Outbreak of Hemolytic Uremic Syndrome Linked to Escherichia Coli of Serotype O104:H4
Outbreak of Hemolytic Uremic Syndrome Linked to Escherichia Coli of Serotype O104:H4 in Bordeaux Urban Area, June 2011: Evaluation of Diagnostic, Prognostic and Pathophysiological Data
Lead Sponsor: University Hospital, Bordeaux
|Source||University Hospital, Bordeaux|
The Hemolytic Uremic Syndrome (HUS) in its typical form occurs after a food born infection with a shiga-toxin secreting bacteria, usually Escherichia coli of the O157H7 serotype. An outbreak of bloody diarrhea followed by HUS begun after a collective meal with 120 persons on June 8th, 2011 in Bègles, a city of Bordeaux urban area (CUB).
At least 9 patients, 8 adults and 1 child have been involved in this HUS outbreak, E. coli of the O104:H4 serotype being demonstrated in most patients. This outbreak is remarkable by its preponderance in adults and women, its aggressiveness with multiorgan involvement , i.e. the kidneys, brain, liver, pancreas, and skin.
Pathophysiology, prognosis, and treatment of typical HUS are poorly defined, particularly in adults who are usually not involved in typical E. coli O157H7 HUS.
The aim of the present study is to gain knowledge on these different aspects of the HUS, including response to therapy.
|Start Date||July 2011|
|Completion Date||March 2012|
|Primary Completion Date||March 2012|
Intervention Type: Other
Intervention Name: HUS standard coverage care (including in ICU)
Description: HUS standard coverage care : plasmaphereses - eculizumab - Immunoadsorption
Arm Group Label: HUS epidemy in Bordeaux, E. coli of the O104H4 serotype
Sampling Method: Non-Probability Sample
Inclusion Criteria: - All patients with HUS concomitant to the outbreak linked to E. coli O104:H4 Exclusion Criteria: - Patient not willing to participate or to sign informed consent
- All patients with HUS concomitant to the outbreak linked to E. coli O104:H4
- Patient not willing to participate or to sign informed consent
Minimum Age: 2 Years
Maximum Age: N/A
Healthy Volunteers: No
|Has Expanded Access||No|
Label: HUS epidemy in Bordeaux, E. coli of the O104H4 serotype
|Acronym||SHU O104 CUB|
|Study Design Info||
Observational Model: Cohort
Time Perspective: Prospective