Clinical Trials on Down Syndrome in United Kingdom

Total 14170 results

Hoffmann-La Roche

Completed

A Molecular and Functional Brain Imaging Study in Individuals With Down Syndrome and Healthy Controls Following Single Dose RG1662

Healthy Volunteer, Down Syndrome

United Kingdom
Institute of Child Health

Completed

Vitamins and Minerals for Children With Downs Syndrome

Trisiomy 21 (Down Syndrome)

United Kingdom
Premaitha Health

Completed

Clinical Evaluation of the IONA Test for Non-invasive Pre Natal Screening in Twin Pregnancies (TWIN)

Down Syndrome | Patau Syndrome | Edward's Syndrome

United Kingdom
Rachel G. Greenberg, MD, MB, MHS
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Not yet recruiting

Guanfacine for Hyperactivity in Children With Down Syndrome (HYPEbeGONE_DS) (HYP01)

Hyperactivity in Children With Down Syndrome | Impulsivity in Children With Down Syndrome

United States
King's College London
Parc de Salut Mar; Fondation Jérôme Lejeune

Recruiting

Elucidating Age-related Comorbidity Patterns in Down Syndrome (DS) (GO-DS21)

Down Syndrome

France, Spain, United Kingdom
Vanderbilt University Medical Center
National Institute on Deafness and Other Communication Disorders (NIDCD)

Completed

Predictors of Speech Ability in Down Syndrome

Speech Intelligibility Intervention in Down Syndrome

United States
King's College London

Unknown

Memantine and Down's Syndrome

Dementia | Learning Disabilities | Down's Syndrome

United Kingdom
Boston Children's Hospital

Completed

JASPER Intervention in Down Syndrome

Down Syndrome, Trisomy 21

United States
Hoffmann-La Roche

Completed

A Study of RG1662 in Individuals With Down Syndrome

Down Syndrome

United States, United Kingdom
Children's Health Ireland
Belfast Health and Social Care Trust; University of Edinburgh; University Hospital... and other collaborators

Recruiting

Clinical Outcomes From Treatment and Evaluation of Obstructive Sleep Apnoea in Children With Down Syndrome (REFRESHED)

Quality of Life | Obstructive Sleep Apnea | Down Syndrome | Behavior | Adherence, Treatment

United Kingdom, Ireland
Hoffmann-La Roche

Completed

A Non-Drug Study of The Suitability of Neurocognitive Tests And Functioning Scales For The Measurement of Cognitive And Functioning Changes in Individuals With Down Syndrome

Down Syndrome

United States, France, Italy, Canada, United Kingdom, Argentina, Spain
AC Immune SA
Worldwide Clinical Trials

Recruiting

A Study to Assess the Effects of ACI-24.060 in Alzheimer's Disease and in Down Syndrome (ABATE Study)

Alzheimer's Disease | Prodromal Alzheimer's Disease | Amyloid Plaque | Beta-Amyloid | Alzheimer's Disease in Down Syndrome

United States, Spain, United Kingdom
Children's Oncology Group
National Cancer Institute (NCI)

Completed

Study of Blood Samples From Newborns With Down Syndrome

Myeloid Proliferations Associated With Down Syndrome

United States, Canada, Australia, Puerto Rico
Axis Shield Diagnostics Ltd
The Clinical Trial Company

Completed

Serum Sample Collection to Determine Analytical Performance Characteristics of the ADVIA Centaur PAPPA and BhCG Assays

Trisomy 21 in Fetus | Trisomy 18 in Fetus | Trisomy 13 in Fetus

United Kingdom
St. Bartholomew's Hospital

Unknown

Erythropoietin (EPO) and Granulocyte-Colony Stimulating Factor (G-CSF) for Low-Risk Myelodysplastic Syndromes (MDS)

Myelodysplastic Syndromes

United Kingdom
Brighton and Sussex University Hospitals NHS Trust
Medtronic Vascular

Completed

Revascularisation or Medical Therapy in Elderly Patients With Acute Anginal Syndromes (RINCAL)

Acute Coronary Syndromes

United Kingdom
University College, London
King's College London; King's College Hospital NHS Trust; University of Oxford; Great Ormond Street Hospital for Children NHS Foundation Trust

