Clinical Trials on Brain Glioma

Total 32456 results

National Cancer Institute (NCI)

Recruiting

A Study to Compare Treatment With the Drug Selumetinib Alone Versus Selumetinib and Vinblastine in Patients With Recurrent or Progressive Low-Grade Glioma

Recurrent WHO Grade 2 Glioma | Recurrent Low Grade Astrocytoma | Refractory Low Grade Astrocytoma | Refractory Low Grade Glioma | Refractory WHO Grade 1 Glioma

United States, Canada
National Cancer Institute (NCI)

Completed

Pazopanib Hydrochloride in Treating Young Patients With Solid Tumors That Have Relapsed or Not Responded to Treatment

Unspecified Childhood Solid Tumor, Protocol Specific | Recurrent Childhood Soft Tissue Sarcoma | Recurrent Childhood Brain Stem Glioma | Recurrent Childhood Visual Pathway Glioma | Childhood Central Nervous System Germ Cell Tumor | Childhood Central Nervous System Choriocarcinoma | Childhood Central... and other conditions

United States
Medical University of South Carolina

Withdrawn

Valproic Acid in Childhood Progressive Brain Tumors

Glioma | Glioblastoma | Medulloblastoma | Anaplastic Astrocytoma | Pediatric Brain Tumor

United States
NYU Langone Health
Bayer Healthcare Pharmaceuticals, Inc./Bayer Schering Pharma

Terminated

Sorafenib in Children and Young Adults With Recurrent or Progressive Low-Grade Astrocytomas

neurofibromatosis1 (NF1) | Recurrent or Progressive Optic Pathway Gliomas (OPG) | Recurrent or Progressive Low-grade Glioma

United States
Peter Siesjö
Lund University; Region Skane; Skane University Hospital; Lantmannen Medical AB

Completed

Antisecretory Factor in Primary Glioblastoma 1 (AFGBM1)

Glioblastoma | Chemotherapy Effect | Cerebral Edema

Sweden
Helsinki University Central Hospital
Turku University Hospital; Oulu University Hospital; Kuopio University Hospital; Tampere University Hospital

Completed

ANGIOCOMB Antiangiogenic Therapy for Pediatric Patients With Diffuse Brain Stem and Thalamic Tumors

Brainstem Glioma

Finland
Northwell Health
Feinstein Institute for Medical Research

Completed

Repeated Super-Selective Intraarterial Cerebral Infusion of Bevacizumab (Avastin) for Treatment of Newly Diagnosed GBM

Brain Tumor | Glioblastoma Multiforme

United States
National Cancer Institute (NCI)

Terminated

Methoxyamine and Temozolomide in Treating Patients With Recurrent Glioblastoma

Adult Brain Glioblastoma

United States
Marcela V. Maus, M.D.,Ph.D.

Recruiting

CARv3-TEAM-E T Cells in Glioblastoma

Glioblastoma | Malignant Glioma | Recurrent Glioblastoma | Recurrent Glioma

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Recruiting

Customized Neuro-Imaging Referenced Symptom Video for the Reduction of Patient and Caregiver Anxiety Around Radiation Treatment for Brain Tumors

Glioblastoma | WHO Grade III Glioma | WHO Grade II Glioma

United States
Imperial College London

Recruiting

[18F]FPIA PET-CT in Glioblastoma Multiforme (GBM) (FAM-GBM)

Glioblastoma Multiforme of Brain

United Kingdom
H. Lee Moffitt Cancer Center and Research Institute
Merck Sharp & Dohme LLC

Completed

Pembrolizumab and Vorinostat Combined With Temozolomide for Newly Diagnosed Glioblastoma

Glioblastoma | Brain Tumor | GBM

United States
Clinique Neuro-Outaouais

Completed

Avelumab in Patients With Newly Diagnosed Glioblastoma Multiforme (SEJ)

Glioblastoma Multiforme of Brain

Canada
National Cancer Institute (NCI)

Active, not recruiting

Olaparib in Treating Patients With Advanced Glioma, Cholangiocarcinoma, or Solid Tumors With IDH1 or IDH2 Mutations

Glioblastoma | WHO Grade 3 Glioma | Advanced Malignant Solid Neoplasm | Recurrent Malignant Solid Neoplasm | Recurrent Glioma | Recurrent Cholangiocarcinoma | WHO Grade 2 Glioma

United States
Washington University School of Medicine

Withdrawn

Autologous Stem Cell Collection and Reinfusion in Newly Diagnosed High Grade Gliomas

Astrocytoma | Ependymoma | Oligodendroglioma | Brainstem Glioma | Mixed Glioma | Optic Nerve Glioma
IRCCS San Raffaele

Recruiting

Glutamate Excitotoxicity and Its Role in Glioblastoma Biology

Brain Tumor, Primary

Italy
National Cancer Institute (NCI)

Completed

Zotiraciclib (TG02) Plus Dose-Dense or Metronomic Temozolomide Followed by Randomized Phase II Trial of Zotiraciclib (TG02) Plus Temozolomide Versus Temozolomide Alone in Adults With Recurrent Anaplastic Astrocytoma and Glioblastoma

Glioblastoma | Astrocytoma | Brain Tumor | Gliosarcoma | Astroglioma

United States
M.D. Anderson Cancer Center
CERN Foundation - Collaborative Ependymoma Research Network

Completed

Bevacizumab and Lapatinib in Children With Recurrent or Refractory Ependymoma

Brain Cancer | Pediatric Cancers

United States
Case Comprehensive Cancer Center

Terminated

Radiosurgery Plus Bevacizumab in Glioblastoma

Glioblastoma | Brain Tumor | Gliosarcoma

United States
National Institute of Neurological Disorders and...

Withdrawn

Bevacizumab With or Without Surgery for Adult Glioblastomas

Glioblastoma | Brain Neoplasm
Ann & Robert H Lurie Children's Hospital of Chicago
Photoelectron Corporation

Completed

A Phase I/II Study of the Photon Radiosurgery System

Glioblastoma Multiforme | Brain Tumor, Recurrent

United States
Children's Oncology Group
National Cancer Institute (NCI); Incuron LLC

Recruiting

CBL0137 for the Treatment of Relapsed or Refractory Solid Tumors, Including CNS Tumors and Lymphoma

Refractory Lymphoma | Refractory Malignant Solid Neoplasm | Recurrent Lymphoma | Recurrent Malignant Solid Neoplasm | Recurrent Osteosarcoma | Refractory Osteosarcoma | Diffuse Midline Glioma, H3 K27M-Mutant | Recurrent Diffuse Intrinsic Pontine Glioma | Metastatic Malignant Neoplasm in the Central... and other conditions

United States
Second Affiliated Hospital, School of Medicine,...

Recruiting

A Prospective Study to Evaluate Clinical Outcomes in Anti-LGI1 Encephalitis

Autoimmune Encephalitis | Leucine-Rich Glioma Inactivated 1 Autoimmune Encephalitis

China
UCB Biopharma SRL

Terminated

A Study to Test the Efficacy, Safety, and Pharmacokinetics of Rozanolixizumab in Adult Study Participants With Leucine-Rich Glioma Inactivated 1 Autoimmune Encephalitis

Leucine-Rich Glioma Inactivated 1 Autoimmune Encephalitis

United States, Australia, Belgium, France, Germany, Italy, Netherlands, Spain, United Kingdom
University Hospital, Bonn

Completed

Therapy Optimization Trial for the Treatment of Relapsed or Refractory Brain Tumors in Children (HIT-REZ-2005)

Ependymomas | Recurrent Brain Tumors | Supratentorial PNETs | Medulloblastomas

Germany
Duke University
Genentech, Inc.

Completed

Bevacizumab Beyond Progression (BBP) (BBP)

Glioblastoma | Malignant Glioma | Gliosarcoma | Grade 4 Malignant Glioma

United States
Annick Desjardins
Tactical Therapeutics, Inc.

Terminated

Ph 1/2 CTO With Lomustine for Bevacizumab-Naive Recurrent Glioma

Malignant Glioma (WHO Grade III or IV)

United States
Annick Desjardins
Tactical Therapeutics, Inc.

Terminated

Phase 1/2 CTO + Bevacizumab for Recurrent Glioma Post-Bevacizumab Failure

Malignant Glioma (WHO Grade III or IV)

United States
Memorial Sloan Kettering Cancer Center
Massachusetts General Hospital; Northwestern University; University of Calgary; Schering-Ploug... and other collaborators

Completed

Intensive Chemotherapy and Autotransplantation for Patients With Newly Diagnosed Anaplastic Oligodendroglioma

CNS Cancer | CNS BRAIN

United States
Amsterdam UMC, location VUmc
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA); Medical...

