Clinical Trials on Cardiopulmonary Disease in South Africa

Total 18767 results

Code Pharma

Recruiting

Phase IIa Randomized Placebo Controlled Clinical Study of Codivir in Hospitalized Patients With Moderate COVID-19

COVID-19

South Africa
Radboud University Medical Center
European and Developing Countries Clinical Trials Partnership (EDCTP); Department... and other collaborators

Completed

Safety, Tolerability, Extended Early Bactericidal Activity and PK of Higher Doses Rifampicin in Adults With Pulmonary TB (HR1)

Pulmonary Tuberculosis (TB)

South Africa
University of California, San Francisco
National Institute of Allergy and Infectious Diseases (NIAID); University Hospital... and other collaborators

Not yet recruiting

Pragmatic Use of Next-generation Sequencing for Management of Drug-resistant Tuberculosis (TSELiOT)

Drug-resistant Tuberculosis | Cost-Benefit Analysis | HIV Coinfection

South Africa
University of Witwatersrand, South Africa

Terminated

Differences Between Stavudine and Tenofovir Each Combined With Lamivudine and Efavirenz in SA HIV-infected Patients (CHRU01)

Metabolic Complications | Mitochondrial Toxicity

South Africa
University of California, Los Angeles

Active, not recruiting

Neighborhood Alcohol & HIV Prevention in South African Townships (Philani)

Nutrition Disorders | HIV | Fetal Alcohol Syndrome

South Africa
The City College of New York
National Institute on Drug Abuse (NIDA)

Completed

Four-Arm Randomized Control Trial of Brief MI Versus Couples-Based HIV/STI Prevention in South Africa (SA R01)

HIV Prevention

South Africa
Convergence Pharmaceuticals

Completed

Efficacy and Safety of CNV2197944 Versus Placebo in Patients With Post-herpetic Neuralgia

Post-herpetic Neuralgia

South Africa
Johns Hopkins University
University of Cape Town

Completed

Assessing PA-824 for Tuberculosis (the APT Trial)

Pulmonary Tuberculosis

South Africa
Novartis
Novartis Vaccines

Withdrawn

Antibody Levels Associated With Reduced Risk of Invasive Group B Streptococcus Disease in Infants Aged Less Than 90 Days

Invasive Group B Streptococcus Disease

South Africa
The Aurum Institute NPC
Ludwig-Maximilians - University of Munich; Chris Hani Baragwanath Academic...

Completed

Tuberculosis as a Risk Factor for a Worse Outcome Post-Sars-CoV-2 Infection (Co-TB)

COVID-19 | Tuberculosis | Post-acute COVID-19 Syndrome

South Africa
Zimmer Biomet
University of Cape Town

Completed

Sternal Closure With SternaLock 360: First in Man Study (SL360)

Sternal Fracture

South Africa
University of Cape Town
University of Zurich; University of Bern; University of Stellenbosch; University...

Recruiting

Atorvastatin to Reduce Inflammation After Tuberculosis Treatment Completion (StatinTB)

Tuberculosis, Pulmonary

South Africa
Microbiome Health Research Institute
University of Cape Town

Terminated

Transfer of Healthy Gut Flora for Restoration of Intestinal Microbiota Via Enema for Patients in the Rehabilitative Phase of Malnutrition (THRIVE)

Moderate Acute Malnutrition | Severe Acute Malnutrition

South Africa
Peter Siesjö
University of Stellenbosch

Completed

Effect of Antisecretory Factor, Given as a Food Supplement to Adult Patients With Severe Traumatic Brain Injury (SASAT)

Brain Trauma

South Africa
Wits Health Consortium (Pty) Ltd
Discovery Vitality

Active, not recruiting

The Vitality Mammography Messaging Study (VMS)

Breast Cancer Female

South Africa
Michael Hoelscher
Radboud University Medical Center; German Federal Ministry of Education and... and other collaborators

Completed

BTZ-043 - Multiple Ascending Dose (MAD) to Evaluate Safety, Tolerability and Early Bactericidal Activity (EBA)

Pulmonary Tuberculoses | Other Specified Pulmonary Tuberculosis

South Africa
University of Witwatersrand, South Africa

Completed

Effect of HIV and/or Active Tuberculosis on the Immune Responses to Trivalent Influenza Vaccine (TIV) in Adults (TIV_HIV_TB)

