Clinical Trials on CNS 2a

Total 3449 results

National Cancer Institute (NCI)

Withdrawn

Wee1 Kinase Inhibitor AZD1775 and Combination Chemotherapy in Treating Children, Adolescents and Young Adults With Relapsed or Refractory Acute Myeloid Leukemia

Recurrent Adult Acute Myeloid Leukemia | Recurrent Childhood Acute Myeloid Leukemia | CNS 2a | CNS 2b | CNS 2c | CNS1
Linda Pax Lowes

Recruiting

Natural History of Limb Girdle Muscular Dystrophy Type 2A and Type 2E

Limb-Girdle Muscular Dystrophy Type 2A | Limb-Girdle Muscular Dystrophy, Type 2E

United States
IRCCS San Camillo, Venezia, Italy
Universita di Verona; Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico and other collaborators

Enrolling by invitation

Clinical and Biochemical Features for the Identification of Dominant Calpainopathies (DOM-CAL)

Calpain-3 Deficiency Limb Girdle Muscular Dystrophy Type 2A

Italy
Sintetica SA
Sintesi Research Srl

Completed

Observational Study on 2-chloroprocaine Hydrochloride 1% (PASS)

Neurological Complication, in Particular TNS or CES

Belgium
Virginia Commonwealth University
University of Colorado, Denver; Washington University School of Medicine; University... and other collaborators

Recruiting

Trial Readiness and Endpoint Assessment in LGMD R1 (GRASP-01-003)

Limb Girdle Muscular Dystrophy | Calpain-3 Deficiency Limb Girdle Muscular Dystrophy Type 2A | Limb Girdle Muscular Dystrophy Type R1 | LGMD2A

United States, Netherlands, United Kingdom
Eisai Inc.

Completed

2-Part Multiple Ascending Dose Study for Safety and Pharmacokinetics in Healthy and Elderly Subjects

CNS

United States
National Cancer Institute (NCI)

Completed

Vandetanib to Treat Children and Adolescents With Medullary Thyroid Cancer

Multiple Endocrine Neoplasia Type 2A | Multiple Endocrine Neoplasia Type 2B | Medullary Thyroid Carcinoma

United States
The Emmes Company, LLC
Jain Foundation; Coalition to Cure Calpain 3 (C3)

Terminated

Limb-Girdle Video Assessment

Limb-Girdle Muscular Dystrophy ; Subtypes 2A, 2B, and 2I

United States
Genmab
BioNTech SE

Recruiting

A Safety and Antitumor Activity Trial of Immunoradiotherapy Combinations as a Treatment Option for Subjects With Metastatic Solid Tumors

Non-CNS Tumor

France
AstraZeneca

Completed

Study to Evaluate the Abuse Potential of AZD7325 in Healthy Recreational Central Nervous System (CNS) Depressant Users

Recreational CNS Depressant Use

Canada
Arbor Pharmaceuticals, Inc.

Active, not recruiting

Vigilant ObservatIon of GlIadeL WAfer ImplaNT Registry (VIGILANT)

CNS Tumor

United States
Columbia University
National Multiple Sclerosis Society; Exegi Pharma

Recruiting

Prebiotic vs Probiotic in Multiple Sclerosis (MS)

Multiple Sclerosis | Clinically Isolated Syndrome (CIS)

United States
Children's Oncology Group
National Cancer Institute (NCI)

Active, not recruiting

Late Effects After Treatment in Patients With Previously Diagnosed High-Risk Neuroblastoma

Recurrent Neuroblastoma | Stage 4S Neuroblastoma | Stage 2A Neuroblastoma | Stage 2B Neuroblastoma | Stage 3 Neuroblastoma | Stage 4 Neuroblastoma

United States, Canada, Australia, New Zealand
Mayo Clinic

Completed

Cognitive Function After Treatment of Primary CNS Malignancy

CNS Malignancy

United States
Mayo Clinic

Enrolling by invitation

A Study of Metabolic Agents Following Brain Radiation

CNS Malignancy

United States
Huashan Hospital
United Imaging Healthcare

Recruiting

Artificial Intelligence Neuropathologist

Neuropathology | CNS Tumor

China
Matthew J. Frigault, M.D.
Novartis

Active, not recruiting

Tisagenlecleucel In Primary CNS Lymphoma

Primary CNS Lymphoma | Refractory Primary CNS Lymphoma | Relapsed Primary CNS Lymphoma

United States
Rigshospitalet, Denmark

Recruiting

Whole Body Metabolism in Children Before and After Treatment of CNS Tumor

CNS Tumor, Childhood

Denmark
Reveal Pharmaceuticals Inc.
National Cancer Institute (NCI)

Recruiting

Phase 2 Ascending Dose Safety and Efficacy Study of RVP-001, a Manganese-based MRI Contrast Agent

Central Nervous System (CNS) Lesions

United States
Guerbet

Completed

P03277 Dose Finding Study in Central Nervous System (CNS) Magnetic Resonance Imaging (MRI)

Blood Brain Barrier Defect | CNS Lesion

Korea, Republic of, United States, Czechia, Italy, Belgium, Poland, Hungary, Mexico
Guerbet
Bracco Imaging S.p.A.

Recruiting

Evaluation of Gadopiclenol for Magnetic Resonance Imaging (MRI) in Japanese Adults and Children

CNS Lesion | Lesion in Body Region

Japan
Guerbet

Completed

Efficacy and Safety of Gadopiclenol for Central Nervous System (CNS) Magnetic Resonance Imaging (MRI) (PICTURE)

Blood Brain Barrier Defect | CNS Lesion

United States, Spain, Korea, Republic of, Taiwan, France, Hungary, Belgium, Germany, Italy, Mexico, Poland
Charite University, Berlin, Germany

Recruiting

Pregnancy Cohort in Multiple Sclerosis (MS)

Multiple Sclerosis (MS) | Clinically Isolated Syndrome (CIS)

Germany
University Hospital Heidelberg
German Cancer Research Center

Recruiting

INFORM2 Study Uses Nivolumab and Entinostat in Children and Adolescents With High-risk Refractory Malignancies (INFORM2 NivEnt)

Solid Tumor | CNS Tumor

France, Germany, Australia, Austria, Sweden, Netherlands, Switzerland
Tata Memorial Centre
Bhabha Atomic Research Centre (BARC)

Active, not recruiting

Artificial Intelligence in CNS Radiation Oncology (AI-RAD)

CNS Tumor

India
National Cancer Center, Korea

Recruiting

Development of Asian Consortium for Data Collection and Clinical Trial of CNS Tumors

CNS Tumor | CNS Germinoma | Asian Consortium

Korea, Republic of
Charite University, Berlin, Germany
NeuroCure Clinical Research Center, Charite, Berlin

Completed

Emotional Processing in Multiple Sclerosis / Clinically Isolated Syndrome: A Neuropsychological fMRI-study

Multiple Sclerosis (MS) | Clinically Isolated Syndrome (CIS)

Germany
Hoffmann-La Roche

Recruiting

A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Alectinib in Pediatric Participants With ALK Fusion-Positive Solid or CNS Tumors

ALK Fusion-positive Solid or CNS Tumors

United States, Korea, Republic of, China, Spain, Canada, United Kingdom, Australia, Denmark, France, Italy, Germany
St. Jude Children's Research Hospital

Recruiting

Characterizing Sleep Among Long-term Survivors of Childhood Cancer

Solid Tumor | CNS Tumor | ALL, Adult

United States
Dr David Ziegler
Engeneic Pty Limited

Terminated

A Study of Intravenous EEDVsMit in Children With Recurrent / Refractory Solid or CNS Tumours Expressing EGFR (ECREST)

Solid Tumours | CNS Tumours

Australia
SynerGene Therapeutics, Inc.

Not yet recruiting

SGT-53 in Children With Recurrent or Progressive CNS Malignancies

Childhood CNS Tumor

United States
Amgen

Terminated

A Phase 1 Study of Oprozomib to Assess Food Effect, Drug-Drug Interaction With Midazolam, and Safety and Tolerability in Patients With Advanced Malignancies

Advanced Non-Central Nervous System (CNS) Malignancies

United States
Bayer

Completed

Contrast Enhanced MRI of the CNS - Patients With Known Cerebral Neoplastic Lesions.

Neoplastic CNS Lesions

Italy
Children's Oncology Group
National Cancer Institute (NCI)

Active, not recruiting

Busulfan, Melphalan, and Stem Cell Transplant After Chemotherapy in Treating Patients With Newly Diagnosed High-Risk Neuroblastoma

Stage 4S Neuroblastoma | Ganglioneuroblastoma | Stage 2A Neuroblastoma | Stage 2B Neuroblastoma | Stage 3 Neuroblastoma | Stage 4 Neuroblastoma | Stage 1 Neuroblastoma | Stage 2 Neuroblastoma

United States, Canada, Australia, New Zealand
University of Pennsylvania
The Cleveland Clinic

Recruiting

Longitudinal Study for Central Nervous System Vasculitis

Vasculitis | CNS Vasculitis | Central Nervous System Vasculitis | CNSV

United States, Canada
Memorial Sloan Kettering Cancer Center
Rockefeller University

Completed

Collection of Tumor Tissue, Blood and Spinal Fluid From Patients With Brain or Spine Tumors

Primary or Metastatic Central Nervous System (CNS) Tumor

United States
St. Jude Children's Research Hospital

Withdrawn

Trial of Idasanutlin and Selinexor Therapy for Children With Progressive/Relapsed AT/RT or Extra-CNS Malignant Rhabdoid Tumors

Rhabdoid Tumor | CNS Tumor | Atypical Teratoid/Rhabdoid Tumor | Atypical Teratoid/Rhabdoid Tumor of CNS

United States
Mingzhi Zhang
Zhengzhou University

Unknown

Treatment of Primary CNS Lymphoma (FVD)

Primary CNS Lymphoma (PCNSL)

China
Orion Corporation, Orion Pharma

Completed

Blood-Brain Barrier Penetration of Therapeutic Agents in Human (BRIAN)

CNS Disease

Finland
Amgen

Completed

Study of Talimogene Laherparepvec In Children With Advanced Non CNS Tumors

Advanced Non CNS Tumors

United States, Belgium, Spain, France, Canada, Italy, Switzerland
Mingzhi Zhang
Zhengzhou University

Completed

Treatment of Primary CNS Lymphoma ( FTD )

Primary CNS Lymphoma (PCNSL)

China
Dana-Farber Cancer Institute

Completed

Comparison of Creatinine Clearance Calculation for Estimation of GFR in Patients Receiving HD Methotrexate

CNS Lymphoma | CNS Involvement of Systemic Lymphoma

United States
Biogen

Completed

Safety, Tolerability, and Pharmacokinetics of Single and Multiple Doses of BIIB033 in Healthy Japanese Participants

Multiple Sclerosis | Central Nervous System (CNS) Demyelinating Disease

United Kingdom
Varian, a Siemens Healthineers Company

Recruiting

HyperArc Registry Study

Brain Metastases | CNS Neoplasm | CNS Disorder, Intracranial

United States, Australia
Huiqiang Huang
Guangdong 999 Brain Hospital

Not yet recruiting

Orelabrutinib in Combination With Thiotepa in Refractory and Relapsed Primary CNS Lymphoma

Non Hodgkin Lymphoma | PCNSL | Refractory and Relapsed Primary CNS Lymphoma

China
GeNeuro Innovation SAS

Completed

Longitudinal Therapeutically Non-interventional Study of MSRV-Env Burden in Patients With Multiple Sclerosis Disease (LOMBARD)

Multiple Sclerosis (MS) | Clinically Isolated Syndrome (CIS) | Secondary Progressive MS | Primary Progressive MS | Relapsing-Remitting MS

France, Spain, Switzerland
Ministry of Health, Malaysia

Unknown

A Clinical Study on Albert Wong Frame-based Stereotactic Biopsy System for Brain (AWF)

Intracranial CNS Disorder

Malaysia
Memorial Sloan Kettering Cancer Center
Massachusetts General Hospital; Northwestern University; University of Calgary; Schering-Ploug... and other collaborators

Completed

Intensive Chemotherapy and Autotransplantation for Patients With Newly Diagnosed Anaplastic Oligodendroglioma

CNS Cancer | CNS BRAIN

United States
Turning Point Therapeutics, Inc.

Recruiting

A Study of Repotrectinib in Pediatric and Young Adult Subjects Harboring ALK, ROS1, OR NTRK1-3 Alterations

Lymphoma | Locally Advanced Solid Tumors | Metastatic Solid Tumors | Primary CNS Tumors

United States, Korea, Republic of, Spain, Singapore, Taiwan, Australia, Italy, Canada, France, Denmark, United Kingdom
Dana-Farber Cancer Institute

Active, not recruiting

Preventative Skin Care for Children Undergoing Targeted CNS Tumor Therapy

Pediatric Cancer | Skin Inflammation | CNS Tumor, Childhood

United States

Clinical Trials on CNS 2a

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Tanzania

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations