Study of the Neural Basis of Analogical Reasoning (ANALOG)

August 27, 2025 updated by: Institut National de la Santé Et de la Recherche Médicale, France

Organisation du Cortex préfrontal ventrolatéral Pour l'Analogie: Approche Bimodale Chez le Sujet Sain et Chez le Patient Ayant un Syndrome Frontal.

Frontal patients are impaired in categorisation and analogical reasoning tasks, and different functional imaging studies from our group have shown the involvement of the prefrontal cortex in categorisation and analogy tasks. The aim of this project is to test our hypotheses about the role of the prefrontal cortex in explicit and implicit categorisation and analogy tasks.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

130

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • France
      • Paris, France, 75013
        • ICM (Institut du cerveau et de la Moelle épinière)

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

20 years to 85 years (Adult, Older Adult)

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

Healthy subjects:

  • subject affiliated to national health insurance
  • informed consent signed
  • normal neurological examination
  • subject aged at least 20

Patients:

  • FTD or PSP diagnostic criteria filled
  • patient affiliated to national health insurance
  • informed consent signed

Exclusion Criteria:

  • Severe psychiatric symptomatology and psychotropic drug use
  • unability to understand or perform the cognitive tasks.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Basic Science
  • Allocation: Non-Randomized
  • Interventional Model: Crossover Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: FTD (frontotemporal dementia) patients
fronto-temporal demential patients
Other: MRI imaging
Other: EEG recording
Behavioral: Neuropsychological examination
Experimental: PSP patients
progressive supra nuclear palsy patients
Other: MRI imaging
Other: EEG recording
Behavioral: Neuropsychological examination
Active Comparator: healthy controls
healthy control education matched, age matched and sex matched with PSP and FTD patients
Other: MRI imaging
Other: EEG recording
Behavioral: Neuropsychological examination
Experimental: healthy participants
healthy participants that will participate to the TMS study.
Device: transcranial magnetic stimulation
Other: MRI imaging
Other: EEG recording
Behavioral: Neuropsychological examination
Experimental: healthy young participants
Healthy participants will be included for an EEG study
Other: EEG recording
Behavioral: Neuropsychological examination

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Performance in the implicat task
Time Frame: day of inclusion (one day)

Reaction time and accuracy will be registered for this categorization task. This task will be used in patients with FTD and in healthy controls (n=60).

Participants will come only once during one day ot the research centre.
day of inclusion (one day)
Performance in the Similitude task
Time Frame: from inclusion to 4 months after inclusion

Reaction time and accuracy will be recorded while healthy subjects perform this categorization task, after a session of rTMS or during on line TMS (n=40).

Participants will come 3 to 5 times at the research centre in a maximum period of 4 months.
from inclusion to 4 months after inclusion

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
recording of EEG
Time Frame: day of inclusion (one day)

EEG will be recorded in patients with FTD and in healthy controls for an analysis of event related potentials.

Participants will come only once during one day a the research centre.
day of inclusion (one day)
Analysis of MRI
Time Frame: day of inclusion (one day)

T1 MRI will be recorded for VBM analysis in patients with FTD and healthy controls.

Participants will come only once during one day at the research centre
day of inclusion (one day)

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Institut National de la Santé Et de la Recherche Médicale, France

Collaborators

Fondation pour la Recherche Médicale

Investigators

  • Principal Investigator: Richard Levy, MD, PhD, Institut du Cerveau et de la Moelle épinière, Paris

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

February 1, 2015

Primary Completion (Actual)

February 1, 2021

Study Completion (Actual)

February 1, 2021

Study Registration Dates

First Submitted

August 28, 2014

First Submitted That Met QC Criteria

September 9, 2014

First Posted (Estimated)

September 11, 2014

Study Record Updates

Last Update Posted (Estimated)

September 4, 2025

Last Update Submitted That Met QC Criteria

August 27, 2025

Last Verified

March 1, 2017

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • C14-17'
  • 140662B-31 (Other Identifier: ANSM (Agence Nationale de Sécurité du Médicament))
  • 2014-A00649-38 (Other Identifier: ANSM ID RCB)

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

UNDECIDED

IPD Plan Description

IPD sharing will be only performed on individual request for a specified study.

Drug and device information, study documents

product manufactured in and exported from the U.S.

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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