Clinical Trials on Elevated LDL Cholesterol in Canada

Total 52 results

PepsiCo Global R&D
Glycemic Index Laboratories, Inc

Completed

Oat and Cholesterol

Elevated LDL Cholesterol

Canada
Unity Health Toronto

Unknown

Effect of Viscous Soluble Fibers on Serum Cholesterol Levels (CHOL-META)

LDL Cholesterol

Canada
Universidad de Granada
University of Copenhagen; University of Oxford; Harvard University; University... and other collaborators

Recruiting

Cardiovascular Risk Prevention With a Mediterranean Dietary Pattern Reduced in Saturated Fat (CADIMED)

LDL Cholesterol

Spain
Biosearch S.A.

Completed

Evaluation of a Probiotic on LDL-cholesterol Levels

Cardiovascular Diseases | LDL-cholesterol

Spain
Nordic Pharma, USA
Nutrasource Pharmaceutical and Nutraceutical Services, Inc.

Completed

Safety and Efficacy of a Natural Health Product in Reducing Cholesterol and Triglyceride Levels.

Triglycerides | LDL Cholesterol

Canada
Fonds de la Recherche en Santé du Québec
Université de Montréal

Completed

TRANSforming InTerprofessional Cardiovascular Prevention in Primary Care (TRANSIT)

Hypertension | Diabetes Mellitus, Type 2 | Dyslipidemias | Cholesterol, LDL | Comorbitdity

Canada
Laval University
Université de Montréal; Centre de Recheche du Centre Hospitalier Université...

Recruiting

Unravelling the Impact of Diet on Cardiovascular Health in Heterozygous Familial Hypercholesterolemia. (FH-Diet)

Cardiovascular Diseases | Familial Hypercholesterolemia | Cholesterol, Elevated | Nutrition, Healthy | Cholesterol; Metabolic Disorder

Canada
Laval University

Recruiting

Unravelling the Impact of Diet on Cardiovascular Health in Treated Heterozygous Familial Hypercholesterolemia.

Familial Hypercholesterolemia | Cholesterol, Elevated | Nutrition, Healthy

Canada
Ethical Naturals, Inc.
KGK Science Inc.

Completed

Pilot Study to Evaluate the Effect of ENI Patented Whole Grape Extract on Antioxidant Status

High Oxidation Stress | Oxidized LDL Level

Canada
University of Manitoba
The Association of Rehabilitation Medicine in Manitoba

Completed

Omega-3 Supplementation for Tetraplegics With Poor Cholesterol Levels

Spinal Cord Injury | Tetraplegia | Quadraplegia | Low HDL-c | High LDL-c

Canada
St. Boniface Hospital
Agriculture and Agri-Food Canada

Active, not recruiting

Flax Muffins and Cholesterol Lowering

Above Optimal Plasma LDL Concentrations

Canada
Ionis Pharmaceuticals, Inc.
Akcea Therapeutics

Completed

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of IONIS APO(a)-LRx in Healthy Volunteers With Elevated Lipoprotein(a)

Elevated Lipoprotein(a)

Canada
Alexion

Recruiting

Lysosomal Acid Lipase (LAL) Deficiency Registry (ALX-LALD-501)

Wolman Disease | Cholesterol Ester Storage Disease | Lysosomal Acid Lipase Deficiency | Acid Cholesteryl Ester Hydrolase Deficiency, Type 2 | Acid Lipase Deficiency | LIPA Deficiency | LAL-Deficiency

France, Belgium, United States, Spain, Germany, Greece, Israel, Italy, Slovenia, United Kingdom, Brazil, Canada, Denmark, Australia, Croatia, Czechia, Ireland, Mexico, Netherlands, Poland, Portugal, Saudi Arabia
Ionis Pharmaceuticals, Inc.
Akcea Therapeutics

Completed

Safety, Tolerability, PK, and Pharmacodynamics(PD) of IONIS APOCIII-LRx in Healthy Volunteers With Elevated Triglycerides

Elevated Triglycerides (TG)

Canada
Alexion Pharmaceuticals

Completed

Extension Study to Evaluate the Long-Term Safety, Tolerability, and Efficacy of SBC-102 (Sebelipase Alfa) in Adult Subjects With Lysosomal Acid Lipase Deficiency

Lysosomal Acid Lipase Deficiency | LAL-Deficiency | Cholesterol Ester Storage Disease (CESD)

France, United Kingdom, United States, Canada, Czechia
Akcea Therapeutics

Completed

Drug-drug Interaction Study to Evaluate the Effect of ISIS 681257 on Warfarin

Cardiovascular Diseases | Elevated Lipoprotein(a)

Canada
Akcea Therapeutics

Completed

Drug-drug Interaction Study to Evaluate the Effect of ISIS 681257 on Clopidogrel

Cardiovascular Diseases | Elevated Lipoprotein(a)

Canada
University Health Network, Toronto

Completed

Optic Nerve Sheath Diameter in Patients With Intracranial Pathology

Elevated Intracranial Pressure (ICP)

Canada
Lashmi Venkatraghavan
University Health Network, Toronto

Completed

Optic Nerve Sheath Diameter (ONSD) With the Raised PCO2 and Internal Jugular Venous Occlusion

Elevated Intracranial Pressure (ICP)

Canada
The Medicines Company

Completed

Inclisiran for Participants With Atherosclerotic Cardiovascular Disease and Elevated Low-density Lipoprotein Cholesterol (ORION-10)

Elevated Cholesterol | ASCVD

United States
Ionis Pharmaceuticals, Inc.