HIV | Tuberculosis | Influenza

South Africa
University of Witwatersrand, South Africa
UNITAID

Completed

CHARACTERISE - A Cross-sectional, Observational Study to Characterise the Transition to Dolutegravir-based Regimens in South Africa in Terms of the Emergence of Obesity, Viral Re-suppression and Integration Into Routine Programme Care (CHARACTERISE)

Dolutegravir

South Africa
University of North Carolina, Chapel Hill
National Institute on Alcohol Abuse and Alcoholism (NIAAA); University of Stellenbosch and other collaborators

Completed

The Trajectory of Fetal Alcohol Spectrum Disorders (FASD) Across the Life Span: Continuing Prevention and Longitudinal Epidemiology

Fetal Alcohol Spectrum Disorders

South Africa
Duke University
National Institute of Mental Health (NIMH); University of Cape Town

Completed

Improving the Health of South African Women With Traumatic Stress in HIV Care (ImpACT)

HIV | Trauma Exposure

South Africa
BioVersys AG
TASK Applied Science

Completed

Pharmacokinetics of Ethionamide and Ethionamide Sulfoxide in Patients Established on Treatment for Tuberculosis.

Tuberculosis, Pulmonary

South Africa
Michael Hoelscher
Quintiles, Inc.; German Federal Ministry of Education and Research; Parexel; European... and other collaborators

Completed

Early Bactericidal Activity (EBA) of SQ109 in Adult Subjects With Pulmonary TB (SQ109EBA)

Tuberculosis, Pulmonary

South Africa
University of KwaZulu
AstraZeneca; Medical Research Council, South Africa

Unknown

Paediatric and Adult African Spirometry II (PAASII)

Lung Diseases

South Africa
University of Johannesburg

Completed

An Observational Study on the Efficacy of Individualised Homoeopathic Treatment on Premenstrual Syndrome

Premenstrual Syndrome

South Africa
Children's Mercy Hospital Kansas City
University of the Western Cape

Completed

Adapting the Diabetes Prevention Program for a Developing World Context

Weight Loss

South Africa
Harriet Shezi Children's Clinic

Unknown

Dosing, Safety and Pharmacokinetic Profile of Rifabutin in Children Receiving Concomitant Treatment With Kaletra (RBT)

Children With Confirmed HIV Infection | Receiving ART Regimen Containing 2 NRTIs + LPV/RTV at Standard Dose | Successfully Completed TB Treatment in the Past 2 to 6 Weeks of Enrollment

South Africa
The Aurum Institute NPC
London School of Hygiene and Tropical Medicine; Johns Hopkins University; United... and other collaborators

Completed

Thol'Impilo: Bringing People Into Care

HIV

South Africa
GlaxoSmithKline
Click-TB Consortium

Recruiting

Early Bactericidal Activity, Safety & Tolerability of Oral GSK3036656 in a Dual Combination With Novel and Established Antitubercular Agents, or Standard of Care in Adults With Rifampicin Susceptible Pulmonary Tuberculosis

Tuberculosis

South Africa
BioMérieux

Completed

Validating the Use of Blood Transcriptomic Signatures for the Diagnosis of Active Pulmonary Tuberculosis (ISIT-TB)

TUBERCULOSIS, PULMONARY

South Africa
University of Cape Town
National Institute of Allergy and Infectious Diseases (NIAID)

Unknown

Rapid Diagnosis of Pulmonary Tuberculosis

Tuberculosis

South Africa
University of Johannesburg

Completed

The Effect of Individualised Homoeopathic Treatment of Autism Spectrum Disorder in Children

Autism Spectrum Disorder

South Africa
National Institute of Allergy and Infectious Diseases...

Completed

Using Biomarkers to Predict TB Treatment Duration

Pulmonary Tuberculosis

South Africa
National Institute of Allergy and Infectious Diseases...

Completed

StAT-TB (Statin Adjunctive Therapy for TB): A Phase 2b Dose-finding Study of Pravastatin in Adults With Tuberculosis

Tuberculosis | Pulmonary Tuberculosis

South Africa
National Institute of Allergy and Infectious Diseases...

Completed

NexGen EBA Radiologic and Immunologic Biomarkers of Sterilizing Drug Activity in Tuberculosis

Pulmonary Tuberculosis

South Africa
Global Alliance for TB Drug Development

Completed

Evaluation of Early Bactericidal Activity in Pulmonary Tuberculosis With(J-M-Pa-Z) (NC-001)

Pulmonary Tuberculosis

South Africa
Global Alliance for TB Drug Development

Completed

Evaluation of Early Bactericidal Activity in Pulmonary Tuberculosis With Clofazimine (C)-TMC207 (J)-PA-824 (Pa)-Pyrazinamide (Z) (NC-003)

Pulmonary Tuberculosis

South Africa
Brigham and Women's Hospital
University of Cape Town

Completed

The Treatment Ambassador Program: A Pilot Intervention to Increase Treatment Initiation

HIV

South Africa
University of California, San Francisco
University of North Carolina, Chapel Hill; University of Witwatersrand, South...

Completed

Activating Treatment as Prevention Through Community Mobilization in South Africa

HIV

South Africa
University of California, Los Angeles
Gilead Sciences; University of Cape Town; Desmond Tutu HIV Foundation

Completed

PK of TAF and TDF for PrEP in Pregnant and Postpartum Women (PrEP-PP PK)

Hiv

South Africa
University of California, Los Angeles
University of Cape Town; Desmond Tutu HIV Foundation

Completed

Evaluation of Pre-exposure Prophylaxis Cascade in Pregnant and Breastfeeding Women in Cape Town (Formative Study) (PrEP-PP)

Hiv

South Africa
University of California, Los Angeles
National Institute of Mental Health (NIMH); University of Stellenbosch

Active, not recruiting

Improving South African Government Workers' Capacities to Deliver HIV Interventions

Depression | Malnutrition | HIV | Partner Violence | Alcohol Use/Abuse

South Africa
Cryonove Pharma
CEISO; Dermatech; Sefako Makgatho Health Sciences University

Not yet recruiting

Tolerance and Performance of Cyto-selective Difluoroethane-based Cryotherapy in the Treatment of Brown Spots (Solar and Senile Lentigines, Post-Inflammatory Hyperpigmentation)

Solar Lentigo | Post Inflammatory Hyperpigmentation | Senile Lentigo

South Africa
DMG Dental Material Gesellschaft mbH
Dental Wellness Trust (DWT); University of Western Cape (UWC)

Completed

Fluoride Varnish Community Trial

Dental Caries | Oral Disease | Costs

South Africa
University of Miami
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Completed

Implementing a Comprehensive Prevention of Mother-to-Child Transmission of HIV Program for South African Couples

Pregnancy | HIV

South Africa
Qurient Co., Ltd.

Completed

A Phase 2 Study to Evaluate Early Bactericidal Activity, Safety, Tolerability, and Pharmacokinetics of Multiple Oral Doses of Telacebec (Q203)

Treatment-naïve, Sputum Smear-positive Patients With Drug-sensitive Pulmonary TB

South Africa
NYU Langone Health
JOHN E FOGARTY INTERNATIONAL CENTER FOR ADVANCED STUDY IN THE HEALTH SCIENCES...

Not yet recruiting

E-cigarette Harm Reduction Among PLWHA in South Africa

Tobacco Smoking

South Africa
University of North Carolina, Chapel Hill
University of California, San Francisco; University of Witwatersrand, South...

Completed

Effect of Community Social Mobilization for the Prevention of HIV in Young South African Women

Gender Relations

South Africa
National Cancer Institute (NCI)

Unknown

Combination Chemotherapy in Patients With Advanced or Recurrent Mycosis Fungoides

Lymphoma

South Africa
University of Cape Town

Unknown

Pregnancy-Related Obesity Prevention Through Education & Communication Technology in AFRICA:The PROTECT-AFRICA STUDY (PROTECT-AFRI)

Obesity

South Africa
Helen Joseph Hospital
University of Johannesburg; Abbott Point of Care; Lodox Systems (Ltd)

Completed

Early Point-Of-Care Blood Tests, ECG & X-rays in the Emergency Department (EPOC-BEX-ED)

Emergency Medicine | Point-of-Care Testing

South Africa

Clinical Trials on Cardiopulmonary Disease in South Africa

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