Clinical Trials on ERK Mutation in United States
Total 852 results
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Joshua HustedtEnrolling by invitation
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US Department of Veterans AffairsCompletedDiabetes Mellitus | Amputation StumpsUnited States
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National Cancer Institute (NCI)TerminatedMetastatic Melanoma | Stage III Cutaneous Melanoma AJCC v7 | Stage IV Cutaneous Melanoma AJCC v6 and v7 | Stage IIIC Cutaneous Melanoma AJCC v7 | BRAF V600E Mutation Present | BRAF V600K Mutation Present | Stage IIIA Cutaneous Melanoma AJCC v7 | Stage IIIB Cutaneous Melanoma AJCC v7United States
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Joanne JeterNational Cancer Institute (NCI)Active, not recruitingLynch Syndrome | Colon Adenoma | Colon Carcinoma | MLH1 Gene Mutation | MSH2 Gene MutationUnited States
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Stephen Bagley, MD, MSCEUniversity of Pennsylvania; Incyte CorporationRecruitingGlioma | Astrocytoma | Oligodendroglioma | IDH MutationUnited States
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VA Office of Research and DevelopmentCompletedLower Extremity AmputationUnited States
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Blueprint Medicines CorporationTerminatedNeoplasms | Respiratory Tract Diseases | Neoplasms by Histologic Type | Lung Diseases | Neoplasms by Site | Adenocarcinoma | Carcinoma | Carcinoma, Non-Small-Cell Lung | Respiratory Tract Neoplasms | Thoracic Neoplasms | Carcinoma, Bronchogenic | Bronchial Neoplasms | Neoplasms, Nerve Tissue | Non Small Cell Lung... and other conditionsUnited States
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Össur EhfCompleted
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Thomas Jefferson UniversityAcelityRecruitingAmputation | Seroma | Wound Infection, Surgical | Wound Dehiscence | Lymph Leakage | Amputation; Postoperative, SequelaeUnited States, Italy
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National Cancer Institute (NCI)RecruitingAcute Myeloid Leukemia With KMT2A Rearrangement | Acute Myeloid Leukemia With NPM1 MutationUnited States
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Symphogen A/SCompletedNSCLC | Non Small Cell Lung Cancer | Oncology | MET Gene Mutation | MET Gene AmplificationUnited States, Korea, Republic of, Denmark, Hong Kong, Taiwan, Spain
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Cynvenio BiosystemsUnknownTriple Negative Breast Cancer | BRCA Mutation | Natural Killer CellsUnited States
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Children's Oncology GroupNational Cancer Institute (NCI)RecruitingCentral Nervous System Tumor | Somatic Mutation | Pediatric Central Nervous System Tumor | Discordant TwinUnited States
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University of South FloridaBoston Children's HospitalCompletedPTEN Gene MutationUnited States
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University of MinnesotaNational Institute of Mental Health (NIMH)Active, not recruitingSelf-Injurious Behavior | Deliberate Self-HarmUnited States
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VA Office of Research and DevelopmentUniversity of TexasCompletedDiabetes Complications | AmputationUnited States
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Duke UniversityCompletedInternal Rotation Contracture-shoulderUnited States
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Sidney Kimmel Comprehensive Cancer Center at Johns...National Cancer Institute (NCI); BeiGeneCompletedRecurrent Glioblastoma | Recurrent WHO Grade III Glioma | Recurrent WHO Grade II Glioma | IDH1 Mutation | IDH2 MutationUnited States
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University of PennsylvaniaMoss Rehabilitation Research InstituteCompletedLower Limb Amputation Below Knee (Injury) | Lower Limb Amputation Above Knee (Injury) | Phantom Limb PainUnited States
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RWJ Barnabas Health at Jersey City Medical CenterUnknownLynch Syndrome | Endometrial Cancer | Somatic Mutation | Cancer Gene MutationUnited States
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Northwestern UniversityNational Cancer Institute (NCI)RecruitingColorectal Cancer | Colorectal Cancer Stage IV | Stage IV Colorectal Cancer Positive for BRAF V600E MutationUnited States
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University of Colorado, DenverCancer League of ColoradoWithdrawnMetastatic Breast Cancer | Triple Negative Breast Cancer | Locally Advanced Breast Cancer | Unresectable Breast Carcinoma | PD-L1 Gene MutationUnited States
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NRG OncologyNational Cancer Institute (NCI)Active, not recruitingGlioma | Oligoastrocytoma | Anaplastic Astrocytoma | Oligodendroglioma | Diffuse Astrocytoma | WHO Grade III Glioma | IDH2 Gene Mutation | IDH1 Gene Mutation | 1p/19q Co-deletionUnited States
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Icahn School of Medicine at Mount SinaiMassachusetts General Hospital; National Institute of Neurological Disorders...RecruitingParkinson Disease | GBA Gene Mutation | LRRK2United States
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QED Therapeutics, Inc.Helsinn Healthcare SATerminatedFGFR2 Gene Mutation | Advanced CholangiocarcinomaUnited States, Belgium, Germany, Italy, Korea, Republic of, Russian Federation, Singapore, Spain, Taiwan, Thailand, United Kingdom
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North Carolina State UniversityRecruitingLower Limb Amputation Below Knee (Injury)United States
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University of California, San DiegoJohns Hopkins University; United States Department of Defense; The Cleveland... and other collaboratorsEnrolling by invitationLower Extremity Surgical Amputation | Post-amputation Phantom Limb PainUnited States
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Rutgers, The State University of New JerseyNational Cancer Institute (NCI)RecruitingBRCA1 Gene Mutation | BRCA2 Gene Mutation | Recurrent Ovarian Carcinoma | Recurrent Malignant Solid Neoplasm | Metastatic Malignant Solid Neoplasm | Stage IV Breast Cancer AJCC v6 and v7 | Stage III Breast Cancer AJCC v7 | Stage IIIA Breast Cancer AJCC v7 | Stage IIIB Breast Cancer AJCC v7 | Stage IIIC... and other conditionsUnited States
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Jacobio Pharmaceuticals Co., Ltd.RecruitingSolid Tumors | ER+ Breast Cancer | ARID1A Gene Mutation | Triple Negative Breast Cancer, TNBC | Small Cell Lung Cancer, SCLCUnited States, China
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Blueprint Medicines CorporationActive, not recruitingNeoplasms | Neoplasms by Histologic Type | Lung Diseases | Neoplasms by Site | Adenocarcinoma | Carcinoma | Carcinoma, Non-Small-Cell Lung | Lung Neoplasms | Respiratory Tract Neoplasms | Thoracic Neoplasms | Carcinoma, Bronchogenic | Bronchial Neoplasms | Neoplasms, Nerve Tissue | EGF-R Positive Non-Small Cell Lung... and other conditionsUnited States, Canada, Taiwan, Korea, Republic of, Singapore, Japan, United Kingdom, France, Netherlands, Spain
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Hideho Okada, MD, PhDNational Cancer Institute (NCI); California Institute for Regenerative Medicine...RecruitingGlioblastoma | Recurrent Glioblastoma | EGFR Gene Mutation | MGMT-Unmethylated GlioblastomaUnited States
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National Cancer Institute (NCI)Glaxosmithkline Biologicals S.A.TerminatedRenal Failure | Solid Neoplasm | BRAF Gene Mutation | Hepatic ComplicationUnited States, Canada
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Taiho Oncology, Inc.TerminatedAdvanced or Metastatic Solid Tumors Irrespective of Gene Alterations | Advanced or Metastatic Solid Tumors With Germline PTEN Inactivating MutationsUnited States, United Kingdom, Austria, France
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BiogenIonis Pharmaceuticals, Inc.Active, not recruitingALS Caused by Superoxide Dismutase 1 (SOD1) MutationUnited States, Canada, Italy, Belgium, New Zealand, Japan, France, Germany, United Kingdom
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Jill M KolesarNational Cancer Institute (NCI); NovartisRecruitingMetastatic Melanoma | BRAF Gene MutationUnited States
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University of WashingtonAbbVieNo longer availableTriple-Negative Breast Cancer | Metastatic Breast Cancer With BRCA 1 or BRCA 2 Genetic MutationUnited States
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M.D. Anderson Cancer CenterNational Cancer Institute (NCI)CompletedRecurrent Acute Myeloid Leukemia | Acute Myeloid Leukemia With FLT3/ITD Mutation | Refractory Acute LeukemiaUnited States
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National Cancer Institute (NCI)CompletedBRCA1 Gene Mutation | BRCA2 Gene Mutation | Recurrent Breast Carcinoma | Estrogen Receptor Negative | Estrogen Receptor Positive | HER2/Neu Negative | Progesterone Receptor Negative | Progesterone Receptor Positive | Triple-Negative Breast Carcinoma | Stage IV Breast Cancer AJCC v6 and v7 | Stage IIIB Breast... and other conditionsUnited States
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Ryan Mountjoy, MDMaineHealthRecruitingPain, Postoperative | AmputationUnited States
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GTxWithdrawnER+ and AR+ Breast CancerUnited States
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National Cancer Institute (NCI)Active, not recruitingMetastatic Melanoma | Stage III Cutaneous Melanoma AJCC v7 | Stage IV Cutaneous Melanoma AJCC v6 and v7 | Metastatic Malignant Solid Neoplasm | Stage IIIC Cutaneous Melanoma AJCC v7 | Unresectable Solid Neoplasm | BRAF V600E Mutation Present | BRAF V600K Mutation Present | Stage IIIA Cutaneous Melanoma... and other conditionsUnited States
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Children's Healthcare of AtlantaEmory University; Brigham and Women's Hospital; University of California, San... and other collaboratorsWithdrawnPentalogy of Cantrell | Mutations in Non-muscle GenesUnited States
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Memorial Sloan Kettering Cancer CenterAgios Pharmaceuticals, Inc.RecruitingChondrosarcoma | IDH1 Gene Mutation | Chondrosarcoma, Grade 2 | Chondrosarcoma, Grade 3United States
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Novartis PharmaceuticalsActive, not recruitingAdvanced Malignancies That Harbor IDHR132 MutationsBelgium, Germany, Spain, Canada, Australia, United States, Netherlands, Singapore
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M.D. Anderson Cancer CenterNational Cancer Institute (NCI)Active, not recruitingObesity | Overweight | Ductal Breast Carcinoma In Situ | Deleterious BRCA1 Gene Mutation | Deleterious BRCA2 Gene Mutation | Premalignant LesionUnited States
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Arog Pharmaceuticals, Inc.CompletedPhase II Study of Crenolanib in Subjects With Relapsed/Refractory AML With FLT3 Activating MutationsRelapsed or Refractory Acute Myeloid Leukemia With FLT3 Activating MutationsUnited States
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AstraZenecaCompletedCaucasian Patients With EGFR Mutation Positive Advanced NSCLCBulgaria, Italy, Poland, Spain, Turkey, United Kingdom, Romania, Norway, Hungary, Portugal, Greece, Switzerland, France
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AstraZenecaCompletedHER2-ve Metastatic Breast Cancer | Germline BRCA1/2 Mutations | Somatic BRCA1/2 MutationsItaly, Spain, Poland, Taiwan, Canada, France, Germany, Korea, Republic of, Hungary, Japan, Russian Federation, Turkey, United Kingdom, United States, Bulgaria
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State University of New York at BuffaloCompletedSupination-external Rotation Ankle FracturesUnited States
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Abramson Cancer Center at Penn MedicinePfizerActive, not recruitingNon-Small Cell Lung Cancer | KRAS Mutation-Related TumorsUnited States