Recruiting

Children's Adaptive Deep Brain Stimulation for Epilepsy Trial (CADET): Pilot (CADET Pilot)

Epilepsy | Lennox-Gastaut Syndrome, Intractable

United Kingdom
Children's Oncology Group
National Cancer Institute (NCI)

Recruiting

A Study to Learn More About the Health of Persons With Down Syndrome After Treatment for Acute Leukemia

Down Syndrome | Myeloid Leukemia Associated With Down Syndrome | B Acute Lymphoblastic Leukemia Associated With Down Syndrome

United States
Children's Oncology Group
National Cancer Institute (NCI)

Active, not recruiting

Response-Based Chemotherapy in Treating Newly Diagnosed Acute Myeloid Leukemia or Myelodysplastic Syndrome in Younger Patients With Down Syndrome

Acute Myeloid Leukemia | Down Syndrome | Myelodysplastic Syndrome | Myeloproliferative Neoplasm | Myeloid Leukemia Associated With Down Syndrome

United States, Canada, Saudi Arabia, Puerto Rico, Australia, New Zealand
University of Portsmouth
Portsmouth Hospitals NHS Trust

Not yet recruiting

The Effects of Prolonged Head-Down Tilt Lithotomy Position on Lower Limb Haemodynamics (HELP)

Compartment Syndrome Nontraumatic Lower Extremity

United Kingdom
The Leeds Teaching Hospitals NHS Trust

Unknown

Cubital Tunnel Syndrome and Diffusion MRI: A Proof of Concept Study

Cubital Tunnel Syndrome

United Kingdom
Oxford University Hospitals NHS Trust

Unknown

Biomarkers in Patients at Risk of Developing Myelodysplastic Syndrome or Other Disorders and in Healthy Participants

Myelodysplastic Syndromes | Leukemia

United Kingdom
Cambridge University Hospitals NHS Foundation Trust

Recruiting

Low-Dose IL-2 For The Reduction Of Vascular Inflammation In ACS -Clinical Outcomes & Follow-up Study (IVORY-FINALE)

Acute Coronary Syndromes

United Kingdom
LuMind IDSC Foundation
Alzheimer's Disease Cooperative Study (ADCS)

Active, not recruiting

Down Syndrome Clinical Trials - Study of Alzheimer's Disease in Down Syndrome (LIFE-DSR)

Alzheimer's Disease in Down Syndrome

United States
Vanderbilt University Medical Center
Vanderbilt Kennedy Center

Recruiting

Cholinergic Integrity in Down Syndrome in Association With Aging, Alzheimer's Disease Pathology, and Cognition

Alzheimer Disease | Down Syndrome | Down Syndrome, Partial Trisomy 21

United States
Cambridge University Hospitals NHS Foundation Trust

Completed

Low-dose Interleukin-2 for the Reduction of Vascular Inflammation in Acute Coronary Syndromes - IVORY (IVORY)

Acute Coronary Syndromes

United Kingdom
King's College Hospital NHS Trust

Completed

The Efficacy and Safety of Lenalidomide Monotherapy in Red Blood Cell Transfusion Dependent Subjects With Myelodysplastic Syndrome (MDS) Associated With Del (5q) Abnormality

Myelodysplastic Syndromes

United Kingdom
Hoffmann-La Roche

Completed

A Study of RG1662 in Adults and Adolescents With Down Syndrome (CLEMATIS)

Down Syndrome

United States, Italy, Argentina, France, Spain, Mexico, Canada, New Zealand, Singapore, United Kingdom
Takeda

Recruiting

A Study Evaluating Soticlestat in Participants With Dravet Syndrome or Lennox-Gastaut Syndrome Who Have Been Exposed to Fenfluramine

Dravet Syndrome (DS) | Lennox-Gastaut Syndrome (LGS)

United Kingdom, Denmark
Imperial College London
The Drummond Foundation (RAMC charity)

Recruiting

Chemical Analysis of Limb Microfluidics (CALM)

Compartment Syndrome of Leg | Limb Ischemia

United Kingdom
Encoded Therapeutics

Recruiting

A Clinical Study to Evaluate the Safety and Efficacy of ETX101, an AAV9-Delivered Gene Therapy in Children With SCN1A-positive Dravet Syndrome (UK Only)

Dravet Syndrome

United Kingdom
Allergan

Terminated

Clinical Study to Evaluate Tear Characteristics Following Acute TrueTear™ Use

Dry Eye Syndromes

United Kingdom
Barts & The London NHS Trust
Cancer Research UK; Amgen

Unknown

Comparison Study of Standard Care Against Combination of Growth Factors Agents for Low-risk Myelodysplastic Syndromes (REGIME)

Myelodysplastic Syndrome

United Kingdom
University Hospital Birmingham NHS Foundation Trust

Completed

The Application of Near Infrared Spectroscopy (NIRS) in the Detection of Lower Limb Compartment Syndrome

Compartment Syndrome

United Kingdom
University of the West of England
Royal United Hospital Bath NHS Trust

Completed

Self Soft Tissue Therapy for Fibromyalgia Syndrome

Fibromyalgia Syndrome

United Kingdom
King's College Hospital NHS Trust

Terminated

Pilot Study of Reduced Intensity Haematopoietic Stem Cell Transplantation in Patients With Poor Risk Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukaemia (AML) Utilising Conditioning With Fludarabine, Busulphan and Thymoglobulin (FB-ATG)

Myelodysplastic Syndromes | Leukemia, Myeloid, Acute

United Kingdom
BioCeryx
University of British Columbia; University College London Hospitals; Brugmann... and other collaborators

Unknown

Automated Screen for Fetal Aneuploidy (FAST1)

Trisomy 21 and Other Fetal Aneuploidy

Australia, United Kingdom, Spain, Canada, Belgium, Portugal
University College, London
Barts & The London NHS Trust

Unknown

Coronary Mortality in South Asians: Aetiologic and Prognostic Effects (CALIBER)

Acute Coronary Syndromes

United Kingdom
Institute of Cancer Research, United Kingdom
Cancer Research UK; National Institute for Health Research, United Kingdom

Completed

Magnetic Resonance Imaging Screening in Li Fraumeni Syndrome (SIGNIFY)

Li-Fraumeni Syndrome

United Kingdom
John Carroll University
University Hospital Southampton NHS Foundation Trust

Active, not recruiting

Development and Validation of an Online Neurobehavioral Evaluation Tool for PTEN Patients

PTEN Hamartoma Tumor Syndrome

United States, United Kingdom
Arizona State University
American Speech-Language-Hearing Foundation

Recruiting

Proactive Speech and Language Intervention for Infants With Down Syndrome (BBC-DS)

Down Syndrome

United States
Boston University Charles River Campus
Boston Children's Hospital

Not yet recruiting

Harness-based Mobility Intervention for Infants With Down Syndrome

Down Syndrome

United States
Eunice Kennedy Shriver National Institute of Child...

Recruiting

DS-Connect {TM}: The Down Syndrome Registry

Down Syndrome

United States
Children's Hospital Medical Center, Cincinnati

Withdrawn

Liq-NOL Efficacy in Pediatric Patients With Down Syndrome

Down Syndrome

United States
Oregon Health and Science University

Completed

Gait Parameters of Persons With Down Syndrome With and Without Orthotics Using GaitRite

Down Syndrome

United States
University of Puget Sound

Completed

Gait in Children With Down Syndrome While Wearing Orthoses

Down Syndrome

United States
Boston Children's Hospital

Recruiting

Investigating the Impact of JASPER Behavioral Therapy in Children With Down Syndrome

Down Syndrome

United States
University of Alabama, Tuscaloosa

Recruiting

Assessing Malleability of Spatial Abilities in Down Syndrome

Down Syndrome

United States
Georgia State University
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Recruiting

Role of Early Motor Experience in Infants With Down Syndrome

Down Syndrome

United States
Milton S. Hershey Medical Center

Terminated

Comparison of Bispectral Index Values in Patients With and Without Down's Syndrome

Down Syndrome

United States

Clinical Trials on Down Syndrome in United Kingdom

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Burkina Faso

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations