Clinical Trials on CNS Neoplasm

Total 110605 results

National Cancer Institute (NCI)

Withdrawn

Wee1 Kinase Inhibitor AZD1775 and Combination Chemotherapy in Treating Children, Adolescents and Young Adults With Relapsed or Refractory Acute Myeloid Leukemia

Recurrent Adult Acute Myeloid Leukemia | Recurrent Childhood Acute Myeloid Leukemia | CNS 2a | CNS 2b | CNS 2c | CNS1
Varian, a Siemens Healthineers Company

Recruiting

HyperArc Registry Study

Brain Metastases | CNS Neoplasm | CNS Disorder, Intracranial

United States, Australia
Arbor Pharmaceuticals, Inc.

Active, not recruiting

Vigilant ObservatIon of GlIadeL WAfer ImplaNT Registry (VIGILANT)

CNS Tumor

United States
Mayo Clinic

Completed

Cognitive Function After Treatment of Primary CNS Malignancy

CNS Malignancy

United States
Mayo Clinic

Enrolling by invitation

A Study of Metabolic Agents Following Brain Radiation

CNS Malignancy

United States
Huashan Hospital
United Imaging Healthcare

Recruiting

Artificial Intelligence Neuropathologist

Neuropathology | CNS Tumor

China
Odense University Hospital
University of Southern Denmark

Completed

Interdisciplinary Rehabilitation of Patients With Glioma During Anti-cancer Treatment

Neoplasms | CNS Neoplasms

Denmark
Rigshospitalet, Denmark

Recruiting

Whole Body Metabolism in Children Before and After Treatment of CNS Tumor

CNS Tumor, Childhood

Denmark
National Cancer Center, Korea

Recruiting

Development of Asian Consortium for Data Collection and Clinical Trial of CNS Tumors

CNS Tumor | CNS Germinoma | Asian Consortium

Korea, Republic of
Sintetica SA
Sintesi Research Srl

Completed

Observational Study on 2-chloroprocaine Hydrochloride 1% (PASS)

Neurological Complication, in Particular TNS or CES

Belgium
University Hospital Heidelberg
German Cancer Research Center

Recruiting

INFORM2 Study Uses Nivolumab and Entinostat in Children and Adolescents With High-risk Refractory Malignancies (INFORM2 NivEnt)

Solid Tumor | CNS Tumor

France, Germany, Australia, Austria, Sweden, Netherlands, Switzerland
Tata Memorial Centre
Bhabha Atomic Research Centre (BARC)

Active, not recruiting

Artificial Intelligence in CNS Radiation Oncology (AI-RAD)

CNS Tumor

India
St. Jude Children's Research Hospital

Recruiting

Characterizing Sleep Among Long-term Survivors of Childhood Cancer

Solid Tumor | CNS Tumor | ALL, Adult

United States
Blueprint Medicines Corporation

Recruiting

A Study of Avapritinib in Pediatric Patients With Solid Tumors Dependent on KIT or PDGFRA Signaling

CNS Tumor | Solid Tumor, Unspecified, Child | Relapsed Solid Neoplasm

United States, Korea, Republic of, United Kingdom, France, Canada, Australia, Austria, Germany, Italy
Hoffmann-La Roche

Recruiting

A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Alectinib in Pediatric Participants With ALK Fusion-Positive Solid or CNS Tumors

ALK Fusion-positive Solid or CNS Tumors

United States, Korea, Republic of, China, Spain, Canada, Australia, United Kingdom, Denmark, France, Italy, Germany, Brazil
SynerGene Therapeutics, Inc.

Not yet recruiting

SGT-53 in Children With Recurrent or Progressive CNS Malignancies

Childhood CNS Tumor

United States
Reveal Pharmaceuticals Inc.
National Cancer Institute (NCI)

Recruiting

Phase 2 Ascending Dose Safety and Efficacy Study of RVP-001, a Manganese-based MRI Contrast Agent

Multiple Sclerosis | Brain Neoplasms | Brain Cancer | Brain Tumor | Neurofibroma | Brain Tumors | Brain Metastases | Brain Tumor, Recurrent | CNS Tumor | Acoustic Neuroma | CNS Cancer | CNS Lymphoma | Brain Neoplasms, Benign | Brain Tumor, Primary | CNS Metastases | CNS Lesion | Multiple Sclerosis Brain Lesion | Brain Neoplasm... and other conditions

United States
Dr David Ziegler
Engeneic Pty Limited

Terminated

A Study of Intravenous EEDVsMit in Children With Recurrent / Refractory Solid or CNS Tumours Expressing EGFR (ECREST)

Solid Tumours | CNS Tumours

Australia
Matthew J. Frigault, M.D.
Novartis

Active, not recruiting

Tisagenlecleucel In Primary CNS Lymphoma

Primary CNS Lymphoma | Refractory Primary CNS Lymphoma | Relapsed Primary CNS Lymphoma

United States
Amgen

Terminated

A Phase 1 Study of Oprozomib to Assess Food Effect, Drug-Drug Interaction With Midazolam, and Safety and Tolerability in Patients With Advanced Malignancies

Advanced Non-Central Nervous System (CNS) Malignancies

United States
St. Jude Children's Research Hospital

Withdrawn

Trial of Idasanutlin and Selinexor Therapy for Children With Progressive/Relapsed AT/RT or Extra-CNS Malignant Rhabdoid Tumors

Rhabdoid Tumor | CNS Tumor | Atypical Teratoid/Rhabdoid Tumor | Atypical Teratoid/Rhabdoid Tumor of CNS

United States
Memorial Sloan Kettering Cancer Center
Rockefeller University

Completed

Collection of Tumor Tissue, Blood and Spinal Fluid From Patients With Brain or Spine Tumors

Primary or Metastatic Central Nervous System (CNS) Tumor

United States
Memorial Sloan Kettering Cancer Center
Massachusetts General Hospital; Northwestern University; University of Calgary; Schering-Ploug... and other collaborators

Completed

Intensive Chemotherapy and Autotransplantation for Patients With Newly Diagnosed Anaplastic Oligodendroglioma

CNS Cancer | CNS BRAIN

United States
Mingzhi Zhang
Zhengzhou University

Unknown

Treatment of Primary CNS Lymphoma (FVD)

Primary CNS Lymphoma (PCNSL)

China
Amgen

Completed

Study of Talimogene Laherparepvec In Children With Advanced Non CNS Tumors

Advanced Non CNS Tumors

United States, Belgium, Spain, France, Canada, Italy, Switzerland
ITM Solucin GmbH

Not yet recruiting

Phase I Trial to Determine the Dose and Evaluate the PK of Lutetium Lu 177 Edotreotide Therapy in Pediatric Participants With SSTR-positive Tumors (KinLET)

Lymphoma | CNS Tumor | Solid Tumor, Childhood | Somatostatin Receptor Positive | NET
Mingzhi Zhang
Zhengzhou University

Completed

Treatment of Primary CNS Lymphoma ( FTD )

Primary CNS Lymphoma (PCNSL)

China
Dana-Farber Cancer Institute

Completed

Comparison of Creatinine Clearance Calculation for Estimation of GFR in Patients Receiving HD Methotrexate

CNS Lymphoma | CNS Involvement of Systemic Lymphoma

United States
Turning Point Therapeutics, Inc.

Recruiting

A Study of Repotrectinib in Pediatric and Young Adult Subjects Harboring ALK, ROS1, OR NTRK1-3 Alterations

Lymphoma | Locally Advanced Solid Tumors | Metastatic Solid Tumors | Primary CNS Tumors

United States, Korea, Republic of, Spain, Singapore, Taiwan, Australia, Italy, Canada, France, Denmark, United Kingdom
Chengcheng Guo

Recruiting

Surveillance of Association of Immune Status and Prognosis of CNS Germ Cell Tumor Survivors

Surgery | Intracranial Germ Cell Tumor | Intracranial Germ Cell CNS Tumor, Childhood

China
Dana-Farber Cancer Institute

Active, not recruiting

Preventative Skin Care for Children Undergoing Targeted CNS Tumor Therapy

Pediatric Cancer | Skin Inflammation | CNS Tumor, Childhood

United States
Seattle Children's Hospital

Recruiting

Study of B7-H3, EGFR806, HER2, And IL13-Zetakine (Quad) CAR T Cell Locoregional Immunotherapy For Pediatric Diffuse Intrinsic Pontine Glioma, Diffuse Midline Glioma, And Recurrent Or Refractory Central Nervous System Tumors

Diffuse Intrinsic Pontine Glioma | Diffuse Midline Glioma | Refractory Primary Malignant Central Nervous System Neoplasm | Recurrent CNS Tumor, Adult | Recurrent, CNS Tumor, Childhood

United States
Eisai Inc.

Completed

2-Part Multiple Ascending Dose Study for Safety and Pharmacokinetics in Healthy and Elderly Subjects

CNS

United States
Huiqiang Huang
Guangdong 999 Brain Hospital

Not yet recruiting

Orelabrutinib in Combination With Thiotepa in Refractory and Relapsed Primary CNS Lymphoma

Non Hodgkin Lymphoma | PCNSL | Refractory and Relapsed Primary CNS Lymphoma

China
St. Jude Children's Research Hospital
Eli Lilly and Company

Active, not recruiting

Evaluation of LY2606368 Therapy in Combination With Cyclophosphamide or Gemcitabine for Children and Adolescents With Refractory or Recurrent Group 3/Group 4 or SHH Medulloblastoma Brain Tumors

Brain Cancer | Brain Tumor | Medulloblastoma | Brain Tumor, Recurrent | CNS Tumor | Medulloblastoma Recurrent | CNS Cancer | Medulloblastoma, Non-WNT/Non-SHH | Brain Tumor, Pediatric | CNS Neoplasm | Brain Tumor, Refractory | Medulloblastoma, Non-WNT/Non-SHH, Group 3 | Medulloblastoma, Non-WNT/Non-SHH, Group 4

United States
Burzynski Research Institute

Terminated

Antineoplaston Therapy in Treating Children With Rhabdoid Tumor of the Central Nervous System

Rhabdoid Neoplasm of CNS

United States
Rigshospitalet, Denmark
Odense University Hospital; Aarhus University Hospital

Recruiting

Integrative Neuromuscular Training in Adolescents and Children Treated for Cancer (INTERACT)

Neoplasms | Lymphoma | Leukemia | Solid Tumor | Pediatric Cancer | CNS Tumor

Denmark
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

Three-Factor Eating Questionnaire in Measuring Eating Behavior in Adolescent and Young Adult Survivors of CNS Tumors

Cancer Survivor

United States
Jules Bordet Institute
Bristol-Myers Squibb; La Fondation contre le cancer, Belgique; Les Amis de l'Institut... and other collaborators

Recruiting

A Brain Metastases Research Platform to Tackle the Challenge of CNS Metastases in Solid Tumours (BrainStorm)

CNS Metastases

Belgium, France, Luxembourg
Children's National Research Institute

Active, not recruiting

Immunotherapy for Malignant Pediatric Brain Tumors Employing Adoptive Cellular Therapy (IMPACT) (IMPACT)

Medulloblastoma, Childhood | Embryonal Tumor With Multilayered Rosettes | Pineoblastoma | Embryonal Tumor of CNS | Atypical Teratoid/Rhabdoid Tumor of CNS

United States
University Health Network, Toronto

Completed

Cognitive Support Program for Patients With Brain Metastases

Metastases, CNS

Canada
Genmab
BioNTech SE

Recruiting

A Safety and Antitumor Activity Trial of Immunoradiotherapy Combinations as a Treatment Option for Subjects With Metastatic Solid Tumors

Non-CNS Tumor

France
AstraZeneca

Completed

Study to Evaluate the Abuse Potential of AZD7325 in Healthy Recreational Central Nervous System (CNS) Depressant Users

Recreational CNS Depressant Use

Canada
Saint Luke's Health System
NovoCure Ltd.

Withdrawn

Use of Optune TTF With Radiation as an Alternative for Elderly Patients With Primary CNS Lymphoma

Central Nervous System Neoplasms, Primary
Memorial Sloan Kettering Cancer Center

Completed

Rituximab, Methotrexate, Procarbazine and Vincristine Followed by High-dose Chemotherapy With Autologous Stem-cell Rescue in Newly-diagnosed Primary CNS Lymphoma (PCNSL)

Non-Hodgkin's Lymphoma | CNS Lymphoma | CNS Brain Cancer

United States
Copenhagen University Hospital at Herlev
Rigshospitalet, Denmark; Glostrup University Hospital, Copenhagen

Terminated

Electrochemotherapy as a Palliative Treatment for Brain Metastases

Brain Metastases | CNS Metastases

Denmark
Memorial Sloan Kettering Cancer Center
University of Michigan; Queens Cancer Center of Queens Hospital

Completed

Intermittent High-Dose Lapatinib in Tandem With Capecitabine for HER2 Overexpressed/Amplified Metastatic Breast Cancer With Central Nervous System (CNS) Metastases

Metastatic Breast Cancer | Central Nervous System (CNS) Metastases

United States
Charite University, Berlin, Germany
Pfizer

Unknown

Temsirolimus in Recurrent Primary Central Nervous System (CNS) Lymphoma

Recurrent or Refractory Primary CNS Lymphoma

Germany
CTI BioPharma

Withdrawn

Dose-Escalation Study of Pixantrone Monotherapy in Pediatric Patients With Relapsed or Refractory Cancer

Lymphoma | Solid Tumor (Excluding CNS)

United States
The Hospital for Sick Children

Completed

COZMOS:Phase I/Ib Trial of Combined 5'Azacitidine and Carboplatin for Recurrent/Refractory Pediatric Brain/Solid Tumors (COZMOS)

Childhood Solid Tumor | Recurrent Childhood CNS Tumor | Ependymoma, Recurrent Childhood

United States, Canada, Australia

Clinical Trials on CNS Neoplasm

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CROs in Malawi

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