Clinical Trials on Congenital Disorders of Glycosylation in South Africa

Total 389 results

Glycomine, Inc.

Recruiting

24-Week Study to Assess the PD, Safety, Tolerability, and PK of GLM101 in Participants With PMM2-CDG

Pmm2-CDG

Spain, Australia, United States
DePuy International

Terminated

A Single Centre Study to Assess the Long-term Performance of the DePuy ASR™ System in Primary Hip Resurfacing Surgery

Osteoarthritis | Rheumatoid Arthritis | Avascular Necrosis | Post-traumatic Arthritis | Congenital Hip Dysplasia | Slipped Capital Femoral Epiphysis | Collagen Disorders | Nonunion of Femoral Fractures

South Africa
University of Witwatersrand, South Africa

Completed

Epidemiology of Congenital Cytomegalovirus in a High HIV Prevalence Setting, South Africa

Neurodevelopmental Disorders | Hearing Loss | Immunogenicity | Stillbirth | Neonatal Death | Cytomegalovirus Congenital

South Africa
AstraZeneca

Completed

Centralized Pan-South African Survey on the Undertreatment of Hypercholesterolaemia (CEPHEUS)

Undertreatment of Hypercholesterolaemia

South Africa
Cycle Pharmaceuticals Ltd.
Parexel

Completed

Assessment of Intra-subject Variability in the Bioavailability of Chlorpromazine Hydrochloride

Acute Intermittent Porphyria | Anti-Psychotic | Management of Manifestations of Psychotic Disorders | Treatment of Schizophrenia | Control Nausea and Vomiting | Relief of Restlessness and Apprehension Before Surgery | Adjunct in the Treatment of Tetanus | Control Manifestations of the Manic Type... and other conditions

South Africa
University of Johannesburg

Completed

The Efficacy of Venavine Intensive® on the Quality of Life in Females With Chronic Venous Insufficiency

Venous Insufficiency

South Africa
University of Cape Town
King's College London; University of KwaZulu

Completed

Collaborative Care for the Detection and Management of Depression Among Adults Receiving Antiretroviral Therapy in South Africa (COBALT)

Depression | HIV/AIDS | Chronic Diseases of Lifestyle

South Africa
University of Maryland, College Park
National Institute of Mental Health (NIMH); Medical Research Council, South...

Completed

Community Health Worker Training to Reduce Depression and Substance Use Stigma in TB/HIV Care in South Africa (Siyakhana)

Substance-Related Disorders | Depression | Tuberculosis | Hiv | Mental Health Disorder | Mental Disorder | Health Care Utilization | Treatment Adherence and Compliance | Social Stigma | Attitude of Health Personnel | Community Health Workers | Health Care Delivery

South Africa
University of Maryland, College Park
National Institute on Drug Abuse (NIDA); Medical Research Council, South Africa

Recruiting

Siyakhana Peer: Evaluating a Peer Recovery Coach Model to Reduce Substance Use Stigma in South African HIV Care

Substance-Related Disorders | HIV | Substance Use | Substance Use Disorders | Treatment Adherence | Treatment Adherence and Compliance | Stigmatization | Delivery of Health Care | Stigma, Social | Attitude of Health Personnel | Community Health Workers | Health Personnel | Health Personnel Attitude | Health Care Seeking... and other conditions

South Africa
University of Pretoria

Completed

A Randomized Trial Comparing Oxytocin and Oxytocin + Ergometrine for Prevention of Postpartum Haemorrhage at Caesarean Section

Prevention of Post Partum Haemorrhage

South Africa
University of Pretoria

Not yet recruiting

Kefazolin Versus Kefazolin Plus Metronidazole to Reduce Postpartum Infection

Prevention of Postpartum Sepsis

South Africa
Novo Nordisk A/S

Completed

Epidemiological Study on Haemophilia Care and Orthopaedic Status in Developing Countries (HAEMOcare)

Congenital Bleeding Disorder | Haemophilia A With Inhibitors | Haemophilia B With Inhibitors | Haemophilia A | Haemophilia B

India, Morocco, South Africa, Oman
Novartis

Completed

A Quality of Life and Safety Study With Pimecrolimus Cream, 1% in Children (Age 2-12 Years) With Atopic Dermatitis

Atopic Eczema

South Africa
University of Pretoria

Completed

Efficacy of Using a Closing Pack to Reduce Postpartum Sepsis

Prevention of Postpartum Sepsis

South Africa
Medical University of South Carolina

Completed

Preoperative Corticosteroid Therapy in Neonates Undergoing Cardiopulmonary Bypass

Congenital Heart Disease | Disorder of Fetus or Newborn

United States
University of Cape Town

Completed

Iron Deficiency Anaemia in Pregnant Patients Presenting for Antenatal Care

Iron Deficiency Anemia of Pregnancy

South Africa
Medical University of South Carolina
National Heart, Lung, and Blood Institute (NHLBI); National Institutes of Health...

Completed

Corticosteroid Therapy in Neonates Undergoing Cardiopulmonary Bypass

Congenital Heart Disease | Disorder of Fetus or Newborn

United States
Agricultural University of Athens

Completed

Determining the Glycemic Effects of Sunflower Pasta

Appetitive Behavior | Potential Abnormality of Glucose Tolerance

Greece
Agricultural University of Athens

Completed

Characterizing Emmer Seeds and Flours, and Determining the Glycemic Effects of Emmer Breads

Appetitive Behavior | Potential Abnormality of Glucose Tolerance

Greece
Agricultural University of Athens

Completed

Effects of Sugar-free Products With Added Sweeteners on Glycemic Responses

Appetitive Behavior | Potential Abnormality of Glucose Tolerance

Greece
Agricultural University of Athens

Completed

Effects of Traditional Greek Meals on Glycemic Responses

Appetitive Behavior | Potential Abnormality of Glucose Tolerance

Greece
Agricultural University of Athens

Completed

Acute Effects of Fruit Juices Consumption on Postprandial Glycemic Responses and Satiety

Appetitive Behavior | Potential Abnormality of Glucose Tolerance

Greece
University of Miami
National Institute of Neurological Disorders and Stroke (NINDS); National Institutes...

Recruiting

Phenotype, Genotype and Biomarkers 2 (PGB2)

Amyotrophic Lateral Sclerosis | Primary Lateral Sclerosis | Frontotemporal Dementia | Progressive Muscular Atrophy | Hereditary Spastic Paraplegia

United States, South Africa
Agricultural University of Athens

Completed

Acute Effects of Spirulina on Postprandial Glycemic Responses and Arterial Blood Pressure

Blood Pressure | Appetitive Behavior | Potential Abnormality of Glucose Tolerance

Greece
Agricultural University of Athens

Completed

Acute Effect of Crocus Sativus on Postprandial Glycemia

Blood Pressure | Appetitive Behavior | Potential Abnormality of Glucose Tolerance

Greece
National Center for Research Resources (NCRR)

Completed

Congenital Adrenal Hyperplasia: Calcium Channels as Therapeutic Targets

Congenital Adrenal Hyperplasia

United States
University of Michigan
Medical University of South Carolina; Emory University; Medical College of Wisconsin and other collaborators

Completed

Genetic Determinants of Congenital Heart Disease Outcomes (GECHO)

Congenital Heart Disease | Hypoplastic Left Heart Syndrome | Hypoplastic Right Heart Syndrome | d-Transposition of the Great Arteries

United States, Australia
King Faisal Specialist Hospital & Research Centre...

Recruiting

To Assess the Efficacy of Early Administration of Energy Enriched and Protein Enriched Formula in Post Cardiac Repair Infants: a Randomized Controlled Trial, Comparative Study

Congenital Heart Disease in Children | Post-cardiac Surgery | Malnutrition, Infant

Saudi Arabia
AstraZeneca

Completed

A Pharmacokinetic (PK) and Pharmacodynamic (PD) Dose-ranging Phase II Study of Ticagrelor in Paediatric Patients With Sickle Cell Disease (HESTIA 1)

Investigation of Platelet Aggregation in Paediatric Patients With Sickle Cell Disease

United States, Canada, United Kingdom, South Africa, Lebanon, Kenya
Leiden University
Netherlands Organisation for Scientific Research; GGZ Delfland; Leids Universitair...

Recruiting

Intervention Social Anxiety: Combining Parent-child Treatment (ISA)

Social Anxiety Disorder of Childhood

Netherlands
Medecins Sans Frontieres, Netherlands
London School of Hygiene and Tropical Medicine; University of Sussex; Ministry... and other collaborators

Completed

Patient-reported Experiences and Quality of Life Outcomes in the TB-PRACTECAL Clinical Trial (PRACTECAL-PRO)

Multidrug Resistant Tuberculosis

Belarus, South Africa, Uzbekistan
The Hawkins Foundation

Completed

Hip Scope Fascia-iliaca (FI) Block Study

Acetabular Labrum Tear | Hip Dysplasia | Femoroacetabular Impingement

United States
Hellenic Breast Surgeons Society

Completed

Impact of Chemotherapy Followed by Aromatase Inhibitors on Bone Health of Women With ER-positive Early Breast Cancer (POCHARBI)

Breast Cancer | Other Disorders of Bone Density and Structure

Greece
Novo Nordisk A/S

Completed

Safety of NNC 0172-0000-2021 in Healthy Male Subjects and Subjects With Haemophilia A or B (Explorer 1)

Healthy | Congenital Bleeding Disorder | Haemophilia A | Haemophilia B

Austria, Sweden, Spain, Switzerland, United Kingdom, Germany, Malaysia, Denmark, South Africa, Thailand, Italy
Cosmetique Active International

Recruiting

Effect of Lipikar Baume AP+M on Quality of Life and Pain of Adults With Dryness or Severe Xerosis

Skin Diseases | Atopic Dermatitis

Croatia, Germany, Portugal, South Africa, Taiwan, Thailand, Vietnam
University of South Carolina
National Institute on Minority Health and Health Disparities (NIMHD)

Recruiting

Evaluating the Fade to Fitness Program: A Barbershop-based Program for Black Men

Health Related Quality of Life

United States
The University of Queensland

Recruiting

The TELO-SCOPE Study: Attenuating Telomere Attrition With Danazol. Is There Scope to Dramatically Improve Health Outcomes for Adults and Children With Pulmonary Fibrosis

Pulmonary Fibrosis | Dyskeratosis Congenita | Telomere Shortening | Telomere Disease

Australia
Children's Hospital Medical Center, Cincinnati
University of Pittsburgh; Vanderbilt University Medical Center; Children's Hospital... and other collaborators

Not yet recruiting

HeartGPS: A Study Exploring the Effects of a Psychological Intervention for Parents and Their Babies After Prenatal Cardiac Diagnosis (HeartGPS)

Depression, Postpartum | Neurodevelopmental Disorders | Heart Defects, Congenital | Trauma, Psychological | Anxiety in Pregnancy

United States, Australia
Erasmus Medical Center
ZonMw: The Netherlands Organisation for Health Research and Development

Recruiting

Effects of a Digital Diary on the Psychological Well-being of Former ICU Patients. (DIPIC)

Quality of Life | Post Traumatic Stress Disorder | Depression, Anxiety

Netherlands
Sheffield Teaching Hospitals NHS Foundation Trust

Completed

A Clinical Decision Aid for Diagnosing Transient Loss of Consciousness

Consciousness Disorder

United Kingdom
Kastle Therapeutics, LLC
Ionis Pharmaceuticals, Inc.

Completed

Study to Assess the Safety and Efficacy of ISIS 301012 (Mipomersen) in Homozygous Familial Hypercholesterolemia (RADICHOL 1)

Metabolic Diseases | Congenital Abnormalities | Infant, Newborn, Diseases | Genetic Diseases, Inborn | Dyslipidemias | Metabolism, Inborn Errors | Lipid Metabolism Disorders | Hypercholesterolemia | Hyperlipidemias | Hyperlipoproteinemias | Lipid Metabolism, Inborn Errors | Hyperlipoproteinemia Type II | Metabolic... and other conditions

United States, Taiwan, Brazil, Canada, South Africa, United Kingdom, Singapore
Otto Bock Healthcare Products GmbH
Hanger Clinic: Prosthetics & Orthotics

Active, not recruiting

Assessing Outcomes With Microprocessor Knee Utilization in a K2 Population (ASCENT K2)

Lower Limb Amputation Above Knee (Injury) | Lower Limb Amputation Knee | Congenital Amputation of Lower Limb

United States
Medical University of South Carolina
National Institute of General Medical Sciences (NIGMS)

Active, not recruiting

NAC +taVNS in IDM Who Are Poor Oral Feeders

Oxidative Stress | Vagus Nerve Stimulation | Infant of Diabetic Mother | Feeding Disorders

United States
Agricultural University of Athens

Completed

Acute Effects of Juice Consumption With Biofunctional Compounds and Probiotics on Glucose Metabolism

Appetite Disorders | Potential Abnormality of Glucose Tolerance

Greece
ACADIA Pharmaceuticals Inc.

Terminated

Extension Study of Pimavanserin in Subjects With Major Depressive Disorder and Inadequate Response to Antidepressant Treatment

Adjunctive Treatment of Major Depressive Disorder

United States, Serbia, Finland, Poland, Russian Federation, Slovakia, South Africa, Ukraine, United Kingdom
Novo Nordisk A/S

Completed

Observational Registry of NovoSeven® Used as On-demand Treatment of Bleeds in Patients With Haemophilia A and B With Inhibitors (ONE)

Congenital Bleeding Disorder | Haemophilia A With Inhibitors | Haemophilia B With Inhibitors

Saudi Arabia, Algeria, Turkey, Germany, Poland, Netherlands, Italy, Belgium, South Africa, United Kingdom, Sweden, Austria, Portugal, France, Czech Republic, Venezuela
Prisma Health-Upstate
Clemson University

Recruiting

Tandem VR: Synchronized Nature-Based Experiences in Virtual Reality for Hospice Patients and Their Caregivers

Pain | Anxiety | Palliative Care | End of Life | Hospice | Fear of Death

United States
Bionano Genomics
Columbia University; University of Iowa; Medical College of Wisconsin; Augusta... and other collaborators

Recruiting

Validation of Optical Genome Mapping for the Identification of Constitutional Genomic Variants in a Postnatal Cohort

Intellectual Disability | Autism Spectrum Disorder | Fragile X Syndrome | Developmental Disability | Congenital Anomaly | Facioscapulohumeral Muscular Dystrophy 1

United States
Neuren Pharmaceuticals Limited

Recruiting

An Open-Label Study of the Safety, Tolerability, and Pharmacokinetics of Oral NNZ-2591 in Angelman Syndrome (AS-001)

Angelman Syndrome

Australia
ACADIA Pharmaceuticals Inc.

Completed

Adjunctive Pimavanserin in Subjects With Major Depressive Disorder and Inadequate Response to Antidepressant Treatment

Adjunctive Treatment of Major Depressive Disorder

United States, Serbia, Finland, Poland, Russian Federation, Ukraine, United Kingdom, Slovakia, South Africa

Clinical Trials on Congenital Disorders of Glycosylation in South Africa

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