Clinical Trials on Corneal Degeneration

Total 6140 results

Sanguine Biosciences

Recruiting

Tissue Repository Providing Annotated Biospecimens for Approved Investigator-directed Biomedical Research Initiatives

Heart Diseases | Stroke | Lymphoma | Multiple Sclerosis | Kidney Diseases | Diabetes | Leukemia | Age-Related Macular Degeneration | Cancer | Arthritis | Schizophrenia | Thyroid Diseases | Parkinson Disease | Hepatitis | Vasculitis | Psoriasis | Asthma | Amyloidosis | Fibromyalgia | Graves Disease | Alzheimer Disease | Celiac Disease | Cirr... and other conditions

United States
University of California, Irvine

Recruiting

Characterization of Inclusion Body Myopathy Associated With Paget's Disease of Bone and Frontotemporal Dementia (IBMPFD)

Frontotemporal Dementia | Myopathy | Inclusion Body Myopathy With Early-onset Paget Disease and Frontotemporal Dementia | Paget Disease of Bone

United States
University College, London

Unknown

Imaging Neuromelanin and Iron in Dystonia/Parkinsonism

Mitochondrial Diseases | Dystonia, Familial | Sporadic Dystonia | Parkinson Disease, Juvenile | Neurodegeneration With Brain Iron Accumulation 5
Maaynei Hayesha Medical Center

Recruiting

COVID 19 ANTOBODIES IN PREGNANT WOMEN AND THEIR CONNECTION TO BETA CELL FUNCTION IN THE FETUS

Generation of Anti COVID-19 Antibodies in a Fetus, Whose Mother Was Exposed to COVID or Was Vaccinated During Pregnancy

Israel
University of Florida
Acorda Therapeutics

Completed

Dalfampridine and Gait in Spinocerebellar Ataxias

Spinocerebellar Ataxias Type 1 | Spinocerebellar Ataxias Type 2 | Spinocerebellar Ataxias Type 3 | Spinocerebellar Ataxias Type 6

United States
Mayo Clinic
National Institute on Aging (NIA); Minnesota HealthSolutions

Recruiting

A Study of Caregiver Connections Via Technology in Dementia

Dementia | Alzheimer Disease | Frontotemporal Dementia | Lewy Body Dementia | Parkinson Disease Dementia | Caregiver Stress

United States
University of Dublin, Trinity College
Motor Neurone Disease Association, UK; Irish Research Council, IE; Thierry Latran... and other collaborators

Recruiting

EEG and TMS-based Biomarkers of ALS, MS and FTD

Multiple Sclerosis | Amyotrophic Lateral Sclerosis | Frontotemporal Dementia

Ireland
University of Miami
National Institute of Neurological Disorders and Stroke (NINDS); National Institutes... and other collaborators

Recruiting

Clinical Procedures to Support Research in ALS (CAPTURE-ALS)

Amyotrophic Lateral Sclerosis | Primary Lateral Sclerosis | Progressive Muscular Atrophy | ALS-Frontotemporal Dementia

United States
Mayo Clinic
National Institute on Aging (NIA); Minnesota HealthSolutions

Withdrawn

A Study to Evaluate Caregiver Connections Via Technology for Patients With Alzheimer's and Other Types of Dementia

Dementia | Frontotemporal Dementia | Alzheimer Dementia | Lewy Body Dementia | Parkinson Disease Dementia | Caregiver Stress
Skane University Hospital
AC Immune SA

Completed

Optimization of Morphomer-based Alpha-synuclein PET Tracers

Parkinson Disease | Multiple System Atrophy | Corticobasal Degeneration | Progressive Supranuclear Palsy | Dementia With Lewy Bodies

Sweden
University of Eastern Finland
University of Sheffield; Sheffield Teaching Hospitals NHS Foundation Trust; VTT... and other collaborators

Completed

Computational Tools for Early Diagnosis of Memory Disorders (ProsKuopio)

Alzheimer Disease | Mild Cognitive Impairment | Frontotemporal Dementia | Dementia, Vascular

Finland
University of Zurich
Swiss National Science Foundation; Swiss Paraplegic Research

Recruiting

Functional and Structural Changes in the Central Nervous System Following Spinal Cord Injury

