Identification of Genomic Changes in Families Having Multiple Members With Tumors

This study will compare genomic alterations between the parents and the patients with high-grade glioma.

Study Overview

• Status: Terminated
• Conditions: Glioma
• Intervention / Treatment: Other: saliva or blood sample collection

Detailed Description

Genomic changes leading to the formation of brain tumors are slowly being discovered. Despite advances in genomic technology, much analysis is hindered by the lack of control samples that could better delineate genomic alterations leading to disease. The ideal genomic control would be the genetic material of the parents of afflicted individuals. The researchers propose to then compare the genomic material from parents of siblings, both of whom have a diagnosis of a high-grade glioma. Additionally, the researchers will then compare the genomic alterations between the parents and the patients. This analysis will provide an unprecedented insight into genomic level changes that take place between parents and patients that resulted in the formation of a high-grade glioma.

• Study Type: Observational
• Enrollment (Actual): 4

Contacts and Locations

Study Locations

• United States
  • Arizona
    • Phoenix, Arizona, United States, 85013
      • Barrow Neurological Institute at St. Joseph's Hospital Medical Center

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: Yes

• Sampling Method: Non-Probability Sample

Study Population

Families having multiple members (1st degree) with tumors.

Description

Inclusion Criteria:

• 18 years or older.
• Family history of brain tumor in first degree relative

Exclusion Criteria:

• less than 18 years

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Total genomic sequencing	Researchers will perform total genomic sequencing using next generation sequencing technology to identify common variants associated with familial brain tumors. Upon sequencing of the genomic material, the data analysis will be done using standard statistical methods. We will use bioinformatics tools (high throughput sequencing of genome) to identify genomic changes between parents and patients.	within 30 days of blood or saliva collection

Collaborators and Investigators

• Sponsor: St. Joseph's Hospital and Medical Center, Phoenix
• Collaborators: Translational Genomics Research Institute
• Investigators: Principal Investigator: Peter Nakaji, MD, Saint Joseph's Hospital and Medical Center/Barrow Neurological Institute

Study record dates

Study Major Dates

• Study Start: March 1, 2015
• Primary Completion (Actual): July 31, 2019
• Study Completion (Actual): July 31, 2019

Study Registration Dates

• First Submitted: March 5, 2015
• First Submitted That Met QC Criteria: March 10, 2015
• First Posted (Estimated): March 11, 2015

Study Record Updates

• Last Update Posted (Actual): April 19, 2024
• Last Update Submitted That Met QC Criteria: April 17, 2024
• Last Verified: April 1, 2024

More Information

Terms related to this study

• Keywords: brain tumor
• Other Study ID Numbers: 14BN108