Clinical Trials on Congenital Disorders

Total 150623 results

Alnylam Pharmaceuticals

Completed

ENDEAVOUR: Phase 3 Multicenter Study of Revusiran (ALN-TTRSC) in Patients With Transthyretin (TTR) Mediated Familial Amyloidotic Cardiomyopathy (FAC)

Amyloid Neuropathies | Amyloid Neuropathies, Familial | Amyloidosis, Hereditary | Transthyretin (TTR) Mediated Familial Amyloidotic Cardiomyopathy (FAC) | Amyloidosis, Hereditary, Transthyretin-Related | Familial Transthyretin Cardiac Amyloidosis

United States, France, Italy, Spain, Canada, Germany, Belgium, Sweden, United Kingdom
Yungjin Pharm. Co., Ltd.

Completed

Safety, Tolerability and Pharmacokinetic Study of KL1333 in Healthy Male Volunteers

MELAS Syndrome | Mitochondrial Respiratory Chain Deficiencies

Korea, Republic of
Duke University
David Grant U.S. Air Force Medical Center

Completed

Genetic Risk and Health Coaching for Type 2 Diabetes and Coronary Heart Disease

Prediabetic State | Coronary Heart Disease, Susceptibility to, 5

United States
Bin Li
Huazhong University of Science and Technology

Completed

Safety and Efficacy Study of rAAV2-ND4 Treatment of Leber Hereditary Optic Neuropathy (LHON) (rAAV2-ND4)

Leber Hereditary Optic Neuropathy

China
Shu-Zhong Cui
Xiangya Hospital of Central South University; Wuhan University; Peking University... and other collaborators

Unknown

Efficacy of HIPEC as NACT and Postoperative Chemotherapy in the Treatment of Advanced-Stage Epithelial Ovarian Cancer (EHNPCTASEOC)

Fallopian Tube Cancer | Epithelial Ovarian Cancer | Primary Peritoneal Carcinoma

China
University of Roma La Sapienza

Terminated

Pancreatic Cancer Can be Detected by Adrenomedullin in New Onset Diabetes Patients (PaCANOD)

Diabetes Complications | Diabetes Mellitus, Adult-Onset | Carcinoma, Pancreatic Ductal | Pancreatic Neoplasm

Italy
Mauna Kea Technologies

Completed

Probe-based and Needle-based Confocal Laser Endomicroscopy During Gynaecological Procedures.

Ovarian Cancer | Cervix Cancer | Endometrium Cancer | Carcinoma in Situ of Fallopian Tube

France
Vanderbilt University Medical Center
National Cancer Institute (NCI)

Completed

Collecting Information From Patients and Family Members With Hereditary Colorectal Cancer Syndromes or Who Are at High Risk of Developing Colorectal Cancer

Colorectal Cancer | Precancerous Condition | Hereditary Non-polyposis Colon Cancer

United States
University of South Florida
National Cancer Institute (NCI)

Withdrawn

Losartan in Treating Pulmonary Fibrosis in Patients With Stage I, II, or III Non-Small Cell Lung Cancer

Lung Cancer | Dyspnea | Pulmonary Complications | Radiation Fibrosis
Dana-Farber Cancer Institute
Massachusetts General Hospital; Beth Israel Deaconess Medical Center; Genentech... and other collaborators

Completed

Safety Study Of Avastin And Pelvic Radiation In Women With Recurrent Gynecological Cancers

Cervical Cancer | Ovarian Cancer | Endometrial Cancer | Vaginal Cancer | Carcinoma of the Vulva

United States
AstraZeneca
RTI Health Solutions; A+A Healthcare Marketing Research; Freelance CRA (FCRA)

Completed

OSCA - Olaparib Standard of CAre Study (OSCA)

Platinum-sensitive Recurrent Serous Ovarian Cancer

France, Italy, Korea, Republic of, Spain, United Kingdom, Germany, Belgium, Israel, Portugal, Netherlands, Switzerland, Canada, Australia
University of Alabama at Birmingham
Children's Health System, Alabama

Completed

Vitamin D Supplementation for Extremely Preterm Infants

Vitamin D Deficiency | Preterm Infants | Bronchopulmonary Dysplasia

United States
Massachusetts General Hospital

Completed

Topical Imiquimod 5% Cream for Treatment of Cutaneous Neurofibromas in Adults With Neurofibromatosis 1

Neurofibromatosis Type 1 | Cutaneous Neurofibromas

United States
Georgetown University
Merck Sharp & Dohme LLC

Terminated

Januvia (Sitagliptin) in Healing Chronic Diabetic Foot Ulcers

Type II Diabetes

United States
John P. Fruehauf
GlaxoSmithKline

Completed

Cisplatin Induction With Paclitaxel Consolidation for Stage III-IV Epithelial Ovarian and Primary Peritoneal Cancer

Epithelial Ovarian Cancer | Primary Peritoneal Cancer

United States
Fondation Ophtalmologique Adolphe de Rothschild

Completed

Prevalence of Cerebral Small Vessel Disease in HIV Infected Patients (MICROBREAK1)

HIV Seropositivity

France
Orano Med LLC

Completed

Safety Study of ²¹²Pb-TCMC-Trastuzumab Radio Immunotherapy

Stomach Neoplasms | Breast Neoplasms | Pancreatic Neoplasms | Ovarian Neoplasms | Peritoneal Neoplasms

United States
City of Hope Medical Center
National Cancer Institute (NCI)

Withdrawn

Ruxolitinib Phosphate, Tacrolimus and Sirolimus in Preventing Acute Graft-versus-Host Disease During Reduced Intensity Donor Hematopoietic Cell Transplant in Patients With Myelofibrosis

Primary Myelofibrosis | Secondary Acute Myeloid Leukemia | Secondary Myelofibrosis | Acute Myeloid Leukemia in Remission | Primary Myelofibrosis, Prefibrotic Stage

United States
University Hospital, Clermont-Ferrand
Université d'Auvergne; R2D2 Retinoids, Reproduction Developmental Diseases

Unknown

Impact of Fluid Resuscitation Therapy on Pulmonary Edema as Measured by Alveolar Fluid Clearance in Patients With Acute Respiratory Distress Syndrome (ARDS) (IROCA)

Pulmonary Edema | Hypovolemia | Acute Respiratory Distress Syndrome (ARDS)

France
Tufts Medical Center
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Completed

Metabolic Abnormalities in HIV-infected Persons

HIV Infection | Lipodystrophy

United States
University of Utah
National Cancer Institute (NCI)

Terminated

Reversible Secondary Myelofibrosis or Clonal Myeloproliferative Disorder

Primary Myelofibrosis | Pulmonary Arterial Hypertension | Secondary Myelofibrosis | Primary Pulmonary Hypertension

United States
Altor BioScience
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Anti-TF Antibody (ALT-836) to Treat Septic Patients With Acute Lung Injury or Acute Respiratory Distress Syndrome

Sepsis | Acute Respiratory Distress Syndrome | Acute Lung Injury

United States
University Hospital, Basel, Switzerland

Withdrawn

Endometriosis and Frequency of Endometriosis-associated Ovarian Carcinomas (EAOC) (EAOC)

Endometriosis | Endometrioid Carcinoma | Clear Cell Carcinoma
Harvard School of Public Health (HSPH)
Bill and Melinda Gates Foundation; St. John's Research Institute; Karnataka Health... and other collaborators

Completed

A Skills and Drills Intervention for Emergency Obstetrics and Neonatal Care at First Referral Units of North Karnataka

Sepsis | Postpartum Hemorrhage | Birth Asphyxia | Preeclampsia/Eclampsia | Obstetric and Perinatal Complications | Obstructed/Prolonged Labor
Azaya Therapeutics, Inc.

Unknown

A Crossover Bioequivalence Study of Intravenously Administered ATI0918 and DOXIL/CAELYX in Patients With Ovarian Cancer

Cancer | Ovarian Cancer | Ovarian Epithelial Cancer Recurrent | Malignant Female Reproductive System Neoplasm | Ovarian Tumor

Canada, United States
University Hospital, Angers

Terminated

Hyperoxia and Hypertonic Saline in Septic Shock (Hyper2S)

Septic Shock | Adult Respiratory Distress Syndrome

France
Jules Bordet Institute

Completed

Imaging of Peritoneal Carcinomatosis From Ovarian Carcinoma Patients (OV-AP-ICG-IV)

Ovarian Cancer | Peritoneal Carcinomatosis

Belgium
Amsterdam UMC, location VUmc

Completed

GH and Cardiovascular Risk Factors

Cardiovascular Diseases | Physical Activity | Metabolic Syndrome | Growth Hormone Deficiency | Cognition

Netherlands
Sheba Medical Center

Completed

Trial of Inquiry Based Stress Reduction (IBSR) Program for BRCA1/2 Mutation Carriers

Hereditary Breast and Ovarian Cancer Syndrome

Israel
Xiang Guang-da

Unknown

Short-Term Alpha Lipoic Acid Therapy for Prevention of Contrast-induced Acute Kidney Injury and Endothelial Dysfunction in Type 2 Diabetes

Acute Kidney Injury | The Changes of Plasma Creatinine | The Changes of Plasma Free Radicals | The Changes of Endothelium-dependent Arterial Dilation

China
Memorial Sloan Kettering Cancer Center
Novartis

Completed

Effect of Imatinib on Bone Metabolism in Patients With Chronic Myelogenous Leukemia or Gastrointestinal Stromal Tumors

Leukemia | Gastric Cancer | Chronic Myelogenous Leukemia

United States
Sanofi

Completed

Single Arm Study of BSI-201 in Patients With BRCA-1 or BRCA-2 Associated Advanced Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

Primary Peritoneal Cancer | Advanced Epithelial Ovarian Cancer

United States
University Hospital, Rouen
Ministry of Health, France

Completed

Neuroprotection by Magnesium Sulfate Given to Women at Risk of Very Preterm Birth

Brain Ischemia | Preterm Birth | Intracranial Hemorrhages | Periventricular Leukomalacia

France
University Hospital, Bordeaux

Completed

Outbreak of Hemolytic Uremic Syndrome Linked to Escherichia Coli of Serotype O104:H4 (SHU O104 CUB)

Escherichia Coli Infections | Hemolytic-uremic Syndrome

France
University of Oklahoma
Actelion

Completed

Iloprost Effects on Gas Exchange and Pulmonary Mechanics

Pulmonary Hypertension | Acute Respiratory Distress Syndrome | Acute Lung Injury

United States
Rennes University Hospital

Terminated

Study of Povidone Iodine to Reduce Pulmonary Infection in Head Trauma and Cerebral Hemorrhage in Intensive Care Unit (SPIRIT-ICU)

Ventilator Associated Pneumonia

France
Kaohsiung Medical University Chung-Ho Memorial...

Completed

Pilot Study of Metabolic Syndromes and HIV Infections in Indian Tibetans

HIV Infection | Metabolic Syndromes

Taiwan
Instituto de Investigação em Imunologia
Butantan Institute

Unknown

Clinical Trial of a Therapeutic Vaccine With NY-ESO-1 in Combination With the Adjuvant Monophosphoryl Lipid A (MPLA)

Cancer. | Melanoma. | Ovarian Cancer. | Lung Cancer.

Brazil
Universitätsklinikum Hamburg-Eppendorf

Completed

Study of Repetitive Intestinal Lavage in Patients With EHEC Associated Hemorrhagic Colitis (EHEC-PEG)

Hemolytic Uremic Syndrome | Hemorrhagic Colitis | Intestinal Infectious Disease | Intestinal Infection Due to E. Coli

Germany
National Taiwan University Hospital

Completed

Intrapleural Methylprednisolone Injection for Multiple Organ Failure With Acute Respiratory Distress Syndrome (IP steroid)

Multiple Organ Failure | Acute Respiratory Distress Syndrome (ARDS)

Taiwan
MedaSorb Technologies, Inc

Completed

Efficacy Study of CytoSorb Hemoperfusion Device on IL-6 Removal in ARDS/ALI Patients With Sepsis

Sepsis | Acute Respiratory Distress Syndrome | Acute Lung Injury

Germany
AGO Study Group
Essex Pharma GmbH; MedServ. GmbH, Wiesbaden

Completed

Combination Chemotherapy Consisting of Pegylated Liposomal Doxorubicin and Carboplatin in Malignant Gynecologic Tumours

Cervical Cancers | Cancer of the Ovary Treated as 2nd Line Therapy | Muellerian Mixed Tumours | Tumours of the Uterus | Non-Epithelial Ovarian Tumours

Germany
University of Texas Southwestern Medical Center
Donald W. Reynolds Foundation

Completed

Dallas Heart Study 2: Return Clinic Visit for the Dallas Heart Study Cohort

Myocardial Infarction | Hypertension | Obesity | Diabetes Mellitus | Atherosclerosis | Congestive Heart Failure | Metabolic Syndrome X | Left Ventricular Hypertrophy

United States
Gynecologic Oncology Group
National Cancer Institute (NCI)

Unknown

Biomarkers in Predicting Response in Patients With Advanced Ovarian Epithelial Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer Treated on GOG-0172 or GOG-0182

Ovarian Cancer | Fallopian Tube Cancer | Peritoneal Cavity Cancer
Hospital Universitario Dr. Jose E. Gonzalez
Laboratorios Valdecasas S.A.

Completed

The Effect of Folic Acid Administration in the Progression of Microalbuminuria

Diabetic Nephropathies | Hyperhomocysteinemia

Mexico
National Center for Research Resources (NCRR)
University of California, Los Angeles

Completed

Study of the Effect of Four Methods of Cardiopulmonary Resuscitation Instruction on Psychosocial Response of Parents With Infants at Risk of Sudden Death

Pulmonary Hypertension | Respiratory Distress Syndrome | Bronchopulmonary Dysplasia
Case Comprehensive Cancer Center
National Cancer Institute (NCI)

Terminated

Etoposide, Filgrastim, and Plerixafor in Improving Stem Cell Mobilization in Treating Patients With Non-Hodgkin Lymphoma

Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue | Nodal Marginal Zone B-cell Lymphoma | Recurrent Adult Burkitt Lymphoma | Recurrent Adult Diffuse Large Cell Lymphoma | Recurrent Adult Diffuse Mixed Cell Lymphoma | Recurrent Adult Diffuse Small Cleaved Cell Lymphoma and other conditions

United States
University of Washington
National Cancer Institute (NCI)

Completed

Vorinostat, Rituximab, Ifosfamide, Carboplatin, and Etoposide in Treating Patients With Relapsed or Refractory Lymphoma or Previously Untreated T-Cell Non-Hodgkin Lymphoma or Mantle Cell Lymphoma

Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue | Nodal Marginal Zone B-cell Lymphoma | Recurrent Adult Burkitt Lymphoma | Recurrent Adult Diffuse Large Cell Lymphoma | Recurrent Adult Diffuse Mixed Cell Lymphoma | Recurrent Adult Diffuse Small Cleaved Cell Lymphoma and other conditions

United States
National Cancer Institute (NCI)

Completed

Study of Akt Inhibitor MK2206 in Patients With Relapsed Lymphoma

Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue | Nodal Marginal Zone B-cell Lymphoma | Recurrent Adult Diffuse Large Cell Lymphoma | Recurrent Adult Diffuse Mixed Cell Lymphoma | Recurrent Adult Diffuse Small Cleaved Cell Lymphoma | Recurrent Adult Immunoblastic... and other conditions

United States
Fred Hutchinson Cancer Center
National Cancer Institute (NCI); National Heart, Lung, and Blood Institute...

Completed

Low-Dose Total Body Irradiation and Donor Peripheral Blood Stem Cell Transplant Followed by Donor Lymphocyte Infusion in Treating Patients With Non-Hodgkin Lymphoma, Chronic Lymphocytic Leukemia, or Multiple Myeloma

Stage II Multiple Myeloma | Stage III Multiple Myeloma | Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue | Nodal Marginal Zone B-cell Lymphoma | Recurrent Adult Burkitt Lymphoma | Recurrent Adult Diffuse Large Cell Lymphoma | Recurrent Adult Diffuse Mixed Cell Lymphoma and other conditions

United States, Germany, Italy

Clinical Trials on Congenital Disorders

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