Clinical Trials on Constitutional Mismatch Repair Deficiency Syndrome

Total 5823 results

The Hospital for Sick Children
Bristol-Myers Squibb

Terminated

Pilot Study of Nivolumab in Pediatric Patients With Hypermutant Cancers

Refractory or Recurrent Hypermutated Malignancies | Biallelic Mismatch Repair Deficiency (bMMRD) Positive Patients

United States, France, Canada, Australia, Israel
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

Evaluation of the Reliability of the Determination of MisMatch Repair Deficiency Status by Endoscopic Biopsies in Oesophagus and Gastric Adenocarcinoma. (BIOPSYGAST MMR)

Gastro-oesophageal Adenocarcinoma
Yu jiren

Recruiting

Perioperative Chemotherapy Plus Toripalimab for dMMR Locally Advanced Gastric or Esophagogastric Junction Adenocarcinoma

Adenocarcinoma of the Stomach | Mismatch Repair Deficiency | Adenocarcinoma of Esophagogastric Junction

China
Bristol-Myers Squibb

Active, not recruiting

A Study of Nivolumab Alone or Nivolumab Combination Therapy in Colon Cancer That Has Come Back or Has Spread (CheckMate142)

Microsatellite Stable Colorectal Cancer | Mismatch Repair Proficient Colorectal Cancer | Microsatellite Unstable Colorectal Cancer | Mismatch Repair Deficient Colorectal Cancer

United States, Australia, Belgium, Canada, Ireland, Italy, Spain, France
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

Cycling in Preventing Colorectal Cancer in Participants With Lynch Syndrome

High-Frequency Microsatellite Instability | Mismatch Repair Gene Mutation | Mutation-Negative Lynch Syndrome | Mutation-Positive Lynch Syndrome

United States
Apollomics (Australia) Pty. Ltd.
Novotech (Australia) Pty Limited; Apollomics Inc. (formerly CBT Pharmaceuticals...

Completed

APL-501 Study for Select Advanced or Relapsed/Recurrent Solid Tumors

Solid Tumor | Microsatellite Instability | Mismatch Repair Deficiency | Cancer of Unknown Primary Site

Australia
WellSpan Health

Active, not recruiting

Frequency of Endometrial Cancer Precursors Associated With Lynch Syndrome

Endometrial Hyperplasia | Lynch Syndrome | Endometrial Cancer | Microsatellite Instability | Mismatch Repair Deficiency

United States
Peking Union Medical College Hospital

Recruiting

Neoadjuvant Immunotherapy for T4 dMMR Colon Cancer (NITDC)

Colon Cancer | Immunotherapy | Mismatch Repair Deficiency

China
National Center for Tumor Diseases, Heidelberg
AstraZeneca; German Cancer Research Center; PharmaMar

Active, not recruiting

Study of Olaparib/Trabectedin vs. Doctor's Choice in Solid Tumors (NCT-PMO-1603)

Cancers With DNA Repair-Deficiency

Germany
National Cancer Institute (NCI)

Recruiting

Pembrolizumab in Treating Younger Patients With Recurrent, Progressive, or Refractory High-Grade Gliomas, Diffuse Intrinsic Pontine Gliomas, Hypermutated Brain Tumors, Ependymoma or Medulloblastoma

Lynch Syndrome | Malignant Glioma | Recurrent Childhood Ependymoma | Recurrent Medulloblastoma | Refractory Ependymoma | Refractory Medulloblastoma | Recurrent Diffuse Intrinsic Pontine Glioma | Refractory Diffuse Intrinsic Pontine Glioma | Recurrent Brain Neoplasm | Refractory Brain Neoplasm | Constitutional...

United States, Canada
Yu jiren

Recruiting

Perioperative Chemotherapy Combined With Serplulimab or Placebo for pMMR Locally Advanced Gastric Adenocarcinoma (FOCUS-05)

Adenocarcinoma of the Stomach | Adenocarcinoma of Esophagogastric Junction | Proficient Mismatch Repair

China
Medical University Innsbruck

Unknown

Prevalence of Constitutional Mismatch-repair Deficiency Among Suspected Neurofibromatosis Type 1/Legius Syndrome Children Without a Malignancy and Without a NF1 or SPRED1 Mutation (CMMRD in NF1)

Neurofibromatosis Type 1
VA Office of Research and Development
Merck Sharp & Dohme LLC

Recruiting

A Study of CHeckpoint Inhibitors in Men With prOgressive Metastatic Castrate Resistant Prostate Cancer Characterized by a Mismatch Repair Deficiency or Biallelic CDK12 Inactivation (CHOMP)

Metastatic Castration Resistant Prostate Cancer

United States
National Center for Research Resources (NCRR)

Completed

Biological Significance of the Bloom's Syndrome Protein

Bloom Syndrome

United States
Federal Research Institute of Pediatric Hematology...

Recruiting

Low Dose Treosulfan Based Conditioning Regimen and PTCy in HSCT for Nijmegen Breakage Syndrome

Nijmegen Breakage Syndrome

Russian Federation
Federal Research Institute of Pediatric Hematology...

Recruiting

Low Dose Treosulfan Based Conditioning Regimen in HSCT for Nijmegen Breakage Syndrome

Nijmegen Breakage Syndrome

Russian Federation
Gustave Roussy, Cancer Campus, Grand Paris

Completed

LIFSCREEN : Evaluation of Whole Body MRI for Early Detection of Cancers in Subjects With P53 Mutation (Li-Fraumeni Syndrome) (LIFSCREEN)

Li Fraumeni Syndrome

France
National Human Genome Research Institute (NHGRI)

Completed

Gene Transfer Therapy for Severe Combined Immunodeficieny Disease (SCID) Due to Adenosine Deaminase (ADA) Deficiency

Severe Combined Immunodeficiency Syndrome

United States
Abramson Cancer Center of the University of Pennsylvania
Children's Hospital of Philadelphia

Recruiting

Li-Fraumeni Syndrome/TP53 Biobank

Li-Fraumeni Syndrome | Li-Fraumeni-Like Syndrome

United States
IRCCS San Raffaele
Fondazione Telethon

Completed

Gene Therapy for ADA-SCID

Severe Combined Immunodeficiency Syndrome
Sun Yat-sen University
The Second Affiliated Hospital of Kunming Medical University

Completed

The mCRC Patients With pMMR/MSS or dMMR/MSI-H Status Received Palliative Chemotherapy Efficacy and Survival

Colorectal Cancer Metastatic | Microsatellite Instability High | Mismatch Repair Deficiency

China
University of Colorado, Denver
National Cancer Institute (NCI); Cancer League of Colorado

Withdrawn

Anti-PD-1 +/- RT for MSI-H Solid Tumors

Colorectal Cancer | Microsatellite Instability High | Mismatch Repair Deficiency

United States
University Health Network, Toronto
AstraZeneca

Active, not recruiting

Basket Combination Study of Inhibitors of DNA Damage Response, Angiogenesis and Programmed Death Ligand 1 in Patients With Advanced Solid Tumors (DAPPER)

Pancreatic Adenocarcinoma | Leiomyosarcoma | Mismatch Repair Proficient Colorectal Cancer

Canada
The Hospital for Sick Children

Enrolling by invitation

Li-Fraumeni Syndrome Imaging Study

Li-Fraumeni Syndrome

Canada
Institute of Cancer Research, United Kingdom
Cancer Research UK; National Institute for Health Research, United Kingdom

Completed

Magnetic Resonance Imaging Screening in Li Fraumeni Syndrome (SIGNIFY)

Li-Fraumeni Syndrome

United Kingdom
National Cancer Institute (NCI)

