Outbreak of Hemolytic Uremic Syndrome Linked to Escherichia Coli of Serotype O104:H4

Outbreak of Hemolytic Uremic Syndrome Linked to Escherichia Coli of Serotype O104:H4 in Bordeaux Urban Area, June 2011: Evaluation of Diagnostic, Prognostic and Pathophysiological Data

Sponsors

Lead Sponsor: University Hospital, Bordeaux

Source University Hospital, Bordeaux
Brief Summary

The Hemolytic Uremic Syndrome (HUS) in its typical form occurs after a food born infection with a shiga-toxin secreting bacteria, usually Escherichia coli of the O157H7 serotype. An outbreak of bloody diarrhea followed by HUS begun after a collective meal with 120 persons on June 8th, 2011 in Bègles, a city of Bordeaux urban area (CUB).

At least 9 patients, 8 adults and 1 child have been involved in this HUS outbreak, E. coli of the O104:H4 serotype being demonstrated in most patients. This outbreak is remarkable by its preponderance in adults and women, its aggressiveness with multiorgan involvement , i.e. the kidneys, brain, liver, pancreas, and skin.

Pathophysiology, prognosis, and treatment of typical HUS are poorly defined, particularly in adults who are usually not involved in typical E. coli O157H7 HUS.

The aim of the present study is to gain knowledge on these different aspects of the HUS, including response to therapy.

Overall Status Completed
Start Date July 2011
Completion Date March 2012
Primary Completion Date March 2012
Study Type Observational
Primary Outcome
Measure Time Frame
Improve scientific knowledge on epidemic HUS in the context of an outbreak of E. coli O104:H4 HUS in the town of Bègles, urban area of Bordeaux, France during patient hospitalization
Secondary Outcome
Measure Time Frame
evaluate efficiency of therapeutic and diagnostic strategies during patient hospitalization
Enrollment 9
Condition
Intervention

Intervention Type: Other

Intervention Name: HUS standard coverage care (including in ICU)

Description: HUS standard coverage care : plasmaphereses - eculizumab - Immunoadsorption

Arm Group Label: HUS epidemy in Bordeaux, E. coli of the O104H4 serotype

Eligibility

Sampling Method: Non-Probability Sample

Criteria:

Inclusion Criteria:

- All patients with HUS concomitant to the outbreak linked to E. coli O104:H4

Exclusion Criteria:

- Patient not willing to participate or to sign informed consent

Gender: All

Minimum Age: 2 Years

Maximum Age: N/A

Healthy Volunteers: No

Overall Official
Location
Facility: Service de Néphrologie, transplantation dialyse - Hôpital Pellegrin
Location Countries

France

Verification Date

November 2012

Responsible Party

Type: Sponsor

Keywords
Has Expanded Access No
Condition Browse
Arm Group

Label: HUS epidemy in Bordeaux, E. coli of the O104H4 serotype

Acronym SHU O104 CUB
Study Design Info

Observational Model: Cohort

Time Perspective: Prospective

Source: ClinicalTrials.gov