Clinical Trials on DNA Strand Breaks

Total 37843 results

AbbVie

Completed

A Phase I Study of ABT-888 in Combination With Temozolomide in Cancer Patients

Breast Cancer | Hepatocellular Carcinoma | Ovarian Cancer | Fallopian Tube Cancer | Metastatic Melanoma | Primary Peritoneal Cancer | Non-hematologic Malignancies
Celldex Therapeutics

Completed

Phase I Study of CDX-1307, hCG-B Vaccine, for Patients With Incurable, Locally Advanced or Metastatic Breast, Colorectal, Pancreatic, Bladder or Ovarian Cancer (CDX1307-02)

Breast Cancer | Colorectal Cancer | Pancreatic Cancer | Ovarian Cancer | Bladder Cancer

United States
National Cancer Institute (NCI)

Completed

Erlotinib in Treating Patients With Solid Tumors and Liver or Kidney Dysfunction

Recurrent Prostate Cancer | Unspecified Adult Solid Tumor, Protocol Specific | Recurrent Bladder Cancer | Stage IV Bladder Cancer | Recurrent Pancreatic Cancer | Stage III Pancreatic Cancer | Stage IV Pancreatic Cancer | Male Breast Cancer | Stage IV Breast Cancer | Stage IV Ovarian Epithelial Cancer | Stage... and other conditions

United States
Fred Hutchinson Cancer Center
National Cancer Institute (NCI)

Completed

Lithium Carbonate in Treating Patients With Acute Intestinal Graft-Versus-Host-Disease (GVHD) After Donor Stem Cell Transplant (GVHD)

Primary Myelofibrosis | Stage I Multiple Myeloma | Stage II Multiple Myeloma | Stage III Multiple Myeloma | Chronic Myelomonocytic Leukemia | Recurrent Adult Acute Myeloid Leukemia | Juvenile Myelomonocytic Leukemia | Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue | Nodal... and other conditions

United States
D'Or Institute for Research and Education
Oswaldo Cruz Foundation; Rio de Janeiro State Research Supporting Foundation... and other collaborators

Not yet recruiting

Extracellular Vesicles From Mesenchymal Cells in the Treatment of Acute Respiratory Failure

Pneumonia | Acute Respiratory Distress Syndrome (ARDS) | Severe Acute Respiratory Syndrome (SARS)

Brazil
Biotest

Recruiting

Efficacy and Safety of Trimodulin (BT588) in Subjects With CAP Including COVID-19 Pneumonia (TRICOVID)

COVID-19 | Pneumonia | Acute Respiratory Distress Syndrome | Community-acquired Pneumonia | Respiratory Infection | Bacterial Pneumonia | Viral Pneumonia | Fungal Pneumonia

Belgium, Brazil, Latvia, Germany, Lithuania, South Africa, Argentina, Austria, France, Hungary, Slovakia, Turkey, Portugal, Spain
Assistance Publique - Hôpitaux de Paris
FAI²R (Auto-immune and auto-inflammatory rare diseases French network)

Not yet recruiting

Identification of Factors Associated With the Occurrence of Severe Forms of COVID-19 Infection in Patients With Inflammatory Rheumatism or Autoimmune Diseases (CovAID)

Autoimmune Diseases | Rare Diseases | SARS-CoV2 Infection | Chronic Inflammatory Rheumatism

France
Thomas Benfield

Recruiting

Changes in Weight, Body Composition and Metabolic Parameters After Discontinuing Dolutegravir or Tenofovir Disproxil (AVERTAS-2)

HIV Infections | Obesity | Renal Insufficiency | Osteoporosis | Hiv | Weight Gain | HIV Lipodystrophy

Denmark
University Hospital, Essen

Recruiting

HIV-HEART Aging Study (HIVH)

Myocardial Infarction | HIV Infections | Heart Failure | Coronary Disease | Aging | Weight Gain | HIV Encephalopathy

Germany
SPP Pharmaclon Ltd.
North-Western State Medical University named after I.I.Mechnikov

Completed

Study of Interferon-Gamma in the Complex Treatment of Patients Infected With HIV and Tuberculosis (MSPB_TB)

RNA Virus Infections | Lentivirus Infections | Tuberculosis, Pulmonary | Human Immunodeficiency Virus | HIV Coinfection | Aids/Hiv Problem

Russian Federation
The University of Texas Medical Branch, Galveston

Completed

Brain and Gut Plasticity in Mild TBI or Post-acute COVID Syndrome Following Growth Hormone Therapy

COVID-19 | Fatigue | Cognitive Impairment | Traumatic Brain Injury

United States
University of Pennsylvania
National Institutes of Health (NIH); Medical College of Wisconsin

Enrolling by invitation

Evaluating a Comprehensive Multimodal Outpatient Rehabilitation Program for PASC Program to Improve Functioning of Persons Suffering From Post-COVID-19 Syndrome: A Randomized Controlled Trial

Cognitive Impairment | Dyspnea | Long COVID | Long Covid19 | Post-Acute COVID-19 | Post-Acute COVID-19 Infection | Post-Acute COVID-19 Syndrome | Orthostasis

United States
University of California, San Diego
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Obstructive Sleep Apnea Endotypes and Impact on Phenotypes of People Living With HIV (PLWH/OSA)

Obstructive Sleep Apnea | Human Immunodeficiency Virus

United States
TidalSense
National Institute for Health Research, United Kingdom; Innovate UK

Completed

Cardiorespiratory Diagnostic Study (CARES)

Healthy | Bronchiectasis | Anemia | Asthma | Lung Cancer | Interstitial Lung Disease | COPD | Long COVID | Upper Respiratory Disease | Congestive Cardiac Failure

United Kingdom
Centre Hospitalier Intercommunal de Toulon La Seyne...

Completed

Comparison of Non-invasive Oxygenation Strategies in Patients Admitted for Covid-19 Acute Respiratory Distress Syndrome (SONIC-19)

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

France
Aytu BioPharma, Inc.

Withdrawn

Respiratory COVID-19: A Randomized, Sham-Controlled Study

Acute Respiratory Distress Syndrome | COVID-19 Pneumonia | COVID-19 Respiratory Infection | COVID-19 Acute Respiratory Distress Syndrome

Spain
Medipol University

Completed

Cognitive Functions After COVID-19

Cognitive Decline | COVID-19 Acute Respiratory Distress Syndrome

Turkey
West Virginia University

Completed

Stellate Ganglion Block (SGB) for COVID-19 Acute Respiratory Distress Syndrome (ARDS)

COVID-19 | Acute Respiratory Distress Syndrome

United States
Apellis Pharmaceuticals, Inc.

Completed

A Study of APL-9 in Adults With Mild to Moderate ARDS Due to COVID-19

Severe Acute Respiratory Syndrome | Coronavirus Infection | Covid-19 | COVID | Acute Respiratory Distress Syndrome | Coronavirus | Ards | Severe Acute Respiratory Syndrome Coronavirus 2 | Sars-CoV2

United States, Brazil
Novacescu Alexandru
University of Medicine and Pharmacy "Victor Babes" Timisoara

Completed

Therapeutic Plasma Exchange Followed by Convalescent Plasma Transfusion in Severe and Critically Ill COVID-19 Patients

Acute Respiratory Distress Syndrome | COVID-19 Pneumonia | COVID-19 Respiratory Infection | Acute Respiratory Failure

Romania
Sanofi Pasteur, a Sanofi Company

Completed

Study to Compare Pediacel® to Infanrix®-IPV+Hib When Both Are Co-Administered With Prevenar® in Infants and Toddlers

Pertussis | Tetanus | Diphtheria | Poliomyelitis | Haemophilus Influenzae Type b

France, Poland
Sanofi Pasteur, a Sanofi Company

Completed

Comparison of Safety and Immunogenicity of Pediacel™ and Infanrix™ IPV+Hib (Penta) Given in a 3 Dose Schedule in Infants

Pertussis | Tetanus | Diphtheria | Poliomyelitis | Haemophilus Influenzae Type b

Finland, Sweden
The Geneva Foundation
Uniformed Services University of the Health Sciences; Brooke Army Medical Center and other collaborators

Recruiting

Passive Detection- SARS-CoV-2 (COVID-19) A&M Breathalyzer (PROTECT Kiosk) for Operational Medicine (COVID-19)

COVID-19 | COVID-19 Pneumonia | COVID-19 Respiratory Infection | COVID-19 Acute Respiratory Distress Syndrome | SARS CoV 2 Virus

United States
University of Chicago

Not yet recruiting

Study of Liraglutide (A Weight Loss Drug) in High Risk Obese Participants With Cognitive and Memory Issues

Multiple Sclerosis | Obesity | Obesity, Morbid | Obese | Long COVID | Long Covid19 | Acute Leukemia in Remission
Gruppo Italiano Malattie EMatologiche dell'Adulto
Fondazione Italiana Linfomi

Recruiting

Incidence of Severe COVID-19 Infection in Patients With CLL or B-NHL Who Received Pre-exposure Prophylaxis With Tixagevimab and Cilgavimab in Italy.

COVID-19 | Chronic Lymphocytic Leukemia | Indolent B-Cell Non-Hodgkin Lymphoma

Italy
Khon Kaen University

Recruiting

Comparison of Prone Position and Standard Electrocardiogram in COVID-19 Patients

Cardiovascular Diseases | Arrhythmias, Cardiac | COVID-19 Acute Respiratory Distress Syndrome

Thailand
National Taiwan University Hospital

Recruiting

HCV Reinfection in in HIV/HCV-coinfected Patients Achieving SVR by Antiviral Therapy

Hepatitis C Virus Infection | Hepatitis C Virus Infection, Response to Therapy of | Human Immunodeficiency Virus (HIV) Coinfection

Taiwan
Thomas Benfield

Completed

Changes in Weight, Body Composition and Cardiac Risk After Discontinuing Abacavir Treatment in HIV-infected Individuals (AVERTAS)

Cardiovascular Diseases | HIV Infections | Hiv | Weight Change, Body | HIV Lipodystrophy | HIV Cardiomyopathy

Denmark
National Cancer Institute (NCI)

Completed

Nivolumab in Treating Patients With HTLV-Associated T-Cell Leukemia/Lymphoma

Acute Adult T-Cell Leukemia/Lymphoma | Adult T-Cell Leukemia/Lymphoma | Chronic Adult T-Cell Leukemia/Lymphoma | HTLV-1 Infection | Lymphomatous Adult T-Cell Leukemia/Lymphoma | Smoldering Adult T-Cell Leukemia/Lymphoma

United States
Hôpital Européen Marseille

Active, not recruiting

Pulmonary Fibrosis During Severe COVID-19 Pneumonia (FIBRO-COVID)

Pulmonary Fibrosis | Acute Respiratory Distress Syndrome | Severe Acute Respiratory Syndrome Coronavirus 2

France
NYU Langone Health
Daxor Corporation

Completed

Blood Volume Assessment in COVID-19 and Bacterial Sepsis (BVAC19)

Covid19 | Bacterial Infections | Acute Respiratory Distress Syndrome | Bacterial Sepsis

United States
Oxford University Clinical Research Unit, Vietnam
Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam

Completed

Awake Prone Positioning in Moderate to Severe COVID-19

COVID-19 | SARS-CoV2 Infection | Respiratory Distress Syndrome, Adult | Acute Hypoxemic Respiratory Failure | COVID-19 Acute Respiratory Distress Syndrome

Vietnam
Jeffrey Bluestone
National Institute of Allergy and Infectious Diseases (NIAID); Immune Tolerance...

Terminated

Tregs for the Treatment of Acute Respiratory Distress Syndrome (ARDS) Associated With COVID-19 (regARDS) (regARDS)

Acute Respiratory Distress Syndrome Due to Disease Caused by 2019-nCoV

United States
Rigshospitalet, Denmark
Aarhus University Hospital

Completed

Use of Prone Position Ventilation in Danish Patients With COVID-19 Induced Severe ARDS Treated With VV-ECMO

Extracorporeal Membrane Oxygenation | ARDS, Human | Adverse Event | Prone Position | COVID-19 Acute Respiratory Distress Syndrome

Denmark
Organicell Regenerative Medicine

Available

Expanded Access to Zofin for Patients With COVID-19

Covid19 | Acute Respiratory Distress Syndrome | Corona Virus Infection | SARS (Severe Acute Respiratory Syndrome)
Mucpharm Pty Ltd
St George Hospital, Australia; Mobius Medical Pty Ltd.

Completed

Nebulised BromAc in Healthy Volunteers

COVID-19 Pneumonia | COVID-19 Acute Respiratory Distress Syndrome | Bromelains Adverse Reaction | Acetylcysteine Adverse Reaction | Mucus; Plug

Australia
Institut de cancérologie Strasbourg Europe
LEAF4Life, Inc.

Completed

A Study of Liposomal Trans Crocetin, LEAF-4L6715, in Patients With Acute Respiratory Distress Syndrome Due to COVID-19, Sepsis or Other Causes

Acute Respiratory Distress Syndrome | COVID19, Sepsis or Other Causes

France
Loma Linda University

Withdrawn

Tazemetostat for the Treatment of Moderate to Severe COVID-19 Infection (IST)

Cytokine Release Syndrome | COVID-19 Acute Respiratory Distress Syndrome
The University of Texas Health Science Center at...
The Claude D. Pepper Older Americans Independence Centers

Withdrawn

Effects of mTOR Inhibition With Sirolimus (RAPA) in Patients With COVID-19 to Moderate the Progression of ARDS (RAPA-CARDS)

Respiratory Failure | Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS) | Sars-CoV2

United States
Amyndas Pharmaceuticals S.A.

Unknown

A Study of the C3 Inhibitor AMY-101 in Patients With ARDS Due to COVID-19 (SAVE) (SAVE)

Acute Respiratory Distress Syndrome Due to SARS-CoV-2 Infection (Severe COVID19)
Central Hospital, Nancy, France

Unknown

Effect of Corticosteroid Treatment on Prognosis in ARDS Secondary to Covid-19 (CoCovSDRA)

Acute Respiratory Distress Syndrome Secondary to Covid-19

France
Koç University

Completed

Physical Rehabilitation in ICU in ARDS Patients With COVID-19

COVID-19 | Rehabilitation | Acute Respiratory Distress Syndrome | Intensive Care Unit Acquired Weakness | Critical Illness Polyneuromyopathy

Turkey
Professor Adrian Covic
Medical Sciences Academy - Romania; Victor Babes Clinical Hospital of Infectious...

Unknown

Integrated Distance Management Strategy for Patients With Cardiovascular Diseases in the Context of COVID-19 (eCardioCovid19)

Coronary Artery Disease | Hypertension | Covid-19 | Angina Pectoris | Acute Coronary Syndrome | Heart Failure, Systolic | Depression, Anxiety | Coronary Syndrome | Stent Restenosis | Angioplasty | Isolation, Social

Romania
GlaxoSmithKline

Completed

Safety of GSK Biologicals' Infanrix-IPV+HibTM Vaccine in Healthy Vietnamese Toddlers

Tetanus | Diphtheria | Acellular Pertussis | Poliomyelitis | Haemophilus Influenzae Type b | Diphtheria-Tetanus-aPertussis-Poliomyelitis-Haemophilus Influenzae Type b Vaccines

Vietnam
Saskatchewan Health Authority - Regina Area
Gilead Sciences

Unknown

Switch to Genvoya Followed by HCV Therapy With Epclusa Followed by Simplification of HIV Therapy With Biktarvy in Patients With HIV-HCV Co-Infected Subjects on Opioid Substitution Therapy

Hepatitis C, Chronic | HIV/AIDS | Bone Diseases, Metabolic | Opioid Dependence | HIV-1-infection | HCV Coinfection | Buprenorphine Dependence | Methadone Dependence | Co-infection

Canada
University of Washington

Completed

Enhance Wellness for Individuals With Long-Term Physical Disabilities

Multiple Sclerosis | Muscular Dystrophy | Spinal Cord Injury | Post-polio Syndrome

United States
Pfizer

Completed

An Open, Multicenter, Randomized, Dose-Ranging Study of Azithromycin in the Treatment of Disseminated Mycobacterium Avium-Intracellulare Complex Infection (MAC) in Patients With Acquired Immune Deficiency Syndrome (AIDS)

HIV Infections | Mycobacterium Avium-Intracellulare Infection

United States
Travera Inc
xCures

Recruiting

Mass Response of Tumor Cells as a Biomarker for Rapid Therapy Guidance (TraveraRTGx) (TraveraRTGx)

Melanoma | Carcinoma, Renal Cell | Carcinoma | Carcinoma, Non-Small-Cell Lung | Carcinoma, Hepatocellular | Carcinoma, Pancreatic | Pancreatic Cancer | Mesothelioma | Cholangiocarcinoma | Carcinoma, Neuroendocrine | Carcinoma, Small Cell | Pleural Effusion, Malignant | Carcinoma, Pancreatic Ductal | Carcinoma of the... and other conditions

United States
Memorial Sloan Kettering Cancer Center

Recruiting

A Study of MQ710 With and Without Pembrolizumab in People With Solid Tumor Cancer

Melanoma | Solid Tumor | Metastatic Cancer | Advanced Cancer | Head and Neck Squamous Cell Carcinoma | Kaposi Sarcoma | Merkel Cell Carcinoma | Angiosarcoma | Basal Cell Carcinoma | Extramammary Paget Disease | HNSCC | Refractory Cancer | Cutaneous Squamous Cell Carcinoma | BCC | Adnexal Carcinoma | BCC - Basal Cell Carcinoma and other conditions

United States
H. Lee Moffitt Cancer Center and Research Institute

Recruiting

The Pancreas Interception Center (PIC) for Early Detection, Prevention, and Novel Therapeutics

Lynch Syndrome | Pancreatic Ductal Adenocarcinoma | Chronic Pancreatitis | Pancreatic Cyst | Ataxia Telangiectasia | FAP | Peutz-Jeghers Syndrome | PALB2 Gene Mutation | BRCA Mutation | Fatty Pancreas | Genetic Pancreatic Cancer | Genetic Pancreatitis | Familial Atypical Multiple Mole-Melanoma

United States

Clinical Trials on DNA Strand Breaks

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Albania

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations