Clinical Trials on Degenerative Intervertebral Discs

Total 4444 results

Radboud University Medical Center
Stichting Ushersyndroom

Active, not recruiting

Characterizing Rate of Progression in USHer Syndrome (CRUSH) Study (CRUSH)

Retinitis Pigmentosa | Usher Syndrome, Type 2A | USH2A

Netherlands
University of British Columbia

Terminated

Transcranial Magnetic Stimulation in Nonfluent/Agrammatic Variant Primary Progressive Aphasia

Primary Progressive Nonfluent Aphasia

Canada
Assistance Publique - Hôpitaux de Paris

Completed

Inhibitory rTMS in Dystonic Wilson Patients (WILSTIM)

Movement Disorders | Wilson Disease | Repetitive Transcranial Magnetic Stimulation

France
Axon Neuroscience SE

Unknown

A 24-month Phase 1 Pilot Study of AADvac1 in Patients With Non Fluent Primary Progressive Aphasia (AIDA)

Primary Progressive Nonfluent Aphasia

Germany
Sensor Technology for Deafblind
Deaf-Blind Support Foundation Con-nection; Federal State Budgetary Institution... and other collaborators

Completed

Clinical and Genetic Testing of Patients With Usher Syndrome

Retinitis Pigmentosa | Usher Syndrome | Congenital Deafness

Russian Federation
Duke University
University of Edinburgh in Scotland; Tan Tock Seng Hospital in Singapore; Queens...

Recruiting

Retinal Imaging in Neurodegenerative Disease

Multiple Sclerosis | Parkinson's Disease | Traumatic Brain Injury | Down Syndrome | Mild Cognitive Impairment | Frontotemporal Dementia | Huntington Disease | Amyotrophic Lateral Sclerosis (ALS) | Alzheimer's Disease | Concussion | Post-Traumatic Stress Disorder | Neuro-Degenerative Disease | Lewy Body Dementia | Normal... and other conditions

United States
Mayo Clinic

Recruiting

Assessment of Hyperphosphorylated Tau PET Binding in Primary Progressive Aphasia and Frontotemporal Dementia (SLD3)

Primary Progressive Aphasia | Behavioral Variant of Frontotemporal Dementia | Frontotemporal Dementia, Behavioral Variant

United States
Northwestern University
Emory University

Completed

PPA Tele-Savvy: A Pilot Study of an Online Intervention for Caregivers of Persons Living With PPA

Primary Progressive Aphasia | Caregiver Burnout

United States
National Institute of Neurological Disorders and...

Completed

Natural History and Biomarkers of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Caused by the C9ORF72 Gene Mutation

Amyotrophic Lateral Sclerosis | Frontotemporal Lobar Degeneration

United States
Wave Life Sciences Ltd.

Terminated

Open-label Extension (OLE) Study of WVE-004 in Patients With C9orf72-associated Amyotrophic Lateral Sclerosis (ALS) and/or Frontotemporal Dementia (FTD)

ALS | FTD

Netherlands, United Kingdom
Transposon Therapeutics, Inc.

Active, not recruiting

A Phase 2a Study of TPN-101 in Patients With C9ORF72 ALS/FTD

Amyotrophic Lateral Sclerosis | Frontotemporal Dementia

Spain, United States, Belgium, France, Germany
ProQR Therapeutics

Terminated

An Open-Label Extension Study to Evaluate Safety & Tolerability of QR-421a in Subjects With Retinitis Pigmentosa (HELIA)

Retinitis Pigmentosa | Usher Syndrome Type 2

United States, Canada, France
Sanofi

Active, not recruiting

A Study to Determine the Long-Term Safety, Tolerability and Biological Activity of SAR421869 in Patients With Usher Syndrome Type 1B

Usher's Syndrome

United States, France
Neuronetrix, Inc.

Completed

Evaluation of a Handheld Event Related Potential (ERP)/Quantitative Electroencephalography (qEEG) System (COGNISION™) as a Useful Cognitive Biomarker for Alzheimer's Disease. (COGNISION™)

Cognitive Impairment | Dementia | Alzheimer Disease | Frontotemporal Dementia | Memory Disorders

United States
Assistance Publique - Hôpitaux de Paris

Terminated

Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

Amyotrophic Lateral Sclerosis | Frontotemporal Dementia

France
Foundation Fighting Blindness

Recruiting

Inherited Retinal Degenerative Disease Registry (MRTR)

Retinitis Pigmentosa | Choroideremia | Usher Syndrome | Batten Disease | Leber Congenital Amaurosis | Goldmann-Favre Syndrome | Kearns-Sayre Syndrome | Retinal Disease | Bardet-Biedl Syndrome | Stargardt Disease | Cone Dystrophy | Retinoschisis | Achromatopsia | Gyrate Atrophy | Eye Diseases Hereditary | Bassen-Kornzweig... and other conditions

United States
Daniel Serrani Azcurra
Zarebski Graciela, Kabanchik Alicia, Marconi Araceli

Recruiting

Multifactorial Approach to Dementia, Multicentric Study

Depression | Dementia of Alzheimer Type | Dementia Frontotemporal | Narcissistic Personality Disorder | Personality Change

Argentina
Johns Hopkins University
National Institute on Aging (NIA)

Recruiting

Transcranial Direct Current Stimulation in the Treatment of Primary Progressive Aphasia

Primary Progressive Aphasia | Logopenic Progressive Aphasia | Non-Fluent Primary Progressive Aphasia

United States, Canada
Hospices Civils de Lyon

Completed

WILSTIM - DBS (WILson STIMulation - Deep Brain Stimulation) (WILSTIM DBS)

Wilson's Disease | Severe Dystonia

France
National Eye Institute (NEI)

Completed

Natural History and Genetic Studies of Usher Syndrome

Retinitis Pigmentosa | Usher Syndrome | Retinitis Pigmentosa Syndromic | Congenital Deafness | Retinitis Pigmentosa and Deafness

United States
Kuopio University Hospital

Active, not recruiting

Sociodemographic Factors and Criminal Behaviour Preceding Neurodegenerative Disease - Retrospective Register Study (DEGERWD)

Parkinson Disease | Neurodegenerative Diseases | Amyotrophic Lateral Sclerosis | Alzheimer Disease | Lewy Body Disease | Multiple System Atrophy | Corticobasal Degeneration | Frontotemporal Dementia | Vascular Dementia | Progressive Supranuclear Palsy | Huntington Disease

Finland
New York Stem Cell Foundation Research Institute

Recruiting

NYSCF Scientific Discovery Biobank

PTSD | Multiple Sclerosis | Cervical Cancer | Diabetes Mellitus, Type 2 | Diabetes Mellitus | Diabetes | Macular Degeneration | Diabetes Mellitus, Type 1 | Parkinson Disease | Amyotrophic Lateral Sclerosis | Dementia | Ovarian Cancer | Alzheimer Disease | ALS | Vulvar Cancer | Post Traumatic Stress Disorder | Lewy Body Disease and other conditions

United States
Assiut University

Not yet recruiting

Evaluation of Cognitive Dysfunction and Psychiatric Comorbidities

Wilson Disease
Northwestern University
National Institute on Aging (NIA)

Recruiting

Tau PET Imaging in Atypical Dementias

Primary Progressive Aphasia With Suspected Alzheimer's Disease

United States
University of Texas Southwestern Medical Center
Texas A&M University; University of Texas Rio Grande Valley

Completed

PST for Care Partners of Adults With Alzheimer's and Alzheimer'S-related Dementia

Mild Cognitive Impairment (MCI) | Alzheimer Disease | Lewy Body Dementia (LBD) | Frontotemporal Degeneration (FTD) | Vascular Contributions to Cognitive Impairment and Dementia (VCID) | Mixed Etiology Dementias (MED)

United States
Fondation Ophtalmologique Adolphe de Rothschild

Terminated

Impact of the Lockdown Due to the COVID Pandemic in French Wilson's Disease Patients (WILL-Ecco)

Wilson's Disease and COVID-19

France
Massachusetts General Hospital

Completed

rTMS as a Treatment for PPA

Logopenic Variant Primary Progressive Aphasia | Non-Fluent Primary Progressive Aphasia

United States
Johns Hopkins University
University of California, San Francisco

Completed

Efficacy of Web-Based Social-Cognitive Interventions in Right Hemisphere Stroke and Frontotemporal Dementia

Frontotemporal Dementia | Right Sided Cerebral Hemisphere Cerebrovascular Accident

United States
Fondazione Telethon

Unknown

Natural History Study in Subjects With Usher Syndrome

Usher Syndrome, Type 1B

Italy, Netherlands, Spain
Haukeland University Hospital
Nordlandssykehuset HF; Helse Møre og Romsdal HF; Helse Fonna HF; Oslo universitetssykehus... and other collaborators

Not yet recruiting

The NADAPT Study: a Randomized Double-blind Trial of NAD Replenishment Therapy for Atypical Parkinsonism (NADAPT)

Multiple System Atrophy | Progressive Supranuclear Palsy | Corticobasal Syndrome

Norway
IRCCS San Camillo, Venezia, Italy
IRCCS Centro San Giovanni di Dio Fatebenefratelli; Università Ca' Foscari Venezia

Recruiting

Exploring the Gut-Brain Axis in Ageing and Neurodegeneration (GutBrain)

Multiple Sclerosis | Healthy | Parkinson Disease | Prodromal Alzheimer's Disease

Italy
University of Arizona

Recruiting

Enhancing Language Function in Aphasia

Language Disorders | Primary Progressive Aphasia | Aphasia, Acquired | Stroke, Cerebrovascular

United States
Neurotech Pharmaceuticals
University of California, San Francisco

Completed

Retinal Imaging in CNTF -Releasing Encapsulated Cell Implant Treated Patients for Early-stage Retinitis Pigmentosa

Retinitis Pigmentosa | Usher Syndrome Type 2 | Usher Syndrome Type 3

United States
University of California, San Francisco

Completed

Mindfulness-Based Stress Reduction in Dementia Caregivers (MBSR)

Dementia | Frontotemporal Dementia | Frontotemporal Lobar Degeneration | Caregiver Stress Syndrome | Caregiver Burnout | Dementia Frontal | Mindfulness Based Stress Reduction

United States
Brigham and Women's Hospital

Completed

Network Modulation in Alzheimer's Disease

Alzheimer Disease | Mild Cognitive Impairment | Primary Progressive Aphasia

United States
Skane University Hospital
Lund University

Recruiting

The Swedish BioFINDER - Primary Care Study (ADetect)

Alzheimer Disease | Frontotemporal Degeneration | Mild Cognitive Impairment | Lewy Body Disease | Vascular Dementia | SCD | Mild Dementia

Sweden
Massachusetts General Hospital
National Institutes of Health (NIH); National Institute on Aging (NIA)

Recruiting

Care Planning for a Loved One With Dementia: Knowledge, Preparing for Decisions, and Emotions

Dementia | Dementia Alzheimers | Caregiver Stress Syndrome | Caregiver Burnout | Dementia, Mild | Dementia Moderate | Dementia Severe | Dementia Frontotemporal

United States
Massachusetts General Hospital
National Institute on Deafness and Other Communication Disorders (NIDCD)

Recruiting

TMS for the Treatment of Primary Progressive Aphasia

Logopenic Variant Primary Progressive Aphasia | Non-fluent Variant Primary Progressive Aphasia | Semantic Variant Primary Progressive Aphasia

United States
Mayo Clinic

Recruiting

The Neurobiology of Two Distinct Types of Progressive Apraxia of Speech (SLD4T)

Primary Progressive Aphasia | Apraxia of Speech | Primary Progressive Nonfluent Aphasia | Non-fluent Aphasia

United States
University of Florida
ALS Association

Active, not recruiting

Safety and Therapeutic Potential of the FDA-approved Drug Metformin for C9orf72 ALS/FTD

Frontotemporal Dementia | C9orf72 Amyotrophic Lateral Sclerosis (ALS)

United States
NeuroActiva, Inc.

Unknown

Safety, Tolerability and Pharmacokinetics of Inhaled Nanoparticle Formulation of Remdesivir (GS-5734) and NA-831 (NEUROSIVIR)

Severe Acute Respiratory Syndrome | Covid19 | Corona Virus Infection | Severe Acute Respiratory Syndrome (SARS) Pneumonia | Neurodegeneration | Neuroinflammatory Response | Severe Acute Respiratory Infection | Severe Acute Respiratory Syndrome of Upper Respiratory Tract

United States
Institut National de la Santé Et de la Recherche...

Unknown

Assessment of Apathy in a Real-life Situation, With a Video and Sensors-based System (ECOCAPTURE)

Parkinson Disease | Depressive Symptoms | Frontotemporal Dementia | Apathy

France
University of Minnesota

Withdrawn

Biomarkers in Neurodegenerative Diseases

Mild Cognitive Impairment (MCI) | Amyotrophic Lateral Sclerosis (ALS) | Dementia With Lewy Bodies (DLB) | Alzheimer Disease (AD) | Frontotemporal Lobar Degeneration (FTLD) | Parkinsons Disease With Dementia (PDD) | Transient Epileptic Amnesia (TEA) | Temporal Lobe Epilepsy (TLE) | Spinocerebellar Ataxias... and other conditions

United States
Skane University Hospital
Lund University

Recruiting

The Swedish BioFINDER - Memory Clinic Study (Validate)

Alzheimer Disease | Frontotemporal Degeneration | Mild Cognitive Impairment | Lewy Body Disease | Vascular Dementia | SCD | Mild Dementia

Sweden
Simon Ducharme, MD
Alzheimer's Drug Discovery Foundation

Active, not recruiting

Nabilone for Agitation in Frontotemporal Dementia (Nabilone-FTD)

Frontotemporal Dementia | Primary Progressive Aphasia | Frontotemporal Dementia, Behavioral Variant | FTD | PPA | bvFTD

Canada
Istituto Auxologico Italiano

Recruiting

Advances in Telephone-based Cognitive Screening Procedures (TBCS)

Cerebrovascular Disorders | Amyotrophic Lateral Sclerosis | Frontotemporal Degeneration | Alzheimer's Disease | Lewy Body Dementia

Italy
Conor Fearon
Queen's University

Recruiting

Unstructured Eye Tracking as a Diagnostic and Prognostic Biomarker in Parkinsonian Disorders

Multiple System Atrophy | Corticobasal Degeneration | Progressive Supranuclear Palsy | Parkinson's Disease and Parkinsonism

Ireland
Kuopio University Hospital

Recruiting

Non-invasive Neurostimulation as a Tool for Diagnostics and Management for Neurodegenerative Diseases

Alzheimer Disease | Frontotemporal Dementia | Dementia With Lewy Bodies

Finland
Chang Gung Memorial Hospital

Recruiting

The Influence of Vascular Burden, Amyloid Plaque and Tau Protein in Patients With Vascular Cognitive Impairment and Dementia With Tauopathy

Vascular Cognitive Impairment, Alzheimer's Disease, Fronto-temporal Dementia

Taiwan
VA Office of Research and Development
VA Boston Healthcare System

Recruiting

Contributions of mTBI to Neurodegeneration Due to Chronic Traumatic Encephalopathy (CTE) and Alzheimer's Disease (AD)

Mild Cognitive Impairment | Mild Traumatic Brain Injury | Moderate Traumatic Brain Injury

United States

Clinical Trials on Degenerative Intervertebral Discs

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Burundi

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Drug Interventions

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