Completed

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ISIS-APO(a)Rx in Participants With High Lipoprotein(a)

Elevated Lipoprotein(a)

Netherlands, United Kingdom, Denmark, Germany, Canada
The Medicines Company

Completed

Trial to Evaluate the Effect of Inclisiran Treatment on Low Density Lipoprotein Cholesterol (LDL-C) in Subjects With Heterozygous Familial Hypercholesterolemia (HeFH) (ORION-9)

Elevated Cholesterol | Heterozygous Familial Hypercholesterolemia

United States, Canada, Czechia, Denmark, Netherlands, South Africa, Spain, Sweden
University of Manitoba
Agriculture and Agri-Food Canada

Completed

Effect of Oat Beta Glucan in Managing Blood Pressure

Elevated Blood Pressure

Canada
Nova Scotia Health Authority

Terminated

FOT Assessment of Hemi-diaphragm Dysfunction After Upper Extremity Nerve Blocks

Paresis | Diaphragm Elevated

Canada
BIO-CAT Microbials, LLC
KGK Science Inc.

Completed

A Study to Evaluate the Effect of GFA-918 on Serum Triglyceride Levels in Individuals With Elevated Serum Triglyceride

Elevated Triglycerides

Canada
Novartis Pharmaceuticals

Completed

Trial to Assess the Effect of Long Term Dosing of Inclisiran in Subjects With High CV Risk and Elevated LDL-C (ORION-8)

Elevated Cholesterol | Homozygous Familial Hypercholesterolemia | Heterozygous Familial Hypercholesterolemia | ASCVD

United States, Canada, Czechia, Denmark, Germany, Hungary, Netherlands, Poland, South Africa, Spain, Sweden, Ukraine, United Kingdom
University of British Columbia
Heart and Stroke Foundation of Canada

Active, not recruiting

Power of Choice on Autonomy, Motivation, Exercise Adherence, and Cardiorespiratory Fitness

Elevated Blood Sugar

Canada
University Health Network, Toronto

Completed

Functional and Morphologic MRI in the Detection of Prostate Cancer in Patients With Prior Negative Biopsy

Prostate Cancer | Elevated PSA

Canada
Novo Nordisk A/S

Completed

A Research Study Looking at New Protein-based Tablets in Healthy Male Participants

Type 2 Diabetes | Healthy Volunteers | High Blood Cholesterol Levels

Germany, Canada
Almond Board of California
KGK Science Inc.

Completed

Investigating the Dose Response of an Almond-enriched Diet on Optimizing HDL-C in a Population With Hypercholesterolemia

Hypercholesterolemia | HDL-C

Canada
University of Toronto

Unknown

Meta-analysis of the Portfolio Dietary Pattern and Cardiometabolic Risk

Cardiovascular Risk Factor | Cholesterol; Lipidosis

Canada
University of Alberta
Canadian VIGOUR Centre

Completed

Providing Rapid Out of Hospital Acute Cardiovascular Treatment (PROACT) (PROACT)

NSTEMI

Canada
Northern Ontario School of Medicine

Recruiting

Complete Lifestyle Medicine Intervention Program (CLIP)

Heart Diseases | Hypertension | Obesity | Diabetes | High Cholesterol

Canada
University of Malaya
University of Muhammadiyah Aceh

Completed

Intermittent Fasting Towards Elevated Blood Pressure

Elevated Blood Pressure | Intermittent Fasting

Indonesia
Galderma R&D

Completed

Treatment of Moderate to Severe Lateral Canthal Lines and Glabellar Lines Alone or in Combination (READY-3)

Glabellar Frown Lines (GL) | Lateral Canthal Lines (LCL)

United States, Canada
Duke University
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Using Allopurinol to Relieve Symptoms in Patients With Heart Failure and High Uric Acid Levels (EXACT-HF)

Heart Failure | Elevated Serum Uric Acid

United States, Canada
Alexion Pharmaceuticals

Completed

An Observational Study of Patients With Lysosomal Acid Lipase Deficiency/Cholesteryl Ester Storage Disease Phenotype

Lysosomal Acid Lipase Deficiency | Cholesterol Ester Storage Disease(CESD)

United States, United Kingdom, France, Canada, Czech Republic, Italy, Poland, Switzerland
Victar Hsieh

Unknown

Study of Coronary Plaque Rupture in Heart Attack Following Surgery Using Optical Coherence Tomography (OCT) (OPTIMUS)

Non-ST Elevation Myocardial Infarction | Peri-operative Myocardial Infarction

Canada
Population Health Research Institute
Canadian Institutes of Health Research (CIHR); Boston Scientific Corporation

Active, not recruiting

Colchicine and Spironolactone in Patients With MI / SYNERGY Stent Registry (CLEAR SYNERGY)

ST Elevation Myocardial Infarction | Non ST Elevation Myocardial Infarction

Canada
AstraZeneca

Terminated

JUPITER - Crestor 20mg Versus Placebo in Prevention of Cardiovascular (CV) Events

Elevated High-sensitivity C-Reactive Protein (hsCRP)

United States, Brazil, Bulgaria, Poland, Russian Federation, South Africa, United Kingdom, Germany, Estonia, Romania, Denmark, Netherlands, Norway, Canada, Mexico, Belgium, Israel, Puerto Rico, Colombia, Argentina, Venezuela, Panama, Urugu... and more
Ottawa Heart Institute Research Corporation

Completed

Risk Stratification of Non ST Elevation ACS With Computed Tomographic Angiography (REACT)

Acute Coronary Syndrome | Unstable Angina | Non-ST-Elevation Myocardial Infarction

Canada
Akcea Therapeutics
Ionis Pharmaceuticals, Inc.

Completed

Phase 2 Study of ISIS 681257 (AKCEA-APO(a)-LRx) in Participants With Hyperlipoproteinemia(a) and Cardiovascular Disease

Cardiovascular Disease | Elevated Lipoprotein(a)

United States, Canada, Denmark, Germany, Netherlands
University of Saskatchewan
Canadian VIGOUR Centre

Recruiting

Beta Blocker De-prescription Following Coronary Artery Bypass Graft Surgery (BEEFBURGER Trial). (BEEFBURGER)

Coronary Artery Disease | ST Elevation Myocardial Infarction | Acute Myocardial Infarction | Coronary Artery Stenosis | Non-ST Elevation Myocardial Infarction (NSTEMI)

Canada
University of British Columbia
Vancouver Coastal Health Research Institute; Genome British Columbia

Recruiting

Advancing Cardiac Care Unit-based Rapid Assessment and Treatment of hypErcholesterolemia (ACCURATE)

Acute Coronary Syndrome | Familial Hypercholesterolemia | STEMI | NSTEMI - Non-ST Segment Elevation MI | Familial Hypercholesterolemia - Heterozygous | Familial Hypercholesterolemia Due to Genetic Defect of Apolipoprotein B | Familial Hypercholesterolemia Due to Heterozygous LDL Receptor Mutation and other conditions

Canada
UniQure Biopharma B.V.
Chiesi Farmaceutici S.p.A.

Withdrawn

Alipogene Tiparvovec for the Treatment of LPLD Patients

LPL Deficiency

Canada, United States
University of Toronto

Unknown

Umbrella Review of the DASH Dietary Pattern and Cardiometabolic Risk

Cardiovascular Diseases | Stroke | Inflammation | Diabetes | Blood Pressure | Coronary Heart Disease | Adiposity | Cardiovascular Risk Factor | Cholesterol; Lipidosis

Canada
Alexion

Completed

A Retrospective Natural History Study of Patients With Lysosomal Acid Lipase Deficiency/Wolman Phenotype

Wolman Disease | Lysosomal Acid Lipase Deficiency

United States, Canada, United Kingdom, Italy, France
Eli Lilly and Company

Recruiting

A Study to Investigate the Effect of Lepodisiran on the Reduction of Major Adverse Cardiovascular Events in Adults With Elevated Lipoprotein(a) - ACCLAIM-Lp(a)

Elevated Lp(a) | Atherosclerotic Cardiovascular Disease (ASCVD)

Taiwan, United States, Spain, Argentina, China, Italy, Australia, France, Canada, Japan, Belgium, Denmark, Germany, Hungary, Israel, Austria, Korea, Republic of, Brazil, Mexico, Netherlands, Romania, United Kingdom, Greece, Czechia, India, Slovak... and more
Alexion Pharmaceuticals

Completed

Safety and Efficacy Study of Sebelipase Alfa in Participants With Lysosomal Acid Lipase Deficiency

Lysosomal Acid Lipase Deficiency

Spain, Germany, Italy, United States, Croatia, Canada, Russian Federation, Denmark, United Kingdom, Belgium, Mexico, Australia, Netherlands, Brazil, Turkey
NewAmsterdam Pharma

Active, not recruiting

Evaluate the Effect of Obicetrapib in Patients With HeFH on Top of Maximum Tolerated Lipid-Modifying Therapies. (BROOKLYN)

Dyslipidemias | Hypercholesterolemia | Hyperlipoproteinemias | Lipid Metabolism, Inborn Errors | Familial Hypercholesterolemia | Metabolic Disease | High Cholesterol | Genetic Disease, Inborn | Lipid Metabolism Disorder

United States, Canada, Czechia, Georgia, Netherlands, Norway, Poland, South Africa, Spain, United Kingdom

Clinical Trials on Elevated LDL Cholesterol in Canada

Sponsors and Collaborators

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CROs in Thailand

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