Spinal Cord Injuries | Neurogenic Bladder Dysfunction | Degenerative Cervical Spinal Stenosis

Switzerland
University of California, San Francisco
National Human Genome Research Institute (NHGRI)

Completed

Clinical Utility of Pediatric Whole Exome Sequencing

Epilepsy | Cerebral Palsy | Intellectual Disability | Developmental Delay | Metabolic Disease | Neuro-Degenerative Disease | Encephalopathy | Birth Defect | Multiple Congenital Anomaly | Developmental Defect

United States
Zimmer Biomet

Terminated

Maxera Large Cups - Canada (Maxera Canada)

Joint Diseases | Osteoarthritis, Hip | Avascular Necrosis of Hip | Congenital Dysplasia of the Hip | Degenerative Joint Disease of Hip | Rheumatoid Arthritis of Hip | Post-Traumatic Osteoarthritis of Hip

Canada
Istituto Ortopedico Rizzoli

Recruiting

Treatment of Upper Cluneal Nerve Entrapment Syndrome for Reduction of Low Back Pain

Superior Cluneal Nerve Entrapment

Italy
Carl Allen
Baylor College of Medicine; Genentech, Inc.; North American Consortium for Histiocytosis

Recruiting

Cobimetinib in Refractory Langerhans Cell Histiocytosis (LCH), and Other Histiocytic Disorders (NACHO-COBI)

Histiocytic Sarcoma | Juvenile Xanthogranuloma | Histiocytic Disorders, Malignant | Erdheim-Chester Disease | Langerhan's Cell Histiocytosis | Rosai Dorfman Disease | Neuro-Degenerative Disease

United States
Université de Montréal

Withdrawn

Performance of a Photoscreener for Vision Screening in a Haitian Pediatric Population (POPH)

Glaucoma | Cataract | Astigmatism | Myopia | Retinopathy of Prematurity | Retinoblastoma | Hyperopia | Amblyopia | Xerophthalmia | Trachoma

Haiti
Université du Québec à Chicoutimi
McGill University; Université de Sherbrooke; University of Alberta; University... and other collaborators

Recruiting

Effects of a Supervised Rehabilitation Program on Disease Severity in Spastic Ataxias

Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay | Spastic Paraplegia 7

Canada
Cadent Therapeutics

Withdrawn

Study of CAD-1883 for Spinocerebellar Ataxia (Synchrony-1)

Spinocerebellar Ataxia Type 3 | Spinocerebellar Ataxias | Spinocerebellar Ataxia Type 1 | Spinocerebellar Ataxia Type 2 | Spinocerebellar Ataxia Type 6 | Spinocerebellar Ataxia Type 10 | Spinocerebellar Ataxia Type 7 | Spinocerebellar Ataxia Type 8 | Spinocerebellar Ataxia Type 17 | ARCA1 - Autosomal Recessive...

United States
Duke University
University of Edinburgh in Scotland; Tan Tock Seng Hospital in Singapore; Queens...

Recruiting

Retinal Imaging in Neurodegenerative Disease

Multiple Sclerosis | Parkinson's Disease | Traumatic Brain Injury | Down Syndrome | Mild Cognitive Impairment | Frontotemporal Dementia | Huntington Disease | Amyotrophic Lateral Sclerosis (ALS) | Alzheimer's Disease | Concussion | Post-Traumatic Stress Disorder | Neuro-Degenerative Disease | Lewy Body Dementia | Normal... and other conditions

United States
Vico Therapeutics B. V.

Recruiting

A Safety and Pharmacokinetics Trial of VO659 in SCA1, SCA3 and HD

Huntington Disease | Spinocerebellar Ataxia Type 3 | Spinocerebellar Ataxia Type 1

Israel, Germany, United Kingdom, Poland, Denmark, Netherlands, France
Rutgers, The State University of New Jersey

Recruiting

Using Wearable and Mobile Data to Diagnose and Monitor Movement Disorders

Parkinson Disease | Movement Disorders | Huntington Disease | Essential Tremor | Spinocerebellar Ataxias | Dystonia, Primary

United States
Samsung Medical Center

Completed

Cerebellar rTMS and Physical Therapy for Cerebellar Ataxia

Spinocerebellar Ataxias | Multiple System Atrophy, Cerebellar Variant (Disorder)

Korea, Republic of
Mandos LLC

Terminated

Open-label Study of VTS-270 in Participants With Neurologic Manifestations of Niemann-Pick Type C1

Niemann-Pick Disease, Type C

Costa Rica
Northwestern University

Completed

Genetics of Familial and Sporadic ALS (ALS)

Amyotrophic Lateral Sclerosis (ALS) | Lou Gehrig's Disease | Primary Lateral Sclerosis (PLS) | Familial Amyotrophic Lateral Sclerosis | ALS With Frontotemporal Dementia (ALS/FTD) | Motor Neuron Disease (MND) | Sporadic ALS (SALS)

United States
National Eye Institute (NEI)

Completed

Saccadic Eye Movements in Patients With Niemann-Pick Type C Disease

Niemann Pick Diseases

United States, United Kingdom
University Rovira i Virgili
Ministerio de Ciencia e Innovación, Spain

Recruiting

Dementias and Microbiota Composition: Is Possible to Revert the Dementia Symptoms Reverting the Microbiota Composition? (DEM-BIOTA)

Mild Cognitive Impairment | Dementia With Lewy Bodies | Dementia Alzheimers | Parkinson Disease Dementia | Dementia Frontotemporal

Spain
National Institute of Neurological Disorders and...

Recruiting

Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

Amyotrophic Lateral Sclerosis | Frontotemporal Dementia | Progressive Supranuclear Palsy

United States
Ontario Neurodegeneration Disease Research Initiative

Completed

The Ontario Neurodegenerative Disease Research Initiative (ONDRI)

Stroke | Parkinson Disease | Amyotrophic Lateral Sclerosis | Alzheimer Disease | Frontotemporal Dementia

Canada
Actelion

Completed

Safety and Efficacy of Miglustat in Chinese NPC Patients

Niemann-Pick Disease, Type C

China
Vtesse, LLC, a Mallinckrodt Pharmaceuticals Company

Withdrawn

Safety and Tolerability Study of VTS-270 in Pediatric Participants With Niemann-Pick Type C (NPC) Disease

Niemann-Pick Disease, Type C
Sanofi
Pulse Infoframe Ltd.

Recruiting

A Real-world Long-term Safety and Immunogenicity Study of Olipudase Alfa Therapy in Pediatric Patients Less Than 2 Years of Age With Acid Sphingomyelinase Deficiency (ASMD)

Niemann-Pick Diseases | Acid Sphingomyelinase Deficiency

United States
University Hospitals Cleveland Medical Center
National Institute of Allergy and Infectious Diseases (NIAID); University of... and other collaborators

Recruiting

Misfolded Proteins in the Skin of People With Parkinson's Disease and Other Parkinsonism

Parkinson Disease | Parkinsonism | Multiple System Atrophy | Corticobasal Degeneration | Progressive Supranuclear Palsy | Dementia With Lewy Bodies

United States
University of California, San Francisco
University of Colorado, Denver; National Institute on Aging (NIA); HealthPartners... and other collaborators

Active, not recruiting

The Care Ecosystem Consortium Effectiveness Study

Dementia | Frontotemporal Dementia | Dementia, Vascular | Dementia With Lewy Bodies | Dementia Alzheimers

United States
Rush University Medical Center

Completed

In-Home Care for Patients With PSP and Related Disorders

Multiple System Atrophy | Progressive Supranuclear Palsy | Corticobasal Syndrome | Dementia With Lewy Bodies | Atypical Parkinson Disease

United States
Aesculap AG

Active, not recruiting

Plasmafit® Revision Structan® Hip Endoprosthesis Cup

Arthroplasty Complications | Prosthesis Failure | Osteolysis | Degenerative Osteoarthritis | Rheumatic Arthritis | Fractures, Hip | Instability of Prosthetic Joint | Femoral Head Avascular Necrosis

Germany
University of Florida
National Institutes of Health (NIH); National Institute on Deafness and Other...

