Clinical Trials on Chronic Migraine, Headache in South Africa

Total 1946 results

Shionogi

Completed

A Study of Naldemedine (S-297995) for the Treatment of Opioid-Induced Constipation in Adults With Non-Malignant Chronic Pain Receiving Opioid Therapy

Opioid-induced Constipation

United States
GlaxoSmithKline

Completed

The Purpose of This Study is to Evaluate the Spirometric Effect (Trough FEV1) of Umeclidinium/Vilanterol 62.5/25 mcg Once Daily Compared With Tiotriopium 18 mcg Once Daily Over a 24-week Treatment Period in Subjects With COPD

Pulmonary Disease, Chronic Obstructive

United States, Germany, Romania, Russian Federation, Spain, Bulgaria, Canada, Hungary, Argentina
Ironwood Pharmaceuticals, Inc.
Allergan Sales, LLC

Completed

A Trial of Linaclotide 290 μg in Patients With Irritable Bowel Syndrome With Constipation (IBS-C)

Irritable Bowel Syndrome Characterized by Constipation

United States
Abbott Medical Devices

Active, not recruiting

Spinal Cord Stimulation vs. Medical Management for Low Back Pain (DISTINCT)

Neuropathic Pain | Refractory Pain | Chronic Low-Back Pain

United States
Novartis Pharmaceuticals

Completed

A Prospective Evaluation of Natriuretic Peptide Based Referral of CHF Patients in Primary Care (PREFER)

Chronic Heart Failure (CHF)

Croatia, Russian Federation, Belgium, Slovenia, Spain, Lithuania, Estonia, Hungary, France, Latvia, Norway, Cyprus, Denmark, Israel, Italy, Malta, Poland, Portugal
Proove Bioscience, Inc.

Unknown

Observational Study of the Impact of Genetic Testing on Healthcare Decisions and Care in Interventional Pain Management (MOSAIC)

Pain | Back Pain | Musculoskeletal Pain | Chronic Pain | Neck Pain | Neuropathic Pain | Pain, Intractable | Nociceptive Pain

United States
Shire

Completed

Efficacy and Safety of SPD476 in Maintaining Remission in Patients With Ulcerative Colitis

Ulcerative Colitis

United States, Spain, Denmark, Korea, Republic of, Australia, Taiwan, Singapore, Sweden, Belgium, France, United Kingdom, Romania, New Zealand, India, Canada, South Africa, Brazil, Germany, Mexico, Hungary, Portugal, Chile, Netherlands and more
AstraZeneca

Completed

A Study of Exercise Endurance and Lung Hyperinflation in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD)

Pulmonary Disease, Chronic Obstructive

United States, Canada
GlaxoSmithKline
Parexel

Completed

A Comparative Study Between Fluticasone Furoate/Umeclidinium/Vilanterol (FF/UMEC/VI) Single Inhaler Triple Therapy Versus Tiotropium Monotherapy in Subjects With Chronic Obstructive Pulmonary Disease (COPD)

Pulmonary Disease, Chronic Obstructive

Poland, United States, Russian Federation
Shire

Completed

A Study Of PF-00547659 In Patients With Moderate To Severe Ulcerative Colitis (TURANDOT)

Ulcerative Colitis

United States, France, Spain, Canada, Korea, Republic of, Australia, Germany, New Zealand, Serbia, Belgium, Czechia, Poland, Hungary, Austria, Bulgaria, Israel, Italy, Netherlands, South Africa, Russian Federation, Slovakia
Organogenesis
Continuum Clinical Inc.

Completed

The RESPOND Registry (RESPOND)

Surgical Wounds | Pressure Ulcer | Venous Ulcer | Partial Thickness Wound | Diabetic Ulcer | Trauma Wounds | Draining Wounds | Chronic Vascular Ulcer

United States
Supernus Pharmaceuticals, Inc.
Solstice Neurosciences

Active, not recruiting

Efficacy and Safety Study of MYOBLOC® in the Treatment of Adult Upper Limb Spasticity

Multiple Sclerosis | Cerebral Palsy | Traumatic Brain Injury | Cerebrovascular Accident | Cervical Spinal Cord Injury | Spasticity

United States, Czechia
Daniel Benjamin
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Completed

Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care (PTN_POPS)

Heart Failure | Epilepsy | Pain | Pneumonia | Sepsis | Inflammation | Hypertension | Chronic Kidney Diseases | Hemophilia | Schizophrenia | Central Nervous System Infections | Nosocomial Pneumonia | Insomnia | Anxiety | Bipolar Disorder | Neutropenia | Staphylococcal Infections | Bradycardia | Seizures | Urinary Tract Infections | Pulmonary... and other conditions

United States, Canada, United Kingdom, Israel, Singapore
Merck Sharp & Dohme LLC

Active, not recruiting

A Study of Coformulated Favezelimab/Pembrolizumab (MK-4280A) Versus Standard of Care in Subjects With Previously Treated Metastatic PD-L1 Positive Colorectal Cancer (MK-4280A-007)

Colorectal Cancer

United States, Australia, Canada, Chile, China, Czechia, France, Germany, Israel, Italy, Japan, Korea, Republic of, Malaysia, Norway, Russian Federation, South Africa, Spain, Taiwan, Turkey, Ukraine, United Kingdom
Boehringer Ingelheim

Completed

Combivent Respimat 1-year Safety Study in Patients With Chronic Obstructive Pulmonary Disease

Pulmonary Disease, Chronic Obstructive

United States
Bellus Health Inc

Completed

Evaluation of the Efficacy and Safety of BLU-5937 in Adults With Refractory Chronic Cough (SOOTHE)

Refractory Chronic Cough

United States, Germany, Canada, Czechia, Hungary, Poland, United Kingdom
GlaxoSmithKline

Completed

Efficacy and Safety of Mepolizumab as an Add-on Treatment in Chronic Obstructive Pulmonary Disease (COPD)

Pulmonary Disease, Chronic Obstructive

United States, Argentina, Germany, Japan, Romania, Ukraine, Chile, Korea, Republic of, Taiwan, Netherlands, United Kingdom, Canada, Denmark, Australia, Slovakia
Leap Therapeutics, Inc.

Recruiting

Phase 2 Study of DKN-01 in Colorectal Cancer (DeFianCe)

Colorectal Cancer | Colorectal Cancer Metastatic | Colo-rectal Cancer | Colorectal Adenocarcinoma

United States, Korea, Republic of, Germany
Gilead Sciences

Completed

Ledipasvir/Sofosbuvir Fixed-Dose Combination Plus Ribavirin in Participants With Chronic HCV With Advanced Liver Disease or Post-Liver Transplant

Chronic HCV Infection

Belgium, Austria, New Zealand, United Kingdom, Germany, Spain, Netherlands, France, Switzerland, Canada, Australia, Italy
AnaptysBio, Inc.

Completed

Etokimab in Adults With Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)

Chronic Rhinosinusitis

United States
Biosplice Therapeutics, Inc.

Active, not recruiting

A Study Evaluating the Safety, Pharmacokinetics, and Preliminary Efficacy of Orally Administered SM08502 Combined With Hormonal Therapy or Chemotherapy in Subjects With Advanced Solid Tumors

Colorectal Cancer | Non-small Cell Lung Cancer | Castration-resistant Prostate Cancer

United States, Australia
Merck Sharp & Dohme LLC

Completed

Efficacy and Safety of Olaparib (MK-7339) With or Without Bevacizumab Compared to Bevacizumab With a Fluoropyrimidine in Unresectable or Metastatic Colorectal Cancer (CRC) (MK-7339-003/LYNK-003)

Metastatic Colorectal Cancer

Canada, Hungary, United States, Australia, Belgium, Chile, Colombia, France, Germany, Japan, Korea, Republic of, Latvia, Lithuania, Russian Federation, South Africa, Spain, Turkey, Ukraine
City of Hope Medical Center
National Cancer Institute (NCI)

Completed

Trametinib and Trifluridine and Tipiracil Hydrochloride in Treating Patients With Colon or Rectal Cancer That is Advanced, Metastatic, or Cannot Be Removed by Surgery

Stage IV Colorectal Cancer AJCC v7 | Stage IVA Colorectal Cancer AJCC v7 | Stage IVB Colorectal Cancer AJCC v7 | Metastatic Colorectal Carcinoma | Stage III Colon Cancer AJCC v7 | Stage III Rectal Cancer AJCC v7 | Stage IIIA Colon Cancer AJCC v7 | Stage IIIA Rectal Cancer AJCC v7 | Stage IIIB Colon... and other conditions

United States
Bayer

Completed

Study to Investigate the Safety of a Drug Called Osocimab at Low and High Doses in Adult Patients With Kidney Failure Requiring Regular Hemodialysis (CONVERT)

Hemodialysis | End-stage Renal Disease | Hemodiafiltration | Prevention of Thromboembolic Events

Spain, Greece, Belgium, Russian Federation, Netherlands, Turkey, Japan, Australia, Austria, Bulgaria, Italy, Ukraine, Czechia, Israel, United States, Hungary, Lithuania, Poland, Portugal
Takeda

Completed

Facilitation of Zolpidem (≥10 mg) Discontinuation Through Use of Ramelteon in Subjects With Chronic Insomnia

Chronic Insomnia

United States
Boehringer Ingelheim

Completed

The ENERGITO® 2 Study Compares 2 Inhaled Medicines for Chronic Obstructive Pulmonary Disease (COPD). One Medicine is a Combination of Tiotropium and Olodaterol (Stiolto®) Taken Using the Respimat® Inhaler and the Other Medicine is a Combination of Fluticasone and Salmeterol Taken Using the Diskus

Pulmonary Disease, Chronic Obstructive

United States
Aeris Therapeutics

Terminated

Study of the AeriSeal System for HyPerInflation Reduction in Emphysema (ASPIRE) (ASPIRE)

Pulmonary Emphysema

United States, Spain, France, Israel, Netherlands, Greece, Italy
Eli Lilly and Company

Recruiting

A Study of Mirikizumab (LY3074828) in Pediatric Participants With Moderately to Severely or Active Ulcerative Colitis (SHINE-2)

Ulcerative Colitis

Canada, United States, Japan, Belgium, Israel, Portugal, Korea, Republic of, France, Australia, Italy, Netherlands, Poland, Germany, United Kingdom
Boehringer Ingelheim

Completed

A Study to Determine the Effect of Tiotropium + Olodaterol Fixed Dose Combination on Exercise Endurance Time During Constant Work Rate Cycle Ergometry Test in COPD

Pulmonary Disease, Chronic Obstructive

United States, Argentina, Canada, Finland, France, Germany, Hungary, Italy, Spain, United Kingdom
Eli Lilly and Company

Completed

A Study of Ramucirumab or Icrucumab in Colorectal Cancer

Rectal Cancer | Colon Cancer

United States, Canada
Pfizer

Terminated

A Study of Tofacitinib in Patients With Ulcerative Colitis in Stable Remission

Ulcerative Colitis

Spain, United States, Korea, Republic of, Serbia, Canada, Poland, Japan, France, New Zealand, South Africa, Germany, Slovakia, Hungary, Belgium, Czechia, Italy, Netherlands, Russian Federation, Ukraine, United Kingdom
Hoffmann-La Roche

Active, not recruiting

A Study to Evaluate the Efficacy and Safety of Fenebrutinib Compared With Ocrelizumab in Adult Participants With Primary Progressive Multiple Sclerosis (FENtrepid)

Multiple Sclerosis, Primary Progressive

United States, Canada, Australia, United Kingdom, Hungary, Bulgaria, Puerto Rico, Poland, Argentina, Brazil, Germany, Greece, Italy, Peru, Portugal, Russian Federation, Spain, Turkey, Ukraine, Israel, France, Switzerland, Colombia, Me... and more
PDL BioPharma, Inc.

Terminated

An Observational Follow-up Study for Subjects Receiving Salvage Therapy After Previous Treatment in a Visilizumab Study for Intravenous Steroid-Refractory Ulcerative Colitis

Ulcerative Colitis

Belgium, France, United States, Italy, Australia, Czech Republic, Netherlands, Ireland, Norway, Canada, Austria, Germany, Hungary, Ukraine
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI)

Active, not recruiting

Collecting and Storing Blood, Bone Marrow, and Other Samples From Patients With Acute Leukemia, Chronic Leukemia, or Myelodysplastic Syndromes

Acute Leukemia | Myelodysplasia | Chronic Leukemia

United States
Novartis Pharmaceuticals

Completed

Exploring the Efficacy and Safety of Siponimod in Patients With Secondary Progressive Multiple Sclerosis (EXPAND)

Secondary Progressive Multiple Sclerosis

China, Germany, United States, Romania, Italy, Austria, Belgium, Czechia, Spain, Australia, Canada, France, Israel, Switzerland, Japan, Bulgaria, Netherlands, United Kingdom, Estonia, Latvia, Lithuania, Russian Federation, Turkey, Slo... and more
Novo Nordisk A/S

Recruiting

A Research Study to See if Kidney Damage in People With Chronic Kidney Disease and Type 2 Diabetes Living With Overweight or Obesity Can be Reduced by CagriSema Compared to Semaglutide, Cagrilintide and Placebo

Obesity | Type 2 Diabetes | Chronic Kidney Disease

United States, Spain, Poland, Thailand, India, France, Argentina, Canada, Japan, Greece, Hungary, Brazil, Slovakia
Novartis

Completed

26 Week Efficacy, Safety and Tolerability Study of Indacaterol in Patients With Chronic Obstructive Pulmonary Disease (COPD)

Lung Diseases, Obstructive | Pulmonary Disease, Chronic Obstructive | COPD

United States, Germany, Spain, Argentina, Italy, Turkey, Canada, India, Sweden, Korea, Republic of, Taiwan, Puerto Rico
GlaxoSmithKline

Completed

Study In Subjects With COPD (Chronic Obstructive Pulmonary Disease)

Pulmonary Disease, Chronic Obstructive

United States
Exact Sciences Corporation
Mayo Clinic; University of Utah; American Cancer Society, Inc.; F!ght Colorectal...

Active, not recruiting

Informed Choice - Compass

Colorectal Cancer

United States
SCRI Development Innovations, LLC
Genentech, Inc.

Completed

5-Fluorouracil, Bevacizumab, and Radiation Followed by Modified FOLFOX6 and Bevacizumab in Stage II/III Rectal Cancer

Colorectal Cancer | Rectal Cancer | Cancer of the Rectum

United States
GlaxoSmithKline

Completed

Eltrombopag To Initiate And Maintain Interferon Antiviral Treatment To Subjects With Hepatitis C Related Liver Disease

Hepatitis C, Chronic

Puerto Rico, United States, Australia, Spain, Taiwan, Germany, Italy, Belgium, France, Thailand, Israel, Korea, Republic of, Canada, Netherlands, Russian Federation, Hong Kong, Pakistan, Slovakia, Romania, Poland, United Kingdom, ... and more
Macrocure Ltd.

Unknown

Evaluation of CureXcell® in Treating Chronic Venous Leg Ulcers

Chronic Venous Leg Ulcers

United States
Takeda

Completed

Long-Term Efficacy and Safety of Ramelteon in Adults With Chronic Insomnia.

Chronic Insomnia

United States, Australia, France, Germany, Belgium, Finland, Russian Federation, Italy, Czech Republic
GlaxoSmithKline

Completed

Eltrombopag To Initiate And Maintain Interferon Antiviral Treatment To Benefit Subjects With Hepatitis C Liver Disease

Hepatitis C, Chronic

Puerto Rico, United States, Australia, Germany, Spain, Taiwan, Italy, Belgium, Israel, Korea, Republic of, Canada, France, Russian Federation, India, Greece, Pakistan, Slovakia, Romania, Czech Republic, Poland, Egypt, Ukraine, Brazil
Theravance Biopharma

Terminated

TD-1473 Long-Term Safety (LTS) Ulcerative Colitis (UC) Study

Ulcerative Colitis (UC)

United States, Australia, Bulgaria, Canada, France, Georgia, Germany, Greece, Hungary, Israel, Italy, Japan, Korea, Republic of, Poland, Portugal, Romania, Serbia, Slovakia, South Africa, Spain, Taiwan, Ukraine
Bayer

Completed

Clinical Study to Evaluate the Efficacy and Safety of Three Different Doses of BAY1817080 Compared to Placebo in Patients With Chronic Cough (PAGANINI)

Refractory and/or Unexplained Chronic Cough

Belgium, Taiwan, Australia, Netherlands, Spain, Japan, United States, Germany, Turkey, United Kingdom, Argentina, Italy, Slovakia, Hungary, France, Canada, Czechia, Poland, Russian Federation
Bayer

Completed

Maintenance Treatment of Anemia in Pre-dialysis Subjects With Chronic Kidney Disease on Darbepoetin Treatment Versus BAY85-3934 (DIALOGUE 2)

Renal Insufficiency, Chronic | Anemia

Japan, Hungary, Spain, United Kingdom, Israel, Bulgaria, Australia, France, Germany, Italy, Korea, Republic of, Poland, Romania, Turkey
Teva Branded Pharmaceutical Products R&D, Inc.

Completed

Study to Evaluate the Long-Term Safety of Hydrocodone Bitartrate Extended-Release Tablets (CEP-33237) in Patients Who Require Opioid Treatment for an Extended Period of Time

Chronic Pain

United States
Novartis Pharmaceuticals

Completed

Efficacy and Safety of 2 Secukinumab Regimens in 90kg or More Weight Group With Moderate/Severe Chronic Plaque Psoriasis

Moderate to Severe Chronic Plaque-type Psoriasis

United States, Hungary, Italy, Russian Federation, Germany, Czechia, Canada
AnGes USA, Inc.

Recruiting

Study of AMG0001 to Improve Ulcer Healing and Perfusion in Subjects With Peripheral Ischemic Ulcers

Peripheral Artery Disease | Chronic Limb Threatening Ischemia | Ischaemic Ulcer of Lower Leg Due to Atherosclerotic Disease | Ischemic Ulcer of Foot

United States

Clinical Trials on Chronic Migraine, Headache in South Africa

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