Clinical Trials on Endocarditis, Subacute Bacterial in South Africa

Total 1183 results

Centers for Disease Control and Prevention
Tuberculosis Trials Consortium

Recruiting

Short-course Regimens for the Treatment of Pulmonary Tuberculosis (CRUSH-TB)

Tuberculosis, Pulmonary | Tuberculosis Infection

Canada, United States, Haiti, South Africa, Uganda, Vietnam
Global Alliance for TB Drug Development

Completed

Trial to Evaluate the Efficacy, Safety and Tolerability of BPaMZ in Drug-Sensitive (DS-TB) Adult Patients and Drug-Resistant (DR-TB) Adult Patients

Tuberculosis | Tuberculosis, Pulmonary | Tuberculosis, Multidrug-Resistant | Tuberculosis, MDR | Drug-Resistant Tuberculosis

Tanzania, Georgia, Russian Federation, Brazil, Malaysia, Philippines, South Africa, Uganda
KNCV Tuberculosis Foundation
Kenya Medical Research Institute; Kenya National AIDS & STI Control Programme; Centres for Disease Control and Prevention, Kenya... and other collaborators

Completed

Feasibility and Effectiveness of Community Based Isoniazid Preventive Therapy in Kenya (IPT)

Tuberculosis

Kenya
AIDS Clinical Trials Group
National Institute of Allergy and Infectious Diseases (NIAID)

Completed

Immediate Versus Deferred Start of Anti-HIV Therapy in HIV-Infected Adults Being Treated for Tuberculosis (STRIDE)

HIV Infection | Tuberculosis

United States, Peru, Kenya, Malawi, Uganda, Brazil, South Africa, Zimbabwe, India, Thailand, Botswana, Haiti, Zambia
GlaxoSmithKline

Active, not recruiting

Safety and Efficacy of GSK Neisseria Gonorrhoeae GMMA (NgG) Investigational Vaccine When Administered to Healthy Adults 18 to 50 Years of Age.

Sexually Transmitted Diseases

United States, Germany, Philippines, France, Spain, South Africa, United Kingdom, Brazil
University of Adelaide

Completed

The Long-term Impact of Invasive Meningococcal Disease in Australian Adolescents and Young Adults (AMEND)

Meningococcal Infections | Neisseria Infection | Neisseria Meningitis Sepsis

Australia
GlaxoSmithKline

Active, not recruiting

A Study on the Safety, Tolerability and Immune Response of Meningococcal Combined ABCWY Vaccine in Healthy Infants

Infections, Meningococcal

Finland, Poland, Spain, United Kingdom, Germany, South Africa, Dominican Republic, Israel, Honduras
Emergent BioSolutions

Completed

Immunogenicity, Safety and Tolerability of the Typhoid Fever Vaccine Candidate M01ZH09 in Healthy Adults

Typhoid

United States
Chantal Kats

Recruiting

External Validation of the Beta-lactam Target Non-attainment (BATMAN) Risk Score in Adult ICU Patients: a Diagnostic Multivariate Predictive Risk Model (BATMAN)

Infection, Bacterial | Beta-lactam Antibiotics | Critical Care | Risk Model | Therapeutic Drug Monitoring

Netherlands
Centers for Disease Control and Prevention
Bayer; Global Alliance for TB Drug Development

Completed

TBTC Study 28: Moxifloxacin Versus Isoniazid for TB Treatment

Tuberculosis

Uganda, United States, South Africa, Canada, Brazil, Spain
Medecins Sans Frontieres, Spain
Ministry of Health, Guinea-Bissau; Institute of Tropical Medicine, University... and other collaborators

Completed

Evaluation of Xpert MTB/RIF Ultra in Stools and Urine to Improve Tuberculosis Diagnosis in Children

Tuberculosis | Pediatric Infectious Disease

Guinea-Bissau, South Sudan
Yunia Irawati

Completed

Modified Tarsorrhaphy vs Gold Weight Implant for Paralytic Lagophthalmos in Leprosy Patients

Paralytic Lagophthalmos | Leprosy--Patients

Indonesia
Scynexis, Inc.

Completed

Study to Evaluate the Safety and Efficacy of the Coadministration of Ibrexafungerp (SCY-078) With Voriconazole in Patients With Invasive Pulmonary Aspergillosis (SCYNERGIA)

Invasive Pulmonary Aspergillosis

United States, Belgium, Canada, Germany, South Africa
BioMérieux

Completed

Performance Evaluation of the VIDAS TB-IGRA Assay.

Active Tuberculosis | Latent Tuberculosis Infection | Non-Tuberculous Mycobacterial (NTM) Pneumonia

United States, France, United Kingdom, India, Brazil, Georgia, Italy, Mexico, South Africa
Merck Sharp & Dohme LLC

Completed

Safety and Immunogenicity of V114 in Children Infected With Human Immunodeficiency Virus (HIV) (V114-030/PNEU-WAY PED) (PNEU-WAY PED)

Pneumococcal Infections

South Africa, Thailand, Ukraine
Scynexis, Inc.

Completed

Open-Label Study to Evaluate the Efficacy and Safety of Oral Ibrexafungerp (SCY-078) in Patients With Candidiasis Caused by Candida Auris (CARES) (CARES)

Candidemia | Candidiasis, Invasive

Pakistan, India, United States, South Africa
Biomedical Advanced Research and Development Authority
Rho, Inc.

Completed

BARDA Securing Anthrax Immunity For the Elderly (B-SAFE)

Anthrax

United States
Murdoch Childrens Research Institute
University of Otago; Sydney Children's Hospitals Network; Royal Children's Hospital and other collaborators

Completed

Improving Dosing of Vancomycin in Young Infants With Infections (VANCAPP)

Sepsis | Bacteremia | Infection

Australia
Murdoch Childrens Research Institute
Royal Children's Hospital; Royal Hospital For Women

Completed

RCT of Continuous Versus Intermittent Infusion of Vancomycin in Neonates

Sepsis | Bacteremia | Infection

Australia
Pfizer

Completed

Evaluation of a 3-dose Vaccination Regimen With One of Three Ascending Dose Levels of Clostridium Difficile Vaccine With or Without Adjuvant in Healthy Adults Aged 50 to 85 Years

Clostridium Difficile Associated Disease

United States
Emergent BioSolutions
National Institute of Allergy and Infectious Diseases (NIAID)

Completed

A Phase 2 Safety and Immunogenicity Study for an Anthrax Vaccine Using 3 Schedules and Two Dose Levels

Anthrax

United States
Bill & Melinda Gates Medical Research Institute
Bill and Melinda Gates Foundation; Wellcome Trust

Recruiting

Study to Assess Efficacy and Safety of M72/AS01E-4 Mycobacterium Tuberculosis (Mtb) Vaccine in Adolescents and Adults

Tuberculosis

Indonesia, Kenya, Malawi, Mozambique, South Africa, Vietnam, Zambia
Emergent BioSolutions
Department of Health and Human Services

Completed

Immunogenicity and Safety Study of a Three-Dose BioThrax® Regimen for Post-Exposure Prophylaxis in Healthy Adults

Anthrax

United States
Pfizer

Completed

Trial to Evaluate the Safety and Immunogenicity of a Multivalent Pneumococcal Vaccine in Healthy Infants

Pneumococcal Infections

United States
Merck Sharp & Dohme LLC

Completed

Safety and Immunogenicity of V116 in Adults Living With Human Immunodeficiency Virus (HIV) (V116-007, STRIDE-7)

Pneumococcal Disease

United States, Belgium, Chile, France, South Africa, Thailand
Bristol-Myers Squibb

Active, not recruiting

A Study to Evaluate Efficacy and Safety of Deucravacitinib in Participants With Active Discoid and/or Subacute Cutaneous Lupus Erythematosus (DLE/SCLE)

Lupus Erythematosus, Discoid | Lupus Erythematosus, Subacute Cutaneous

Mexico, Argentina, Australia, United States, France, Germany, Poland, Taiwan
Centers for Disease Control and Prevention

Completed

TBTC Study 27: Moxifloxacin vs Ethambutol for TB Treatment

Tuberculosis, Pulmonary

Uganda, United States, Canada, South Africa
Pfizer

Completed

Evaluation of a Single Vaccination of One of Three Ascending Dose Levels of a 4-Antigen Staphylococcus Aureus Vaccine (SA4Ag) and a Single Dose Level of a 3-Antigen Staphylococcus Aureus Vaccine (SA3Ag) in Healthy Adults Aged 65 to <86 Years

Staphylococcal Infections

United States
GlaxoSmithKline

Completed

Immunogenicity & Reactogenicity of Boostrix 10 Years After Previous Booster Vaccination in Study NCT01267058

Tetanus | Diphtheria | Acellular Pertussis | Diphtheria-Tetanus-acellular Pertussis Vaccines

Australia
Hasanuddin University
Chulalongkorn University

Completed

Artificial Inteligent for Diagnosing Drug-Resistant Tuberculosis

Resistance to Tuberculostatic Drugs | MDR Tuberculosis

Indonesia
Sanofi Pasteur, a Sanofi Company

Completed

Study to Evaluate the Immune Response After a Booster Dose of a Quadrivalent Meningococcal (MenACYW) Conjugate Vaccine When Administered Alone or Concomitantly With a Licensed Meningococcal Serogroup B Vaccine, in Participants Who Received Primary Quadrivalent Meningococcal Conjugate Vaccine (MCV4)

Meningococcal Immunisation (Healthy Volunteers)

United States, Puerto Rico
Emergent BioSolutions

Completed

A Phase 1 Ascending Dose Study to Assess the Safety and Immunogenicity of Adenovirus Anthrax Vector Candidate Vaccines

Anthrax Infection

United States
Global Alliance for TB Drug Development
Sanofi; University College, London; European and Developing Countries Clinical... and other collaborators

Completed

Controlled Comparison of Two Moxifloxacin Containing Treatment Shortening Regimens in Pulmonary Tuberculosis (REMoxTB)

Pulmonary Tuberculosis

China, Zambia, Tanzania, India, Kenya, Malaysia, Mexico, South Africa, Thailand
Kirby Institute
Monash University; South Australian Health and Medical Research Institute

Active, not recruiting

Impact of the Daily Doxycycline Pre-exposure Prophylaxis (PrEP) on the Incidence of Syphilis, Gonorrhoea and Chlamydia (Syphilaxis)

STIs Prevention

Australia
Instituto de Atención Pediátrica
Pfizer; Ben-Gurion University of the Negev

Suspended

Costa Rica Epidemiological Study on S. Pneumoniae

Streptococcus Pneumoniae

Costa Rica
GlaxoSmithKline

Completed

Topical SB-275833 Ointment, 1% For The Treatment Of Impetigo

Skin Infections, Bacterial

Netherlands, Costa Rica, Germany, Mexico, Canada, India, Poland, South Africa, France, Peru
PharmAthene UK Limited
National Institute of Allergy and Infectious Diseases (NIAID)

Completed

Safety, Tolerability and Immunogenicity of Recombinant Anthrax Vaccine Compared With Anthrax Vaccine Adsorbed

Bacillus Anthracis (Anthrax)

United States
National Institute of Allergy and Infectious Diseases...
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Recruiting

Pharmacokinetic Properties of Antiretroviral and Anti-Tuberculosis Drugs During Pregnancy and Postpartum

HIV Infections | Tuberculosis

United States, Malawi, Puerto Rico, South Africa, Thailand, Zimbabwe, Brazil, Kenya, Uganda, India, Tanzania, Botswana
Melinta Therapeutics, Inc.
National Institute of Allergy and Infectious Diseases (NIAID)

Completed

Efficacy and Safety Study of Oral Solithromycin Compared to Intramuscular Ceftriaxone Plus Oral Azithromycin in the Treatment of Patients With Gonorrhea (SOLITAIRE-U)

Uncomplicated Urogenital Gonorrhea

United States, Australia
Kirby Institute
Griffith University

Active, not recruiting

Efficacy Study of 4CMenB (Bexsero®) to Prevent Gonorrhoea Infection in Gay and Bisexual Men (GoGoVax)

Neisseria Gonorrheae Infection

Australia
Medical University of South Carolina
Oregon Health and Science University; Cystic Fibrosis Foundation

Completed

A Proof of Concept Study of Inhaled Nitric Oxide for Adults With Pulmonary Non-Tuberculous Mycobacterial Infection

Nontuberculous Mycobacterium Infection

United States
GlaxoSmithKline

Completed

Retapamulin Versus Placebo in Secondarily-Infected Traumatic Lesions (SITL)

Skin Infections, Bacterial

United States, South Africa, India, Argentina, Brazil
Melinta Therapeutics, Inc.

Completed

Efficacy and Safety Study of Oral Solithromycin (CEM-101) Compared to Oral Moxifloxacin in Treatment of Patients With Community-Acquired Bacterial Pneumonia (SOLITAIRE-ORAL)

Community-acquired Bacterial Pneumonia

Spain, United States, Hungary, Canada, Estonia, Russian Federation, Argentina, Bulgaria, Czech Republic, Dominican Republic, Ecuador, Germany, Latvia, Poland, Puerto Rico, Romania, South Africa
Wyeth is now a wholly owned subsidiary of Pfizer

Completed

Study Evaluating the Pharmacokinetics (PK), Safety, and Tolerability of Tigecycline in Patients 8 to 11 Years of Age

Bacterial Infections | Skin Diseases, Infectious | Skin Diseases, Bacterial | Pneumonia, Bacterial | Intra-Abdominal Infection

Taiwan, United States, South Africa, Belgium, Mexico, Ukraine
Novo Nordisk A/S

Completed

An International Chart Review and Survey for the Prevalence and Clinical Management of Atherosclerotic Cardiovascular Diseases in Patients With Type 2 Diabetes Across Countries in the Middle East and Africa (PACT-MEA)

Diabetes Mellitus, Type 2

Bahrain, Egypt, Jordan, Kuwait, Qatar, South Africa, United Arab Emirates
GlaxoSmithKline

Completed

A Study to Investigate the Safety and Immunogenicity of Different Formulations of GSK Biologicals' Meningococcal ACWY Conjugate Vaccine (GSK3536820A and Menveo) Administered to Healthy Adolescents and Young Adults 10 to 40 Years of Age

Meningitis, Meningococcal

Spain, Finland, Estonia, South Africa, Brazil, Mexico, Russian Federation, France, Turkey
Bayside Health
National Health and Medical Research Council, Australia

Completed

A Multicentre Randomised Controlled Trial Comparing Two Strategies for the Diagnosis of Invasive Aspergillosis in High-risk Haematology Patients

Invasive Aspergillosis

Australia
MicroPhage, Inc.

Terminated

Study of the Performance of the KeyPath MRSA/MSSA Blood Culture Test - BTA

Bacteremia

United States
Shire

Completed

Treatment of Bacterial Conjunctivitis With SHP640 Compared to PVP-Iodine and Placebo

Bacterial Conjunctivitis

United States, Australia, Austria, Israel, Poland, Hungary, South Africa, Canada, Estonia, France, Italy, Spain, Puerto Rico
Menzies School of Health Research
The University of Queensland; Australasian Society for Infectious Diseases; Singapore... and other collaborators

Terminated

Combination Antibiotic Therapy for Methicillin Resistant Staphylococcus Aureus Infection (CAMERA2)

Methicillin-Resistant Staphylococcus Aureus

Australia, New Zealand, Israel, Singapore

Clinical Trials on Endocarditis, Subacute Bacterial in South Africa

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in South Africa

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations