannkind Corporation

Terminated

Pulmonary Function Substudy for Subjects Enrolled in Studies MKC-TI-161, MKC-TI-162 or MKC-TI-166

Type 2 Diabetes Mellitus | Type 1 Diabetes Mellitus

United States
The National Institute of Lymphology
The DrMarga Practice Group; The Center for Restorative Breast Surgery, LLC

Unknown

Outcomes After Perforator Flap Reconstruction for Breast Reconstruction and/or Lymphedema Treatment

Breast Cancer | Hereditary Breast/Ovarian Cancer (brca1, brca2) | Congenital Lymphedema | Acquired Lymphedema

United States
Bispebjerg Hospital

Completed

Cut Down on Carbohydrate Usage in the Diet of Type 2 Diabetes - Mechanisms of Effective Therapy of Diabetes by Selective Choice of Macronutrients - The Phenotype Study (CutDM)

Type 2 Diabetes

Denmark
Rana McKay, MD
University of California, San Diego; AstraZeneca

Recruiting

Study of Neoadjuvant PARP Inhibition Followed by Radical Prostatectomy in Patients With Unfavorable Intermediate-Risk or High-Risk Prostate Cancer With BRCA1/2 Gene Alterations (NePtune)

Prostate Cancer | BRCA1 Mutation | BRCA2 Mutation | Prostatic Adenocarcinoma | High-Risk Cancer

United States
Assembly Biosciences

Not yet recruiting

A Study to Assess the Safety, Pharmacokinetics, and Antiviral Activity of ABI-5366 in Healthy Participants and Participants Seropositive for HSV-2 With Recurrent Genital Herpes

Recurrent Genital Herpes Simplex Type 2

New Zealand
Memorial Sloan Kettering Cancer Center
Memorial Health University Medical Center

Completed

BRCA1 Haploinsufficiency and Gene Expression

BRCA1 Mutations

United States
Memorial Sloan Kettering Cancer Center

Active, not recruiting

Rapid Pancreatic and Ovarian Screening MR Imaging With Motion Corrected T1, T2, and Advanced Diffusion Weighted Imaging for Patients With BRCA Mutation Who Undergo Screening Breast MRI

Screening Breast MRI in Patients Who Are BRCA Mutation Carriers

United States
Beijing InnoCare Pharma Tech Co., Ltd.

Active, not recruiting

A Study of Tyrosine Kinase Inhibitor Orelabrutinib (ICP-022) in Patients With r/r B-Cell Malignancies

Part 1：r/r B-cell Malignancies | Part 2：B-cell Malignancies

United States, Poland, Israel, Ukraine
Murdoch Childrens Research Institute
Royal Children's Hospital

Completed

What is the Incidence of an Immune Disorder in Children With Invasive Pneumococcal Disease (IPD)?

Primary Immunodeficiency | Invasive Pneumococcal Disease, Protection Against | Invasive Pneumococcal Disease, Recurrent Isolated, 1 | Invasive Pneumococcal Disease, Recurrent Isolated, 2

Australia, New Zealand
Baxalta now part of Shire

Completed

Efficacy and Safety Study of Augmentation Therapy With ARALAST Fraction IV-1 (Human Alpha 1 - Proteinase Inhibitor)

Alpha 1-Antitrypsin Deficiency

New Zealand, Australia
Sanofi

Completed

Comparison of SAR341402 to NovoLog/NovoRapid in Adult Patients With Diabetes Mellitus Also Using Insulin Glargine (GEMELLI1)

Type 1 Diabetes Mellitus-Type 2 Diabetes Mellitus

Hungary, Russian Federation, Germany, Poland, Japan, United States, Finland
Valneva Austria GmbH

Completed

VLA2001 Booster in Adult Participants After Priming With mRNA COVID-19 Vaccine and/or Natural SARS-CoV-2 Infection

SARS-CoV-2 Infection

New Zealand, Netherlands
Center for International Blood and Marrow Transplant...
Patient-Centered Outcomes Research Institute; National Marrow Donor Program

Completed

Randomized Study of Individualized Care Plans for Hematopoietic Cell Transplant Survivors

Adult Hematopoietic Cell Transplant (HCT) Survivors 1-2 Yrs Post Most Recent HCT

United States
Avid Radiopharmaceuticals

Terminated

A Trial of 18F-AV-133 Positron Emission Tomography (PET)

Type 1 Diabetes | Type 2 Diabetes

United States
Baxalta now part of Shire
Baxter Healthcare, Ltd. (New Zealand), Baxter Healthcare Pty. Ltd. (Australia)

Completed

Pharmacokinetic Study of ARALAST (Human Alpha1- PI)

Alpha 1-Antitrypsin Deficiency

Australia, New Zealand
AstraZeneca

Completed

An Observational Study Evaluating SYMLIN® (Pramlintide Acetate) Injection Use in Insulin Using Patients With Type 2 and Type 1 Diabetes

Type 2 Diabetes Mellitus | Type 1 Diabetes Mellitus

United States
AstraZeneca

Completed

Clinical Utility and Safety of Pramlintide in Subjects With Type 1 and Type 2 Diabetes Mellitus

Type 2 Diabetes Mellitus | Type 1 Diabetes Mellitus

United States
Valneva Austria GmbH

Completed

Safety and Immunogenicity of VLA2001 Adults Aged ≥56 Years

SARS-CoV-2 Virus Infection

New Zealand
The University of New South Wales
National Health and Medical Research Council, Australia; Novo Nordisk A/S; Sydney...

Completed

Rosiglitazone and Insulin in T1DM Adolescents

Type 1 Diabetes | Puberty: >Tanner 2 Breast Development or Testis >4ml

Australia

Clinical Trials on BRCA 1/2 in New Zealand

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