Clinical Trials on Drug Action Reversal in Canada

Total 308 results

Population Health Research Institute

Completed

Clopidogrel and Aspirin Interaction Study-2 (Interaction2)

Drug Action Increased

Canada
University of British Columbia
Eli Lilly and Company; Merck Sharp & Dohme LLC; Pfizer; Canadian Institutes of... and other collaborators

Recruiting

National Active Surveillance Network and Pharmacogenomics of Adverse Drug Reactions in Children

Adverse Drug Reaction (ADR)

Canada
University of British Columbia
Genome British Columbia; Genome Canada; Dynacare Laboratories, Inc.

Recruiting

Integrating Pediatric Pharmacogenomic Testing Into the Canadian Health Care System

Adverse Drug Reaction (ADR)

Canada
University of Calgary
Alberta Health services; Hotchkiss Brain Institute, University of Calgary

Recruiting

Pharmacogenetics of Antidepressant-Induced Disinhibition (PGx-AID)

Obsessive-Compulsive Disorder | Anxiety Disorders | Major Depressive Disorder | Antidepressant Drug Adverse Reaction

Canada
J.J.Swen
Karolinska Institutet; Medical University of Vienna; Uppsala University; St. Antonius... and other collaborators

Completed

PREemptive Pharmacogenomic Testing for Preventing Adverse Drug REactions (PREPARE)

Adverse Drug Reaction

Austria, Netherlands, Italy, Greece, Slovenia, Spain, United Kingdom
Universitaire Ziekenhuizen KU Leuven
University of Pittsburgh; Sheba Medical Center; Mount Sinai Hospital, Canada; Leiden... and other collaborators

Unknown

TRAP Intervention STudy: Early Versus Late Intervention for Twin Reversed Arterial Perfusion Sequence (TRAPIST)

Twin Reversal Arterial Perfusion Syndrome

Spain, Germany, Israel, Belgium, Netherlands, Canada, United States, Austria, France, Italy, United Kingdom
Sunnybrook Health Sciences Centre
University Health Network, Toronto

Completed

Effect of an Automated Paging System on Response to Critical Laboratory Values

Drug Drug Interactions | Critical Laboratory Values | Drug Laboratory Interactions

Canada
Antios Therapeutics, Inc

Completed

A Drug-Drug Interaction Study Between ATI-2173 and Midazolam or Clarithromycin in Healthy Subjects

Drug Drug Interaction

Canada
Centre for Addiction and Mental Health

Completed

Using Non-invasive Brain Stimulation (tDCS) With Varenicline for Treating Tobacco Dependence

Smoking Cessation | Tobacco Smoking | Tobacco Use Disorder | Substance Use Disorders | Molecular Mechanisms of Pharmacological Action | Tobacco Dependence | Physiological Effects of Drugs

Canada
Ottawa Hospital Research Institute
McGill University; Canadian Institutes of Health Research (CIHR)

Completed

Information Systems-enabled Outreach Program for Adverse Drug Events (ISTOP-ADE)

Adverse Drug Events

Canada
McGill University
Canadian Institutes of Health Research (CIHR)

Completed

Using Novel Canadian Resources to Improve Medication Reconciliation at Discharge

Adverse Drug Events | Medication Reconciliation

Canada
University of British Columbia
Canadian Institutes of Health Research (CIHR)

Completed

5-HT3 Antagonists (Antiemetics) and Cardiac Safety

Adverse Reaction to Other Drugs and Medicines

Canada
Westview Physician Collaborative

Completed

Eliminating Risk of Preventable Adverse Drug Events at the Hospital-community Interface of Care (CMR)

Adverse Drug Events

Canada
Desitin Arzneimittel GmbH
BioPharma Services, Inc

Completed

Bioavailability and Food Effect of Sodium Valproate Minitablets in Healthy Subjects.

Food-drug Interaction

Canada
Emalex Biosciences Inc.
Syneos Health; Cambridge Cognition Ltd

Recruiting

Drug Interaction Study

Drug Interaction

Canada
Abbott

Completed

A Study to Evaluate the Interaction Between Vicodin® CR and Ethanol in Healthy Male and Female Moderate Alcohol Drinkers

Drug Interactions

Canada
SignalChem Lifesciences Corporation
Syneos Health

Completed

Crossover Study to Evaluate the Effect of Food on the Pharmacokinetics of SLC-391 in Healthy Adult Subjects

Food-drug Interaction

Canada
Desitin Arzneimittel GmbH
BioPharma Services, Inc

Completed

Bioavailability of Orfiril Long 500 mg Prolonged-Release Minitablets and Ergenyl Chrono 500 mg Prolonged-Release Tablets

Multiple Drug Use

Canada
Antios Therapeutics, Inc

Completed

A Drug-Drug Interaction Study Between ATI-2173 and Tenofovir Disoproxil Fumarate in Healthy Subjects

Drug Interaction

Canada
Unity Health Toronto

Recruiting

Susceptibility for Entrainment: Role of Ventilator Settings on the Occurrence of Reverse Triggering and Its Physiological Consequences - the SEVeRe Study (SEVERE)

Respiration, Artificial | Reverse Triggering

Canada
Lawson Health Research Institute

Completed

Coffee Interaction With the Antihypertensive Drug Felodipine

Food-Drug Interactions

Canada
Centre hospitalier de l'Université de Montréal...
Centre de Recherche du Centre Hospitalier de l'Université de Montréal

Completed

Drug-drug Interaction Study in Healthy Male Volunteers Following the Administration of Pantoprazole and Rosuvastatin

Drug Interaction Potentiation

Canada
University of British Columbia
BC Centre on Substance Use

Terminated

The Impact of Alternative Social Assistance Disbursement on Drug-related Harm (TASA)

Drug Use

Canada
Nova Scotia Health Authority

Unknown

In Vivo Lithium Treatment Effects on Gene Expression Levels in Lymphoblastoid Cell Lines From Human Healthy Subjects

Drug Mechanism

Canada
Akebia Therapeutics

Completed

Drug-Drug Interaction Study of Vadadustat With Rosuvastatin, Sulfasalazine, Pravastatin, Atorvastatin and Simvastatin

Drug Interaction Potentiation

Canada
Centre de recherche du Centre hospitalier universitaire...
Lallemand Health Solutions

Completed

Validation of the In-utero Transmission of Probiotics (PROBIO)

In Utero Drug Exposure

Canada
Akebia Therapeutics

Completed

Drug-Drug Interaction Study of Vadadustat With Cyclosporine, Probenecid and Rifampin

Drug Interaction Potentiation

Canada
Akebia Therapeutics

Completed

Drug-Drug Interaction Study of Vadadustat With Digoxin, Adefovir and Furosemide

Drug Interaction Potentiation

Canada
The Hospital for Sick Children
St. Justine's Hospital

Completed

Deep Brain Stimulation Post Failed Vagal Nerve Stimulation (DBSpostVNS)

Epilepsy, Drug Resistant

Canada
St. Justine's Hospital
CIUSSS du Nord-de-l'Île-de-Montréal

Recruiting

Monitoring of Metabolic Adverse Events of Second Generation Antipsychotics in a Naive Pediatric Population (MEMAS)

Adverse Drug Event

Canada
McGill University Health Centre/Research Institute...
Centre for Aging and Brain Health Innovation; MED e-care Healthcare Solutions; OMNI Health Care

Withdrawn

MedSafer E-care: an Automated Deprescribing Solution (E-CARE Study) (E-CARE)

Deprescribing | Polypharmacy | Adverse Drug Event

Canada
Akebia Therapeutics

Completed

Study to Evaluate the Effect of Rabeprazole on the Pharmacokinetics of Vadadustat

Pharmacokinetics | Drug Interaction Potentiation

Canada
Nova Scotia Health Authority

Not yet recruiting

Enhancing Epilepsy Management With Precision Deep Brain Stimulation (EPI-BOOST)

Epilepsy, Drug Resistant

Canada
Ravindra Mehta
International Serious Adverse Event Consortium

Completed

The Drug Induced Renal Injury Consortium (DIRECT)

Acute Kidney Injury | Kidney Failure | Acute Kidney Failure | Kidney Disease | Adverse Drug Reaction

United States, United Kingdom, Chile, Bolivia, Canada, India
INSYS Therapeutics Inc

Completed

A Study of the Abuse Potential of Dronabinol in Recreational Cannabinoid Users

Drug Abuse, Medication

Canada
Centre hospitalier de l'Université de Montréal...
Fonds de la Recherche en Santé du Québec

Terminated

Comparison of OraQuick HCV Rapid Antibody Test and Standard Serologic Screening for Hepatitis C: Validity, Acceptability and Impact on Linkage to Care

Active or Ex-injection Drug Users | Indication of Hepatitis C Screening

Canada
Lawson Health Research Institute

Completed

CYP2D6 Screening for Adverse Drug Reactions to Codeine in Breast Milk

Cytochrome P450 2D6 Ultra-rapid Metabolism

Canada
Sunnybrook Health Sciences Centre
University Health Network, Toronto; McMaster University; London Health Sciences...

Recruiting

Cognitive Outcomes After Dexmedetomidine Sedation in Cardiac Surgery Patients (CODEX)

Mental Disorders | Nervous System Diseases | Neurologic Manifestations | Delirium | Confusion | Neurobehavioral Manifestations | Neurocognitive Disorders | Cognitive Dysfunction | Dexmedetomidine | Molecular Mechanisms of Pharmacological Action | Signs and Symptoms | Physiological Effects of Drugs | Analgesics,... and other conditions

Canada
Centre for Addiction and Mental Health

Recruiting

"Extended" (Alternate Day) Antipsychotic Dosing

Drug Therapy | Schizophrenia and Related Disorders | Antipsychotic Agents | Drug Administration Schedule

Canada
University Health Network, Toronto

Terminated

An Evaluation of the Development of Nevirapine Induced Mutations in HIV Patients Initiating or Discontinuing Combination Antiretroviral Therapy

Drug Resistance

Canada
CHU de Quebec-Universite Laval

Unknown

Amoxicillin Challenge for Penicillin Allergy Diagnosis (Pen-VIE)

Penicillin Allergy

Canada
AHS Cancer Control Alberta

Terminated

Novel Surrogate Markers as Predictors of Radiation Toxicity in Breast Cancer Patients Undergoing Helical Tomotherapy Compared to Standard Radiation Therapy

Cardiac Toxicity | Genetic Markers | Breast and Skin Motion

Canada
Harvard School of Public Health (HSPH)
Bill and Melinda Gates Foundation; Institute for Clinical Effectiveness and... and other collaborators

Completed

Health Facility Networking for Maternal Health

Maternal Health | Provider Skill | Provider Confidence | Referral Systems

Ethiopia
University of British Columbia

Completed

The Effect of Medication Review in High-risk Emergency Department Patients

Adverse Drug Events | Adverse Drug Reactions | Medication-related Problems

Canada
Centre for Innovation and Research in Aging, Canada
McGill University Health Centre/Research Institute of the McGill University... and other collaborators

Unknown

Spread and Scale of a Polypharmacy App

Deprescribing | Polypharmacy | Adverse Drug Event

Canada
University of Manitoba

Enrolling by invitation

Evaluating Patient Tolerability and Success for Penile and Scrotal Urologic Procedures Under Conscious Sedation: A Prospective Study

Testicular Diseases | Penile Diseases | Varicocele | Hydrocele | Circumcision | Spermatocele | Orchiectomy | Epididymal Cyst | Testicular Biopsy | Frenulectomy | Penile Plication | Vasectomy Reversal

Canada
Partner Therapeutics, Inc.

Completed

Study to Evaluate Pharmacokinetics, Pharmacodynamics, and Safety of Sargramostim Administered Subcutaneously, Intravenously, or by Inhalation

Drug Kinetics | Drug Effects on Physiology

Canada
Vishal Uppal
Maisonneuve-Rosemont Hospital; IWK Health Centre

Unknown

A Randomized Controlled Trial Comparing Intrathecal Morphine With Quadratus Lumborum Block for Post-cesarean Delivery Analgesia

Cesarean Section

Canada
Vancouver Infectious Diseases Centre
Gilead Sciences; Regina General Hospital

Unknown

STRIBILD in Non-Nucleoside Resistant Patients (SINNR STUDY) (SINNR)

HIV | Illicit Drug User

Canada
University of Valencia
Hospital General Universitario Gregorio Marañon; General University Hospital...

Completed

Multi-center Study of Residual Neuromuscular Block Incidence in the Post-anesthesia Care Unit (ReCuSS)

Incomplete Reversal of Neuromuscular Block | Postoperative Respiratory Complications

Spain

Clinical Trials on Drug Action Reversal in Canada

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