Clinical Trials on Cataplexy

Total 35 results

NLS Pharmaceutics

Completed

An Open Label Study of NLS-2 (Mazindol Extended Release) in Subjects With Narcolepsy

Narcolepsy | Narcolepsy Without Cataplexy | Narcolepsy With Cataplexy

United States
University of Dublin, Trinity College
St. James's Hospital, Ireland

Suspended

'A Profile of Physical Performance Variables in an Out-patient Adult Population With Narcolepsy'

Narcolepsy | Hypersomnolence | Narcolepsy Type 1 | Narcolepsy Without Cataplexy | Narcolepsy With Cataplexy | Narcolepsy 1 | Narcolepsy and Hypersomnia

Ireland
Northwestern University
National Center for Complementary and Integrative Health (NCCIH)

Completed

Awareness and Self-Compassion Enhancing Narcolepsy Treatment (ASCENT)

Narcolepsy | Narcolepsy Without Cataplexy | Narcolepsy With Cataplexy

United States
Bioprojet

Active, not recruiting

Efficacy and Safety of Pitolisant in Pediatric Narcoleptic Patients With or Without Cataplexy, Double-blind Study Followed by a Prolonged Open-label Period

Narcolepsy Without Cataplexy | Narcolepsy With Cataplexy

France, Italy, Russian Federation, Finland, Netherlands
Emory University
National Institute of Neurological Disorders and Stroke (NINDS)

Recruiting

Clarithromycin Mechanisms in Hypersomnia Syndromes

Idiopathic Hypersomnia | Narcolepsy Without Cataplexy | Narcolepsy With Cataplexy

United States
Harmony Biosciences, LLC

No longer available

Expanded Access Program to Provide Treatment With Pitolisant to Adult Patients in the U.S. With Excessive Daytime Sleepiness Associated With Narcolepsy With or Without Cataplexy

Narcolepsy Without Cataplexy | Narcolepsy With Cataplexy

United States
Northwestern University

Active, not recruiting

Narcolepsy Nightmare Study

Narcolepsy | Narcolepsy Type 1 | Narcolepsy Without Cataplexy | Narcolepsy With Cataplexy | Narcolepsy Type 2

United States
Northwestern University

Not yet recruiting

Decreasing Nightmares in Adults With Narcolepsy (DAWN)

Nightmare | Narcolepsy | Narcolepsy Type 1 | Narcolepsy Without Cataplexy | Narcolepsy With Cataplexy | Nightmare Disorder With Associated Other Sleep Disorder
NLS Pharmaceutics

Completed

Four-week Study of the Safety and Efficacy of NLS-2 (Mazindol Extended Release) in the Treatment of Narcolepsy

Narcolepsy | Excessive Daytime Sleepiness | Cataplexy Narcolepsy

United States
Bioprojet

Completed

Pitolisant to Assess Weekly Frequency of Cataplexy Attacks and EDS in Narcoleptic Patients (HARMONY CTP)

Excessive Daytime Sleepiness | Narcolepsy With Cataplexy

Hungary
Lynn Marie Trotti
Georgia Research Alliance

Completed

Flumazenil for the Treatment of Primary Hypersomnia

Idiopathic Hypersomnia | Hypersomnia | Narcolepsy Without Cataplexy | Primary Hypersomnia

United States
UCB Pharma SA

Completed

Exploratory Clinical Study to Evaluate Sodium Oxybate (Xyrem) on Potential Endocrine Changes

Narcolepsy With Cataplexy

Belgium
Jazz Pharmaceuticals

Completed

A Study of the Efficacy and Safety of JZP-258 in Subjects With Narcolepsy With Cataplexy

Narcolepsy With Cataplexy

Belgium, United States, Spain, Czechia, France, Finland
Jazz Pharmaceuticals

Completed

A Multicenter Study of the Efficacy and Safety of Xyrem With an Open- Label Pharmacokinetic Evaluation and Safety Extension in Pediatric Subjects With Narcolepsy With Cataplexy

Narcolepsy With Cataplexy

United States, Netherlands, France, Italy
Centre for Addiction and Mental Health

Completed

Xyrem and Brain Dopamine in Narcolepsy

Healthy Controls | Narcolepsy With Cataplexy

Canada
Axsome Therapeutics, Inc.

Completed

Clinical Outcomes in Narcolepsy and Cataplexy: An Evaluation of Reboxetine Treatment (CONCERT) (CONCERT)

Narcolepsy | Excessive Sleepiness | Cataplexy Narcolepsy

United States
Arena Pharmaceuticals

Completed

Single-dose Safety Study of APD916 in Healthy Volunteers

Narcolepsy With or Without Cataplexy

United States
Emory University
American Academy of Sleep Medicine

Completed

Modafinil Versus Amphetamines for the Treatment of Narcolepsy Type 2 and Idiopathic Hypersomnia

Idiopathic Hypersomnia | Narcolepsy Without Cataplexy

United States
Balance Therapeutics

Completed

A Study of Safety and Efficacy of BTD-001 in Treatment of Patients With Idiopathic Hypersomnia (IH) or Narcolepsy Type 2

Idiopathic Hypersomnia | Narcolepsy Without Cataplexy

United States
NLS Pharmaceutics

Not yet recruiting

A Eight-Week Study of NLS-2 (Mazindol Extended Release) in Participants With Narcolepsy Type 1 (AMAZE)

Narcolepsy Type 1 | Narcolepsy With Cataplexy
Sunovion

Completed

This is a Study to Determine the Effect of Multiple Doses of an Investigational Drug, Taken by Mouth, in People With Narcolepsy-cataplexy. Accepting Both Males and Females Ages of 18 Years to 55 Years. This Study Will be Conducted in the US and Will Require Approximately 13 Weeks Participation.

Narcolepsy

United States
Centre Hospitalier Universitaire de Saint Etienne

Completed

Cardiovascular Variability and Heart Rate Arousal Response in Idiopathic Hypersomnia

Narcolepsy | Cataplexy

France
Suven Life Sciences Limited

Completed

A Study to Evaluate Safety, and Efficacy of SUVN-G3031 (Samelisant) in Patients With Narcolepsy With and Without Cataplexy (SUVN-G3031)

Narcolepsy

United States, Canada
Ohio State University
United States Air Force

Terminated

Transcranial Direct Current Stimulation Therapy for Central Hypersomnia Without Cataplexy (tDCS)

Hypersomnia

United States
University Hospital, Montpellier

Not yet recruiting

Spectrometry (MRM) Versus I 125 Radioimmunoassay (RIA) for Quantification of Orexin-A of Patients With Hypersomnolence (MRM-OREX)

Narcolepsy | Cataplexy | Idiopathic Hypersomnia
Bioprojet

Completed

Long Term Open Label Study in Narcolepsy With BF2.649 (Pitolisant) (HARMONYIII)

Narcolepsy | Cataplexy

France
Axsome Therapeutics, Inc.

Enrolling by invitation

A Study to Assess the Long-term Efficacy and Safety of AXS-12 (Reboxetine) in Subjects With Narcolepsy

Narcolepsy | Cataplexy | Excessive Daytime Sleepiness

United States, Canada
Avadel

Completed

Once-Nightly Sodium Oxybate for Treatment of Excessive Daytime Sleepiness and Cataplexy in Narcolepsy

Narcolepsy | Cataplexy | Excessive Daytime Sleepiness

United States, Germany, Australia, Canada, Czechia, France
Bioprojet

Completed

Efficacy and Safety Study of BF2.649 and BF2.649 Add on Modafinil on Cataplexy in Patients With Narcolespy (Harmony2)

Narcolepsy | Cataplexy | Excessive Daytime Sleepiness

Switzerland
Axsome Therapeutics, Inc.

Completed

A Study to Assess the Efficacy and Safety of AXS-12 (Reboxetine) in Patients With Narcolepsy (SYMPHONY)

Narcolepsy | Cataplexy | Excessive Daytime Sleepiness

United States, Canada
National Taiwan University Hospital

Completed

Provigil (Modafinil) Study by Taiwan Biotech Co.

Sleep Disorders | Narcolepsy | Cataplexy | Excessive Sleepiness | Hypersomnolence
Bioprojet

Completed

Efficacy and Safety Study of BF2.649 in the Treatment of Excessive Daytime Sleepiness in Narcolepsy (Harmony1)

Sleep Disorders | Narcolepsy | Cataplexy | Excessive Daytime Sleepiness

Switzerland
Avadel

Completed

An Open Label Study of FT218 in Subjects With Narcolepsy (RESTORE)

Sleep Wake Disorders | Sleep Disorder | Sleep Disturbance | Narcolepsy | Cataplexy | Excessive Daytime Somnolence

United States, Canada
University Hospital, Clermont-Ferrand
Jacques Lacarin Hospital Center; CH Montluçon

Unknown

Exploration of the Reward System by Functional MRI in Narco-cataplexy Patients With and Without REM Sleep Behavior Disorder (NC-TCSP-IRMf)

Narcolepsy | Cataplexy

France
Sanford Health
National Ataxia Foundation; Beyond Batten Disease Foundation; Pitt Hopkins Research... and other collaborators

Recruiting

Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford (CoRDS)

Mitochondrial Diseases | Retinitis Pigmentosa | Myasthenia Gravis | Eosinophilic Gastroenteritis | Multiple System Atrophy | Leiomyosarcoma | Leukodystrophy | Anal Fistula | Spinocerebellar Ataxia Type 3 | Friedreich Ataxia | Kennedy Disease | Lyme Disease | Hemophagocytic Lymphohistiocytosis | Spinocerebellar Ataxia... and other conditions

United States, Australia

Clinical Trials on Cataplexy

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Equatorial Guinea

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Rare Diseases

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Dietary Supplements

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