Completed

A Pilot Study of Metformin in Patients With a Diagnosis of Li-Fraumeni Syndrome

Li-Fraumeni Syndrome

United States
University of British Columbia

Unknown

Melatonin and DNA Damage Study

Oxidative Stress | Sleep Quality | DNA Damage Repair Deficiency
Scripps Health
J. Craig Venter Institute

Completed

Biomarker Monitoring in TP53 Mutation Carriers

Li-Fraumeni Syndrome | Hereditary Cancer Syndromes | TP53 Gene Germline Mutation Carrier

United States
National Cancer Institute (NCI)

Recruiting

Clinical and Genetic Studies of Li-Fraumeni Syndrome

Neoplasms | Li-Fraumeni Syndrome | Tp53 Mutations

United States
Istituto Ortopedico Rizzoli

Recruiting

Registry of Li Fraumeni and Li Fraumeni Like Syndromes (ReLF)

Li-Fraumeni Syndrome | Li-Fraumeni-Like Syndrome

Italy
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Recruiting

Willingness to Participate in a Trial Comparing Standard Genetic Counseling Versus Personalized Genetic Counseling

Li-Fraumeni Syndrome

United States
National Cancer Institute (NCI)

Withdrawn

Testing the Combination of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) in Children, Adolescent, and Young Adult Patients With Relapsed/Refractory Cancers That Have an Increased Number of Genetic Changes, The 3CI Study

Hematopoietic and Lymphoid Cell Neoplasm | Lynch Syndrome | Refractory Lymphoma | Refractory Malignant Solid Neoplasm | Recurrent Lymphoma | Recurrent Malignant Solid Neoplasm | Recurrent Neuroblastoma | Refractory Neuroblastoma | Recurrent Primary Central Nervous System Neoplasm | Refractory Primary Central... and other conditions

United States, Canada
LiuYing

Not yet recruiting

Cadonilimab as Neoadjuvant Therapy in Resectable Stage II-III MSI-H/dMMR Colorectal Cancer (MSI-H/dMMR)

Colorectal Cancer | Neoadjuvant Therapy | Mismatch Repair-deficient (dMMR) | Microsatellite Instability-high (MSI-H)

China
Third Affiliated Hospital, Sun Yat-Sen University

Recruiting

Envafolimab as Neoadjuvant Immuntherapy in Resectable Local Advanced dMMR/MSI-H Colorectal Cancer

Colorectal Cancer | Neoadjuvant Therapy | Mismatch Repair-deficient (dMMR) | Microsatellite Instability-high (MSI-H)

China
Sun Yat-sen University

Recruiting

Toripalimab With or Without Celecoxib as Neoadjuvant Therapy in Resectable dMMR/MSI-H Colorectal Cancer (PICC)

Colorectal Cancer | Neoadjuvant Therapy | Mismatch Repair-deficient (dMMR) | Microsatellite Instability-high (MSI-H)

China
Dana-Farber Cancer Institute

Active, not recruiting

Screening With Whole Body MRI For Detection Of Primary Tumors In Children And Adults With Li-Fraumeni Syndrome (LFS) And Other Cancer Predisposition Syndromes

Li-Fraumeni Syndrome

United States
Dana-Farber Cancer Institute
National Cancer Institute (NCI); Baylor College of Medicine; City of Hope Medical...

Recruiting

Li-Fraumeni & TP53 (LiFT UP): Understanding and Progress (LiFT_UP)

TP53 Gene Mutation | Li-Fraumeni Syndrome | Hereditary Cancer Syndrome | Mosaicism | Clonal Hematopoiesis

United States
Sun Yat-sen University

Recruiting

Cadonilimab for PD-1/PD-L1 Blockade-refractory, MSI-H/dMMR, Advanced Colorectal Cancer

Colorectal Cancer Stage IV | Mismatch Repair-deficient (dMMR) | Microsatellite Instability-high (MSI-H)

China
Idience Co., Ltd.

Active, not recruiting

Basket Trial of IDX-1197, a PARP Inhibitor, in Patients With HRR Mutated Solid Tumors (VASTUS) (VASTUS)

Solid Tumors | Homologous Recombination Deficiency | Homologous Recombination Repair Gene Mutation

Korea, Republic of
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Role of p53 Gene in Metabolism Regulation in Patients With Li-Fraumeni Syndrome

Mitochondrial Disorders | Li-Fraumeni Syndrome | Carriers of p53 Mutation

United States
Yang Li
Ruijin Hospital

Recruiting

Arsenic Trioxide Combined With Chemotherapy for the Treatment of p53-mutated Pediatric Cancer

Pediatric Cancer | Li-Fraumeni Syndrome | p53 Mutations

China
Assistance Publique - Hôpitaux de Paris

Recruiting

Safety and Efficacy Study of Transplantation of Autologous CD34+ Cells Transduced With the G2ARTE Lentiviral Vector Expressing the DCLRE1C cDNA in Artemis (DCLRE1C) Deficient Severe Combined Immunodeficiency Patients (ARTEGENE) (ARTEGENE)

Artemis (DCLRE1C ) Deficient Severe Combined Immunodeficiency

France
National Institute of Allergy and Infectious Diseases...
National Center for Advancing Translational Sciences (NCATS); Primary Immune...

Enrolling by invitation

Patients Treated for SCID (1968-Present)

ADA-SCID | Omenn Syndrome | SCID | Reticular Dysgenesis | XSCID | Leaky SCID

United States, Canada
PRG Science & Technology Co., Ltd.

Not yet recruiting

Phase 2, Open-Label Study to Evaluate the Safety and Tolerability of Progerinin in Werner Syndrome

Werner Syndrome
National Center for Research Resources (NCRR)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) and other collaborators

Completed

Descriptive Study of Recombinant Human Insulin-Like Growth Factor for Osteoporosis in Werner's Syndrome

Werner's Syndrome
BeiGene

Recruiting

A Study Investigating the Efficacy and Safety of LBL-007 Plus Tislelizumab in Combination With Bevacizumab Plus Fluoropyrimidine Versus Bevacizumab Plus Fluoropyrimidine in Participants With Unresectable or Metastatic Colorectal Cancer

Unresectable or Metastatic Microsatellite Stable/Mismatch Repair Proficient Colorectal Cancer

China, United States, Australia, Puerto Rico
PRG Science & Technology Co., Ltd.
Amarex Clinical Research

Completed

Phase I Study of Progerinin in Healthy Volunteers

Hutchinson-Gilford Progeria Syndrome | Werner Syndrome

United States
National Institute of Allergy and Infectious Diseases...

Enrolling by invitation

Matched Related and Unrelated Donor Stem Cell Transplantation for Severe Combined Immune Deficiency (SCID): Busulfan-based Conditioning With h-ATG, Radiation, and Sirolimus

Severe Combined Immune Deficiency (SCID)

United States
Replimune Inc.

Recruiting

Study of RP1 Monotherapy and RP1 in Combination With Nivolumab (IGNYTE)

Cancer | NSCLC | Melanoma (Skin) | Microsatellite Instability | Cutaneous Melanoma | Mismatch Repair Deficiency | Non-melanoma Skin Cancer

United States, Spain, France, United Kingdom, Germany
National Institute of Allergy and Infectious Diseases...
National Center for Advancing Translational Sciences (NCATS); Office of Rare... and other collaborators

Enrolling by invitation

Natural History Study of SCID Disorders

Omenn Syndrome | Reticular Dysgenesis | Severe Combined Immunodeficiency (SCID) | XSCID | Leaky SCID | ADA SCID

United States, Canada

Clinical Trials on Constitutional Mismatch Repair Deficiency Syndrome

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Cambodia

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Rare Diseases

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