Clinical Trials on Disorders of Excessive Somnolence

Total 9810 results

University of California, San Diego

Withdrawn

Start Times and Restful Sleep (STaRtS)

Sleep Deprivation | Excessive Daytime Somnolence

United States
Avadel

Completed

An Open Label Study of FT218 in Subjects With Narcolepsy (RESTORE)

Sleep Wake Disorders | Sleep Disorder | Sleep Disturbance | Narcolepsy | Cataplexy | Excessive Daytime Somnolence

United States, Canada
University Hospital, Montpellier
INSERM U1061 Montpellier

Recruiting

Constitution of a Clinical, Neurophysiological and Biological Cohort for Chronic Sleep Disorders Responsible of Hypersomnolence (Somnobank)

Somnolence Disorder, Excessive

France
Axsome Therapeutics, Inc.

Completed

Evaluate Sunosi® PK in Breast Milk and Plasma of Healthy Postpartum Women Following Single Dose Oral Administration

Obstructive Sleep Apnea | Narcolepsy | Postpartum | Excessive Sleepiness | Excessive Daytime Somnolence

United States
Cephalon

Completed

Study of the Effect of Armodafinil Treatment in Healthy Subjects With Excessive Sleepiness Associated With Jet Lag Disorder

Excessive Sleepiness

United States
University of Wisconsin, Madison

Completed

Improving the Assessment of Hypersomnolence

Disorders of Excessive Somnolence

United States
Charles A. Czeisler, PhD, MD
Axsome Therapeutics, Inc.

Recruiting

Clinical Trial of Solriamfetol for Excessive Sleepiness Related to Shift Work Disorder

Excessive Sleepiness | Shift-work Disorder

United States
Bioprojet

Completed

Effects of BF2.649 in the Treatment of Excessive Daytime Sleepiness in Narcolepsy.

Treatment of Excessive Daytime Sleepiness in Narcolepsy

France
Cephalon

Completed

Efficacy and Tolerability of Armodafinil in Adults With Excessive Sleepiness Associated With Shift Work Disorder

Excessive Sleepiness

United States
XWPharma

Not yet recruiting

Valiloxybate (XW10172 MR) Efficacy and Safety Parkinson's Disease Study

Parkinson Disease | Excessive Daytime Somnolence
Ron Postuma
Canadian Institutes of Health Research (CIHR); University of Toronto

Completed

Caffeine for Excessive Daytime Somnolence in Parkinson's Disease

Parkinson's Disease | Excessive Daytime Somnolence

Canada
Hospices Civils de Lyon

Recruiting

Analysis of New Salivary Biomarkers to Evaluate Excessive Diurnal Sleepiness in Children With Hypersomnia (BIOSOM)

Hypersomnia | Sleepiness, Excessive Daytime

France
Assistance Publique - Hôpitaux de Paris

Completed

Alternative Epworth Sleepiness Scale ESS-ALT in French (SOMNOLD)

Excessive Daytime Sleepiness

France
Concert Pharmaceuticals

Completed

A Phase 1, Single Dose Study of JZP-386 to Evaluate Safety, Pharmacokinetics and Pharmacodynamics

Narcolepsy, Excessive Daytime Sleepiness

United Kingdom
University of Thessaly
University of Nicosia; University of Cyprus

Completed

Integral Physiological Adaptations to Carbohydrate Periodization (IPACP)

Fatigue | Sleepiness | Feeding Patterns | Daytime Sleepiness, Excessive

Greece, Cyprus
Jazz Pharmaceuticals

Completed

A Study of the Safety and Effectiveness of ADX-N05 in the Treatment of Excessive Daytime Sleepiness

Narcolepsy

United States
Jazz Pharmaceuticals

Completed

A Study of the Safety and Effectiveness of ADX-N05 for Excessive Daytime Sleepiness in Subjects With Narcolepsy

Narcolepsy

United States
Jazz Pharmaceuticals

Completed

Study Assessing Effects of JZP-110 on Driving Performance in the Treatment of Excessive Sleepiness in Narcolepsy

Narcolepsy | Excessive Sleepiness

Netherlands
Kasr El Aini Hospital

Completed

Cognitive Assessment in Excessive Daytime Sleepiness: Electrophysiological Study.

Cognitive Impairment
Abbott

Completed

Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Study of ABT-652 in Subjects With Excessive Daytime Sleepiness

Sleep Disorder

United States
Pfizer

Completed

A Study Of A Novel Compound For Excessive Daytime Sleepiness Associated With Narcolepsy

Narcolepsy | Excessive Daytime Sleepiness

United States
Bioprojet

Completed

Long Term Open Label Study in Narcolepsy With BF2.649 (Pitolisant) (HARMONYIII)

Narcolepsy | Cataplexy

France
Axsome Therapeutics, Inc.

Completed

A Study to Assess the Efficacy and Safety of AXS-12 (Reboxetine) in Patients With Narcolepsy (SYMPHONY)

Narcolepsy | Cataplexy | Excessive Daytime Sleepiness

United States, Canada
University Hospital, Bordeaux

Recruiting

Voice Biomarkers to Predict Excessive Daytime Sleepiness (SOMVOICE)

Sleep Deprivation

France
Axsome Therapeutics, Inc.

Enrolling by invitation

A Study to Assess the Long-term Efficacy and Safety of AXS-12 (Reboxetine) in Subjects With Narcolepsy

Narcolepsy | Cataplexy | Excessive Daytime Sleepiness

United States, Canada
Avadel

Completed

Once-Nightly Sodium Oxybate for Treatment of Excessive Daytime Sleepiness and Cataplexy in Narcolepsy

Narcolepsy | Cataplexy | Excessive Daytime Sleepiness

United States, Germany, Australia, Canada, Czechia, France
Bioprojet

Completed

Efficacy and Safety Study of BF2.649 and BF2.649 Add on Modafinil on Cataplexy in Patients With Narcolespy (Harmony2)

Narcolepsy | Cataplexy | Excessive Daytime Sleepiness

Switzerland
University Health Network, Toronto
Organon

Completed

Sedating Antidepressant Improves Driving Safety in Patients With Major Depressive Disorder

Depression | Excessive Daytime Sleepiness

Canada
NLS Pharmaceutics

Completed

Four-week Study of the Safety and Efficacy of NLS-2 (Mazindol Extended Release) in the Treatment of Narcolepsy

Narcolepsy | Excessive Daytime Sleepiness | Cataplexy Narcolepsy

United States
Axsome Therapeutics, Inc.

Completed

Clinical Outcomes in Narcolepsy and Cataplexy: An Evaluation of Reboxetine Treatment (CONCERT) (CONCERT)

Narcolepsy | Excessive Sleepiness | Cataplexy Narcolepsy

United States
Harmony Biosciences, LLC

Active, not recruiting

A Long-Term Safety and Effectiveness Study to Evaluate Pitolisant in Adult Patients With Idiopathic Hypersomnia

Idiopathic Hypersomnia | Excessive Daytime Sleepiness

United States
Cephalon

Completed

Study to Evaluate Armodafinil Treatment in Improving Prefrontal Cortical Activation and Working Memory Performance

Excessive Sleepiness

United States
Vanda Pharmaceuticals

Completed

VSF-173 Study in Healthy Adult Volunteers for Treatment of Induced Excessive Sleepiness

Excessive Somnolence

France
Bioprojet

Completed

Pitolisant to Assess Weekly Frequency of Cataplexy Attacks and EDS in Narcoleptic Patients (HARMONY CTP)

Excessive Daytime Sleepiness | Narcolepsy With Cataplexy

Hungary
Citrine Medicine Limited

Completed

A Clinical Study to Evaluate the Efficacy and Safety of Pitolisant in the Treatment of EDS in Patients With OSA

Excessive Daytime Sleepiness

China
Milton S. Hershey Medical Center
GlaxoSmithKline

Completed

Comparing Fluticasone-salmeterol in Chronic Obstructive Pulmonary Disease (COPD) and Sleep

COPD

United States
Veterans Medical Research Foundation
Cephalon

Completed

Modafinil Augmentation Therapy for Excessive Daytime Sleepiness and Negative Symptoms in Patients With Schizophrenia

Schizophrenia

United States
National Taiwan University Hospital

Completed

Provigil (Modafinil) Study by Taiwan Biotech Co.

Sleep Disorders | Narcolepsy | Cataplexy | Excessive Sleepiness | Hypersomnolence
University of Pennsylvania
Jazz Pharmaceuticals

Recruiting

Disentangling the Role of Depression in Hypersomnia

Hypersomnia

United States
Chang Gung Memorial Hospital

Recruiting

A Multi-Signal Based Monitoring System for CNS Hypersomnias

Hypersomnia

Taiwan
Bioprojet

Completed

Efficacy and Safety Study of BF2.649 in the Treatment of Excessive Daytime Sleepiness in Narcolepsy (Harmony1)

Sleep Disorders | Narcolepsy | Cataplexy | Excessive Daytime Sleepiness

Switzerland
Power Life Sciences Inc.

Not yet recruiting

Discovering Factors in Narcolepsy Patients' Clinical Research Experiences

Narcolepsy
Jazz Pharmaceuticals

Completed

An Interventional Safety Switch Study (Segue Study) of XYWAV in Narcolepsy

Narcolepsy

United States
Taisho Pharmaceutical Co., Ltd.

Completed

A Study to Evaluate the Safety and Efficacy of TS-091 in Patients With Narcolepsy

Narcolepsy

Japan, Korea, Republic of
Suven Life Sciences Limited

No longer available

Expanded Access to SUVN-G3031 (Samelisant) for the Treatment of Subjects With Narcolepsy

Narcolepsy
Jazz Pharmaceuticals

Completed

A Patient-Centric, Prospective, Observational, Non-Interventional Switch Study of XYWAV in Narcolepsy

Narcolepsy

United States
Orphan Medical

Completed

Safety and Efficacy of Xyrem Oral Solution (Sodium Oxybate) Compared With Placebo in Narcoleptic Patients

Narcolepsy

United States, Canada, Switzerland
Harmony Biosciences, LLC

No longer available

Expanded Access Program to Provide Treatment With Pitolisant to Adult Patients in the U.S. With Excessive Daytime Sleepiness Associated With Narcolepsy With or Without Cataplexy

Narcolepsy Without Cataplexy | Narcolepsy With Cataplexy

United States
Centro Hospitalar de Lisboa Central
Universidade Nova de Lisboa

Terminated

CPAP to Reduce Arterial Stiffness in Non Sleepy, Moderate to Severe Obstructive Sleep Apnea (STIFFSLEEP) (STIFFSLEEP)

Obstructive Sleep Apnea | Vascular Stiffness | Sleep Disorder Daytime Somnolence

Portugal
Sunovion

Completed

This is a Study to Determine the Effect of Multiple Doses of an Investigational Drug, Taken by Mouth, in People With Narcolepsy-cataplexy. Accepting Both Males and Females Ages of 18 Years to 55 Years. This Study Will be Conducted in the US and Will Require Approximately 13 Weeks Participation.

Narcolepsy

United States

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