Unknown

Correlation Between SV2A Expression in Tumour Tissue and Efficacy of Levetiracetam in Glioma Patients With Epilepsy

Glioma | Epilepsy

Netherlands
St. Joseph's Hospital and Medical Center, Phoenix
Translational Genomics Research Institute

Terminated

Identification of Genomic Changes in Families Having Multiple Members With Tumors

Glioma

United States
National Cancer Institute (NCI)

Completed

Tandutinib in Treating Patients With Recurrent or Progressive Glioblastoma

Adult Giant Cell Glioblastoma | Adult Glioblastoma | Adult Gliosarcoma | Recurrent Adult Brain Tumor | Adult Brain Tumor

United States
Beijing Neurosurgical Institute
Beijing Tiantan Hospital

Unknown

Connectivity Alterations After Levetiracetam Application

Glioma | Epilepsy

China
Bristol-Myers Squibb
Ono Pharmaceutical Co. Ltd

Completed

An Investigational Immuno-therapy Study of Temozolomide Plus Radiation Therapy With Nivolumab or Placebo, for Newly Diagnosed Patients With Glioblastoma (GBM, a Malignant Brain Cancer) (CheckMate548)

Brain Neoplasms

United States, Australia, Austria, Belgium, Canada, Denmark, France, Germany, Israel, Italy, Japan, Netherlands, Norway, Poland, Russian Federation, Spain, Sweden, Switzerland, United Kingdom
Ulrik Lassen
University of Copenhagen; Herlev Hospital

Active, not recruiting

Translational Study of Nivolumab in Combination With Bevacizumab for Recurrent Glioblastoma

Recurrent Adult Brain Tumor

Denmark
Karolinska University Hospital
Celluminova AB

Recruiting

Mapping of Tumor Stem Cells in the Resection Marigin During Extirpation of Highly Malignant Gliomas Using GlioStem (CeNo2)

Glioma, Malignant

Sweden
King's College Hospital NHS Trust
King's College London

Not yet recruiting

Establishing Radiolabelled PSMA as a Target for Glioma Treatment

Glioma, Malignant

United Kingdom
Mayo Clinic
Brains Together for the Cure

Active, not recruiting

A Pilot Study Using 18F-DOPA PET-guided Radiotherapy in Gliomas

Malignant Glioma

United States
Hellenic Cooperative Oncology Group

Completed

Molecular Characterization of Gliomas Using a Broad Next Generation Sequencing (NGS)Panel

Malignant Glioma
Duke University
Duke Cancer Institute

Completed

Early Palliative Care Intervention in Malignant Glioma

Malignant Glioma

United States
Eisai Co., Ltd.

Completed

Post-Marketing Surveillance of Gliadel 7.7mg Implant (All-case Observational Study)

Malignant Glioma

Japan
AHS Cancer Control Alberta

Completed

Comparative 2-D Tumor Analysis in Familial Gliomas

Malignant Glioma

Canada
AHS Cancer Control Alberta

Completed

Characterization of Serial Magnetic Resonance Spectroscopy Imaging in Patients With Malignant Glioma Undergoing Radiotherapy

Malignant Glioma

Canada
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI); Agenus Inc.

Terminated

Vaccine Therapy With Bevacizumab Versus Bevacizumab Alone in Treating Patients With Recurrent Glioblastoma Multiforme That Can Be Removed by Surgery

Gliosarcoma | Recurrent Glioblastoma | Recurrent Adult Brain Tumor

United States
Amsterdam UMC, location VUmc

Recruiting

A Phase II/III Study of High-dose, Intermittent Sunitinib in Patients With Recurrent Glioblastoma Multiforme (STELLAR)

Glioblastoma | Glioblastoma Multiforme | GBM | Glioblastoma, Adult | Recurrent Brain Tumor

Netherlands
National Institutes of Health Clinical Center (CC)
CERN Foundation - Collaborative Ependymoma Research Network

Completed

Dose-Dense Temozolomide + Lapatinib for Recurrent Ependymoma

Brain Tumors | Spinal Cord Tumors

United States
Children's Cancer and Leukaemia Group

Unknown

Erlotinib Alone or in Combination With Radiation Therapy in Treating Young Patients With Refractory or Relapsed Malignant Brain Tumors or Newly Diagnosed Brain Stem Glioma

Brain and Central Nervous System Tumors

United Kingdom, Ireland
Sidney Kimmel Comprehensive Cancer Center at Johns...
Bristol-Myers Squibb; National Cancer Institute (NCI)

Completed

Anti-LAG-3 Alone & in Combination w/ Nivolumab Treating Patients w/ Recurrent GBM (Anti-CD137 Arm Closed 10/16/18)

Glioblastoma | Gliosarcoma | Recurrent Brain Neoplasm

United States
University of Maryland, Baltimore
NovoCure Ltd.

Terminated

Optune(NOVOTTF-100A)+ Bevacizumab+ Hypofractionated Stereotactic Irradiation Bevacizumab-Naive Recurrent Glioblastoma (GCC 1344)

Brain Tumor | RECURRENT GLIOBLASTOMA

United States
Providence Health & Services
Aduro Biotech, Inc.

Completed

Phase I Study of Safety and Immunogenicity of ADU-623

Brain Tumor | Glioblastoma Multiforme | Anaplastic Astrocytoma | Astrocytic Tumors

United States

Clinical Trials on Brain Glioma

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