Withdrawn

Laryngeal Adaptation for Speech and Swallowing

Stroke | Dysphagia | Spinocerebellar Ataxia | Dysarthria | Cerebral Stroke
First Affiliated Hospital of Fujian Medical University

Recruiting

Treatment of Transcranial Alternating Current Stimulation（tACS）on Cerebellar Ataxia

Spinocerebellar Ataxia Type 3 | Multiple System Atrophy-cerebellar Type

China
McMaster University
Joseph Brant Hospital

Completed

The Effects of Whole-body Exercise to Improve Swallowing Function in Older Adults With Dementia

Parkinson Disease | Cough | Neuro-Degenerative Disease | Swallowing Disorder | Old Age; Dementia

Canada
Mandos LLC

Completed

VTS-270 to Treat Niemann-Pick Type C1 (NPC1) Disease

Niemann-Pick Disease, Type C

United States, Australia, United Kingdom, Germany, France, New Zealand, Singapore, Spain, Turkey
InSightec

Active, not recruiting

ExAblate Transcranial MRgFUS for the Management of Treatment-Refractory Movement Disorders

Parkinson's Disease | Movement Disorders | Tardive Dyskinesia | Dystonia | Essential Tremor | Huntington's Disease | Wilson's Disease | Holmes Tremor | Orofacial Dyskinesias

Canada
University Hospitals Coventry and Warwickshire...

Recruiting

Volume Mode Non-invasive Ventilation in Amyotrophic Lateral Sclerosis

Nervous System Diseases | Neuromuscular Diseases | Respiratory Failure | Respiratory Insufficiency | Amyotrophic Lateral Sclerosis | Sleep-Disordered Breathing | Neuro-Degenerative Disease | Neuron Disease, Motor

United Kingdom
University Hospital, Strasbourg, France

Recruiting

Cerebro Spinal Fluid Collection (CSF) (Analzheimer)

Alzheimer Disease | Multiple System Atrophy | Frontotemporal Dementia | Dementia With Lewy Bodies | Parkinson's Disease Dementia

France
Hospital del Mar Research Institute (IMIM)

Enrolling by invitation

The Clinical Impact of the Novel Alzheimer's Blood-based Biomarkers (PLASMAR)

Neurodegenerative Diseases | Cognitive Impairment | Dementia | Alzheimer Disease | Lewy Body Disease | Frontotemporal Dementia | Vascular Dementia

Spain
Azafaros A.G.

Active, not recruiting

Phase 2 Study Evaluating the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Oral AZ-3102 in Patients With GM2 Gangliosidosis or Niemann-Pick Type C Disease (RAINBOW)

Niemann-Pick Disease, Type C | GM2 Gangliosidosis

Brazil
HealthMode Inc.

Completed

Feasibility of Passive Data Collection in Dementia Subjects With Agitation

Dementia | Alzheimer Disease | Frontotemporal Dementia | Vascular Dementia | Lewy Body Dementia | Mixed Dementia

United States
Xinhua Hospital, Shanghai Jiao Tong University...

Unknown

Study of Lithium Carbonate to Treat Niemann-Pick Type C1 Disease

Niemann-Pick Disease, Type C1

China
DanceStream Projects
Alzheimer's Association

Recruiting

Stories in the Moment: Dance Program for People Living With Dementia

Dementia | Alzheimer Disease | Mild Cognitive Impairment | Lewy Body Disease | Frontotemporal Dementia | Vascular Dementia

United States
University of Rochester
University of Colorado, Denver; Massachusetts General Hospital; Stanford University

Recruiting

Community Outreach for Palliative Engagement -- Parkinson Disease (COPE-PD)

Parkinson Disease | Multiple System Atrophy | Corticobasal Degeneration | Progressive Supranuclear Palsy | Parkinson's Disease and Parkinsonism | Dementia With Lewy Bodies | Vascular Parkinsonism | Parkinson Disease Dementia | Lewy Body Parkinsonism

United States
Kinto
Alzheimer's Association

Completed

Efficacy Study of Kinto Care Coaching for Dementia Family Caregivers

Dementia | Alzheimer Disease | Lewy Body Disease | Frontotemporal Dementia | Vascular Dementia | Mixed Dementia

United States

Clinical Trials on Corneal Degeneration

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