Study of the Neural Basis of Analogical Reasoning (ANALOG)

Organisation du Cortex préfrontal ventrolatéral Pour l'Analogie: Approche Bimodale Chez le Sujet Sain et Chez le Patient Ayant un Syndrome Frontal.

Frontal patients are impaired in categorisation and analogical reasoning tasks, and different functional imaging studies from our group have shown the involvement of the prefrontal cortex in categorisation and analogy tasks. The aim of this project is to test our hypotheses about the role of the prefrontal cortex in explicit and implicit categorisation and analogy tasks.

Study Overview

• Status: Completed
• Conditions: Healthy Subjects; Frontotemporal Dementia; Progressive Supranuclear Palsy
• Intervention / Treatment: Device: transcranial magnetic stimulation; Other: MRI imaging; Other: EEG recording; Behavioral: Neuropsychological examination

• Study Type: Interventional
• Enrollment (Actual): 130
• Phase: Not Applicable

Contacts and Locations

Study Locations

• France
  • Paris, France, 75013
    • ICM (Institut du cerveau et de la Moelle épinière)

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 20 years to 85 years (Adult, Older Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

Description

Inclusion Criteria:

Healthy subjects:

• subject affiliated to national health insurance
• informed consent signed
• normal neurological examination
• subject aged at least 20

Patients:

• FTD or PSP diagnostic criteria filled
• patient affiliated to national health insurance
• informed consent signed

Exclusion Criteria:

• Severe psychiatric symptomatology and psychotropic drug use
• unability to understand or perform the cognitive tasks.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: Non-Randomized
• Interventional Model: Crossover Assignment
• Masking: None (Open Label)

Number of Arms

5

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: FTD (frontotemporal dementia) patients; fronto-temporal demential patients	Other: MRI imaging; Other: EEG recording; Behavioral: Neuropsychological examination
Experimental: PSP patients; progressive supra nuclear palsy patients	Other: MRI imaging; Other: EEG recording; Behavioral: Neuropsychological examination
Active Comparator: healthy controls; healthy control education matched, age matched and sex matched with PSP and FTD patients	Other: MRI imaging; Other: EEG recording; Behavioral: Neuropsychological examination
Experimental: healthy participants; healthy participants that will participate to the TMS study.	Device: transcranial magnetic stimulation; Other: MRI imaging; Other: EEG recording; Behavioral: Neuropsychological examination
Experimental: healthy young participants; Healthy participants will be included for an EEG study	Other: EEG recording; Behavioral: Neuropsychological examination

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Performance in the implicat task	Reaction time and accuracy will be registered for this categorization task. This task will be used in patients with FTD and in healthy controls (n=60). Participants will come only once during one day ot the research centre.	day of inclusion (one day)
Performance in the Similitude task	Reaction time and accuracy will be recorded while healthy subjects perform this categorization task, after a session of rTMS or during on line TMS (n=40). Participants will come 3 to 5 times at the research centre in a maximum period of 4 months.	from inclusion to 4 months after inclusion

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
recording of EEG	EEG will be recorded in patients with FTD and in healthy controls for an analysis of event related potentials. Participants will come only once during one day a the research centre.	day of inclusion (one day)
Analysis of MRI	T1 MRI will be recorded for VBM analysis in patients with FTD and healthy controls. Participants will come only once during one day at the research centre	day of inclusion (one day)

Collaborators and Investigators

• Sponsor: Institut National de la Santé Et de la Recherche Médicale, France
• Collaborators: Fondation pour la Recherche Médicale
• Investigators: Principal Investigator: Richard Levy, MD, PhD, Institut du Cerveau et de la Moelle épinière, Paris

Study record dates

Study Major Dates

• Study Start (Actual): February 1, 2015
• Primary Completion (Actual): February 1, 2021
• Study Completion (Actual): February 1, 2021

Study Registration Dates

• First Submitted: August 28, 2014
• First Submitted That Met QC Criteria: September 9, 2014
• First Posted (Estimate): September 11, 2014

Study Record Updates

• Last Update Posted (Actual): April 1, 2022
• Last Update Submitted That Met QC Criteria: March 21, 2022
• Last Verified: March 1, 2017

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Mental Disorders; Metabolic Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Eye Diseases; Neurologic Manifestations; Neurobehavioral Manifestations; Neurocognitive Disorders; Basal Ganglia Diseases; Movement Disorders; Neurodegenerative Diseases; TDP-43 Proteinopathies; Proteostasis Deficiencies; Dementia; Tauopathies; Cranial Nerve Diseases; Ocular Motility Disorders; Language Disorders; Communication Disorders; Paralysis; Speech Disorders; Frontotemporal Lobar Degeneration; Ophthalmoplegia; Aphasia; Frontotemporal Dementia; Aphasia, Primary Progressive; Pick Disease of the Brain; Supranuclear Palsy, Progressive
• Other Study ID Numbers: C14-17'; 140662B-31 (Other Identifier: ANSM (Agence Nationale de Sécurité du Médicament)); 2014-A00649-38 (Other Identifier: ANSM ID RCB)

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED
• IPD Plan Description: IPD sharing will be only performed on individual request for a specified study.