Clinical Trials on Chromosome Abnormality

Total 1357 results

Instituto Bernabeu

Completed

Validation of a NICS Method Using the Culture Medium

Chromosome Abnormality | Abnormality

Spain
Changhai Hospital

Unknown

Application of UCAD for Diagnosing Urothelial Carcinoma.

Diagnoses Disease | Urothelial Carcinoma | Chromosomal Abnormality | Urine Marking

China
Igenomix

Completed

Clinical Value of Mosaicism Diagnosis on the Trophectoderm Biopsies (NS-MOSAICISM)

Aneuploidy | Chromosome Abnormality

Italy
Nanfang Hospital of Southern Medical University
Xiangya Hospital of Central South University; Peking University People's Hospital and other collaborators

Unknown

Risk-stratified Therapy Based on Molecular Cytogenetic Aberration and Treatment Response in AML

MRD | Risk-directed Therapy | Cytogenetic Abnormality | Molecular Abnormality

China
Shanghai First Maternity and Infant Hospital
Children's Hospital of Fudan University; International Peace Maternity and...

Unknown

Prenatal Screening, Diagnosis and Intrauterine Intervention of Fetal Abnormal Chromosome and Structure in Twins Pregnancy

Twin Pregnancy With Antenatal Problem | Chromosome Abnormality
Assisting Nature

Recruiting

Invasive PGT-A Embryo Selection Versus Non Invasive PGT-A Assisted Embryo Selection

Infertility | Aneuploidy | Chromosome Abnormality

Greece
Assisting Nature

Recruiting

Time Lapse Assisted Embryo Selection Versus Non Invasive PGT-A Assisted Embryo Selection

Infertility | Aneuploidy | Chromosome Abnormality

Greece
Igenomix

Recruiting

RCT Study to Validate niPGT-A Clinical Benefit. (niPGT-A_RCT)

Infertility | Aneuploidy | Chromosome Abnormality

France, Argentina, Spain, United States, Brazil, Italy
Igenomix

Completed

Multi-center Study to Validate niPGT-A (niPGT-A)

Infertility | Aneuploidy | Chromosome Abnormality

Mexico, Turkey, United States, Argentina, Spain, Brazil, Italy, Peru
Peking University Third Hospital
The Second Hospital of Hebei Medical University; First Affiliated Hospital,... and other collaborators

Recruiting

Embryo Selection by Noninvasive Preimplantation Genetic Test (ESNi-PGT)

Infertility | Chromosome Abnormality

China
Saglik Bilimleri Universitesi Gulhane Tip Fakultesi

Completed

Efficacy of Counseling for Prenatal Screening and Diagnostic Tests on Pregnant Women: Randomised Controlled Study

Anxiety | Knowledge, Attitudes, Practice | Decision Making | Chromosome Abnormality

Turkey
Illumina, Inc.

Completed

Method Comparison and Clinical Specificity Study: Evaluation of the Infinium HD Cytogenetic Abnormality Test

Post-natal Cytogenetics

United States
Karolinska Institutet
Karolinska University Hospital

Enrolling by invitation

Structural Chromosome Rearrangements and Brain Disorders

Rare Diseases | Genetic Disease | Chromosome Abnormality

Sweden
Hospital Clínico Universitario de Valladolid

Completed

Genomic Instability in Vascular Surgeons (IRADIENT)

Radiation Exposure | Cytogenetic Abnormality

Spain
University Hospital, Montpellier

Unknown

Breakpoint Analysis of de Novo Apparently Balanced Chromosomal Translocations

Balanced Chromosomal Translocation

France
Nanfang Hospital of Southern Medical University
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University; First People's Hospital... and other collaborators

Completed

Influence of Molecular Abnormalities on Response of VAH vs. VEN+HMA in RR-AML

Refractory Acute Myeloid Leukemia | Relapsed Acute Myeloid Leukemia | Gene Abnormality | Cytogenetic Abnormality

China
Reproductive Medicine Associates of New Jersey

Completed

Predicting Normal vs. Carrier Status in Euploid Embryos of Translocation Carriers

Balanced Chromosomal Translocation

United States
Gillette Children's Specialty Healthcare
Lite Run Inc.

