Clinical Trials on Degeneration of Macula and Posterior Pole in United Kingdom

Total 1016 results

Brighton and Sussex University Hospitals NHS Trust

Completed

Ocular Coherence Tomography During Cataract Assessment

Age Related Macular Degeneration | Cataract Senile | Epiretinal Membrane | Vitreomacular Traction | Macula Hole

United Kingdom
National Eye Institute (NEI)

Terminated

Treatment of Non-infectious Intermediate and Posterior Uveitis Associated Macular Edema With Intravitreal Methotrexate (MEXX)

Non-infectious Intermediate and Posterior Uveitis

United States
Bayer

Recruiting

The SPECTRUM Study: An Observational Study to Learn More About How Well Aflibercept 8 mg Works in Treating Visual Impairment Due to Neovascular Age-related Macular Degeneration or Diabetic Macula Edema

Visual Impairment | Neovascular Age-related Macular Degeneration (nAMD) | Diabetic Macula Edema (DME)

Germany, Canada, Denmark, France, Italy, Saudi Arabia, Switzerland, Australia, Finland, Netherlands, Sweden, Norway, United Arab Emirates, Japan, United Kingdom
Allergan

Completed

A Long-Term Safety Study of OZURDEX® in Clinical Practice

Macular Edema | Retinal Vein Occlusion | Uveitis, Posterior

France, Spain, Germany, United Kingdom
Tampa Bay Uveitis Center, LLC
Mallinckrodt

Completed

Study of H.P. ACTHAR Subcutaneous Gelatin (Gel)(Highly Purified Gel Injection) in Uveitis Patients

Uveitis | Posterior Uveitis | Intermediate Uveitis | Anterior Uveitis | Scleritis | Clinically Significant Macular Edema

United States
Optos, PLC
Johns Hopkins University; University of Southern California

Completed

Evaluation of the Precision of the Microperimetry Function of the Spectral OCT/SLO

Age-Related Macular Degeneration | Diabetic Retinopathy | Macular Edema | Retinal Vein Occlusion | Geographic Atrophy | Epiretinal Membrane | Macular Hole | Pattern Dystrophy of Macula | Central Serous Retinopathy

United States
Moorfields Eye Hospital NHS Foundation Trust
King's College London; Cardiff University; University College, London; Newcastle... and other collaborators

Recruiting

Quality-Assured Follow-up of Quiescent Neovascular Age -Related maculaR dEgeneration by Non-medical Practitioners (FENETRE)

AMD

United Kingdom
Newtricious R&D BV
Sprim Advanced Life Sciences

Completed

Intervention Trial in Early Age-related Macular Degeneration (I-TEAM)

Age-related Macular Degeneration (AMD)

United States, Germany, Netherlands, United Kingdom
Aviceda Therapeutics, Inc.

Recruiting

A Multiple Dose Study of AVD-104 for Geographic Atrophy (GA) Secondary to Age-Related Macular Degeneration (AMD) (SIGLEC)

Macular Degeneration | Geographic Atrophy of the Macula

United States
Oraya Therapeutics, Inc.

Withdrawn

Study to Evaluate the Safety and Effectiveness of IRay in Wet Age-related Macular Degeneration (AMD) Patients With Recurrent Leakage Secondary to Choroidal Neovascularisation (CNV)

Macular Degeneration | Age-related Macular Degeneration | AMD | Wet AMD | Wet Age-related Macular Degeneration

United Kingdom, Italy
Moorfields Eye Hospital NHS Foundation Trust
Brighton and Sussex University Hospitals NHS Trust; University Hospitals Bristol... and other collaborators

Completed

Multicentre Randomised Clinical Trial Comparing Fixed vs Pro re Nata (PRN) Dosing of 700 μg Dexamethasone (OZDRY)

Diabetic Macular Edema

United Kingdom
Bayer
Regeneron Pharmaceuticals

Terminated

A Study to Learn How Well Aflibercept Injected Into the Eye Works and How Safe it is When Given in Customized Treatment Intervals in Patients With an Eye Disease Called Neovascular Age-related Macular Degeneration After Start of Treatment (XPAND)

Neovascular (Wet) Age-related Macular Degeneration

Canada, United Kingdom
Manchester University NHS Foundation Trust
Topcon Corporation; Optos, PLC

Withdrawn

Sub-threshold Photocoagulation of Diabetic Macular Oedema (MEM)

Diabetic Macular Oedema

United Kingdom
University of Oxford
Pfizer

Completed

Intravitreal Macugen for Ischaemic Diabetic Macular Oedema (MIDME)

Diabetic Macular Oedema

United Kingdom
National Eye Institute (NEI)
The Emmes Company, LLC

Completed

Ranibizumab and Bevacizumab for Diabetic Macular Edema

Diabetic Macular Edema

United States, United Kingdom
VisionCare, Inc.

Recruiting

Post-market Clinical Investigation of the SING IMT System, Model NG SI IMT 3X in Patients With End-stage Age-related Macular Degeneration

Age-Related Macular Degeneration | AMD

Italy, Ireland, Spain, Germany, United Kingdom
Oraya Therapeutics, Inc.

Unknown

An Open-label Study to Evaluate the Clinical and Economic Benefits of I-Ray in Patients With Choroidal Neovascularization Secondary to Age-related Macular Degeneration (ENDEAVOUR)

Eye Diseases | Age-Related Macular Degeneration | Macular Degeneration | Retinal Diseases | Wet Macular Degeneration

United Kingdom
Portsmouth Hospitals NHS Trust

Completed

Epiretinal Membrane and Cystoid Macular Oedema Post-cataract Surgery (EPIC)

Epiretinal Membrane | Pseudophakic Cystoid Macular Oedema

United Kingdom
Novartis

Completed

Safety and Tolerability of an Intravenous Infusion of ACZ885 in Patients With Wet Age-Related Macular Degeneration

Wet Age-Related Macular Degeneration

United Kingdom, Switzerland
Clearside Biomedical, Inc.

Completed

Suprachoroidal Injection of CLS-TA in Subjects With Macular Edema Associated With Non-infectious Uveitis (PEACHTREE)

Uveitis, Anterior | Panuveitis | Uveitis | Uveitis, Posterior | Uveitis, Intermediate

United States, Israel, India
Guy's and St Thomas' NHS Foundation Trust
Macusoft

Not yet recruiting

Artificial Intelligence Diagnostic Aid (AID)

Diabetic Macular Edema | Retinal Vein Occlusion | Wet Macular Degeneration

United Kingdom
Clearside Biomedical, Inc.

Completed

Suprachoroidal Injection of Triamcinolone Acetonide in Subjects With Macular Edema Following Non-Infectious Uveitis (DOGWOOD)

Uveitis, Anterior | Panuveitis | Uveitis | Macular Edema | Uveitis, Posterior | Uveitis, Intermediate

United States
King's College Hospital NHS Trust

Completed

Intravitreal tPA and C3F8 for the Treatment of Submacular Haemorrhage as a Complication of Neovascular AMD (TAPAS)

Exudative Macular Degeneration | Retinal Hemorrhage

United Kingdom
NeoVista

Unknown

A Study of the NeoVista Ophthalmic System for the Treatment of Subfoveal CNV Associated With Wet AMD in Patients That Require Persistent Anti-VEGF Therapy (MERITAGE)

Age Related Macular Degeneration

United Kingdom, Israel, United States
VisionCare, Inc.

Completed

A Study of an Implantable Miniature Telescope in Patients With With End-Stage AMD

End Stage Macular Degeneration

United Kingdom
Manhattan Eye, Ear & Throat Hospital
Alcon Research

Completed

Treatment of Conditions With Open Label-Anecortave Acetate Sterile Suspension ( 15mg.) Where Lesions do Not Meet Acceptable Criteria for Standard Care.

Age-Related Macular Degenerations. | Subfoveal Neovascularization.

United States
Massachusetts Eye and Ear Infirmary

Withdrawn

Use of Self-management Group to Improve Quality of Life in Patients With Low Vision

Age Related Macular Degeneration

United States
Moorfields Eye Hospital NHS Foundation Trust
Novartis

Completed

The LIMO Study, Lucentis for Treatment of Uveitic Patients With Refractory Cystoid Macular Oedema

Uveitis Related Cystoid Macular Edema | Steroid-induced Glaucoma - Borderline

United Kingdom
Frank G. Holz
Radboud University Medical Center; Bayer; Hoffmann-La Roche; Novartis Pharmaceuticals and other collaborators

Active, not recruiting

Development of Novel Clinical Endpoints in Intermediate AMD (MACUSTAR)

Age Related Macular Degeneration (AMD)

Germany, Italy, Netherlands, United Kingdom, France, Portugal, Denmark
South Warwickshire NHS Foundation Trust
Aston University

Unknown

Polarization Perception in Health and Disease. Testing a New Sight Test (TaNSiT)

Diabetic Retinopathy | Cataract | Age Related Macular Degeneration | Macular Disease | Pseudophakia | Retinal Disease

United Kingdom
University of Illinois at Chicago

Completed

Treatment of Cystoid Macular Edema in Patients With Retinal Degeneration

Retinal Degenerations

United States
Pfizer

Terminated

A Study Of Early Markers Of Choroidal Neovascularization

Age-related Macular Degeneration (AMD) | Choroidal Neovascularization (CNV) | Early Markers

Italy, Portugal, United Kingdom
EyeBiotech Ltd.

Recruiting

A 2-part Study Consisting of Multiple Ascending Dose (MAD) Safety Study, and a Dose-finding Masked Study to Assess the Safety and Efficacy of Intravitreal (IVT) EYE103 in Patients With Diabetic Macular Edema (DME) or Neovascular Age-related Macular Degeneration (NVAMD) (AMARONE)

Diabetic Macular Edema (DME) | Neovascular Age-related Macular Degeneration (NVAMD)

United States, Argentina, Puerto Rico, United Kingdom
King's College Hospital NHS Trust
King's College London; Fight for Sight (Funder)

Recruiting

Vitrectomy, Subretinal Tissue Plasminogen Activator (TPA) and Intravitreal Gas for Submacular Haemorrhage Secondary to Exudative (Wet) Age-related Macular Degeneration (TIGER). (TIGER)

Eye Diseases | Macular Degeneration, Wet | Sub-Macular Hemorrhage

United Kingdom
Bayer
Regeneron Pharmaceuticals

Completed

Evaluation of Changes in Visual Acuity in Patients With Diabetic Macular Edema (DME) Starting Treatment With an Approved Anti-VEGF Therapy (POLARIS)

Macular Degeneration | Macular Edema | Ophthalmology

Slovakia, France, Germany, Spain, Russian Federation, United Kingdom, Portugal, Greece
King's College Hospital NHS Trust
King's College London

Active, not recruiting

Stereotactic Radiotherapy for Wet AMD (STAR) (STAR)

Neovascular (Wet) Age-related Macular Degeneration (AMD)

United Kingdom
The New York Eye & Ear Infirmary

Completed

Comparison of a Spectral OCT/SLO With the Stratus OCT for Imaging Various Retinal Pathologies

Posterior Vitreous Detachment | Epiretinal Membrane | Macular Hole | RPE Detachment

United States
University of Miami
Genentech, Inc.

Completed

Prospective OCT Study With Lucentis for Neovascular AMD (PrONTO Study)

Neovascular Age-Related Macular Degeneration

United States
Bayer

Completed

A Study to Assess the Effectiveness of Aflibercept in Routine Clinical Practice in Patients With Diabetic Macular Oedema (DRAKO)

Macular Edema

United Kingdom
Astellas Institute for Regenerative Medicine

Completed

A Follow up Study to Determine the Safety and Tolerability of Sub-retinal Transplantation of Human Embryonic Stem Cell Derived Retinal Pigmented Epithelial (hESC-RPE) Cells in Patients With Stargardt's Macular Dystrophy (SMD)

Stargardt's Macular Dystrophy

United Kingdom
Moorfields Eye Hospital NHS Foundation Trust
Bayer

Completed

Aflibercept for Macular Oedema With Underlying Retinitis Pigmentosa (AMOUR) Study (AMOUR)

Retinitis Pigmentosa | Macular Oedema

United Kingdom
The Retina Center of St. Louis County, PC
ZeaVision, Inc.

Completed

Addition of 20mg/Day Zeaxanthin to Triple Therapy Treatment Options for Age Related Macular Degeneration (ARMD) (ARMD)

Exudative Age-Related Macular Degeneration

United States
ThromboGenics

Completed

Safety and Efficacy Study of Intravitreal Ocriplasmin in Subjects With AMD With Focal Vitreomacular Adhesion (MIVI-5)

Exudative Age-Related Macular Degeneration | Focal Vitreomacular Adhesion

United States, United Kingdom, Germany, France, Belgium, Italy
Sequenom, Inc.

Completed

Association of Macular Pigment Optical Density (MPOD) and Genetic Variants in Complement Factor H in Subjects With Choroidal Neovascular (CNV)

Age-related Macular Degeneration | Choroidal Neovascular Age-related Macular Degeneration

United States
Vitreous -Retina- Macula Consultants of New York

Unknown

Intense Treatment Regimen With Intravitreal Aflibercept Injection (I-TRAP)

Neovascular Age-Related Macular Degeneration

United States
Astellas Institute for Regenerative Medicine

Completed

Safety and Tolerability of Sub-retinal Transplantation of Human Embryonic Stem Cell Derived Retinal Pigmented Epithelial (hESC-RPE) Cells in Patients With Stargardt's Macular Dystrophy (SMD)

Stargardt's Macular Dystrophy

United Kingdom
Retinal Consultants of Arizona
Ophthotech Corporation

Completed

An Open-Label Investigator Sponsored Trial to Investigate the Safety, Tolerability and Development of Subfoveal Fibrosis By Intravitreal Administration of Altering Regimens of Fovista and Anti-VEGF Therapy in Subjects With Neovascular Age-Related Macular Degeneration

Neovascular Age-Related Macular Degeneration

United States
Vance Thompson Vision - MT

Unknown

The PRIME Study: A Randomized, Controlled, Prospective Study

Patient Preference | Post-Operative Inflammation | Patient Outcomes | Grade of Post-Operative Cystoid Macular Edema | Rate of Post-Operative Cystoid Macular Edema

United States
Mid-Atlantic Retina Consultations, Inc.
West Virginia University

Unknown

Supplemental Adjuvants for Intracellular Nutrition and Treatment (SAINTS)

Diabetic Macular Edema | Neovascular Age-related Macular Degeneration

United States
Bayer

Completed

Investigation of the Change of Vision-related Quality of Life in Subjects Treated With Aflibercept According to EU Label for DME. (AQUA)

Macular Edema

Spain, Canada, Switzerland, Portugal, Austria, Poland, Slovakia, United Kingdom, France, Czechia, Germany, Hungary, Italy, Lithuania

Clinical Trials on Degeneration of Macula and Posterior Pole in United Kingdom

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