Clinical Trials on Degenerative Changes

Total 8270 results

Charite University, Berlin, Germany

Not yet recruiting

Hyperthermia Enhanced Re-irradiation of Loco-regional Recurrent Tumors (HETERERO)

Sarcoma | Cervical Cancer | Esophageal Cancer | Rectal Cancer | Prostate Cancer | Neuroendocrine Tumors | Pancreas Cancer | Anal Cancer | Squamous Cell Carcinoma | Recurrent Cancer

Germany
City of Hope Medical Center
National Cancer Institute (NCI)

Completed

Metformin Hydrochloride and Ritonavir in Treating Patients With Relapsed or Refractory Multiple Myeloma or Chronic Lymphocytic Leukemia

Fatigue | Anemia | Weight Loss | Thrombocytopenia | Fever | Refractory Plasma Cell Myeloma | Lymphadenopathy | Refractory Chronic Lymphocytic Leukemia | Recurrent Plasma Cell Myeloma | Splenomegaly | Recurrent Chronic Lymphocytic Leukemia | Lymphocytosis | Night Sweats

United States
Nantes University Hospital

Not yet recruiting

Premorbid Personality Profile of Patients With Cognitive and Behavioral Disorders

Bipolar Disorder | Behavioral Variant of Frontotemporal Disorder (bvFTD) | Phenocopy Frontotemporal Dementia (phFTD) | Frontal Variant of Alzheimer Disease
University of Texas at Austin
Hospital Clinic of Barcelona; Fundació Institut de Recerca de l'Hospital de...

Recruiting

Cognitive Reserve and Response to Speech-Language Intervention in Bilingual Speakers With Primary Progressive Aphasia

Neurocognitive Disorders | Neurodegenerative Diseases | Dementia | Alzheimer Disease | Language Disorders | Communication Disorders | Primary Progressive Aphasia | Aphasia | Speech Disorders | Frontotemporal Lobar Degeneration | Dysarthria | Apraxia, Motor | Dementia, Frontotemporal | Bilingual Aphasia

Spain, United States
University College, London
University of Oxford; Newcastle University; University of Cambridge; University... and other collaborators

Recruiting

PROgressive Supranuclear Palsy CorTico-Basal Syndrome Multiple System Atrophy Longitudinal Study UK (PROSPECT-M)

Corticobasal Degeneration | Multiple System Atrophy (MSA) | Progressive Supranuclear Palsy (PSP)

United Kingdom
Geisinger Clinic

Completed

Group-Based Telehealth Music Therapy Intervention for Patients With Dementia: A Pilot Study

Alzheimer Disease | Lewy Body Disease | Frontotemporal Dementia | Behavioral and Psychiatric Symptoms of Dementia

United States
Thomas Jefferson University
Independence Blue Cross

Active, not recruiting

Telehealth-enabled Integrated Palliative Care for People With Dementia (IBC)

Alzheimer Disease | Frontotemporal Degeneration | Vascular Dementia | Dementia of Alzheimer Type | Lewy Body Dementia | Mixed Dementia | Vascular Cognitive Impairment

United States
University of California, San Francisco
National Institute on Aging (NIA); University of Nebraska; Centers for Medicare...

Completed

Care Ecosystem: Navigating Patients and Families Through Stages of Care, Extension Trial

Dementia | Alzheimer Disease | Lewy Body Disease | Dementia, Vascular | Frontotemporal Lobar Degeneration | Memory Disorders
ProQR Therapeutics

Active, not recruiting

Study to Evaluate the Efficacy Safety and Tolerability of Ultevursen in Subjects With RP Due to Mutations in Exon 13 of the USH2A Gene (Sirius)

Eye Diseases | Retinitis Pigmentosa | Eye Diseases, Hereditary | Vision Disorders | Retinal Disease | Eye Disorders Congenital | Usher Syndrome Type 2 | Deaf Blind

United States, Netherlands, United Kingdom, Germany
Institut National de la Santé Et de la Recherche...
Fondation pour la Recherche Médicale

Completed

Study of the Neural Basis of Analogical Reasoning (ANALOG)

Healthy Subjects | Frontotemporal Dementia | Progressive Supranuclear Palsy

France
University of Colorado, Denver

Completed

Defining Phenotypes of Movement Disorders :Parkinson's Plus Disorders (PD), Essential Tremor (ET), Cortical Basal Degeneration (CBD), Multiple Systems Atrophy (MSA), Magnetoencephalography. (PHENO)

Parkinson Disease | Supranuclear Palsy, Progressive | Multiple System Atrophy | Corticobasal Degeneration | Essential Tremor

United States
Centre Hospitalier Princesse Grace
Association de Recherche Bibliographique pour les Neurosciences

Completed

Eye Gaze Strategies During Facial Emotion Recognition in Neurodegenerative Diseases: Links With Neuropsychiatric Disorders (EYE-ToM Study) (EYE-ToM)

Parkinson Disease(PD) | Alzheimer's Dementia | Fronto-Temporal Dementia
Asan Medical Center
Korea Health Industry Development Institute

Completed

Evaluation of [18F]PI-2620 as a Potential Positron Emission Computed Tomography Radioligand for Imaging Tau Protein in the Brain

Parkinson Disease | Alzheimer Disease | Healthy Volunteer | Frontotemporal Dementia

Korea, Republic of
Wroclaw Medical University

Enrolling by invitation

Selected Disorders and Sleep Bruxism

Cardiovascular Diseases | Hypertension | Sleep Apnea | Cardiovascular Risk Factor | Sleep Disorders | Temporomandibular Disorder | Sleep Bruxism | Thyroid Dysfunction | Mental Status Change

Poland
Greece 2021 Committee
Greek Alzheimer's Association and Related Disorders; Ionian University

Enrolling by invitation

Digitally-enhanced, Decentralized, Multi-omics Observational Cohort (ANANEOS)

Dementia | Cognitive Change | Alzheimer Disease | Mild Cognitive Impairment | Parkinson's Disease and Parkinsonism | Presymptomatic Disease | Memory Loss (Excluding Dementia)

Greece
Queen Mary University of London

Not yet recruiting

The Use of the CUE1 in People With Parkinson's Disease and Related Disorders

Dystonia | Multiple System Atrophy | Corticobasal Degeneration | Progressive Supranuclear Palsy | Tremor | Parkinson's Disease and Parkinsonism | Vascular Parkinsonism
Chinese University of Hong Kong

Recruiting

Localized Analysis of Normalized Distance From Scalp to Cortex and Personalized Evaluation (LANDSCAPE) (LANDSCAPE)

Parkinson Disease | Aging | Dementia Alzheimers | Depression in Old Age | Dementia Frontotemporal

Hong Kong
Xuanwu Hospital, Beijing
H. Lundbeck A/S; Hoffmann-La Roche; Millennium Pharmaceuticals, Inc.; Biogen; XINGIMAGING... and other collaborators

Recruiting

Tau Protein and SV2a Imaging in Patients With Tau Protein-related Diseases

Alzheimer Disease | Frontotemporal Dementia | Progressive Supranuclear Palsy

China
Mayo Clinic
Astellas Pharma Inc; Casimir, LLC

Recruiting

Genomic Profiling of Mitochondrial Disease - Imaging Analysis for Precise Mitochondrial Medicine

Mitochondrial Diseases | Mitochondrial Myopathies | Kearns-Sayre Syndrome | Mitochondrial DNA Mutation | Chronic Progressive External Ophthalmoplegia With Myopathy

United States
University of Novi Sad
Merck Sharp & Dohme LLC

Recruiting

Neuroinflammation and Neurodegeneration in HIV-positive Subjects Switched and Initially Treated With INSTI

Metabolic Syndrome | Aging | HIV I Infection | HIV Associated Lipodystrophy

Serbia
University of Wisconsin, Madison
National Institute on Aging (NIA)

Completed

A Relational Research Recruitment and Engagement Intervention for Cognitive Aging Research

Cognitive Dysfunction | Dementia | Alzheimer Disease | Lewy Body Disease | Frontotemporal Dementia

United States
ProQR Therapeutics

Terminated

Study to Evaluate the Efficacy Safety and Tolerability of QR-421a in Subjects With RP Due to Mutations in Exon 13 of the USH2A Gene With Early to Moderate Vision Loss (Celeste)

Eye Diseases | Retinitis Pigmentosa | Eye Diseases, Hereditary | Vision Disorders | Retinal Disease | Eye Disorders Congenital | Usher Syndrome Type 2 | Deaf Blind

United States, United Kingdom
Centre Hospitalier Princesse Grace
Association de Recherche Bibliographique pour les Neurosciences

Completed

Assessment of Empathetic Process by Scanpath Study of an Artwork (EYE-EMPATH)

Parkinson Disease | Alzheimer Dementia | Fronto-Temporal Dementia

Monaco
Mayo Clinic

Completed

PiB PET Scanning in Speech and Language Based Dementias

Primary Progressive Aphasia | Aphasia | Semantic Dementia | Apraxia of Speech | Primary Progressive Nonfluent Aphasia | PPA | Non-fluent Aphasia | Progressive Aphasia

United States
Mayo Clinic

Completed

Amyloid-related Imaging Abnormalities (Microbleeds) in Atypical AD

Posterior Cortical Atrophy (PCA) | Atypical Alzheimers Disease | Logopenic Variant of Primary Progressive Aphasia (LPA)

United States
Hospices Civils de Lyon

Recruiting

Is Myocardial Stunning Induced by Continuous Renal Replacement Therapy a Reality in Critically Ill Patients? (MS-CRRT)

Myocardial Stunning | Acute Kidney Injury KDIGO 3 | Continuous Renal Replacement Therapy Initiated by the Clinician in Charge Without Emergency

France
Hospital de Niños R. Gutierrez de Buenos Aires

Recruiting

Implementation Strategy of Bio-molecular Techniques for Early Diagnose of Congenital Syphilis and Chagas Diseases

Chagas Disease | Syphilis

Argentina
Michael Iv

Completed

Using Ferumoxytol-Enhanced MRI to Measure Inflammation in Patients With Brain Tumors or Other Conditions of the CNS

Brain Injury | Brain Cancer | Brain Tumors | Primary Brain Neoplasm | Ischemic Cerebrovascular Accident | Central Nervous System Degenerative Disorder | Central Nervous System Infectious Disorder | Central Nervous System Vascular Malformation | Hemorrhagic Cerebrovascular Accident

United States
Lawson Health Research Institute

Recruiting

Investigating Genetic Status in Patients Presenting to Clinic

Lewy Body Dementia (LBD) | Alzheimer Dementia (AD) | Dementia, Frontotemporal

Canada
Mayo Clinic
National Institute on Deafness and Other Communication Disorders (NIDCD)

Recruiting

Longitudinal Multi-Modality Imaging in Progressive Apraxia of Speech

Primary Progressive Aphasia | Apraxia of Speech | PPA | Non-fluent Aphasia | Primary Progressive Non-fluent Aphasia

United States
University of Miami
National Institute of Neurological Disorders and Stroke (NINDS); National Institutes...

Active, not recruiting

TRIAL READY (Clinical Trial Readiness)

Amyotrophic Lateral Sclerosis | Primary Lateral Sclerosis | Frontotemporal Dementia | Progressive Muscular Atrophy | ALS-Frontotemporal Dementia

United States
University of Alberta

Withdrawn

Digital Smartwatch Measurements as Potential Biomarkers for Remote Disease Tracking in ALS

Healthy | Amyotrophic Lateral Sclerosis | Primary Lateral Sclerosis | Frontotemporal Dementia | Muscular Atrophy, Progressive

Canada
Boston Sight
EYEdeal scanning, LTC

Completed

Pilot Study to Investigate the Feasibility, Reliability and Efficacy of Utilizing OCT to Automate PROSE Fitting

Dry Eye Syndromes | Keratoconjunctivitis Sicca | Keratoconus | Sjogren's Syndrome | Ocular Surface Disease | Ectasia | Pellucid Marginal Corneal Degeneration | Corneal Trauma | Corneal Scar

United States
Ultragenyx Pharmaceutical Inc

Terminated

Adeno-Associated Virus (AAV) Antibody Study in Subjects OTC Deficiency, GSDIa, and Wilson Disease

Wilson Disease | Ornithine Transcarbamylase Deficiency | Glycogen Storage Disease Type IA

Spain, United Kingdom, Canada, United States, Brazil
Chang Gung Memorial Hospital

Completed

18F-PM-PBB3 PET Study in Tauopathy Including Alzheimer's Disease, Other Dementias and Normal Controls

Frontotemporal Dementia | Progressive Supranuclear Palsy | Alzheimer's Disease | Vascular Cognitive Impairment | Cortical Basal Syndrome

Taiwan
Sanguine Biosciences

Recruiting

Tissue Repository Providing Annotated Biospecimens for Approved Investigator-directed Biomedical Research Initiatives

Heart Diseases | Stroke | Lymphoma | Multiple Sclerosis | Kidney Diseases | Diabetes | Leukemia | Age-Related Macular Degeneration | Cancer | Arthritis | Schizophrenia | Thyroid Diseases | Parkinson Disease | Hepatitis | Vasculitis | Psoriasis | Asthma | Amyloidosis | Fibromyalgia | Graves Disease | Alzheimer Disease | Celiac Disease | Cirr... and other conditions

United States
Lei Li
Beijing Hospital; China-Japan Friendship Hospital; Navy General Hospital, Beijing and other collaborators

Unknown

Granulocyte Colony Stimulating Factor for for the Prevention of Febrile Neutropenia in Epithelial Ovarian Cancer

Quality of Life | Epithelial Ovarian Cancer | Chemotherapy-induced Neutropenia | Overall Survival | Progression-free Survival | Febrile Neutropenia, Drug-Induced | Colony Stimulating Factors Adverse Reaction | Granulocyte Colony Stimulating Factor | Cost-effectiveness Analysis

China
University of California, Irvine

Recruiting

Characterization of Inclusion Body Myopathy Associated With Paget's Disease of Bone and Frontotemporal Dementia (IBMPFD)

Frontotemporal Dementia | Myopathy | Inclusion Body Myopathy With Early-onset Paget Disease and Frontotemporal Dementia | Paget Disease of Bone

United States
University College, London

Unknown

Imaging Neuromelanin and Iron in Dystonia/Parkinsonism

Mitochondrial Diseases | Dystonia, Familial | Sporadic Dystonia | Parkinson Disease, Juvenile | Neurodegeneration With Brain Iron Accumulation 5
Wuhan University
Peking University; Pfizer

Unknown

Efficacy and Safety of Ziprasidone to Treat Depressive Symptoms in Patients With Schizophrenia

The Primary Evaluation is the Change From Baseline at End of Study for CDSS Total Scores. | The Secondary Efficacy Evaluations Include: MADRS, PANSS Total Scores and Subscales and Responder Rate; CGI-S and CGI-I Scales. | Safety Evaluations Include: Laboratory Test Abnormalities; BARS... and other conditions
Mayo Clinic
National Institute on Aging (NIA); Minnesota HealthSolutions

Recruiting

A Study of Caregiver Connections Via Technology in Dementia

Dementia | Alzheimer Disease | Frontotemporal Dementia | Lewy Body Dementia | Parkinson Disease Dementia | Caregiver Stress

United States
University of Dublin, Trinity College
Motor Neurone Disease Association, UK; Irish Research Council, IE; Thierry Latran... and other collaborators

Recruiting

EEG and TMS-based Biomarkers of ALS, MS and FTD

Multiple Sclerosis | Amyotrophic Lateral Sclerosis | Frontotemporal Dementia

Ireland
University of Miami
National Institute of Neurological Disorders and Stroke (NINDS); National Institutes... and other collaborators

Recruiting

Clinical Procedures to Support Research in ALS (CAPTURE-ALS)

Amyotrophic Lateral Sclerosis | Primary Lateral Sclerosis | Progressive Muscular Atrophy | ALS-Frontotemporal Dementia

United States
Mayo Clinic
National Institute on Aging (NIA); Minnesota HealthSolutions

Withdrawn

A Study to Evaluate Caregiver Connections Via Technology for Patients With Alzheimer's and Other Types of Dementia

Dementia | Frontotemporal Dementia | Alzheimer Dementia | Lewy Body Dementia | Parkinson Disease Dementia | Caregiver Stress
Skane University Hospital
AC Immune SA

Completed

Optimization of Morphomer-based Alpha-synuclein PET Tracers

Parkinson Disease | Multiple System Atrophy | Corticobasal Degeneration | Progressive Supranuclear Palsy | Dementia With Lewy Bodies

Sweden
University of Eastern Finland
University of Sheffield; Sheffield Teaching Hospitals NHS Foundation Trust; VTT... and other collaborators

Completed

Computational Tools for Early Diagnosis of Memory Disorders (ProsKuopio)

Alzheimer Disease | Mild Cognitive Impairment | Frontotemporal Dementia | Dementia, Vascular

Finland
Stanford University
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Recruiting

Interventions in Mathematics and Cognitive Skills

Cognitive Dysfunction | Cognitive Change | Learning Disabilities | Individuality | Child Development | Developmental Disability | Behavior | Cognition | Learning Curve | Decision Making | Behavior and Behavior Mechanisms | Behavior, Child | Cognitive Impairment, Mild | Cognition Disorder | Neuroscience | Cognitive Orientation and other conditions

United States
Augusta University

Completed

Contribution of Dolutegravir to Obesity and Cardiovascular Disease

Vascular Diseases | Body Weight Changes | Cardiovascular Abnormalities | HIV-1-infection | Body Fat Disorder | HIV-Associated Lipodystrophy Syndrome | Antiviral Drug Adverse Reaction | Abnormality of Adipose Tissue

United States
University Hospital, Geneva
University of Khartoum; Institute of Tropical Medicine, Belgium; Institut National... and other collaborators

Completed

Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases In Patients With Persistent Fever in Cambodia, Nepal, Democratic Republic of the Congo and Sudan (NIDIAG-Fever)

HIV | Tuberculosis | Malaria | Visceral Leishmaniasis | Brucellosis | Relapsing Fever | Leptospirosis | Melioidosis | Human African Trypanosomiasis | Enteric Fever | Rickettsial Diseases | Amoebic Liver Abscess

Congo, The Democratic Republic of the, Cambodia, Nepal, Sudan
Maria Sklodowska-Curie National Research Institute...

Unknown

Hypofractionated Radiotherapy With Hyperthermia in Unresectable or Marginally Resectable Soft Tissue Sarcomas (SINDIR)

Sarcoma | Leiomyosarcoma | Fibrosarcoma | Myxoid Liposarcoma | Synovial Sarcoma | Undifferentiated Pleomorphic Sarcoma | Alveolar Soft Part Sarcoma | Liposarcoma, Dedifferentiated | Clear Cell Sarcoma | Malignant Peripheral Nerve Sheath Tumors | Pleomorphic Rhabdomyosarcoma

Poland

Clinical Trials on Degenerative Changes

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Bahamas

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations