Clinical Trials on Cancer With POLE Exonucleasic Domain Mutation
Total 54 results
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Federation Francophone de Cancerologie DigestiveRecruitingTumors | POLD1 Gene Mutation | POLE Exonuclease Domain MutationFrance
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Mayo ClinicNational Cancer Institute (NCI)TerminatedSecondary Acute Myeloid Leukemia | Untreated Adult Acute Myeloid Leukemia | Acute Myeloid Leukemia With FLT3/ITD Mutation | Acute Myeloid Leukemia With Gene Mutations | FLT3 Tyrosine Kinase Domain Point MutationUnited States
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UNICANCERBristol-Myers Squibb; National Cancer Institute, France; Ligue contre le cancer...CompletedCarcinoma, Renal Cell | Skin Neoplasms | Microsatellite Instability | Penile Neoplasms | Head and Neck Neoplasm | Cancer With POLE Exonucleasic Domain MutationFrance
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San Carlo Public Hospital, Potenza, ItalyCompletedWoman With Cancer Resorting Fertility PreservationItaly
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Novartis PharmaceuticalsNo longer availableAcute Myeloid Leukemia (AML) With | FLT3 Mutation, Internal Tandem Duplication (ITD) or Tyrosine Kinase Domain (TKD)United States
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Royal Marsden NHS Foundation TrustMerck KGaA, Darmstadt, Germany; University of Oxford; University of SurreyTerminatedMicrosatellite Instability | Stage III Colon Cancer | POLE Exonuclease Mutant Colon CancerUnited Kingdom
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Samsung Medical CenterUnknownMacular Hole With High Myopia (Spherical Equivalent ≤ -6.0 Diopters) or, | Large Size Macular Hole (Diameter > 600 Microns) or | Recurred or Failed Macular Hole From Previous Surgery | or Chronic Macular Hole (Symptom Duration > 6 Months)Korea, Republic of
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Novartis PharmaceuticalsCompletedAdvanced Solid Tumors With Alterations of FGFR1, 2 and or 3 | Squamous Lung Cancer With FGFR1 Amplification | Bladder Cancer With FGFR3 Mutation or Fusion | Advanced Solid Tumors With FGFR1 Amplication | Advanced Solid Tumors With FGFR2 Amplication | Advanced Solid Tumors With FGFR3 MutationFrance, Spain, Taiwan, Germany, Netherlands, Singapore, United States, Australia, Korea, Republic of, Thailand, Israel, Italy, Turkey, Austria
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Jiangsu HengRui Medicine Co., Ltd.RecruitingTreatment in HER2-negative Metastatic Breast Cancer Patients With Germline BRCA MutationChina
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Five Prime Therapeutics, Inc.Worldwide Clinical TrialsWithdrawnEndometrial Cancers With FGFR2 Mutations
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University of WashingtonAbbVieNo longer availableTriple-Negative Breast Cancer | Metastatic Breast Cancer With BRCA 1 or BRCA 2 Genetic MutationUnited States
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Karolinska InstitutetCompletedWomen With Mutations in the Breast Cancer Susceptibility Genes BRCA1,2Sweden
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Rutgers, The State University of New JerseyNational Cancer Institute (NCI)RecruitingBRCA1 Gene Mutation | BRCA2 Gene Mutation | Recurrent Ovarian Carcinoma | Recurrent Malignant Solid Neoplasm | Metastatic Malignant Solid Neoplasm | Stage IV Breast Cancer AJCC v6 and v7 | Stage III Breast Cancer AJCC v7 | Stage IIIA Breast Cancer AJCC v7 | Stage IIIB Breast Cancer AJCC v7 | Stage IIIC... and other conditionsUnited States
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Gustave Roussy, Cancer Campus, Grand ParisActive, not recruitingMetastatic Radioactive Iodine Refractory Thyroid Cancer Patients With RAS or BRAF MutationFrance
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Novartis PharmaceuticalsRecruitingHormone Receptor Positive HER2 Negative Breast Cancer With a PIK3CA MutationSpain, Italy, Austria
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Alexandru EniuIuliu Hatieganu University of Medicine and PharmacyCompletedTo Determine the Prevalence, Penetrance of BRCA1 and BRCA2 Mutations in Romanian Womens With Breast or Ovarian CancerRomania
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NYU Langone HealthRecruitingNon-small Cell Lung Cancer With STK11/LKB1 MutationUnited States
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Assiut UniversityNot yet recruitingFinding New Biomarkers That Could be Evaluated in Patients With Prostate Cancer and Clarify Their Role in Early Detection of Prostate CancerEgypt
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Suzhou Genhouse Bio Co., Ltd.RecruitingNon-Small Cell Lung Cancer With EGFR MutationChina
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NYU Langone HealthWithdrawnAdvanced Non-small Cell Lung Cancer With KRAS G12C MutationUnited States
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NYU Langone HealthRecruitingAdvanced Non-small Cell Lung Cancer With KRAS G12C MutationUnited States
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Kunming Medical UniversityRecruitingNon-Small Cell Lung Cancer With Mutation in Epidermal Growth Factor ReceptorChina
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Universitaire Ziekenhuizen KU LeuvenRecruitingNon-Small Cell Lung Cancer With Mutation in Epidermal Growth Factor ReceptorBelgium
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University of UtahActive, not recruitingNon-Small Cell Lung Cancer With Mutation in Epidermal Growth Factor Receptor (Disorder)United States
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Frontier Medicines CorporationRecruitingColorectal Cancer | Pancreatic Cancer | Non Small Cell Lung Cancer | Metastatic Solid Tumor | Solid Tumor, Adult | Unresectable Solid Tumor | KRAS G12C | Advanced Solid Tumors With KRAS G12C MutationsUnited States
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Daiichi SankyoDaiichi Sankyo Co., Ltd.Active, not recruitingNon-Small Cell Lung Cancer Metastatic | Non-Small Cell Lung Cancer With Mutation in Epidermal Growth Factor ReceptorUnited States, Spain, Korea, Republic of, France, United Kingdom, Taiwan, Australia, Japan, China, Netherlands, Italy, Germany, Austria, Belgium, Bulgaria, Singapore
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AIO-Studien-gGmbHBoehringer IngelheimTerminatedNon-small-cell Lung Cancer With Somatic EGFR MutationsGermany
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PfizerCompletedNon-small Cell Lung Cancer With EGFR-Activating MutationsItaly, Poland, China, Hong Kong, Spain, Korea, Republic of, Japan
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Instituto Nacional de Cancerologia de MexicoRecruitingNon-Small Cell Lung Cancer With EGFR MutationMexico
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Universität Duisburg-EssenTerminatedNon-small-cell Lung Cancer With Somatic EGFR Mutations
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Shanghai Chest HospitalRecruitingMetastatic Cancer | Adenocarcinoma of Lung | Non-Small Cell Lung Cancer With EGFR Mutation | Locally Advanced Solid TumorChina
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Criterium, Inc.EMD Serono Research & Development Institute, Inc.TerminatedAdvanced Non-Small Cell Lung Cancer With MET MutationsUnited States
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Queen Mary University of LondonAstraZeneca; Cancer Research UKUnknownSquamous Cell Lung Cancer | Triple-Negative Breast Cancer | Non-squamous Cell Lung Cancer With KRAS Mutations | Non-squamous Cell Lung Cancer With Wild-type KRASUnited Kingdom
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Radiotherapy Oncology Centre "Santa Maria" HospitalPaola Anselmo,MD; Michelina Casale,PhD; Fabio Trippa,MDRecruitingNSCLC | Non Small Cell Lung Cancer | EGF-R Positive Non-Small Cell Lung Cancer | Non Small Cell Lung Cancer Metastatic | NSCLC Stage IV | Oligometastatic Disease | Non-Small Cell Squamous Lung Cancer | Non-Small Cell Lung Cancer With Mutation in Epidermal Growth Factor Receptor | Non-Small Cell Adenocarcinoma and other conditionsItaly
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Taiho Oncology, Inc.RecruitingAdvanced or Metastatic NSCLS With Exon 20 Insertion MutationUnited States, Spain, Canada, Italy, Israel, Japan, United Kingdom, Korea, Republic of, Germany, France, Turkey, Belgium, Netherlands, Philippines, Poland, Singapore
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Oncoethix GmbHCompletedTriple Negative Breast Cancer | Pancreatic Ductal Adenocarcinoma | Castrate-resistant Prostate Cancer | CRPC | NUT Midline Carcinoma | Non-small Cell Lung Cancer With Rearranged ALK Gene/Fusion Protein or KRAS Mutation
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Astellas Pharma IncTerminatedEGFR-TKI-naïve Patients With NSCLC Harboring EGFR Activating MutationsJapan
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AstraZenecaNo longer availablePSR Ovarian Cancer With a BRCA MutationJapan
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Samsung Medical CenterActive, not recruitingNon-Small Cell Lung Cancer With EGFR T790M Mutation | With Brain and/or Leptomeningeal Metastasis | Failed Tyrosine Kinase InhibitorsKorea, Republic of
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Novartis PharmaceuticalsRecruitingLocally Advanced or Metastatic KRAS G12C-mutated NSCLC With a PD-L1 Expression <1% or a PD-L1 Expression ≥ 1% and an STK11 Co-mutationItaly, Spain, United States, France, Thailand, Malaysia, China, Germany, India, Turkey, Belgium, Argentina, Bulgaria, Netherlands, Hungary, Greece, Portugal, Austria, Singapore, Brazil, United Kingdom
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Guangzhou Institute of Respiratory DiseaseShanghai Junshi Bioscience Co., Ltd.UnknownIIIb/IV NSCLC With T790M Positive Mutations Failed to Osimertinib TherapyChina
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Lynkcell EuropeAvailableKidney Cancer | Clear Cell Kidney Cancer | Kidney Cancer With PBRM1/BAP1/VHL/SETD2 Mutations
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Associazione Italiana per lo Studio del PancreasRecruitingLynch Syndrome | BRCA1 Mutation | BRCA2 Mutation | Familial Pancreatic Cancer | Hereditary Pancreatitis | Peutz-Jeghers Syndrome | FAMMM - Familial Atypical Mole Malignant Melanoma SyndromeItaly
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Lei LiRecruitingEpithelial Ovarian Cancer | Homologous Recombination Deficiency | Homologous Recombination Repair Gene Mutation | Drug Resistance | Overall Survival | Progression-free Survival | Poly(ADP-ribose) Polymerase InhibitorChina
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RenJi HospitalPeking University First Hospital; Shanghai Zhongshan Hospital; First Affiliated... and other collaboratorsRecruitingKidney Cancer | Renal Cell Carcinoma | ALK Gene Mutation | MET Gene Mutation | HLRCC | Renal Tumor Histology | Cutaneous Leiomyoma | BAP1 Tumor Predisposition Syndrome | VHL Syndrome | Birt-Hogg-Dube Syndrome | Familial Renal Cancer | FLCN Gene Mutation | FH Gene Mutation | Cutaneous Leiomyomata With Uterine LeiomyomataChina
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Medolution Ltd.RecruitingBrain Metastases | Non-Small Cell Lung Cancer With EGFR MutationChina
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AbbVieNo longer availableHigh Grade Serous Ovarian Cancer | Solid Tumors With Documented BRCA, BARD, or PALB or Other Acceptable DNA Mutations or Anomalies That Are Scientifically Sound | Triple Negative Breast Cancer (TNBC) | Patients Requiring Veliparib Suspension Formulation
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Tempest TherapeuticsActive, not recruitingColorectal Cancer | Solid Tumor | Gastric Adenocarcinoma | Non Small Cell Lung Cancer | Squamous Cell Carcinoma of Head and Neck | Endometrial Cancer | Urothelial Carcinoma | Gastroesophageal Junction Adenocarcinoma | Solid Tumors With PIK3Ca MutationUnited States
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Fujian Cancer HospitalNot yet recruitingNon-small Cell Lung Cancer Confirmed by Histopathology or Cytology | The TNM (8th) Phase is IV | With EGFR Mutations | Meningeal Progression Occurred After Previous Platinum-containing Two-drug Chemotherapy and Third-generation EGFR-TKI Treatment | Male or Female | The Age of 18 Years Old or... and other conditions
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University of ArkansasWithdrawnPancreatic Neoplasms | Colorectal Neoplasms, Hereditary Nonpolyposis | BRCA1 Gene Mutation | BRCA2 Gene Mutation | Hereditary Pancreatitis | Ataxia Telangiectasia | Peutz-Jegher's Syndrome | Familial Atypical Mole-Malignant Melanoma SyndromeUnited States