Completed

Post-operative Lite Run Study

Cerebral Palsy | Neurologic Disorder | Spina Bifida | Chromosome Abnormality

United States
KU Leuven

Unknown

Chromosomal Analysis of Single Cells in Human Embryos

Chromosomal Abnormalities

Belgium
Instituto Valenciano de Infertilidad, IVI VALENCIA

Completed

Preimplantation Genetic Screening in Women of Advanced Maternal Age

Chromosomal Abnormalities

Spain
Cervesi Hospital, Cattolica, Italy

Unknown

Genomic DNA in Human Blastocoele Fluid

Chromosomal Aneuploidies | Single Gene Desease

Italy
YiYang Zhu

Unknown

Comparison of Karyotyping, CMA and NIPT for Prenatal Diagnosing Chromosomal Anomalies

Prenatal Diagnosis

China
University Health Network, Toronto
Novartis; Mount Sinai Hospital, Canada; Princess Margaret Hospital, Canada

Terminated

Chromosome Abnormalities in Chronic Myeloid Leukemia (CML) on Imatinib. GIST Patients on Imatinib (GIST)

Chronic Myeloid Leukemia | Chromosome Abnormality | Gastrointestinal Stromal Cell Tumors

Canada
University Hospital, Brest

Recruiting

Biocollection in MyeloDysplastic Syndrome (P-MDS) (P-MDS)

Myelodysplastic Syndromes | Chromosome Abnormality | Acute Myeloid Leukemia With Multilineage Dysplasia | Myelodysplastic Syndrome With Ring Sideroblasts | Myelodysplastic Anemia | Myelodysplastic Syndrome With Isolated Del(5Q)

France
First Affiliated Hospital Xi'an Jiaotong University

Active, not recruiting

The Value of Prenatal Ultrasound in Complicated Twin Pregnancy and Its Correlation With Chromosomal Anomalies

Complicated Twin Pregnancy

China
Celgene

Completed

Lenalidomide Safety/Efficacy in Myelodysplastic Syndromes (MDS) Associated With a Deletion (Del)(5q) Cytogenetic Abnormality

Myelodysplastic Syndromes

United States, Germany
University of Aarhus
Aarhus University Hospital

Recruiting

Endocrine, Metabolic, Cardiovascular and Immunological Aspects of Sex Chromosome Abnormalities in Relation to Genotype (EMKISCA)

Cardiovascular Diseases | Turner Syndrome | Metabolic Disease | Klinefelter Syndrome | Immunologic Disease | Sex Chromosome Abnormality

Denmark
Centre Hospitalier Universitaire, Amiens
Centre Henri Becquerel; Hôpital Jeanne de Flandre LIlle

Recruiting

Evaluation of Optical Genome Mapping in Phi Negative Myeloproliferative Neoplasia in the Detection of Acquired Cytogenetic Abnormalities (MYELOCARTOCH)

Myeloproliferative Neoplasm | Optical Genome Mapping | Cytogenetics | Clonality | Prognostic Stratification

France
University of North Carolina, Chapel Hill
National Human Genome Research Institute (NHGRI); East Carolina University; Mission...

Active, not recruiting

North Carolina Genomic Evaluation by Next-generation Exome Sequencing, 2 (NCGENES2)

Neuromuscular Diseases | Movement Disorders | Intellectual Disability | Autism Spectrum Disorder | Microcephaly | Hearing Loss | Genetic Disease | Inborn Errors of Metabolism | Epilepsy; Seizure | Brain Malformation | Hypotonia | Development Delay | Chromosome Abnormality | Dysmorphic Features | Skeletal Dysplasia | Congenital... and other conditions

United States
King's College London

Completed

Azacytidine for the Treatment of Myelodysplastic Syndromes/Acute Myeloid Leukemia (MDS/AML) With High Risk (Chromosome 7 and or Complex) Cytogenetic Abnormalities

Myelodysplastic Syndromes | Leukemia, Myeloid, Acute

United Kingdom
Maastricht University Medical Center

Withdrawn

Diagnostics for the Treatment of Progressive Mucosal Lesions of the Oral Cavity: a Prospective Study

Chromosomal Instability | Low Grade Dysplasia Oral Cavity | Loss of Heterozygostiy | Fluorescence In Situ Hybridization

Netherlands
Rambam Health Care Campus

Unknown

Electronic Nose and Fetal Chromosomal Disorders

Detecting Abnormal Fetal Karyotype by the Electronic Nose
Taizhou Hospital of Zhejiang Province affiliated...
Sir Run Run Shaw Hospital; First Affiliated Hospital of Wenzhou Medical University and other collaborators

Recruiting

Application of Chromosomal Instability in Early Diagnosis of Biliary Tract Carcinoma

Biliary Tract Carcinoma

China
Goethe University

Completed

Evaluation of Efficacy and Safety of Nilotinib in Combination With Chemotherapy in Elderly Patients With Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia

Philadelphia Chromsome Positive Acute Lymphoblastic Leukemia

Spain, Germany, France
Guangzhou Women and Children's Medical Center

Recruiting

Diagnosis and Management of Intrauterine Growth Restriction and Congenital Anomalies

Pregnancy | Intrauterine Growth Restriction | Fetal Anomaly | Chromosomal Anomalies

China
Masonic Cancer Center, University of Minnesota

Recruiting

MT2021-08T Cell Receptor Alpha/Beta Depletion PBSC Transplantation for Heme Malignancies

Acute Myeloid Leukemia | Juvenile Myelomonocytic Leukemia | Acute Lymphoblastic Leukemia | AML | Acute Leukemia | Neurofibromatosis 1 | Hematologic Malignancy | Myelodysplasia | Minimal Residual Disease | Chromosome Abnormality | Monosomy 7 | Remission | Somatic Mutation | Cytogenetic Abnormality | TP53 | Fetal Hemoglobin | Intrachromosomal Amplification of Chromosome... and other conditions

United States
Natera, Inc.

Completed

Non-invasive Prenatal Diagnostic Validation Study (NIPD)

Sex Chromosome Aberrations | Chromosome 13 Aneuploidy | Chromosome 18 Aneuploidy | Chromosome 21 Aneuploidy | Other Microdeletions

United States
Istanbul Medipol University Hospital

Completed

Antibiotic, Gingival-biopsy, and Oral-smear Samples.

Anti-bacterial Agents | Cytology | Histopathology | Chromosome-defective Micronuclei

Turkey
University Hospital Muenster
Study Chair and Principal Investigator: Univ.-Prof. Dr. Alexander Zarbock; Principal...

Recruiting

PLAIAR-Trial: Platelets in Inflammation and Resolution (PLAIAR)

ARDS | Platelet Abnormality

Germany
National Cancer Institute (NCI)
Centers for Disease Control and Prevention; National Institute for Occupational...

Completed

Study of Markers of Cosmic Radiation Exposure and Effect Among Flight Crews

Frequency of Chromosome Aberrations

United States
Assiut University

Not yet recruiting

Balloon Vaginoplasty for Treatment of Vaginal-aplasia

Vaginal Abnormality
Sharp HealthCare

Completed

Umbilical Cord Milking in Non-Vigorous Infants Developmental Followup (MINVIFU) (MINVIFU)

Neurodevelopmental Abnormality

Canada, United States, Poland
Washington University School of Medicine
Dickson, Patricia I., M.D.; Milbrandt, Jeffrey, MD, PhD; Mitra, Rob, PhD; Turner...

Recruiting

Chromosome 9 P Minus Syndrome

Chromosome 9P Deletion Syndrome | 9p Minus Syndrome | Alfi Syndrome | 9P Monosomy | 9P Partial Monosomy Syndrome

United States
Merck Sharp & Dohme LLC

Terminated

Growth Factor Signature (GFS) Pilot Study (MK0000-098)(COMPLETED)

Blast Phase Philadelphia Chromosomes Positive (Ph+) Chronic Myelogenous Leukemia (CML) | Philadelphia Chromosome Positive (Ph+) Acute Lymphocytic Leukemia (ALL)
Instituto Valenciano de Infertilidad, IVI Alicante
Igenomix; IVI Murcia

Terminated

Aneuploidies in Embryos and Spermatozoa From Patients With Y-chromosome Microdeletions

Male Sterility Due to Y-chromosome Deletions

Spain
Al Baraka Fertility Hospital
Ibn Sina Hospital; Sadat City University

Completed

Utilizing Free DNA in Embryo Culture for PGT

Genetic Diseases, Inborn | Mutation | Chromosome Abnormalities
Shanghai Pulmonary Hospital, Shanghai, China

Unknown

Chromosomal Instability as a Surrogate Biomarker of Drug Resistance in Immunotherapy for Lung Cancer Patients (CINSBDRILCP)

Lung Cancer

China
Montreal Heart Institute

Not yet recruiting

Harnessing ECG Artificial Intelligence for Rapid Treatment and Accurate Interpretation, an Open Label Randomized Controlled Trial (HEART-AI)

Structural Heart Abnormality
Centre Psychothérapique de Nancy
Centre Hospitalier Régional et Universitaire de Nancy

Recruiting

Creation and Evaluation of a Mobile Intervention Team in Perinatal Psychiatry (0-3 Years) in Meurthe-et-Moselle Sud (EMPER)

Abnormality

France
National Taiwan University Hospital

Completed

The Construction of a Chinese Picture Naming Test and Its Preliminary Normative Data

Normality

Taiwan

Clinical Trials on Chromosome Abnormality

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Ecuador

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations